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tandem duplication     
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  串联重复
     AIM: To explore the relationship of FLT3/internal tandem duplication (ITD) mutation and chromosome translocation with acute myeloid leukaemia (AML) prognosis.
     目的:探讨FLT3跨膜区内部串联重复(FLT3/internal tandem duplication,FLT3/ITD)突变和染色体易位与急性髓性白血病预后的关系。
短句来源
     Results Among AML patients, FLT3-TKD point mutation (FLT3-TKD~ +) rate was 6.3%(9/143), an incidence significantly lower than that of internal tandem duplication (ITD) mutation (37/143, 25.9%, P<0.01).
     结果143例AML患者中9例(6.3%)存在FLT3TKD点突变(FLT3TKD+),阳性率显著低于FLT3基因内部串联重复(ITD)突变(25.9%,P<0.01)。
短句来源
     Objective To evaluate the prevalence of FLT3 gene mutation-internal tandem duplication (FLT3/ITD) in patients with acute myeloid leukemia (AML) and its clinical significance.
     目的研究FLT3基因内部串联重复(internal tandemduplication,ITD)突变与急性髓细胞性白血病(AML)的关系及临床意义。
短句来源
     Tandem duplication on chromosome 17p11.2, encompassing the PMP22 gene is the main mutation type of CMT1A.
     17p 11 2区包含PMP 2 2基因在内的 1 5Mb(偶尔 <1 5Mb)的正向串联重复突变是CMT 1A最主要的突变型。
短句来源
     Analysis on Flt_3 internal tandem duplication mutation in malignant hematopoietic diseases
     恶性血液病Flt_3基因内部串联重复突变分析
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  串联复制
     The genome and tandem duplication has contributed to the neofunctionalization and formation of new rice subclasses, but the mechanism of diploidization and limited tandem duplication have contributed to fewer LBD genes in rice than in Arabidopsis.
     相比拟南芥LBD基因家族,基因组复制和串联复制导致了LBD基因在水稻中产生新功能,从而形成新的亚类,但是二倍体化机制和较少的串联复制导致了相比拟南芥,水稻中LBD基因的数量反而减少了。
短句来源
  “tandem duplication”译为未确定词的双语例句
     Prevalence of FLT3 gene internal tandem duplication mutation in acute myeloid leukemia and its clinical significance
     FLT3基因突变与急性髓细胞性白血病的关系及临床意义
短句来源
     Objective To investigate Flt 3 tandem duplication mutation (ITD) and its distribution in different malignant hematopoietic diseases.
     目的 :研究 Flt3- ITD在恶性血液病中的突变及分布情况。
短句来源
     Results Among the leukemia and lymphomas, we identified 14 samples harboring various MLL rearrangements, including 5 of MLL/AF6, 7 of MLL partial tandem duplication (PTD) and 1 of MLL/AF10. We also detected 1 of MLL/AF4 among 11 MDS,All of AML with MLL/AF6 fusion gene were M5 with classic monoblastic characters: large blast cells with delicate, lacy chromatin, presenting one to two large prominent nucleoli.
     结果患者中发现MLL基因异常者14例,其中有MLL/AF6融合基因者5例,骨髓细胞形态学均为FABM5型,具有典型的原始单核细胞白血病的特征在光镜下均表现为细胞体积大,染色质疏松,细胞核折叠,有1~2个大而清晰的核仁,胞质嗜碱性呈毛玻璃样。
短句来源
     MLL rearrangements consisting of MLL/AF6 (1 case), MLL/AF9 (1 case), MLL/AF17 (2 cases), MLL/ELL (2 cases) and MLL partial tandem duplication(2 cases) were detected in 8 cases by RT-multiplex nested PCR.
     多重PCR证实了7例核型分析显示11q23易位标本中的6例,例3核型分析揭示46,XX,t(6;11)(q27;q23),多重PCR检测MLL/AF6为阴性;
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  tandem duplication
A common evolutionary precursor of their genes arose via a tandem duplication.
      
In this work, an extended tandem duplication in the deooperon of E.
      
A heterozygous tandem duplication in the Escherichia coli deo operon region deoA??deoB::Tn5/ deoC??deoD??thr::Tn9 with the total length approximately 150 kb, which was obtained in the conjugational mating in the HfrH strain, was examined.
      
A 400-kb tandem duplication within the dystrophin gene leads to severe Becker muscular dystrophy
      
Sequence analysis of the regulatory regions of erm genes revealed that mutation type of ermB was just point mutation, by contraries the mutation type of ermA was either deletion or tandem duplication.
      
