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cmv-ip
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  cmv间质性肺炎
     The deaths in GCV group were caused by bacterial and fungal infection, CMV-interstitial pneumonia (CMV-IP), or relapse.
     预防组的死因分别为并发细菌和真菌感染、CMV间质性肺炎或原发病复发 ;
短句来源
     CMV interstitial pneumonia(CMV-IP)was treated with ganciclovir and large number of globulin[the dose of 0.4?g/(kg·d)].
     CMV间质性肺炎(CMV-IP)则在上述治疗方案的基础上加用膦甲酸钠和丙种球蛋白[0.4 g/(kg.d)]。
短句来源
     (3) The CMV gB DNA positive samples were screened, which were sufficient for enzyme digestion. Glycoprotein B typing was performed through digesting PCR products with Rsa I and Hinf I . The distribution of gB genotypes and the correlation between genotypes and pathogenesis of CMV-IP as well as GVHD were analyzed.
     (3)筛选出CMV-gB DNA阳性并且PCR产物量足够酶切的患者标本,用Rsa Ⅰ和Hinf Ⅰ两种限制性内切酶进行酶切分型,分析CMV感染患者gB蛋白基因型分布和不同基因型与CMV间质性肺炎和GVHD的相关性。
短句来源
     The incidence of CMV-IP in patients of gB3 was significantly higher than in gBland the symptoms of CMV-IP in gB3 were more severe than in gBl.
     111型患者CMV间质性肺炎发生率高,症状重;
短句来源
     And the deaths in placebo group were caused by CMV-IP.
     对照组的死因均是CMV间质性肺炎
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  发展成cmv-ip
     Results:Six patients of CMV infection occurred Ⅱ~Ⅳ GVHD,2 of 6 patients occurred CMV-IP and one died.
     结果:6例合并CMV感染者均存在Ⅱ~Ⅳ度GVHD,其中4例为活动性感染,2例发展成CMV-IP(1例治疗无效死亡)。
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  “cmv-ip”译为未确定词的双语例句
     Results Of the 56 recipients,8 (14.3%) developed CMV-IP.
     结果56例患者发生CMV肺炎8例(14.3%)。
短句来源
     The best index to predict CMV-IP was viral load above 1×10~4 copies/ml in 3 consecutive tests during a period of 5-15 weeks after operation. The sensitivity,specificity,positive predictive value and negative predictive value were 62.5%, 93.8%,62.5% and 93.8%,respectively. Conclusions After renal transplantation the recipient keeps a high level of viral load until the development of CMV-IP.
     以术后5~15周内连续3次CMVDNA载量>1×104拷贝/ml作为预测CMV肺炎指标,灵敏度、特异度、阳性预测值、阴性预测值分别为62.5%、93.8%、62.5%、93.8%,Kappa值0.5625(95%CI=0.2503~0.8747),预警时间2~10周。
短句来源
     Dynamic detection of plasma CMV DNA can predict the CMV-IP,and viral load above 1×10~4 copies/ml in 3 consecutive tests during a period of 5-15 weeks after renal transplantation can be used as a threshold value.
     结论肾移植后CMV肺炎发病前血浆CMVDNA载量值呈持续高水平状态,5~15周内连续3次CMVDNA载量>1×104拷贝/ml是预测CMV肺炎的良好指标。
短句来源
     Interstitial pneumonia was discovered in 3 patients(12.5%),CMV-DNA was normal in 2 of them,while the rest one was affected by CMV-IP.
     有3例(12.5%)发生IP,其中2例CMV-DNA在正常范围,1例患者为巨细胞病毒间质性肺炎(CMV-IP)。
短句来源
     After two weeks to six month, the infection reoccurred in 12 patients who had been cured. CMV-IP developed in 20 patients (27.03%). The median day of onset of CMV-IP was 65 days.
     20/74例(27.03%)患者发生CMV疾病,中位发生时间为65天,7例(35%)死亡。
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  cmv-ip
Gancyclovir was shown to be effective in both prophylaxis and treatment of CMV-IP.
      
5 cases of CMV-IP were successfully treated with GCV, but 3 cases died of CMV-IP.
      
Graft-versus-host-disease (GVHD) may be associated with a high risk of CMV-IP.
      
Results: 9 patients in non-GCV prophylaxis group developed late CMV-IP (P>amp;lt;0.05).
      
A comparison was made of the incidence of CMV-IP in patients given or not given prophylactic gancyclovir.
      
