DATA SOURCES: A computer-based online search of Medline database and CHKD database was undertaken for literature about nano-hydroxyapatite published from January 1979 to December 2005 with the keywords of "hydroxyapatite, nano-hydroxyapatite, hydroxyapatite toxicity" in Chinese and English respectively.
The HA/PCL composites biomaterial were prepared through solvent-cast technique and melt-blend method with polycaprolactone matrix and nano-hydroxyapatite phase. The influence of compose and coupling agent on composites were discussed through studying the structure, component and mechanical properties of composites. The HA/PCL composites biomaterial were immersed in Simulated Body Solution (SBF) to examine its bioactivity.
Part one: In vitro study of n-HA/PVA composite for keratoprosthesisObjective: Through cell culture in vitro to evaluate the cytotoxicity andhistocompatibility of n-HA/PVA (nano-hydroxyapatite/polyvinyl alcohol) hydrogel composite for keratoprosthesis.
The keratoprosthesis was designed, consisting of a transparent core polyvinyl alcohol (PVA) hydrogel with a porous peripheral skirt nano-hydroxyapatite/polyvinyl alcohol (n-HA/PVA) hydrogel sponge. This keratoprosthesis should improve biocompatibility with the host tissue and ability to interlock with the host cornea.
In the present study, nano-hydroxyapatite (n-HA) and novel aliphatic polyetheresteramide-based polyurethane (PEEA-U) was used to prepare biocomposite through routine solvent casting technique and novel electrospinning to form two different architechture topography.
Methods Nano-hydroxyapatite/collagen composite was developed by biomimetic method. The material was used in clinical operation,the healing effects of bone defects were assessed by methods of radiography.