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This thesis describes the process and results of transformaing Phanerochaete chrysosporium to G418 resistance. On the bases of results from determination of sensitivity of Phanerochaete chrysosporium to G418 and Hygromycin B, Phanerochaete chrysosporium BKM F1767 using protoplast protocol was tansformed with linearized plasmids containing fused kanamycin resistance gene, whose promoters were isolated from Phanerochaete chrysosporium genome...

This thesis describes the process and results of transformaing Phanerochaete chrysosporium to G418 resistance. On the bases of results from determination of sensitivity of Phanerochaete chrysosporium to G418 and Hygromycin B, Phanerochaete chrysosporium BKM F1767 using protoplast protocol was tansformed with linearized plasmids containing fused kanamycin resistance gene, whose promoters were isolated from Phanerochaete chrysosporium genome in E.coli with promoter probe vectors. Sixteen G418 resistant transformants were successfully obtained at the concentration of 200×10 -6 g/mL G418. After the measurement of the G418 resistant level of each transformant and analysis of their mitotic stability, both Southern hybridization and PCR method were used to identify the exsistance of gene promoter sequence in these fused Kanr genes in the genome of G418r transformants. The results showed that all fused kanr genes were integrated into the chromosome of Phanerochaete chrysosporium in a single or a tandem duplication pattern, indicating that these fused G418r genes can be used as domiant selectable markers for the transformation system of Phanerochaete chrysosporium. These results can also be as a critical evidence for the biological function of gene promoters isolated directly in Escherichia coli from Phanerochaete chrysosporium by using promoter probe vectors. Both plasmids pAN7 1 and pCSN43 containing hybridized hygromycin B resistant gene, whose promoters were from other fungi , could not transform Phanerochaete chrysosporium into hygromycin resistant.

作者描述了黄孢原毛平革菌抗性转化的经过和结果 .在测定黄孢原毛平革菌对G4 18和潮霉素的敏感性的基础上 ,将在实验室已经分离到的由黄孢原毛平革菌基因启动子所构建成的融合卡那霉素抗性基因质粒切为线状 ,用原生质体转化法将其转化黄孢原毛平革菌 ,用浓度为 2 0 0 μg/mL的G4 18成功地筛选到 16个G4 18r 转化子 .在测定了这些G4 18r 转化子的抗性水平和稳定性的基础上 ,用PCR扩增G4 18r 转化子中融合卡那霉素抗性基因启动子片段和Southern杂交两种方法 ,对G4 18r 转化子进行分析和鉴定 .结果表明 :融合卡那霉素抗性基因以单个或串状重复的形式整合入黄孢原毛平革菌基因组中 .G4 18r 转化子的确定不仅可为建立黄孢原毛平革菌的转化系统提供选择标记基因 ,而且证明所分离的基因启动子在黄孢原毛平革菌中的功能 ,同时还证明了以Escherichiacoli为宿主菌 ,直接用基因启动子探针型载体分离真核生物的基因启动子是完全可行的 .实验结果还表明 ,由异源基因启动子构建的融合潮霉素抗性基因质粒 pAN7 1和 pCSN4 3不能转化黄孢原毛平革菌 .

Objectives To study the FLT3 gene expression and its internal tandem duplication(ITD) mutation in acute nonlymphoblastic leukemia(ANLL) patients.Method Polymerase chain reaction was used to detect the FLT3/ITD mutation in 71 ANLL patients.Results The expression of FLT3 gene were detected in 65/71(91 5%) ANLL cases and ITD mutation was found in 17 cases. 23 9% of ANLL cases were found with FLT3/ITD mutation. The leucocyte count and the percentage of bone marrow blast cells were higher in ANLL patient...

Objectives To study the FLT3 gene expression and its internal tandem duplication(ITD) mutation in acute nonlymphoblastic leukemia(ANLL) patients.Method Polymerase chain reaction was used to detect the FLT3/ITD mutation in 71 ANLL patients.Results The expression of FLT3 gene were detected in 65/71(91 5%) ANLL cases and ITD mutation was found in 17 cases. 23 9% of ANLL cases were found with FLT3/ITD mutation. The leucocyte count and the percentage of bone marrow blast cells were higher in ANLL patient with FLT3/ITD mutation than that in the ANLL patient without FLT3/ITD mutation (P<0 01 and P<0 05). The relapse rate within one year were higher in those ANLL patients with FLT3/ITD mutation than that in the ANLL patient without FLT3/ITD mutation (P<0 05). Conclusions FLT3/ITD can be used as a gene marker to detect minimal residual disease in partly ANLL patients. ANLL patients with FLT3/ITD mutation were associated with leukocytosis, a high percentage of bone marrow blast cells and increased relapse risk. It shows that FLT3/ITD mutation in ANLL define poor prognosis.

