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fibrinogen beta
相关语句
  纤维蛋白原
     Genotypes and allele frequencies of fibrinogen beta gene -455G/A, -148C/T polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).
     应用聚合酶链反应(PCR)、HaeⅢ限制性内切酶、HindⅢ限制性内切酶分别检测纤维蛋白原β-455G/A、-148C/T多态性位点。
短句来源
  纤维蛋白原β
     Genotypes and allele frequencies of fibrinogen beta gene -455G/A, -148C/T polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).
     应用聚合酶链反应(PCR)、HaeⅢ限制性内切酶、HindⅢ限制性内切酶分别检测纤维蛋白原β-455G/A、-148C/T多态性位点。
短句来源
  “fibrinogen beta”译为未确定词的双语例句
     Results Regarding fibrinogen beta gene -455G/A and -148C/, the allele frequencies G and A of fibrinogen beta -455 in the controls were 0.931, 0.069 while C and T of -148 were 0.777, 0.223 respectively, which were in good agreement with Hardy-Weinberg equilibrium.
     (2)-455G基因AA、GA、GG基因型在PTE病例组分布为3(3.0%)、33(32.7%)、65(64.4%),在对照组分布为1(1%)、12(11.9%)、88(87.1%),χ2=14.258,差异有统计学意义;
短句来源
  相似匹配句对
     The relationship of beta-fibrinogen gene polymorphisms and ischaemic cardiocerebral vascular disease
     纤维蛋白原基因多态性与缺血性心脑血管病的关系
短句来源
     Polymorphism of plasma fibrinogen B beta gene and hypoxic ischemic encephalopathy in newborns
     新生儿缺氧缺血性脑病与血浆纤维蛋白原Bβ基因多态性的相关性研究
短句来源
     THE COMPILATION OF BETA PROGRAM
     HI-13串列加速器运行参数计算程序BETA的编制
短句来源
     L p Approximation for Beta Operators
     Beta算子的L_p-逼近
短句来源
     Fibrinogen (Fg) were measured.
     1(PAI!1)、纤维蛋白原(Fg)。
短句来源
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Degradation product of fibrinogen beta-chain, P6A and derivatives have vasoactive potency. The bioassay indicated that the modification of amino acid residue at the -terminal of P6A had important influence. In compound (1) and (2), the N-terminal residues are Lys1 and Arg1 respectively and the introduction with basic residue resulted in the abolition of relaxation action. In compound (3) and (5) the N-terminal residues are Asp1 and Glu1 respectively, the amino acids with acidic side were introduced and...

Degradation product of fibrinogen beta-chain, P6A and derivatives have vasoactive potency. The bioassay indicated that the modification of amino acid residue at the -terminal of P6A had important influence. In compound (1) and (2), the N-terminal residues are Lys1 and Arg1 respectively and the introduction with basic residue resulted in the abolition of relaxation action. In compound (3) and (5) the N-terminal residues are Asp1 and Glu1 respectively, the amino acids with acidic side were introduced and the related effect of P6A was converted into contraction. The N-terminal residues for compound (4) and (6) are Asn1 and Gln1 respectively, which have amide side chain, the relaxation effect of the former is approximately the same as that of P6A and the relaxation effect of the latter is approximately 6 times stronger as that of P6A. These results indicated the bioactivities of them were structure-dependent. In the present paper, the most stable comformations of P6A and (7) derivatives were calculated with discover program(Biosy Inc. ). It was shown that the total energy of β-strade is the lowest one in all three kinds of conformations of α-L-helix, α-R-helix and β-strade for these 8 compounds, suggesting β-strade may be their conformations in solution. Some important atomic distances and dihedral angles were also calculated here and Gln1-P6A had particular interesting values.

纤维蛋白β链的降解产物P6A及相关的类似物,具有明确的血管效应。生物检测表明,当P6A的N端用不同的氨基酸替代时,可以导致不同的结果。就舒血管作用而言,或增强P6A的效应,或减弱P6A的效应,或与P6A相当,或无活性,因而是结构依赖的。本文采用Biosy公司设计的Discover程序,计算了8种化合物可能的优势构象。结果表明,在α-右手螺旋、α-左手螺旋和β-伸展三种可能的构象状态中,8个化合物的β-伸展构象的总能量都比α-螺旋低,β-伸展可能就是它们在溶液中的构象。本文计算了分子中有重要影响的某些原子间距离以及二面角,发现舒血管活性最强的Gln-P6A的有关二面角具有特殊性,这是一项有意义的发现。

Objective To determine the prevalence of beta-fibrinogen gene -455G/A, -148C/T polymorphisms in Chinese Han population and to investigate whether they were associated with pulmonary thromboembolism(PTE). Methods The subjects consisted of 101 patients with PTE and 101 healthy controls matched with age and sex, from the same geographic area. All patients were diagnosed by high probability of lung ventilation/perfusion scan and/or multi-slice CT pulmonary angiography as well as medical history and clinical manifestations....