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Objective: To investigate the incidence of CMV infection(CMV I) and CMV related diseases (CMV D) after allogeneic hematopoietic stem cells transplantation in 70 consecutive allogeneic hematopoietic stem cells transplantation(allo HSCT) patients and to search for the optimal prophylactic strategy.Methods: Blood samples were monitored using the CMV pp 65 antigenemia assay.Of the 70 patients observed,30 patients with chronic myeloid leukemia[CML:CP(27),AP(2),BC(1)],12 with acute myeloblastic leukemia(AML),10...

Objective: To investigate the incidence of CMV infection(CMV I) and CMV related diseases (CMV D) after allogeneic hematopoietic stem cells transplantation in 70 consecutive allogeneic hematopoietic stem cells transplantation(allo HSCT) patients and to search for the optimal prophylactic strategy.Methods: Blood samples were monitored using the CMV pp 65 antigenemia assay.Of the 70 patients observed,30 patients with chronic myeloid leukemia[CML:CP(27),AP(2),BC(1)],12 with acute myeloblastic leukemia(AML),10 with acute lymphoblastic leukemia(ALL)and other cases were NHL(3), AA(5), MDS(7), SCLC with pancytopenia (1),CLL(1), and MF (1). Sixty six patients received HLA identical siblings transplantation and four received tranplants from their HLA haploidentical donors. Seventy cases included allo PBPCT (64 cases) , allo BMT (4 cases) and allo PB+BMT (2). Before transplantation, all patients and donors received CMV serological examination except 4 pairs of donors/recepients. All 66 patients (3 cases were CMV IgM positive) and 64/66 donors were CMV IgG positive. Results:After transplantation, 64/70 patients developed CMV viremia during monitoring period. Forty three of 70 patients developed CMV D.Thirty five of them suffered from CMV associated interstitial pneumonia(CMV IP). The high peak levels of CMV antigenemia were associated with development of CMV disease. Close correlation was found between acute graft vs host disease (GVHD) and CMV disease. The patients were followed up for 2 to 24 months. The patients who received preemptive therapy(group A)had significantly better outcome than CMV disease group(group B, P= 0.0001) . Conclusions: The results suggest that CMV antigenemia has high predictive value for subsequent CMV disease and CMV pp 65 antigenemia guided early therapy has particular advantage for avoiding morbidity and mortality caused by CMV disease. [

目的 :巨细胞病毒 (CMV)感染和巨细胞病毒疾病是异基因造血干细胞移植 (allo HSCT)术后的主要并发症 ,如发现和处理不及时则病死率高。我院对 70例异基因造血干细胞移植患者于移植后进行巨细胞病毒血症监测 ,以指导CMV感染防治。方法 :采用CMVpp65单克隆抗体免疫组化法监测。结果 :移植后CMV抗原血症见于 94 .3% (6 6 / 70 )患者。 6 1.4 % (43/ 70 )发展为CMV疾病。其中 35例为CMV相关性间质性肺炎 (CMV IP)。随访 2~ 2 4个月 ,2 5例 (2 5/ 70 ,35.7% )病故 ,其中CMV疾病相关性死亡率为 19例 (19/ 2 5,76 % )。巨细胞病毒感染和急性移植物抗宿主病 (GVHD)之间密切相关。CMV疾病伴Ⅲ~Ⅳ度急性GVHD或慢性GVHD者占CMV疾病例数的 54.3% (19/4 3)。症状前治疗组与CMV疾病组比较显示 ,CMV疾病组的CMV疾病发生率 ,继发细菌、真菌感染 ,严重GVHD发生率以及死亡率均显著高于症状前治疗组 (P <0 .0 0 1) ;随访 2~ 2 4个月 ,CMV疾病组的总体生存率仅为 31....