目的 探讨急性非淋巴细胞白血病 (ANLL)患者FLT3基因及内部串联重复 (ITD)突变及临床意义。方法 采用聚合酶链反应 (PCR )方法扩增 71例ANLL患者FLT3 /ITD基因突变。结果  71例ANLL患者中有 65例 ( 91 5% )FLT3基因检测阳性 ,其中有 17例出现FLT3 /ITD基因突变 ,71例ANLL患者FLT3 /ITD基因突变阳性率为 2 3 9%。FLT3 /ITD基因突变阳性ANLL患者外周血白细胞计数及骨髓白血病细胞比例显著高于FLT3 /ITD基因突变阴性ANLL患者 (P <0 0 1和P <0 0 5)。FLT3 /ITD基因突变阳性ANLLCR后 1年内复发率显著高于FLT3 /ITD基因突变阴性组(P <0 0 5)。结论 FLT3 /ITD基因突变可作为部分ANLL患者微小残留病检测的新的基因标记 ;FLT3 /ITD基因突变阳性ANLL常伴外周血高白细胞数、骨髓中高白血病细胞比例及明显增高的复发率 ,FLT3 /ITD基因突变阳性ANLL预后较差

Objective To study the clinical, neuro-electrophysiology features of Charcot-Marie-Tooth disease type 1A (CMT1A) and its gene mutation analysis.Methods 9 members of the family with CMT1A underwent detailed clinical examinations and gene mutation analysis was carried out in 7 of them. The probands accepted electromyography and nerve, muscle biopsy.Results Five patients of the family were attacked and consistent with autosomal dominant inheritance type. Except one asymptomatic patient, age at onset was in...

Objective To study the clinical, neuro-electrophysiology features of Charcot-Marie-Tooth disease type 1A (CMT1A) and its gene mutation analysis.Methods 9 members of the family with CMT1A underwent detailed clinical examinations and gene mutation analysis was carried out in 7 of them. The probands accepted electromyography and nerve, muscle biopsy.Results Five patients of the family were attacked and consistent with autosomal dominant inheritance type. Except one asymptomatic patient, age at onset was in the first or second decade. The clinical features were slowly progressive distal muscle weakness, atrophy and end-brush form sensory decrement, diminished or absent tendon reflexes, foot deformity(pes cavus).The probands showed highly decreased sensory and motor conduction velocities. Gene mutation analysis showed large fragment tandem duplication containing peripheral myelin protein 22(PMP22) gene in all four patients out of the seven family members who attended the gene diagnosis.Conclusion CMT1A is the most common form of CMT. The disease usually begins in childhood or adolescence. Clinical featurs include progressive distal muscle weekness and atrophy, diminished or absent tendon reflexes. The motor nerve conduction velocity is slowed below the limit of 38 m/s. Tandem duplication on chromosome 17p11.2, encompassing the PMP22 gene is the main mutation type of CMT1A.

目的 观察腓骨肌萎缩症 (CMT) 1A型的临床、神经电生理特点和疾病基因的突变分析。方法对一CMT家系中 9个成员进行详尽的临床检查、疾病基因突变分析 ,对先证者进行神经电生理检查和神经肌肉活检。结果 本家系中 5人发病 ,符合常染色体显性遗传模式 ,除 1例患者无临床症状外 ,其余 4例均在2 0岁前起病。临床特点为进行性四肢远端肌无力、肌萎缩 ,末梢型感觉障碍 ,腱反射减弱或消失 ,足部畸形(高弓足 )。神经电生理检查示运动和感觉神经传导速度减慢。基因突变分析发现 17号染色体短臂 11 2区(17p11 2 )包含周围髓鞘蛋白 (PMP) 2 2基因的正向串联重复突变。结论 CMT1A型是CMT最常见类型 ,多于儿童期或青少年期起病 ,表现为进行性四肢远端肌无力、肌萎缩 ,腱反射减弱或消失。神经电生理特点为运动神经传导速度均一性减低 (<38m/s)。 17p 11 2区包含PMP 2 2基因在内的 1 5Mb(偶尔 <1 5Mb)的正向串联重复突变是CMT 1A最主要的突变型。

 
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