Objective To determine the prevalence of beta-fibrinogen gene -455G/A, -148C/T polymorphisms in Chinese Han population and to investigate whether they were associated with pulmonary thromboembolism(PTE). Methods The subjects consisted of 101 patients with PTE and 101 healthy controls matched with age and sex, from the same geographic area. All patients were diagnosed by high probability of lung ventilation/perfusion scan and/or multi-slice CT pulmonary angiography as well as medical history and clinical manifestations. Genome DNA was extracted from whole blood using KI-phenol-chloroform. Genotypes and allele frequencies of fibrinogen beta gene -455G/A, -148C/T polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Restriction enzyme HaeⅢ and HindⅢ digestion were used for detecting -455G/A, -148C/T polymorphisms respectively. Results Regarding fibrinogen beta gene -455G/A and -148C/, the allele frequencies G and A of fibrinogen beta -455 in the controls were 0.931, 0.069 while C and T of -148 were 0.777, 0.223 respectively, which were in good agreement with Hardy-Weinberg equilibrium. There was significant difference of -455G/A genotype frequencies distribution of AA, GA, GG between cases and in controls respectively, but no significant difference was found in the -148C/T polymorphisms. The frequencies of mutation allele -455A were 0.193, 0.169 in cases and in controls with P< 0.05 but there was no statistically significant difference of -148T allele. The presence of A allele of fibrinogen beta -455 was found to be a greater risk factor in cases than in controls. The odds ratio(OR) of GA and GA+AA were 3.723( 1.786- 7.759), 3.749( 1.842- 7.630),respectively. When compared with GG genotype, the P value was 0.0001. Conclusion There was a complete linkage disequilibrium between fibrinogen beta -148C/T and -455G/A found. The frequencies of -455A, alleles in PTE disease were apparently higher than that of healthy adults but there was no diferrence in -148T alleles.

目的探讨纤维蛋白原基因β链启动子区域-455G/A、-148C/T多态性与中国汉族人群肺血栓栓塞症(PTE)发生的相关性。方法采用病例对照研究,病例组为经放射性核素肺通气/灌注显像和(或)螺旋CT肺动脉造影(CTPA)检查并结合临床资料确诊的PTE患者101例;对照组为与PTE患者来自相同地区汉族人群,性别、年龄相匹配的健康对照101人。应用碘化钾-氯仿-异丙醇法提取基因组。应用聚合酶链反应(PCR)、HaeⅢ限制性内切酶、HindⅢ限制性内切酶分别检测纤维蛋白原β-455G/A、-148C/T多态性位点。结果(1)健康对照人群纤维蛋白原-455位点等位基因G和A的频率分别为0.931、0.069,-148位点等位基因C和T的频率分别为0.777、0.223,基因型分布均符合Hardy-Weinberg平衡定律。(2)-455G基因AA、GA、GG基因型在PTE病例组分布为3(3.0%)、33(32.7%)、65(64.4%),在对照组分布为1(1%)、12(11.9%)、88(87.1%),χ2=14.258,差异有统计学意义;-148C基因TT、CT、CC的分布在病例组和对照组差异无统计学意义。(3)-4...

