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racemic bupivacaine
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  布比卡因
     Conclusion PCEA with 0.125% levobupivacaine containing fentanyl 2 μg·ml-1 provides adequate pain relief after cesarean section with recovery of motor function similar to that with 0.2% ropivacaine and 0.125% racemic bupivacaine.
     结论 0.125%左旋布比卡因混合芬太尼(2μg·ml-1)用于产科术后硬膜外镇痛可获得满意的镇痛效果且无明显毒副作用。
短句来源
     Comparison of ropivacaine and racemic bupivacaine in epidural analgesia after cesarean section
     罗哌卡因与布比卡因复合芬太尼用于剖宫产术后硬膜外镇痛的比较
短句来源
     Conclusions 1 There were no significant effects of racemic bupivacaine, levobupivacaine and ropivacaine at low concentration on intracellular Ca2+ in rat ventricular myocytes induced by KCI.
     1、低浓度的消旋布比卡因、左旋布比卡因和罗呱卡因对KCI诱导的大鼠心室肌细胞内[C a2+]i无明显影响。
短句来源
     2. Racemic bupivacaine, levobupivacaine and ropivacaine at high concentraton could inhibit significantly the effects on [Ca2+]j in rat ventricular myocytes induced byKCL.
     2、高浓度的消旋布比卡因、左旋布比卡因和罗呱卡因则明显抑制KCI诱导的大鼠心室肌细胞内[C a 2+]1。
短句来源
     Comparison of levobupivacaine, ropivacaine and racemic bupivacaine in patient-controlled epidural analgesia after cesarean section
     左旋布比卡因、罗哌卡因及布比卡因硬膜外镇痛效果比较
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  消旋布比卡因
     Conclusions 1 There were no significant effects of racemic bupivacaine, levobupivacaine and ropivacaine at low concentration on intracellular Ca2+ in rat ventricular myocytes induced by KCI.
     1、低浓度的消旋布比卡因、左旋布比卡因和罗呱卡因对KCI诱导的大鼠心室肌细胞内[C a2+]i无明显影响。
短句来源
     2. Racemic bupivacaine, levobupivacaine and ropivacaine at high concentraton could inhibit significantly the effects on [Ca2+]j in rat ventricular myocytes induced byKCL.
     2、高浓度的消旋布比卡因、左旋布比卡因和罗呱卡因则明显抑制KCI诱导的大鼠心室肌细胞内[C a 2+]1。
短句来源
     5. The fluorescent intensity (Fl) of intracellular Ca2+ in single culturedcardiomyocytes of newborn rats loaded with Fluo 3 was observed by LSCM in order to compare the effects of racemic bupivacaine, levobupivacaine and ropivacaine in different concentration on [Ca2+]i induced by KCI.
     5、运用激光扫描共聚焦显微动态观察Fluo-3负载的单个心室肌细胞内钙荧光强度的变化,比较不同浓度的消旋布比卡因、左旋布比卡因和罗哌卡因对KCl诱导的心室肌细胞内游离钙离子浓度的影响。
短句来源
     Objective To compare the effects of racemic bupivacaine, levobupivacaine and ropivacaine at different concentrations on intracellular calcium concentration ([Ca2+]j) in rat ventricular myocytes induced by KCI using laser scanning confocal microscope (LSCM), and to investigate the mechanism of cardiotoxicity of local anesthetics.
     运用激光扫描共聚焦显微镜观察不同浓度的消旋布比卡因、左旋布比卡因和罗哌卡因对KCl诱导的大鼠心室肌细胞内游离钙离子浓度的影响,进而探讨局麻药心肌抑制作用的机制。
短句来源
     Comparison of motor block potential of epidural levobupivacaine and racemic bupivacaine during gynecological surgery
     妇科硬膜外左旋与消旋布比卡因运动阻滞效能比较
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  “racemic bupivacaine”译为未确定词的双语例句
     Levobupivacaine versus racemic bupivacaine for epidural anesthesia
     左旋布吡卡因与消旋布吡卡因用于硬膜外麻醉的比较
短句来源
     3.The higher the concentration of racemic bupivacaine, levobupivacaine and ropivacaine, the more significant of inhibition of Intracellular Ca2+ fluorescent intensity in rat ventricular myocytes induced by KCI.
     3、三种局麻药均为浓度越高对Kcl诱导的大鼠心室肌细胞内[C a2+]i的抑制程度越大。
短句来源
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  racemic bupivacaine
To preparatively separate racemic bupivacaine, the desirable injection volumes were 0.05 ml at 2.0 mg/ml of the concentration of racemic mixture or 0.01 ml at 20 mg/ml.
      
HPLC (High Performance Liquid Chromatography) was utilized for the chiral separation of racemic bupivacaine, and mathematical modeling with competitive Langmuir isotherm was performed to determine the optimum feed condition.
      
