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orthotopic implantation
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  原位移植
     Establishment of the prostate cancer orthotopic implantation model in C57BL6 syngenic mice and its value of application
     C57BL6近交系小鼠前列腺癌原位移植瘤模型的建立
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     Reversion of ovarian carcinoma metastasis by adeno-associated virus-mediated gene transfer of nm23H_1 in orthotopic implantation model
     重组腺相关病毒介导的nm23H_1对转移性卵巢癌原位移植模型的逆转研究
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     A Study of Regulation on the CD147 Expression of Ovarian Cancer and Establishment of Human Ovarian Cancer Orthotopic Implantation High Metastatic Nude Mice Model
     CD147在卵巢癌中的表达调节作用及人卵巢癌原位移植裸鼠模型的构建
短句来源
     Experimental study on the establishment for orthotopic implantation model of human glioma cells in nude mice
     人脑胶质瘤细胞裸鼠原位移植动物模型的建立
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     Establishment of orthotopic implantation model of human CHG-5 glioma cell line in nude mice and analysis of its biological features
     人CHG-5胶质瘤细胞裸鼠原位移植模型的建立及其生物学特性分析
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  原位种植
     Establishment of human hilar cholangiocarcinoma cell fine QBC939 orthotopic implantation tumor model in nude mice
     胆管癌细胞系QBC939裸鼠肝门部胆管原位种植瘤模型的建立
短句来源
     Establishment of orthotopic implantation tumor and metastasis model of human colon cancer in nude mice
     人结肠癌裸鼠原位种植癌及转移模型的建立
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     Conclusions The orthotopic implantation tumor and metastasis model provide useful tools for the study of mechanism of metastasis and its treatment of human colon cancer.
     结论 该实验的裸鼠原位种植转移模型的生物学行为与临床病程非常相似 ,为研究结肠癌转移机制和抗转移治疗提供理想的动物模型。
短句来源
     Objective To establish an orthotopic implantation and metastasis model of human colon cancer in nude mice.
     目的 建立人结肠癌裸鼠原位种植瘤模型 ,为研究结肠癌的转移机制和抗转移治疗提供动物模型。
短句来源
     Cell growth kinetics was assessed by MTT assay, and in vitro invasive ability was assessed with Boyden chamber. Xenograft and orthotopic implantation of histologically intact tumor in nude mice were constructed to observe the effect of exogenous expression of heparanase gene on invasive ability of HT29 cells.
     方法:Hpa全长基因真核表达载体转染HT29细胞,MTT法检测转化细胞增殖能力,Boyden小室体外侵袭实验比较转染前后细胞侵袭能力的变化,通过转化细胞裸鼠异种接种成瘤和实体瘤回盲部原位种植转移模型建立,观察Hpa基因外源性表达对HT29细胞侵袭性的影响。
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  原位接种
     The development of animal model created by surgical orthotopic implantation gives the researchs an ideal instrument similar with the condition of patients to research the mechanism of bone metastasis and the treatment.
     经外科原位接种制作骨转移模型为骨转移机理及治疗方法的研究提供了较为理想的工具。
短句来源
     After orthotopic implantation of tumor tissue into nude mouse liver for 35 d, wide spread regional and distant metastases occurred, the metastatic rate was 100% for abdominal wall, 80% for organs in abdominal cavity, 100% for liver, 70% for diaphragm, and 100% for lung. The median number of lung metastatic lesions was 268 per mouse.
     瘤组织原位接种于裸鼠肝脏 ,5周后腹壁转移 10 0 %、腹腔内转移 80 %、肝内转移 10 0 %、膈肌转移 70 %、肺转移10 0 % ,肺转移灶中位数 2 6 8个 /裸鼠。
短句来源
     Objective To compare the biological character between the model of human prostate cancer cell DU145 and 22Rvl utilizing ectopic and orthotopic implantation in nude mice.
     目的比较人前列腺癌细胞DU145和CWR22Rv1(22Rv1)(下面简称22Rv1)分别在皮下和前列腺原位接种后的成瘤性和转移率。
短句来源
     Results The 22Rv1 cells were equally tumorigenic with 10/10 frequency in the prostate and subcutis,they exhibited highly metastasis potentiality with 9/10 lymph node metastasis after orthotopic implantation in nude mice for 40 days,whereas no lymph node metastasis after ectopic implantation.
     结果原位接种22Rv1组的裸小鼠成瘤率达到10/10,淋巴结转移率为9/10;
短句来源
     The DU145 cells were equal tumorigenic with 10/10 frequency in the prostate and subcutis,they exhibited lowly metastasis potential- ity with 1/10 lymph node metastasis after orthotopic implantation in nude mice,and no lymph node metastasis after ectopic implantation.
     原位接种DU145组的裸小鼠成瘤率达到10/10,而淋巴结转移率为1/10。 两种细胞皮下接种法的裸小鼠成瘤率均达10/10,但未检测到任何淋巴结转移。
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  “orthotopic implantation”译为未确定词的双语例句
     Treatment of C6 orthotopic implantation in rat brains with Nordy and its effects on the expression of STAT3 and p-STAT3
     诺帝对大鼠C6脑胶质瘤的诱导分化治疗作用及对信号转导分子STAT3和p-STAT3蛋白表达的影响
短句来源
     Conclusion The lymph node metastasis model established by orthotopic implantation in nude mice is successful,and it may become a valuable model for the study of metastasis mechanism and experimental therapy of prostate cancer.
     结论对这两种细胞株采用原位接种法建立裸鼠人前列腺癌原位模型获得成功,用22Rv1细胞建立的原位模型淋巴结转移率高于DU145组,为前列腺癌转移机制的研究及筛药提供了模型。
短句来源
     Three groups of ovarian carcinoma orthotopic implantation nude model were applied by PBS (as control) (12 mice), rAAV-Laz (13 mice), rAAV-nm23H 1 (13 mice) intraperitoneally on the day 10 after transplantation. Then the effect of rAAV-nm23H 1 on survival and liver metastastic incident rates in models were observed.
     肿瘤原位移植术后第 10天对空白对照组 (12只小鼠 )、rAAV Laz组 (13只小鼠 )和rAAV nm2 3H1组 (13只小鼠 )分别行腹腔注射 ,观察rAAV nm2 3H1对转移性卵巢癌模型的肝转移率和生存时间的影响。
短句来源
     P-gp protein expression in multidrug resistant groups (42.6% ± 1.7%) was higher than controls (2.6% ± 0. 1%), P < 0.01. Conclusions Multidrug resistant model in nude mice via orthotopic implantation of multidrug resistant human hepatocellular carcinoma cells was successfully established.
     耐药组P-gp蛋白表达为(42.6±1.7)%远高于对照组(2.6± 0.1)%,差异有统计学意义(t=6.43,P<0.01)。 结论成功建立肝癌多药耐药动物模型并且为研究肝癌多药耐药逆转提供基础。
短句来源
     This study was designed to evaluate the mo nitoring impact of urinaryβ-human chorionic gonadotropin(β-HCG)on tumor growth in orthotopic implantation model.
     本文评价β-人绒毛膜促性腺激素(βhumanchorionicgonadotropin,β-HCG)系统对肿瘤原位模型内肿瘤生长的监测作用。
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  orthotopic implantation
We used the Src-deficient mouse model to determine the role of Src in the maintenance of the BBB following orthotopic implantation and growth of glioma cells in the brain.
      
