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transdermal gel
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  凝胶
     METHODS: A single dose of 0.1 g OXY transdermal gel (2 mg OXY) was applied to abdominal area about 4 cm~2 and 0.5 mg immediate-release tablet was orally given to 48 rats in a randomized, open-label, control design test.
     方法:48只大鼠随机分为两组:一组外用给予单剂0 .1 g奥昔布宁自制凝胶(2 mg OXY) ,一组给予单剂0 .5 mg普通片剂。
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  “transdermal gel”译为未确定词的双语例句
     Study on absorption and distribution of oxybutynin oral tablet and transdermal gel in rats
     大鼠奥昔布宁片剂口服给药与凝胶剂经皮给药吸收与组织分布研究(英文)
短句来源
     AIM: To study the absorption and distribution characteristics of oxybutynin (OXY) oral tablet and transdermal gel.
     目的:考察口服和外用给药奥昔布宁在大鼠体内的吸收和分布。
短句来源
     RESULTS: The C_ max of OXY transdermal gel and oral tablets in bladder are approximately 800 and 70 times higher than those in plasma.
     结果:凝胶剂外用给药奥昔布宁膀胱组织浓度为血浆的800倍,而口服给药为70倍。
短句来源
  相似匹配句对
     Study on transdermal iontophoresis of piroxicam gel
     吡罗昔康凝胶离子导入经皮给药研究
短句来源
     Experiment of Diclofenac Gel Transdermal Absorption
     双氯灭痛凝胶的透皮试验
短句来源
     TRANSDERMAL FENTANYL
     芬太尼缓释透皮贴剂
短句来源
     Studies on Tofu-gel
     豆腐凝胶的研究
短句来源
     C-S-H Gel and Its Determination Methods
     C-S-H凝胶及其研究方法
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  transdermal gel
The Food and Drug Administration recently approved the labeling for two new testosterone products, a 1% transdermal gel and a buccal tablet.
      
Pope and col59 added testosterone via a transdermal gel to an existing antidepressive therapy in 23 men.
      


AIM: To study the absorption and distribution characteristics of oxybutynin (OXY) oral tablet and transdermal gel. METHODS: A single dose of 0.1 g OXY transdermal gel (2 mg OXY) was applied to abdominal area about 4 cm~2 and 0.5 mg immediate-release tablet was orally given to 48 rats in a randomized, open-label, control design test. The plasma, bladder and liver tissue were collected, disposed and analyzed and OXY pharmacokinetic parameters were calculated and evaluated. RESULTS: The C_ max of OXY...

AIM: To study the absorption and distribution characteristics of oxybutynin (OXY) oral tablet and transdermal gel. METHODS: A single dose of 0.1 g OXY transdermal gel (2 mg OXY) was applied to abdominal area about 4 cm~2 and 0.5 mg immediate-release tablet was orally given to 48 rats in a randomized, open-label, control design test. The plasma, bladder and liver tissue were collected, disposed and analyzed and OXY pharmacokinetic parameters were calculated and evaluated. RESULTS: The C_ max of OXY transdermal gel and oral tablets in bladder are approximately 800 and 70 times higher than those in plasma. The plasma half life of OXY gel delayed 5.99 h, tablets 2.18 h. CONCLUSION: OXY gel show better pharmacokinetic properties, characterized with long half life and high target organ concentrations than those of tablets.

目的:考察口服和外用给药奥昔布宁在大鼠体内的吸收和分布。方法:48只大鼠随机分为两组:一组外用给予单剂0 .1 g奥昔布宁自制凝胶(2 mg OXY) ,一组给予单剂0 .5 mg普通片剂。收集血样、膀胱和肝脏样本,采用高效液相色谱-质谱法测定奥昔布宁浓度。结果:凝胶剂外用给药奥昔布宁膀胱组织浓度为血浆的800倍,而口服给药为70倍。奥昔布宁凝胶剂半衰期延长为5 .99 h,而口服给药为2 .18 h。结论:奥昔布宁凝胶剂半衰期延长,作用部位膀胱组织浓度高,与片剂相比具有明显的优势。

 
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