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antibody affinity     
相关语句
  抗体亲和力
     The results indicated that there was an obvious mutation of antibody affinity (affinity constant raised from 1.6×108 L/mol to 6.9×108 L/mol) after the second immunity response.
     抗体亲和力水平在二次免疫应答时存在一个明显的突变过程,小鼠的抗体亲和常数从1.6×108L/mol上升到6.9×108L/mol。
短句来源
     Conclusion The results provided a model for the study of structure and function of antibody as well as antibody affinity maturation.
     结论 实验结果为抗血管内皮生长因子人源单链抗体的应用奠定了基础 ,同时为抗体结构与功能研究以及抗体亲和力体外成熟提供了参考模型。
短句来源
     A Primary Study on the Assay of Different Specific IgG Subclasses to the Hepatitis C Virus, Antibody Affinity and It's Significance
     丙型肝炎病毒不同区段特异性IgG亚类、抗体亲和力测定及其意义的初步研究
短句来源
     In this review, the advance of antibody affinity maturation which is one of the important elements of antibody engineering is described.
     而抗体工程发展所面临的两大难点问题之一就是如何提高基因工程抗体的亲和力。 本文综述了有关基因工程抗体体外抗体亲和力成熟方面的最新进展。
短句来源
     Random mutation method for the gene did not result in any improvement in antibody affinity. By chain-shuffling technique, however, affinity level was markedly increased and an antibody with affinity of 8×1010/M was isolated.
     对抗体基因的随机突变未产生预期的性能改进,又选择其中活性最好的一株IgG抗体,通过轻链替换和重链替换使抗体亲和力得到了有效提高,达到8×1010/M的理想水平。
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  亲合力
     A simplified method for measurement of antibody affinity of engineered human ant i-HBsFab
     生物工程人源抗-HBsFab的抗原特异亲合力简易测定
短句来源
     Objective To investigate a simple antibody affinity measu ring tech nique in determination of the affinity of bio engineered human anti HBsFab fra gment s.
     目的 建立一种简易的抗体亲合力测定技术 ,对生物工程抗 HBsFab进行抗原特异亲合力测定。
短句来源
  抗体亲合力
     Objective To investigate a simple antibody affinity measu ring tech nique in determination of the affinity of bio engineered human anti HBsFab fra gment s.
     目的 建立一种简易的抗体亲合力测定技术 ,对生物工程抗 HBsFab进行抗原特异亲合力测定。
短句来源
  “antibody affinity”译为未确定词的双语例句
     Methods Purity and yield ratio and conjugated activity of purified Fab fragment were analyzed with three purified ways of goat anti human Fab affinity chromatography and 14F7 monoclonal antibody affinity column, as well as Ion exchange Size exclusion column.
     方法采用羊抗人Fab抗体亲和层析柱、14F7单克隆抗体亲和层析柱、离子交换分子筛层析柱,分别纯化由酵母工程菌(GS115/Fab)发酵的重组人抗HBsAgFab抗体,并对3种纯化方法所得Fab抗体的纯度、收率、与HBsAg的结合活性进行比较。
短句来源
     Fluorimetric Determination of Aflatoxin B_1 in Peanut and Corn With Monoclonal Antibody Affinity Column Cleanup and Bromine Treatment
     单克隆抗体亲和柱分离荧光法测定花生和玉米中黄曲霉毒素B_1的研究
短句来源
     Methods Isolate and purify HSP70-polypeptide compound from oesophageal carcinoma tissue by ConA-Sepharose,ADP-Agarose,MonoQ and HSP70 antibody affinity chromatography.
     方法以食管癌组织为材料,通过一系列的层析柱(ConA-Sepharose、ADP-Agarose、MonoQ及HSP70抗体亲和层析柱)进行分离及纯化。
短句来源
     APPLICATION OF MONOCLONAL ANTIBODY AFFINITY COLUMN TO MEASUREMENT OF AFLATOXIN B_1 IN SOY SAUCE AND FERMENTED BEAN CURD
     单克隆抗体亲和层析柱在测定酱油与乳腐中黄曲霉霉素B_1的应用
短句来源
     Objective To research the isolation and purification process of interferon α2a without using monocloning antibody affinity chromatography.
     目的探索无单克隆抗体亲和层析的重组人干扰素α2a分离纯化工艺。
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  antibody affinity
The resulting preparations were suitable for direct application to an antibody affinity chromatography column.
      
The release of calcein from TG-S liposome occurred when the various target cells were contacted with liposomes and it was proportionally increased with the increase of antibody affinity to the target cells.
      
While such an effect should be highly sensitive to fluctuations in antibody affinity and titer, it may present a means of extending the circulation of potent but rapidly cleared therapeutic agents.
      
There was no direct correlation between the two spectral shift populations and antibody affinity, fluorescence polarization, fluorescence quenching, or fluorescence lifetimes of bound ligand.
      
Replacement of valine with alanine at position 102 has much less impact on antibody affinity.
      
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This report presents the study of determination of DNA in different Namalva IFN preparation by a microassay method using ethidium bromide. The results show that the purified IFN,by antibody affinity chromatography, contains no DNA, which indicates this purified IFN can be used clinically as a safe drug.

