助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   morphine addition 的翻译结果: 查询用时:0.006秒
图标索引 在分类学科中查询
所有学科
中药学
更多类别查询

图标索引 历史查询
 

morphine addition
相关语句
  “morphine addition”译为未确定词的双语例句
     Conclusion The ribozyme specially cleaving per1 mRNA has potential function in inhibiting the transcription and expression of c-fos and blocking the morphine addition.
     结论重组质粒表达的per1RZ可以干扰生物节律基因per1的表达,抑制海马c-fos基因的转录和表达,从而控制吗啡成瘾的发生。
短句来源
  相似匹配句对
     In addition, F.
     另与本亚种团的F.
短句来源
     In addition,M.
     并非是M.
短句来源
     Morphine Immunoassay
     吗啡的免疫测定
短句来源
     Quantitative Determination of Morphine in Opium Powder by Addition and Correlation Method Using Capillary Electrophoresis
     毛细管电泳叠加对比法测定阿片粉中吗啡的含量
短句来源
     (2) morphine group (M);
     吗啡组(M组),鞘内应用吗啡20 μg;
短句来源
查询“morphine addition”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
没有找到相关例句


Objective To study the change of c-fos mRNA and protein in hippocampus of morphine addicted mice after injected with ribozyme specially cleaving per1 mRNA. Method The recombined plasmid pcDNA 3.1—per1RZ DNA was injected into the ventricles of morphine addited mice to transcript the corresponding ribozyme which cleaves per1 mRNA particularly. And then, the brains of mice were fixed by perfusion. The level of c-fos mRNA was assayed by in situ hybridization and c-fos protein was detected by immunohistochemical...

Objective To study the change of c-fos mRNA and protein in hippocampus of morphine addicted mice after injected with ribozyme specially cleaving per1 mRNA. Method The recombined plasmid pcDNA 3.1—per1RZ DNA was injected into the ventricles of morphine addited mice to transcript the corresponding ribozyme which cleaves per1 mRNA particularly. And then, the brains of mice were fixed by perfusion. The level of c-fos mRNA was assayed by in situ hybridization and c-fos protein was detected by immunohistochemical staining. Result The level of c-fos mRNA and protein decreased after injection of the recombined plasmid pcDNA 3.1—per1RZ DNA expressing the ribozyme cleaving per1 mRNA. Conclusion The ribozyme specially cleaving per1 mRNA has potential function in inhibiting the transcription and expression of c-fos and blocking the morphine addition.

目的研究用特异性核酶阻断生物节律基因per1的表达对吗啡成瘾小鼠海马c-fos基因转录及表达的影响。方法制备吗啡成瘾小鼠模型,向小鼠脑室内注射脂质体包裹的重组质粒pcDNA3.1—per1RZDNA,在脑内产生特异性核酶-per1RZ,阻断小鼠脑内生物节律基因per1的表达。作脑组织冰冻切片,用原位杂交和免疫组化法测定小鼠海马c-fos基因转录及表达的变化。结果per1RZ能使吗啡成瘾小鼠海马的c-fos基因转录及表达明显减弱。结论重组质粒表达的per1RZ可以干扰生物节律基因per1的表达,抑制海马c-fos基因的转录和表达,从而控制吗啡成瘾的发生。

AIM: To study the effect of compound detoxification peptide on the levels of N-methyl-D-aspartate receptor 1 (NMDAR1) and nitric oxide synthase (NOS) in mice with morphine addiction. METHODS: The experiment was conducted in the Animal Test Room of Department of Biochemistry and Molecular Biology of the Basic Medical College as well as the First Laboratory for Research Center of Refraining Drugs of Zhengzhou University from March 2003 to May 2004. Compound detoxification peptide was prepared by brain peptide,...

AIM: To study the effect of compound detoxification peptide on the levels of N-methyl-D-aspartate receptor 1 (NMDAR1) and nitric oxide synthase (NOS) in mice with morphine addiction. METHODS: The experiment was conducted in the Animal Test Room of Department of Biochemistry and Molecular Biology of the Basic Medical College as well as the First Laboratory for Research Center of Refraining Drugs of Zhengzhou University from March 2003 to May 2004. Compound detoxification peptide was prepared by brain peptide, mainly including acidic peptide bovine neuropeptide and some other micromolecular neuropeptides. Eighty healthy Kunming mice (half female and half male) with an age ranged 8-10 weeks and the body mass of (20±2) g were selected and randomly divided into 8 groups with 10 mice in each group. Mice in the normal control group were not interfered. Establishment of animal models of morphine addiction: No treatment was conducted on the models. Normal saline group: Gastric perfusion of normal saline was given to models of morphine addiction at 1 mL each time for totally 15 days. Natural refraining group: Mice were normally fed for 15 days after establishment of morphine addiction models without any other treatments. High, middle, low dose compound detoxification peptide treatment groups: Mice with morphine addiction were given gastric perfusion of 80 mg/kg, 40 mg/kg,20 mg/kg of compound refraining peptide at the actual neuropeptide dose of 1 mL, 0.5 mL, 0.25 mL respectively for totally 15 days. Simple compound refraining peptide group: mice were only given gastric perfusion of compound refraining peptide 80 mg/kg for 15 days. Materials were obtained after the experiment, and the levels of NMDAR1 and NOS were measured by histochemical method and Biosens Digital Analyzer.RESULTS: A total of 80 mice were involved in the analysis of results. Comparison in level of NMDAR1 and NOS among each group: compared with the normal control group, those in the morphine addiction model group were increased (134.93±6.83, 117.24±3.91; 116.26±8.64, 96.81±6.16, P < 0.05), while those were significantly decreased in the 80 mg/kg compound refraining peptide group than those in the morphine addition group, natural refraining group, normal saline group, 40 mg/kg, 20 mg/kg compound refraining peptide group 134.93±6.83, 117.24±3.91; 133.10±8.97, 115.82 ±5.61; 134.92±8.51, 116.55±5.10; 120.02±7.49, 106.03±8.99; 120.02±7.49, 106.03±8.99; 128.59±9.26, 112.59±2.93; 130.50±2.50, 113.22±5.14, P < 0.05).CONCLUSION: The levels of NUDAR1 and NOS in brain of mice with morphine addiction can be decreased by 80 mg/kg of compound refraining peptide.

