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single priming
相关语句
  单式起爆
     Production practice of major blasting single priming system
     大爆破单式起爆系统生产实践
短句来源
  “single priming”译为未确定词的双语例句
     The rats then were given a single priming injection of morphine 4 mg·kg -1 to reinstate the morphine CPP.
     单次sc 4mg·kg- 1 吗啡以唤起消退的CPP的恢复。
短句来源
  相似匹配句对
     Production practice of major blasting single priming system
     大爆破单式起爆系统生产实践
短句来源
     Single thinking
     思维单一是缺陷
短句来源
     from single to unity;
     从单一到统一;
     Study on the Priming
     水基底漆的研究
短句来源
     Development of YYB20-24 Single-phase Self-priming Pump
     YYB20-24单相自吸泵的研制
短句来源
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  single priming
1-methyl-1,2,3,4-tetrahydroisoquinoline (50?mg/kg i.p.) completely inhibited the expression of reinstatement of cocaine self-administration and accompanying neurochemical changes induced by a single priming cocaine dose (10?mg/kg i.p.).
      


Objective To establish the conditioned place preference (CPP) model in rats and to explore the effects of melatonin (MT) on relapse behavior in morphine-dependent rats. Methods After morphine was administered via subcutaneous injection with gradually increasing doses for 6 days to induce morphine CPP in morphine control and treatment groups, the rats were subjected to saline instead of morphine for 10 days to extinct the previous CPP. The rats were then given a single priming injection of morphine 4 mg/kg...

Objective To establish the conditioned place preference (CPP) model in rats and to explore the effects of melatonin (MT) on relapse behavior in morphine-dependent rats. Methods After morphine was administered via subcutaneous injection with gradually increasing doses for 6 days to induce morphine CPP in morphine control and treatment groups, the rats were subjected to saline instead of morphine for 10 days to extinct the previous CPP. The rats were then given a single priming injection of morphine 4 mg/kg to reinstate the CPP. Three treatment groups were treated with melatonin (20mg/kg, 40mg/kg and 80mg/kg, ip) prior to priming injection of morphine. The behaviors of rats were observed. Results After training with injection of morphine for 6 days, there were marked increases in time spent in the drug-paired compartment in morphine control and treatment groups and the morphine CPP was established. The morphine CPP disappeared following a 10 day drug-free period and appeared again after given a single injection of morphine 4 mg/kg. During the relapse phase, acute treatment with melatonin 30 min before priming injection of morphine had dose-dependent effects to attenuate the reacquisition of the place preference induced by morphine. Conclusion Morphine could induce the CPP in rats. MT could partly inhibit reinstatement of relapse behavior to morphine in morphine-dependent rats.

目的 建立大鼠条件性位置偏爱模型(CPP),探讨褪黑素对吗啡依赖大鼠复吸行为的影响。方法连续6d按剂量递增法于大鼠皮下注射吗啡,诱导实验组和吗啡对照组大鼠CPP形成,然后用盐水替代吗啡皮下注射大鼠10d,使CPP逐渐消退后,再用吗啡4mg/kg单次引燃注射激发消退的条件性位置偏爱复燃,3个实验组分别在注射吗啡前30min腹腔注射褪黑素20mg/、40mg/kg和80mg/kg,分别观察各组大鼠行为。结果 经6d吗啡训练后,实验组和吗啡对照组大鼠在伴药箱的停留时间显著延长,吗啡诱导的大鼠CPP形成;停用吗啡后,经10d的生理盐水注射,吗啡诱导的大鼠CPP逐渐消退;吗啡4mg/kg单次引燃注射使大鼠消退的CPP恢复,而实验组可以剂量依赖性地减弱大鼠CPP恢复。结论 吗啡诱导大鼠CPP形成,褪黑素在一定程度抑制吗啡依赖大鼠的复吸行为。

Objective: To study the inhibitory efficacy of melatonin (Mel) on relapse behavior in morphine-dependent rats. Methods: Morphine was administered via subcutaneous injection at gradually increasing doses (from 10 mg·kg -1 to 60 mg·kg -1 ) for 6 days to establish morphine conditioned place preference(CPP). From Day 7, the rats were administered saline instead of morphine for 10 days to induce CPP extinction. The rats then were given a single priming injection of morphine 4 mg·kg -1 to reinstate...

Objective: To study the inhibitory efficacy of melatonin (Mel) on relapse behavior in morphine-dependent rats. Methods: Morphine was administered via subcutaneous injection at gradually increasing doses (from 10 mg·kg -1 to 60 mg·kg -1 ) for 6 days to establish morphine conditioned place preference(CPP). From Day 7, the rats were administered saline instead of morphine for 10 days to induce CPP extinction. The rats then were given a single priming injection of morphine 4 mg·kg -1 to reinstate the morphine CPP. Some rats were treated by ip melatonin (20, 40 and 80 mg·kg -1 ) prior to priming injection of morphine. Results: After priming injection of morphine 4 mg·kg -1 , the time spent on the drug-paired side was significantly reduced because of the treatment with Mel(40 and 80 mg·kg -1 ), compared with Mor Group P<0 05, P<0 01. No significant statistical differences were observed between Mor Group and Mel 20 Group (P> 0 05). Conclusion: Mel has some effects on the inhibitory of relapse behavior induced by priming injection of morphine in morphine-dependent rats.

目的 :研究褪黑素对吗啡依赖大鼠复吸行为的抑制作用。方法 :以剂量递增法连续皮下注射 (sc)吗啡 6d建立吗啡诱导的大鼠条件性位置偏爱 (CPP)模型 ,d7用生理盐水替代吗啡训练大鼠 10d ,以使形成的CPP逐渐消退。单次sc 4mg·kg- 1 吗啡以唤起消退的CPP的恢复。部分大鼠在注射吗啡前 30min分别腹腔注射 (ip)褪黑素 2 0、4 0和 80mg·kg- 1 进行治疗。结果 :与吗啡依赖组相比 ,在sc 4mg·kg- 1 吗啡引燃刺激前 30min应用褪黑素 4 0和 80mg·kg- 1 急性治疗 ,可以使大鼠在伴药箱的停留时间明显缩短 ,(P <0 0 5、P <0 0 1) ;而褪黑素 2 0mg·kg- 1 急性治疗亦使大鼠在伴药箱的停留时间缩短 ,但无统计学意义 ,P >0 0 5。结论 :褪黑素在一定程度上可以抑制吗啡引燃的吗啡依赖大鼠的复吸行为

 
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