目的探讨纤维蛋白原基因β链启动子区域-455G/A、-148C/T多态性与中国汉族人群肺血栓栓塞症(PTE)发生的相关性。方法采用病例对照研究,病例组为经放射性核素肺通气/灌注显像和(或)螺旋CT肺动脉造影(CTPA)检查并结合临床资料确诊的PTE患者101例;对照组为与PTE患者来自相同地区汉族人群,性别、年龄相匹配的健康对照101人。应用碘化钾-氯仿-异丙醇法提取基因组。应用聚合酶链反应(PCR)、HaeⅢ限制性内切酶、HindⅢ限制性内切酶分别检测纤维蛋白原β-455G/A、-148C/T多态性位点。结果(1)健康对照人群纤维蛋白原-455位点等位基因G和A的频率分别为0.931、0.069,-148位点等位基因C和T的频率分别为0.777、0.223,基因型分布均符合Hardy-Weinberg平衡定律。(2)-455G基因AA、GA、GG基因型在PTE病例组分布为3(3.0%)、33(32.7%)、65(64.4%),在对照组分布为1(1%)、12(11.9%)、88(87.1%),χ2=14.258,差异有统计学意义;-148C基因TT、CT、CC的分布在病例组和对照组差异无统计学意义。(3)-455A等位基因在病例组与对照组分别为0.193、0.169,两组比较χ2=13.573,差异有统计学意义;-148T等位基因在病例组与对照组差异无统计学意义。(4)进行单变量logistic回归探讨β-455G/A基因多态性与PTE的关系,相对于GG基因型而言,GA杂合型与GA+AA均能显著增加PTE发生的危险性,OR值(95%CI)分别为3.723(1.786~7.759)、3.749(1.842~7.630),P<0.05。在β-148C/T基因多态性中,相对于CC基因型而言,CT+TT、TT、CT基因型都没有显著增加个体PTE发生的危险。结论纤维蛋白原β链启动子区域-455G/A基因多态性可能与PTE有关,GA杂合型与GA+AA型与PTE发生显著相关,A等位基因可能是与PTE发病有关的遗传因素,β-148C/T基因多态性可能与PTE无关。

A higher prevalence of atherosclerosis has been observed in subjects with diabetes than in the general population.However,the pathogenic mechanisms underlying this relationship remain to be determined.In this study,we evaluated the risk factors attributed to peripheral vascular disease(PVD)in diabetic Chinese patients.Blood pressure(BP),anthropometric,and potential biochemical risk factors for PVD were measured in 65 diabetic Chinese patients.The arterial-systolic pressure ratio(ABR)was used as an index of PVD...

A higher prevalence of atherosclerosis has been observed in subjects with diabetes than in the general population.However,the pathogenic mechanisms underlying this relationship remain to be determined.In this study,we evaluated the risk factors attributed to peripheral vascular disease(PVD)in diabetic Chinese patients.Blood pressure(BP),anthropometric,and potential biochemical risk factors for PVD were measured in 65 diabetic Chinese patients.The arterial-systolic pressure ratio(ABR)was used as an index of PVD with an ABR<0.9 indicative of PVD.The ABR significantly correlated with age(r=-0.46,p<0.001),creatinine(r=-0.37,p=0.002),fibrinogen(r=-0.53,p<0.001),total homocysteine(tHcy)(r=-0.45,p<0.001)and systolic blood pressure(r=-0.42,p<0.001).Using stepwise multiple regression analyses,plasma fibrinogen(beta coefficient-0.407,p<0.001),tHcy(beta coefficient-0.471,p=0.001),and urate(beta coefficient 0.279,p=0.031)were found to be independent predictors of the ABR in patients(ABR=1-0.669×fibrinogen-0.450×tHcy+0.449×urate,p<0.001).In summary,fibrinogen,tHcy,and urate as well as blood pressure were found to be important factors related to the development of PVD in this population of diabetic Chinese patients.

研究表明糖尿病病人动脉粥样硬化发病率较一般人群高。但其病因学机制尚不明了。本研究评估了患糖尿病的病人外周血管疾病(PVD)的危险因素。检测了65名糖尿病患者的血压、人类学指标、潜在的外周血管疾病生物化学的危险因素。取踝/肱动脉收缩压比(ABR)<0.9作为判定PVD的指标。ABR与如下指标明显相关,年龄(r=-0.46,p<0.001),肌酐(r=-0.37,p<0.02),纤维蛋白原(r=-0.53,p<0.001),总同型半胱胺酸(tHcy)(r=-0.45,p<0.001)。通过逐步多元回归分析,如下因素为ABR的独立判定指标,血浆纤维蛋白原(β系数-0.47,p<0.001),tHcy(p系数-0.471,p=0.001)及尿酸盐(β系数0.279,p=0.031),公式如下:(ABR=1-0.669×血浆纤维蛋白原-0.450×tHcy+0.449×尿酸盐,p<0.001)。综上所述,在糖尿病病人中血浆蛋白纤维蛋白原,同型半胱胺酸尿、尿酸盐及血压为PVD发展的重要因素。

 
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