目的 :巨细胞病毒 (CMV)感染和巨细胞病毒疾病是异基因造血干细胞移植 (allo HSCT)术后的主要并发症 ,如发现和处理不及时则病死率高。我院对 70例异基因造血干细胞移植患者于移植后进行巨细胞病毒血症监测 ,以指导CMV感染防治。方法 :采用CMVpp65单克隆抗体免疫组化法监测。结果 :移植后CMV抗原血症见于 94 .3% (6 6 / 70 )患者。 6 1.4 % (43/ 70 )发展为CMV疾病。其中 35例为CMV相关性间质性肺炎 (CMV IP)。随访 2~ 2 4个月 ,2 5例 (2 5/ 70 ,35.7% )病故 ,其中CMV疾病相关性死亡率为 19例 (19/ 2 5,76 % )。巨细胞病毒感染和急性移植物抗宿主病 (GVHD)之间密切相关。CMV疾病伴Ⅲ~Ⅳ度急性GVHD或慢性GVHD者占CMV疾病例数的 54.3% (19/4 3)。症状前治疗组与CMV疾病组比较显示 ,CMV疾病组的CMV疾病发生率 ,继发细菌、真菌感染 ,严重GVHD发生率以及死亡率均显著高于症状前治疗组 (P <0 .0 0 1) ;随访 2~ 2 4个月 ,CMV疾病组的总体生存率仅为 31.3% (10 / 32 ) ,而症状前治疗组为 93.8% (30 / 32 )。结论 :HSCT后CMV感染和CMV疾病常见 ,于CMV疾病之前的症状前期及时进行抗CMV治疗多可挽救患者生命 ,争取较好的临床转归

Cytomegalovirus infection(CMV I) and CMV related diseases (CMV D) occurred after allogeneic hematopoietic stem cell transplantation(Allo HSCT) seem to be with high morbidity and mortality. This study is a retrospective analysis of the incidence of CMV infection and diseases in Allo HSCT patients known to be CMV seropositive before transplantation. To review the efficacy of CMV pp65 antigen guided ganciclovir prophylaxis in preventing CMV infection and to search the optimal determination methods, 45...

Cytomegalovirus infection(CMV I) and CMV related diseases (CMV D) occurred after allogeneic hematopoietic stem cell transplantation(Allo HSCT) seem to be with high morbidity and mortality. This study is a retrospective analysis of the incidence of CMV infection and diseases in Allo HSCT patients known to be CMV seropositive before transplantation. To review the efficacy of CMV pp65 antigen guided ganciclovir prophylaxis in preventing CMV infection and to search the optimal determination methods, 45 consecutive Allo HSCT patients have been observed. Using the CMV pp65 antigenemia assay and serological analysis monitored blood samples from 23 patients with chronic myeloid leukemia(CML), 7 acute myeloblastic leukemia(AML), 6 acute lymphoblastic leukemia(ALL); other: 4 myelodysplastic syndrome(MDS), 3 non Hodgkin′s lymphoma(NHL) and 2 aplastic anemia. Forty three patients received HLA identical siblings transplantation and 2 from their HLA haploidentical donors. Forty five cases included Allo PBPCT (38 cases), Allo BMT (2 cases) and Allo PBPCT+BMT 5 cases. Before transplantation, all donors/recipients have taken CMV serological detection. All donor/recipients were CMV IgG positive and one donor and one recipient with CMV IgM positive, respectively. After transplantation, all patients developed CMV antigenemia during monitoring period. Twenty five patients developed CMV related interstitial pneumonia(CMV IP). Patients have been followed from 6 to 28 months (median of 18 months) after transplantation. The patients who received preemptive therapy had a significantly better outcome than patients who did not received preemptive therapy. CMV related mortality was 1/29 cases in preemptive group vs. 12/16 cases in non preemptive group. The results suggest that prompt and early institution of effective therapy with ganciclovir upon detection of CMV pp65 antigenemia, provides optimal protection against progress of CMV disease for patients undergoing Allo HSCT.

人巨细胞病毒感染及巨细胞病毒疾病是异基因造血干细胞移植后的常见并发症 ,巨细胞病毒性间质性肺炎是移植后巨细胞病毒疾病的主要类型 ,如未能及时检出和救治则病死率极高。为探讨采用免疫组化法测定人巨细胞病毒的方法学 ,指导临床治疗 ,我们采用免疫组化法对 4 5例(慢性粒细胞白血病 2 3例 ,急性髓性白血病 7例 ,急性淋巴细胞白血病 6例 ,骨髓增生异常综合征4例 ,非何杰金氏淋巴瘤 3例 ,再生障碍性贫血 2例 )进行造血干细胞移植后巨细胞病毒抗原血症的检测 ,并与巨细胞病毒血清学检测进行了对比。 4 5例中 38例患者进行了异基因外周血干细胞移植 ,2例骨髓移植 ,5例外周血与骨髓共移植。移植前 ,对供 受者均进行巨细胞病毒抗体检查 ;移植后 ,受者采用本方法进行抗原检查。结果表明 ,有 2 5例患者发生巨细胞病毒相关性间质性肺炎 ,移植后随访时间为 6 - 2 8个月 (平均时间为 18个月 ) ,根据巨细胞病毒检测结果进行预防性治疗的患者预后较未进行预防性治疗的患者有明显差异。预防组巨细胞病毒相关的死亡率为 1 2 9,未预防组为 12 16。提示采用免疫组化法对异基因造血干细胞移植患者进行定期随访...

