The protection of the renal blood vessel might be the mechanism that leads to prominent effect of lowering blood pressure using QinReJiangYa mixture as well as the better protection of the early stage of damage to kidney.
Regardless of the choice of solute, the hypo-osmotic solutions caused damage to kidney and brain tissue by inducing marked interstitial and cellular oedema.
Down regulation of trefoil factor 3 and up regulation of cathepsin L may contribute to lack of protection and increased age related tissue damage to kidney in aging.
The alteration seems to be a result of damage to kidney function.
Damage to kidney cells was assessed by measuring the release of lactate dehydrogenase (LDH), γ-glutamyltranspeptidase (GTP), and β-N-acetylglucosaminidase (NAG) from cells into the medium and the cellular concentration of protein.
By light and electron microscope and immunofluorescent technique, the damage to kidney in groups A, B and C was found much milder than that in group D with lesion in group A being slightest.