The aim of this study was to establish an orthotopic implantation model with high metastasis of gastric cancer to the peritoneum which is more faithful to clinical metastasis.
      
The technique of surgical orthotopic implantation (SOI) has allowed the development of clinically relevant metastatic models of human cancer in immunodeficient rodents such as the nude and SCID mouse.
      
Collectively, the results demonstrate that the orthotopic implantation of HCC cells can yield metastatic subpopulations of cells suitable for the study of metastasis.
      
Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metast
      
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A comparing study of orthotopic and heterotopic implantation of nerve was performed in rectus femoral muscles of twenty-eight rats. Fourth and sixth month postoperatively, the muscle weight, silver staining method for nerve fibre and gold staining method for end-plate counting were used as for the evaluation of the results. It was demonstrated that orthotopic implantation is far more superior to heterotopic implantation. Nerves implanted in different regions of the muscle regenerated in different...

A comparing study of orthotopic and heterotopic implantation of nerve was performed in rectus femoral muscles of twenty-eight rats. Fourth and sixth month postoperatively, the muscle weight, silver staining method for nerve fibre and gold staining method for end-plate counting were used as for the evaluation of the results. It was demonstrated that orthotopic implantation is far more superior to heterotopic implantation. Nerves implanted in different regions of the muscle regenerated in different way. The experiment also indicated that the nerve implanted in muscle can regenerate and establish connection with the end-plate very well.

本实验对28只大鼠双侧股直肌进行原位与异位神经植入,分别于术后120天和180天做肌肉称重、神经纤维和终板染色,并做了终板分布范围和计数检查。全部实验结果都证明,原位神经植入再生和肌肉再神经化效果明显优于异位植入,不同部位植入的神经是以不同方式再生的。

A highly metastatic giant cell carcinoma (PG) and a poorly metastatic adenocarcinoma (PAa) were orthotopically implanted into nude mice, and the take rates were 74% for PG and 56% for PAa. Invasive tumors located in hilar region or peripheral part of lung, or spread diffusely, which were quite similar to three macroscopic types of primary lung carcinomas and different from well-circumscribed masses of ectopically implanted tumors. It is interesting to point out that the metastatic incidence of PAa cells in regional...

