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   细胞癌 在 眼科与耳鼻咽喉科 分类中 的翻译结果: 查询用时:0.765秒
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细胞癌
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  cell carcinomas
To reveal early genetic alterations of chromosome 6 that are important for CC progression, we analyzed the loss of heterozygosity (LOH) in DNAs from 45 CIN cases, 47 microcarcinomas, and 19 invasive squamous cell carcinomas stage IB.
      
No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected.
      
We investigated 37 head and neck squamous cell carcinomas (HNSCC) at different stages, using immunohistochemical staining for CD4+ infiltrates and real-time reverse transcription polymerase chain reaction (RT-PCR) detection of CD4 mRNA.
      
Signet ring cell carcinomas frequently contained strong CD97stalk and CD55-staining.
      
Effect of the Hypoxic Cell Sensitizer Isometronidazole on Local Control of Two Human Squamous Cell Carcinomas after Fractionated
      
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  cell carcinoma cases
Seventy percent of renal cell carcinoma cases had preoperatively elevated serum levels of B2m.
      
The response rate of six lower lip squamous cell carcinoma cases treated with recombinant interferon alpha 2c was 67% and the complete response rate was 17%.
      
It is concluded that ultrastructural investigation of transplanted chimera from squamous cell carcinoma cases may be useful for examining the site of action and clinical effects of anticancer drugs on this kind of tumor.
      
Methods: A nationwide Swedish population-based case-control study including 189 and 262 esophageal and cardia adenocarcinoma cases, respectively, 167 esophageal squamous-cell carcinoma cases, and 820 controls.
      
Differences of Onset Age and Survival Rates in Esophageal Squamous Cell Carcinoma Cases with and without Family History of Upper
      
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Xeroderma pigmentosum (XP) is anexceedingly rare disease, which isautosomal recessive genetically, chron-ically progressive and multisystemicwith the skin as the major targetorgan. The eyes are often involved.The characteristics of XP, just asGrindon described, are "a rare, chron-ic, fatal disease, beginning in infan-cy, characterized by freckking,atrophic stops, telangiectasis andkeratosis, and later by the developmentof carcinomata and sarcomata." Thesesigns usually occur at a very early age.The Desanctis-Cacchione...

Xeroderma pigmentosum (XP) is anexceedingly rare disease, which isautosomal recessive genetically, chron-ically progressive and multisystemicwith the skin as the major targetorgan. The eyes are often involved.The characteristics of XP, just asGrindon described, are "a rare, chron-ic, fatal disease, beginning in infan-cy, characterized by freckking,atrophic stops, telangiectasis andkeratosis, and later by the developmentof carcinomata and sarcomata." Thesesigns usually occur at a very early age.The Desanctis-Cacchione syndrome isthe most severe form of XP. In additionto the skin lesions, the syndromeconsists of microcephaly with mentaldeficiency premature closure of thesutures retarded growth and sexualdevelopment choreoathetosis, cerebellarataxia eventual quadriparesis withshortening of the achilles tendons andsometimes sensorineural deafness. In this paper seven patients withXP seen in last 20 years in GeneralHospital, Sichuan Medical College arepresented. Three were in-patients andfour out-patients. Besides the skinlesions in exposed regions, ocularaffections were seen in all the patients,especially on the skin of eyelids. Theyappeared often early and were severe.The conjunctiva and orbits might besimultaneously involved. Biopsy wasperformed on six patients and malign-ancies were confirmed in five. Theyall were proved to be either basal cellcarcinoma or squamous cell carcinoma,except one case of orbital malignantmelanoma. The onset of XP occurs most com-monly in early childhood. Five patientshad their onsets before the age of 3. Inthis series the youngest one had the ill-ness at the age of 6 months. The oldestcase had his onset at the age of 13,and he got cancer at 16. The patientdied 17 years after the discovery ofthe malignancy. The relatively lateonset and long survival of the patientmight be due to the optimal remedieshe had received. This was a ratherrare case in XP. The occurrence of this disease iscommonly seen in summer and spring.In this series four occurred in summertwo in spring, and one obscure. Skinlesions have a predilection for theexposed parts of the body in typicalcases.But one patient in this series hadcutaneous changes all over the bodyincluding freckles and white flecks onthe skin of the buttocks, scrotum penisand inner and outer surface of thethighs. Seven patients in this series camefrom 5 families. The development ofXP is closely related to heredity,especially consanguineous marriage of parents or grand-parents. In 2 of thefamilies, the patients' parents weremarried in sibship, and in one of therest 3 families there were 2 or 3 mem-bers suffering from XP simultaneously.Cases 4 and 5 were sib brother andsib sister and in their family 4 of 5siblings had similar clinical manifes-tations. Case 5 was an advanced patientclinically but biopsies of skin of theforearm and bulbar conjunctiva failedto reveal malignant change. Nothingabnormal was discovered by karyotypeexamination in 3 cases. In 1968, JE Cleaver demonstratedthat the main biochemical defect wasthe failure of excision-repair of ultra-violet (UV) damage of DNA in fibro-blasts in the skin of patient with XP.This aberration was believed to beassociated with the UV-endonucleasethat initiates excision. Subsequentstudies suggested that XP might involveenzymatic defects in more than onesystem. Lynch reported an eight-yearfollow up a pair of 16 year-old identi-cal twin brothers. Histological findingsfrom skin biopsy of each twin werefound consistent with XP. But theyhad been assiduously protected fromsolar radiation since birth. They didnot develop any evidence of skincancer. The prognosis of this disease isbad. All the patients have a tend todevelop canceration at the advancedstage. Lynch indicated that malignantskin tumors, most commonly basal andsquamous cell carcinomas, occurred inparticular all of the patients at a veryearly age. Malignant melanoma occurredin at least 3% of these patients. Pa-tients with XP usually died within thefirst two decades of their lives due tometastasis from the malignant skintumors In this series, 5 patients with XPdeve