目的:观察复方戒毒肽对吗啡成瘾小鼠脑内N-甲基-D-天门冬氨酸受体1和一氧化氮合酶水平的影响。方法:实验于2003-03/2004-05在郑州大学基础医学院生物化学与分子生物学教研室动物室和郑州大学志愿戒毒研究中心第一实验室完成。复方戒毒肽由脑肽配制而成熏主要含有酸性肽,牛神经肽FF等小分子神经肽。80只健康的昆明种小鼠,雌雄各半,8~10周龄,体质量(20±2)g。抽签随机分为8组,每组10只。正常对照组:不做任何处理。成瘾模型建立:腹腔注射吗啡,1次/d熏100mg/kg,共11d。成瘾模型组:成瘾模型建立后,不做任何处理。生理盐水组:成瘾模型建立后,用生理盐水1mL/次灌胃治疗15d。自然戒断组:成瘾模型建立后,正常喂养15d,期间不做任何处理;高、中、低剂量的复方戒毒肽治疗组:成瘾模型建立后,给成瘾小鼠按80mg/kg,40mg/kg,20mg/kg的复方戒毒肽进行灌胃治疗,神经肽溶液的实际用量为1mL熏0.5mL熏0.25mL,时间为15d。单独使用复方戒毒肽组:仅给正常小鼠按80mg/kg剂量的复方戒毒肽灌胃15d。实验结束后取材,通过免疫组化和Biosens数字成像系统分析仪测定海马内N-甲基-...

目的:观察复方戒毒肽对吗啡成瘾小鼠脑内N-甲基-D-天门冬氨酸受体1和一氧化氮合酶水平的影响。方法:实验于2003-03/2004-05在郑州大学基础医学院生物化学与分子生物学教研室动物室和郑州大学志愿戒毒研究中心第一实验室完成。复方戒毒肽由脑肽配制而成熏主要含有酸性肽,牛神经肽FF等小分子神经肽。80只健康的昆明种小鼠,雌雄各半,8~10周龄,体质量(20±2)g。抽签随机分为8组,每组10只。正常对照组:不做任何处理。成瘾模型建立:腹腔注射吗啡,1次/d熏100mg/kg,共11d。成瘾模型组:成瘾模型建立后,不做任何处理。生理盐水组:成瘾模型建立后,用生理盐水1mL/次灌胃治疗15d。自然戒断组:成瘾模型建立后,正常喂养15d,期间不做任何处理;高、中、低剂量的复方戒毒肽治疗组:成瘾模型建立后,给成瘾小鼠按80mg/kg,40mg/kg,20mg/kg的复方戒毒肽进行灌胃治疗,神经肽溶液的实际用量为1mL熏0.5mL熏0.25mL,时间为15d。单独使用复方戒毒肽组:仅给正常小鼠按80mg/kg剂量的复方戒毒肽灌胃15d。实验结束后取材,通过免疫组化和Biosens数字成像系统分析仪测定海马内N-甲基-D-天门冬氨酸受体1和一氧化氮合酶水平。结果:80只小鼠均进入结果分析。各组N-甲基-D-天门冬氨酸受体1和一氧化氮合酶的水平的比较:与正常对照组相比,成瘾模型组两者水平均增高(134.93±6.83,117.24±3.91;116.26±8.64,96.81±6.16,P<0.05);与成瘾模型组、自然戒断组、生理盐水组、40mg/kg和20mg/kg复方戒毒肽组相比,80mg/kg复方戒毒肽组两者水平均明显降低(134.93±6.83,117.24±3.91;133.10±8.97,115.82±5.61;134.92±8.51,116.55±5.10;120.02±7.49,106.03±8.99;120.02±7.49,106.03±8.99;128.59±9.26,112.59±2.93;130.50±2.50,113.22±5.14,P<0.05)。结论:80mg/kg的复方戒毒肽能够降低吗啡成瘾小鼠脑内N-甲基-D-天门冬氨酸受体1和一氧化氮合酶的水平。

 
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关morphine addition的内容
在知识搜索中查有关morphine addition的内容
在数字搜索中查有关morphine addition的内容
在概念知识元中查有关morphine addition的内容
在学术趋势中查有关morphine addition的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社