The mechanisms responsible for the cardiac depression induced by a large blood concentration of racemic bupivacaine are unclear.
      
The fatal dose for levobupivacaine was significantly greater than racemic bupivacaine; 277 50 mg versus 156 31 mg, respectively.
      
Resuscitation from racemic bupivacaine-induced cardiovascular collapse has been difficult and often unsuccessful.
      
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Objective To compare levobupivacaine with ropivacaine and racemic bupivacaine for patient-controlled epidural analgesia (PCEA) after cesarean section with respect to their relative efficay and side effects. Methods Fifty-one ASA Ⅰ-Ⅱ full-term nulliparous women aged 22-38 yrs, weighing 60-85 kg undergoing elective cesarean section under epidural anesthesia were enrolled in this prospective, randomized, double-blind study. Epidural puncture was performed at L2-3 interspace and a catheter was advanced 3-4...

Objective To compare levobupivacaine with ropivacaine and racemic bupivacaine for patient-controlled epidural analgesia (PCEA) after cesarean section with respect to their relative efficay and side effects. Methods Fifty-one ASA Ⅰ-Ⅱ full-term nulliparous women aged 22-38 yrs, weighing 60-85 kg undergoing elective cesarean section under epidural anesthesia were enrolled in this prospective, randomized, double-blind study. Epidural puncture was performed at L2-3 interspace and a catheter was advanced 3-4 cm in the epidural space. Cesarean section was performed under epidural anesthesia with a mixture of 1% lidocaine and 0.25% tetracaine. After operation the patients were randomized to receive 0.125% levobupivacaine (group L, n = 17) or 2% ropivacaine (group R, n = 17) or 0.125% bupivacaine (group B, n = 17) for PCEA. The PCEA solutions in the 3 groups contained fentanyl 2 μg·ml-1 . PCEA pump was set with a 6 ml bolus dose and a 15-min lock-out interval. Intramuscular pethidine was available for rescue analgesia if required. The visual analog scale (VAS) score, high satisfaction rate, the ratio of the number of attempts calculated ( D1) to the number of successfully delivered doses ( D2), modified Bromage Motor Scale score, cardiovascular variables and side effects were recorded at regular intervals after operation. Results The three groups were comparable with respect to demographic data, efficacy of analgesia, motor blockade and side effects. There was no significant difference in D1 /D2 and high satisfaction rate [88.2% (L group); 76.5% (R group); 81.3% (B group) P > 0.05] between group L and other two groups.Conclusion PCEA with 0.125% levobupivacaine containing fentanyl 2 μg·ml-1 provides adequate pain relief after cesarean section with recovery of motor function similar to that with 0.2% ropivacaine and 0.125% racemic bupivacaine.

目的 比较左旋布比卡因、罗哌卡因和布比卡因复合芬太尼用于剖宫产术后硬膜外镇痛的效果和副作用。方法 采用随机双盲法,将51例择期行剖宫产术的足月、单胎孕妇分为三组:左旋布比卡因组(L组)、罗哌卡因组(R组)和布比卡因组(B组),每组17例。术后分别采用0.125%左旋布比卡因、0.2%罗哌卡因及0.125%布比卡因复合小剂量芬太尼(2μg·ml-1)行病人自控硬膜外镇痛(PCEA)。观察各组术后48 h内镇痛效果、运动阻滞程度变化以及恶心呕吐、尿潴留等副作用的发生率。结果 三组产妇术后视觉模拟评分、改良Bromage评分比较差异均无显著性(P>0.05)。三组产妇对PCEA的非常满意率差异无显著性(L组88.2%,R组76.5%,B组81.3%,P>0.05)。三组不良反应发生率及排气时间差异无显著性(P>0.05)。结论 0.125%左旋布比卡因混合芬太尼(2μg·ml-1)用于产科术后硬膜外镇痛可获得满意的镇痛效果且无明显毒副作用。

Objective:Levobupivacaine is the S(-)-enantiomer of the racemic bupivacaine.Data of pharmacological studies suggest that levobupivacaine has a lower potential of toxicity for central nervous and cardiovascular systems than does bupivacaine.This study was undertaken to compare the safety and efficacy between levobupivacaine and bupivacaine in epidural anesthesia.Methods:A prospective randomized,parallel controlled and double-blind clinical study was conducted in 40 ASA Ⅰ-Ⅱpatients undergoing...