本文报告7例着色性干皮病,该病除皮肤损害外,均合并有眼部病变。6例经病理检查证实有癌变者5例,其中以基底细胞癌和鳞状上皮癌为多,仅1例为眼眶恶性黑色素瘤。作者对本病的好发部位、发病年龄和季节进行了分析,并着重对本病的发病机理、遗传因素以及癌变和预防措施等问题,进行了简要的讨论。

55 Patients were treated by liquid nitrogen cryosurgery of the lids and conjunctiva diseases. 28 patients With eyelids angioma, 5patients conjunctiva angioma, 4 patients with basal cell carcinoma, 2 patients with squamous cell carcinoma,2patients with meibomian carcinoma, 2 patients precancerous melanosis; and 6 patients with spring catarrh. Forty-seven patients were followed-up, and the average duration was 28 months(range 18~48 months),All cases obtained extremely good results with cryosurgery and without...

55 Patients were treated by liquid nitrogen cryosurgery of the lids and conjunctiva diseases. 28 patients With eyelids angioma, 5patients conjunctiva angioma, 4 patients with basal cell carcinoma, 2 patients with squamous cell carcinoma,2patients with meibomian carcinoma, 2 patients precancerous melanosis; and 6 patients with spring catarrh. Forty-seven patients were followed-up, and the average duration was 28 months(range 18~48 months),All cases obtained extremely good results with cryosurgery and without serious complications.

本文介绍55例液氮冷冻治疗眼病的患者,其中眼睑血管瘤28例,结膜血管瘤5例,基底细胞癌4例,鳞形细胞癌2例,睑板腺癌2例,黑色素痣癌前期2例,春季卡他性结膜炎6例,疗效满意,无严重并发症,值得推广。

81 cases of histological controlled excision and 20 cases of simple excision of the eyelid malignant tumors were followed up. The result showed that the recurrence rate of histological controlled excision is markedly lower than the simple excision. It can save normal eyelid and help its reconstruction.

报告眼脸恶性肿瘤81例进行组织学控制切除;20例进行单纯性切除。追踪结果显示:组织学控制切除之复发率比单纯切除明显降低,且能保存更多健康眼睑组织,有利于它的重建成形。肿瘤边缘与切除的最适宜距离在睑板腺癌为6~10毫米,在基底细胞癌为3~5毫米。

 
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