本文报道了用溴乙锭DNA微量测定法对不同Namalva IFN制品中DNA测定的研究。结果表明,经抗体亲和层析纯化的IFN不含有DNA,从而证实该纯化IFN制剂能够作为安全制品用于临床。

Results of the establishment and application of anti-interferon antibody column are reported. Antiserum against human lymphoblastoid interferon (HuLyIFN) was obtained by immunizing sheep with partially purified Namalva interferon. After they were isolated from antiserum, the immunoglobulins against HuLylFN were adsorbed repeatedly on the "mock interferon"column and trypsin inhibitor column. Anti-interferon anti-body column was established by coupling the adsorbed anti-interferon antibody to Sepharose 4B. Crude...

Results of the establishment and application of anti-interferon antibody column are reported. Antiserum against human lymphoblastoid interferon (HuLyIFN) was obtained by immunizing sheep with partially purified Namalva interferon. After they were isolated from antiserum, the immunoglobulins against HuLylFN were adsorbed repeatedly on the "mock interferon"column and trypsin inhibitor column. Anti-interferon anti-body column was established by coupling the adsorbed anti-interferon antibody to Sepharose 4B. Crude Namalva interferon was purified by antibody affinity chro-matography in one step to a specific activity of 8×108 to 8×107units/mg protein with the recovery of over 100%. Peak of purified interferon activity in elution was seen mostly in fractions 1-3(3-8ml). Similar results were obtained in purification of human leukocyte interferon(HuLeIFN)by this column.The polyclonal antibody column purified recombined leukocyte interferon-αD (LrIFN-αD) to homogeneity as analyzed on SDS-polyacrylamide gel electrophoresis.

本文报道了人α干扰素(IFN)抗体亲和层析技术建立与应用的研究。通过用初提和部分纯化的人Namalva IFN免疫绵羊,获得了抗IFN血清。在将抗血清中的抗体分离出之后,用“假IFN制剂”柱进行反复吸附,去除其中的抗杂质抗体。并用蛋白酶抑制剂柱去除其中的蛋白水解活性。然后,与Sepharose 4B结合,制备成抗IFN抗体柱。该柱能将粗制人Namalva IFN一步纯化至比活性达10~7U/mg以上,回收率>100%。纯化IFN的活性峰集中于1~3个洗脱组分(3~8ml)中。用该柱纯化人白细胞IFN也获得了类似的效果。本研究还表明,以此法制成的多克隆抗自然IFN抗体柱可将重组人IFN-αD型纯化至电泳均一性。

A range of monoclonal antibodies specific for P. falciparum were tested in vitro for their abilities to inhibit the multiplication of a partially synchronized culture of P. falciparum, to augment the phagocytosis of the parasites by macro-phages, and to enhance the killing of parasites by peritoneal cells depleted of adherent cells. Seven of 17 monoclonal antibodies, ranging from culture supernatant and ascitic fluid to purified IgG, were shown to have a dose-and time-dependent inhibition of the...

A range of monoclonal antibodies specific for P. falciparum were tested in vitro for their abilities to inhibit the multiplication of a partially synchronized culture of P. falciparum, to augment the phagocytosis of the parasites by macro-phages, and to enhance the killing of parasites by peritoneal cells depleted of adherent cells. Seven of 17 monoclonal antibodies, ranging from culture supernatant and ascitic fluid to purified IgG, were shown to have a dose-and time-dependent inhibition of the parasite growth in vitro. At a concentration of 0.6mg/ml, the inhibitory capacity of these monoclonal IgG were above 94% over a 3-day culture period, much higher than that of the relevant polyclonal TgG. Four of six monoclonal antibodies tested augmented the phagocytosis of the parasites by macrophages, which occurred as a result of the opsonization of the parasites.Four of seven monoclonal antibodies examined showed cytotoxic activity on malaria parasites. Peritoneal cells depleted of adherent cells were capable of killing the parasites in the presence of monoclonal antibodies. The results indicate that there may be "monofunction", bifunction",and "multifunction" types of monoclonal antibodies against P. falci-parum.The putative protective antigen of malaria parasite purified by"multifunctio-nal monoclonal antibody" affinity chromatography may have potential interest as a vaccine against the parasite.

用体外抑制试验、调理试验和细胞毒试验等方法,对抗恶性疟原虫红内期McAb之功能特性进行了研究。17株McAb中有7株对同步化培养的恶性疟原虫的体外增殖具有明显的抑制作用;抑制强度取决于剂量和作用时间。在McAb—IgG浓度为0.6mg/ml时,上述7株McAb的抑制活性均在94%以上。在6株McAb中,有4株能促进巨噬细胞吞噬疟原虫而发挥调理作用。在7株McAb中,有4株能加强腹腔细胞杀伤和杀死疟原虫而表现出细胞毒活性。结果提示,恶性疟原虫McAb似有“多功能”、“双功能”和”单功能”之分,用“多功能性McAb”纯化的疟疾抗原,在制备疟疾亚单位疫苗方面可能更有意义。

 
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