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arctic region
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  北极
    Based on the comparison of Caryophyllaceae cyclopeptides from boththe Qinghai-Xizang (Tibet) Plateau and Arctic region, it is proposed that cyclopeptides are characteristiccomponents of Caryophyllaceae and Arctic region is one part of the distribution center of Caryophyllaceae.
    通过对北极石竹科环肽与青藏高原石竹科环肽的比较,证明了环肽是石竹科的特征成分以及北极地区是石竹科植物分布中心的一个区域。
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  arctic region
Peoples of the arctic region and the short peoples of the equatorial regions are less dimorphic in stature than midlatitude peoples.
      
Very closely related plants to the new taxon are known from Central Siberia and from the Arctic region.
      
Carex bigelowii complex is a group of taxa distributed over the whole Arctic region and in the mountains of the temperate zone.
      
A small portion of Hg emissions in Eurasia and North America is deposited in the Arctic region, perhaps 60 to 80 t annually.
      
The attenuation model is used to explain the evolution of the Arctic region.
      
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Five new cyclopeptides named arcticumin A (1), arcticumin B (2), arcticumin C (3), regelin A(4) and crassipin B (5) were isolated from three arctic Caryophyllaceae species (<100 g), Cerastiumarcticum Lange, C. regelii Ostenf. and Stellaria crassipes Hult., with structures elucidated primarily byFAB+-MS and amino acids analysis. Based on the comparison of Caryophyllaceae cyclopeptides from boththe Qinghai-Xizang (Tibet) Plateau and Arctic region, it is proposed that cyclopeptides are characteristiccomponents...

Five new cyclopeptides named arcticumin A (1), arcticumin B (2), arcticumin C (3), regelin A(4) and crassipin B (5) were isolated from three arctic Caryophyllaceae species (<100 g), Cerastiumarcticum Lange, C. regelii Ostenf. and Stellaria crassipes Hult., with structures elucidated primarily byFAB+-MS and amino acids analysis. Based on the comparison of Caryophyllaceae cyclopeptides from boththe Qinghai-Xizang (Tibet) Plateau and Arctic region, it is proposed that cyclopeptides are characteristiccomponents of Caryophyllaceae and Arctic region is one part of the distribution center of Caryophyllaceae.

用HPLC等现代分离技术,从各样少于100g的北极3种石竹科(Caryophyllaceae)植物StellariacrassipesHult.、CerastiumarcticumLange和C.regeliiOstenf.中分得5个新环肽,分别命名为arcticuminA(1)、arcticuminB(2)、arcticuminC(3)、regelinA(4)和crassipinB(5),并通过FAB+-MS和氨基酸组成分析初步鉴定了它们的结构;通过对北极石竹科环肽与青藏高原石竹科环肽的比较,证明了环肽是石竹科的特征成分以及北极地区是石竹科植物分布中心的一个区域。

Through the improved biological screening mothods,the role of natural products in drug discovery has been greatly enhanced in the last few years. This is particularly true for marine natural products,which show an interesting array of diverse and novel chemical structures with strong biological activities and unique mechanisms. Research into the pharmacological properties of marine natural products has led to the discovery of many potently active agents to be considered worthy for clinical application or pre-clinical...

Through the improved biological screening mothods,the role of natural products in drug discovery has been greatly enhanced in the last few years. This is particularly true for marine natural products,which show an interesting array of diverse and novel chemical structures with strong biological activities and unique mechanisms. Research into the pharmacological properties of marine natural products has led to the discovery of many potently active agents to be considered worthy for clinical application or pre-clinical research. Sponges are aquatic animals that occur in all oceans and have a wide distribution from tropical to temperate to arctic regions.They occasionally develop symbiotic (mutually beneficial) relationship with both algae and bacteria and may contain many complex chemicals that have medicinal value. Because of their prevalence,ease of collection,and ability to biosynthesize a variety of natural product structural classes,sponges have become one of the dominant sources of biologycally active marine natural products. This paper reviews the progress in the chemistry and bioactivities of the secondary metabolites from sponges. On this basis,a perspective on the pharmaceutical potential of the bioactive compounds from the title animal is made.

近年来国际上对海洋天然产物的研究日益深入,依托现代大规模药理筛选,目前已有多种结构新颖、药理活性显著且作用机制特殊的海洋天然产物进入临床试验阶段或正在进行临床前研究。海绵种类繁多,代谢途径独特,生存环境多样,共生现象复杂而普遍,多年来一直是海洋天然产物领域最富成果的研究领域之一。本文简要介绍近几年海绵化学成份及其药理活性的研究进展,以供国内同行参考。

 
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