Objective:Levobupivacaine is the S(-)-enantiomer of the racemic bupivacaine.Data of pharmacological studies suggest that levobupivacaine has a lower potential of toxicity for central nervous and cardiovascular systems than does bupivacaine.This study was undertaken to compare the safety and efficacy between levobupivacaine and bupivacaine in epidural anesthesia.Methods:A prospective randomized,parallel controlled and double-blind clinical study was conducted in 40 ASA Ⅰ-Ⅱpatients undergoing lower extremity surgery.Patients were randomized to receive either 0.5% bupivacaine(control group) or 0.5% levobupivacaine(study group) in a double-blinded fashion.Blood pressure,heart rate,pulse oxygen saturation,ECG,pre- and post-operative liver and kidney function were used to evaluate the safety.Onset time of sensory and motor blockade,sensory block level,degree of motor blockade and anesthesia quality were used to evaluate the efficacy.Results:Both groups of patients experienced smooth anesthesia.The onset time of sensory and motor block were similar between these two groups.The sensory block level reached T8 and T10 in levobupivacaine and bupivacaine group respectively.The motor blockade was deeper in bupivacaine group.There was no other serious adverse event that happened in both groups.Conclusion:The onset of sensory and motor blockade,quality of anesthesia,and overall quality of anesthesia as assessed were comparable between two groups.In comparison,levobupivacaine have the same efficacy and safety character as bupivacaine in epidural anesthesia.

目的:采用随机、双盲、平行对照的Ⅱ期临床试验,评价0.5%左旋布吡卡因与0.5%消旋布吡卡因用于硬膜外麻醉的安全性与有效性。方法:40例行下肢静脉曲张手术的患者随机分为两组,均实施连续硬膜外麻醉:试验组采用0.5%左旋布吡卡因,对照组采用0.5%的消旋布吡卡因。药物安全性通过血压、心率、脉搏氧饱和度、心电图、术前与术后24h的肝肾功能等指标进行评定。药物的有效性通过感觉阻滞起效时间、运动阻滞起效时间、感觉阻滞范围、运动阻滞程度与麻醉质量等指标评定。结果:0.5%左旋布吡卡因与消旋布吡卡因的感觉阻滞与运动阻滞起效时间相似,但左旋布吡卡因的感觉阻滞范围略宽,消旋布吡卡因的运动阻滞程度较左旋布吡卡因略强。结论:0.5%左旋布吡卡因用于硬膜外麻醉感觉和运动神经阻滞起效时间、阻滞范围、麻醉质量与消旋布吡卡因相似,且具有与消旋布吡卡因相同的安全性。

Objective:Levobupivacaine, a new local anesthetic, is less cardiotoxic than racemic bupivacaine, while retaining similar local anesthetic property and potency to racemic bupivacaine. The authors evaluated the clinical effects and hemodynamic effects of levobupivacaine compared with bupivacaine when given for caudal blocks in children.Methods:78 patients were randomly divided into two groups of 39 patients each.Group A and group B received a caudal injection of 0.25% levobupivacaine (0.8 ml/kg)...

Objective:Levobupivacaine, a new local anesthetic, is less cardiotoxic than racemic bupivacaine, while retaining similar local anesthetic property and potency to racemic bupivacaine. The authors evaluated the clinical effects and hemodynamic effects of levobupivacaine compared with bupivacaine when given for caudal blocks in children.Methods:78 patients were randomly divided into two groups of 39 patients each.Group A and group B received a caudal injection of 0.25% levobupivacaine (0.8 ml/kg) and of 0.25% bupivacaine (0.8 ml/kg) respectively.. Postoperative observations included the duration of analgesia, hemodynamic, invalid anesthetic time and motion recovery time in recovery room.Results:All patients had satisfactory anesthesia and similar longer duration of analgesia was observed in both group..Analgesic duration were (223±37) min in group A and(216±29)min in group B.All patients showed a significant decrease in mean arterial blood pressure and heart rate.The lowest mean systolic blood pressure and heart rate were, respectively,(74±19)mmHg and (70±16) beats/min in group A versus (77±18) mmHg and (73±21) beats/min in group B.Conclusion:Caudal levobupivacaine could provid effective analgesia in small children.

目的:对小儿病人实施新的局部麻醉剂左布比卡因骶管麻醉,将左布比卡因及布比卡因的临床作用及血液动力学影响进行比较,并对左布比卡因的药效学进行了分析。方法:将78名2004年6~12月在我院施行择期手术的小儿随机分为A、B两组,每组39例,A组注入0.25%左布比卡因0.8ml/kg;B组注入0.25%布比卡因0.8ml/kg。术后在苏醒室监测病人的麻醉镇痛时间、血液动力学改变并观察两组的麻醉时间及运动恢复时间。结果:所有小儿均获得满意的麻醉效果,两组的镇痛时间类似,A组的镇痛时间为223±37min,B组的镇痛时间为216±29min,差异不显著。所有小儿均出现明显的平均动脉压下降及心率减慢,A组的平均动脉压及心率分别下降到74±19mmHg及70±16次/min,而B组为77±18mmHg及73±21次/min,两组差异不显著。结论:左布比卡因骶管麻醉提供了有效的小儿麻醉镇痛。麻醉效果与布比卡因类似而心脏毒性较低。

 
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