A highly metastatic giant cell carcinoma (PG) and a poorly metastatic adenocarcinoma (PAa) were orthotopically implanted into nude mice, and the take rates were 74% for PG and 56% for PAa. Invasive tumors located in hilar region or peripheral part of lung, or spread diffusely, which were quite similar to three macroscopic types of primary lung carcinomas and different from well-circumscribed masses of ectopically implanted tumors. It is interesting to point out that the metastatic incidence of PAa cells in regional lymph nodes was 56% when implanted orthotopically which was even higher than the metastatic incidence in beige nude mice bearing subcutaneous tumors. Collectly, the results demonstrate that the orthotopic implantation of human lung carcinomas favour the expression of metastatic phenotype suitable for experimental study of metastasis. The comparation of expressions of oncogenes and antioncogenes in orthotopically implanted tumors with those in subcutaneously implanted tumors of the same kind will contribute to searching for molecular basis of tumor invasion and metastasis.

将高转移人肺巨细胞癌和低转移人肺腺癌常位移植于裸鼠肺内,其移植成功率分别为74%和56%,肺内移植瘤仍保持人原发肿瘤的病理组织学形态,其肉眼类型可呈肺门肿块,周围结节和弥散浸润型,与人类原发肺癌亦相似,而与局限膨胀生长或较少浸润的裸鼠皮下移植瘤有明显区别。肺内常位移植瘤较广泛地浸润胸部脏器,特别应当指出的是低转移肺腺癌细胞肺内移植其淋巴结转移率可达56%,甚至高于该癌系在beige裸鼠体内的淋巴结转移率。说明常位移植有利于恶性肿瘤表达其浸润转移表型。常位移植之肿瘤生物学行为更接近人体内原发性肿瘤的生物学行为,将成为研究人类肿瘤特性和实验治疗的更为适宜的实验模型。研究裸鼠皮下移植瘤和常位移植瘤基因表达的差异亦将为肿瘤浸润转移分子生物学基础的揭示作出贡献

Growth pattern,metastatic behaviour and serial alph-a-fetoprotein(AFP)level of highly metastatic model of human hepatocellular carcinoma in nude mice(LCI-D20),which constructed by using orthotopic implantation of histologically intact patient specimens,were studied by implanting into the liver, subcutis andperitoneum of nude mice.Pathologic(by light and electronmicroscopic examination)and biologic(chromosome karyotype and DNA contents by flow cytometry)characteristics of LCI-D20 were also observed.The...

Growth pattern,metastatic behaviour and serial alph-a-fetoprotein(AFP)level of highly metastatic model of human hepatocellular carcinoma in nude mice(LCI-D20),which constructed by using orthotopic implantation of histologically intact patient specimens,were studied by implanting into the liver, subcutis andperitoneum of nude mice.Pathologic(by light and electronmicroscopic examination)and biologic(chromosome karyotype and DNA contents by flow cytometry)characteristics of LCI-D20 were also observed.The results showed that transplantability of LCI-D20 was 100% in 12 generations(passage time:20 days)and all of these mice implanted tumors died within 40 days after transplantation due to serious metastasis.After LCI-D20 implanted into the liver of nude mice,growing implant-tumors in progress were negatively related to their double time during animal survival.LCI-D20 maintained 100%(70/70) metastatic rate in nude mice that showed early intrahepatic metastasis and late lymphatic and pulmonary metastasis.The high metastatic potentials of LCI-D20 tumor cells were kept in subcutis and peritoneum (70%,100% respectively). The increase of the serial AFP secreting from the tumor cells was correlated with the implantation tumor growth rate(797.5μg/L/5th week).The data from histological and electronmicroscopic findings,chromosome karyotype and DNA content analysis of the tumor cells revealed characteristics of human hepatocellular carcinoma.The results indicated that LCI-D20 exhibited the variety of clinical behaviours seen in hepatoma patients and it could be a useful model for investigating the metastasis mechanism of human hepatoma and anti-metastasis therapy.

为了研究癌转移的机理和筛选抗转移治疗因子,用原位移植方法建立了裸鼠人肝癌高转移模型LCI-D20。对该模型的体内生长与转移规律、宿主血清甲胎蛋白(AFP)水平,不同植入环境对转移能力的影响进行了观察,并检测了其细胞形态学、染色体核型和DNA含量。结果:LCI-D20模型传代12次,移植生长率为100%,宿主生存期40天,传代周期20天。移植生长曲线呈直线递增,倍增时间则呈直线递减。转移初始于肝内,3周后发生淋巴结与肺转移,转移率100%(70/70)。皮下与腹腔接种后,仍表现高转移特性,肺转移分别为70%(7/10)和100%(10/10)。宿主血清AFP水平呈曲线递增,第5周达最高值(797.5μg/L)。光镜与电镜观察示人肝癌细胞特征。染色体与DNA含量分析示异倍体核型。结果表明:由原位移植方法建立的裸鼠人肝癌转移模型,能在人体外模拟人肝癌转移的自然过程,是一株可供研究人肝癌转移问题的较为理想的模型。

 
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