人巨细胞病毒感染及巨细胞病毒疾病是异基因造血干细胞移植后的常见并发症 ,巨细胞病毒性间质性肺炎是移植后巨细胞病毒疾病的主要类型 ,如未能及时检出和救治则病死率极高。为探讨采用免疫组化法测定人巨细胞病毒的方法学 ,指导临床治疗 ,我们采用免疫组化法对 4 5例(慢性粒细胞白血病 2 3例 ,急性髓性白血病 7例 ,急性淋巴细胞白血病 6例 ,骨髓增生异常综合征4例 ,非何杰金氏淋巴瘤 3例 ,再生障碍性贫血 2例 )进行造血干细胞移植后巨细胞病毒抗原血症的检测 ,并与巨细胞病毒血清学检测进行了对比。 4 5例中 38例患者进行了异基因外周血干细胞移植 ,2例骨髓移植 ,5例外周血与骨髓共移植。移植前 ,对供 受者均进行巨细胞病毒抗体检查 ;移植后 ,受者采用本方法进行抗原检查。结果表明 ,有 2 5例患者发生巨细胞病毒相关性间质性肺炎 ,移植后随访时间为 6 - 2 8个月 (平均时间为 18个月 ) ,根据巨细胞病毒检测结果进行预防性治疗的患者预后较未进行预防性治疗的患者有明显差异。预防组巨细胞病毒相关的死亡率为 1 2 9,未预防组为 12 16。提示采用免疫组化法对异基因造血干细胞移植患者进行定期随访监测可更早期、快速的检出巨细胞病毒感染 ,对患者预后有重要意义。

Objective: To explore risk factors,prevention and treatment of cytomegaloviral interstitial pneumonitis (CMV IP) after allogeneic peripheral blood stem cell transplantation (allo PBSCT ).Methods: Forty patients who received allo PBSCT were allocated to gancyclovir (GCV) group ( n =18) and control group ( n =22).The incidence of CMV IP in patients given prophylactic gancyclovir was compared with that in control group.Results: Five patients in control group developed CMV IP ,while none of patients...

Objective: To explore risk factors,prevention and treatment of cytomegaloviral interstitial pneumonitis (CMV IP) after allogeneic peripheral blood stem cell transplantation (allo PBSCT ).Methods: Forty patients who received allo PBSCT were allocated to gancyclovir (GCV) group ( n =18) and control group ( n =22).The incidence of CMV IP in patients given prophylactic gancyclovir was compared with that in control group.Results: Five patients in control group developed CMV IP ,while none of patients in GCV prophylaxis group developed CMV IP ( P < 0.05 ).Female donor and graft versus host disease (GVHD) were associated with a high risk of CMV IP.Four cases of CMV IP were successfully treated with GCV,but one case resistant to GCV died of CMV IP.Conclusion: CMV infection is a major cause of interstitial pneumonitis after allo PBSCT,which is associated strongly with the severity of GVHD and female donor.Gancyclovir may be effective in both prevention and treatment of CMV IP.

目的 :探讨异基因外周血造血干细胞移植 (Allo-PBSCT)后间质性肺炎 (IP)的病因 ,危险因素及防治方法。方法 :将 Allo-PBSCT患者分为更昔洛韦 (GCV)预防组 1 8例和对照组 (未预防组 ) 2 2例 ,比较两组巨细胞病毒间质性肺炎 (CMV-IP)的发生率。结果 :对照组 Allo-PBSCT患者中并发 CMV-IP5例 ,预防组无 1例发生 CMV-IP。发生 CMV-IP的高危因素为女性供者 ,合并移植物抗宿主病 (GVHD)。 4例治愈 ,1例治疗无效死亡。结论 :Allo-PBSCT后 CMV感染是 IP的主要病因 ,IP的发生与 GVHD严重程度及女性供者密切相关 ,GCV能有效预防和治疗 CMV-IP

 
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