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gene delivery vehicle
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  基因转染
     Synthesis of New Gene-loaded Microbubbles Serve as Gene Delivery Vehicle Applied in Reporter Gene Transfer into Cardiac Myocytes
     新型载基因微泡的制备及其在心肌细胞报告基因转染中的应用
短句来源
     Objective To preparation a new cationic liposome of which the positive component is a new cytofectin as a gene delivery vehicle for laboratory research of gene transfection and gene therapy in lung diseases.
     目的 制备以新型细胞转染素为阳性成分的阳离子脂质体 ,作为基因载体 ,用于基因转染的实验研究和肺部疾病的基因治疗。
短句来源
     These results suggested that ultrasonic destruction of the gene-loaded microbubbles can enhance the cardiac myocytes exogenous gene transfer efficiency significantly and new gene-loaded microbubble is an efficient and safe gene delivery vehicle.
     提示经改良法制备的新型载基因微泡是一种安全高效的基因转运载体,超声破裂载基因微泡能明显增强心肌细胞的基因转染效率。
短句来源
  “gene delivery vehicle”译为未确定词的双语例句
     Objective To synthesize new cationic liposome cytofectin N 4 spermine cholesteryl carbamate as a gene delivery vehicle for gene therapy of lung diseases.
     目的 合成新型阳离子脂质体 细胞转染素N4 精氨胆固醇羰酰氨 ,作为基因载体 ,用于肺部疾病的基因治疗。
短句来源
     Preliminary Studies on Preparation and Application of Chitosan Nanoparticles as the Nonviral Gene Delivery Vehicle
     壳聚糖—基因疫苗纳米颗粒的制备与作用研究
短句来源
     Methods (1)A new compound, cytofectin N4-spermine cholesteryl carbamate, was synthesized with organic chemical methods to serve as gene delivery vehicle in gene therapy of lung diseases. The structure of the obtained compound was identified.
     方法:(1)用有机化学合成法合成新型细胞转染素:N4-精胺胆固醇羰酰氨,并对其结构进行鉴定。
短句来源
     LPD may be a good non-viral gene delivery vehicle for applications in gene delivery.
     LPD是基因治疗的临床应用中一种更具前景的载体系统。
短句来源
  相似匹配句对
     Liposomes for Gene Delivery
     脂质体——基因载体
短句来源
     Ultrasound-mediated Gene Delivery
     超声波介导的基因输送技术
短句来源
     The gene of PNGase F from F.
     为了获得大量廉价的N-糖酰胺酶F,本论文研究的主要内容为根据目的基因N-糖酰胺酶F的cDNA序列设计引物,以F.
短句来源
     GENE IMMUNITY
     基因免疫
短句来源
     Delivery and Stocky
     配送与库存
短句来源
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  gene delivery vehicle
Based on these results, NiMOS show significant potential as novel gene delivery vehicle for therapeutic and vaccination purposes.
      
Thermosensitive Hydrogel as a Tgf-β1 Gene Delivery Vehicle Enhances Diabetic Wound Healing
      
The key to success for any gene therapy strategy is to design a vector able to serve as a safe and efficient gene delivery vehicle.
      
Studies have reported that PEI's efficiency as a gene delivery vehicle depends on its molecu lar weight.
      
In order for a biomaterial to function as a gene delivery vehicle, it must possess several characteristics.
      
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Retroviral vectors are the most used gene delivery vehicle in human gene therapy.When the therapeutic gene is packagedfrom producer cell line, one has to determined whether thereplication-competent retrovirus(RCR) is being generated. In this study, two methods, namely the marker rescue assay and RT/PCR, were employed to detect RCR in the cells. While the marker rescue assay can detect RCR with a limit at 6×102CFU/ml, RT/PCR can be used to detect RCR at as low as lCFU/103ml. Combining the specificity...

Retroviral vectors are the most used gene delivery vehicle in human gene therapy.When the therapeutic gene is packagedfrom producer cell line, one has to determined whether thereplication-competent retrovirus(RCR) is being generated. In this study, two methods, namely the marker rescue assay and RT/PCR, were employed to detect RCR in the cells. While the marker rescue assay can detect RCR with a limit at 6×102CFU/ml, RT/PCR can be used to detect RCR at as low as lCFU/103ml. Combining the specificity of the marker rescue assay and the sensitivity of RT/PCR, both assays together should serve as an adequate test for detecting the generation of RCR in retroviral producer cell lines.

运用逆转录病毒作为外源基因导入的载体,在实际临床运用时需要检测包装细胞在表达目的基因的同时,是否会产生有复制能力的逆转录病毒。本实验运用了Marker Rescue Assay(补救分析)和RT/PCR(逆转录PCR)两种方法。补救分析可检测到6×10~2CFU/ml(Colony Forming Units/ml)的有复制能力的逆转录病毒,RT/PCR的灵敏度为1CFU/10~3ml。这两种检测方法的建立,为逆转录病毒载体用于临床基因治疗的安全性提供一定的保证。

Objective To synthesize new cationic liposome cytofectin N 4 spermine cholesteryl carbamate as a gene delivery vehicle for gene therapy of lung diseases. Methods Selective coupling, deprotection, isolation and purification by column chromatograph were performed. Results The target compound was synthesized in a total yield of 25.46 % and its structure was determined by spectroscopy. Conclusion The obtainment of the target compound with high purity by the establishment of the method for selective...

Objective To synthesize new cationic liposome cytofectin N 4 spermine cholesteryl carbamate as a gene delivery vehicle for gene therapy of lung diseases. Methods Selective coupling, deprotection, isolation and purification by column chromatograph were performed. Results The target compound was synthesized in a total yield of 25.46 % and its structure was determined by spectroscopy. Conclusion The obtainment of the target compound with high purity by the establishment of the method for selective coupling, isolation and purification provides a basis for gene transfection and gene therapy.

目的 合成新型阳离子脂质体 细胞转染素N4 精氨胆固醇羰酰氨 ,作为基因载体 ,用于肺部疾病的基因治疗。方法 用胆固醇羰酰氯为原料 ,与苄氧羰酰基保护的精氨选择性缩合 ,去保护 ,柱层析分离纯化。结果 以 2 5 .46%收率获得目标化合物 ,由波谱分析证实其结构。结论 建立选择性缩合和分离纯化方法 ,获得高纯度目标化合物 ,为基因转染和基因治疗打下基础

Objective To investigate exogenous gene expressing ability of adipose tissue derived stromal cell (ADSCs) and cell distribution after they were transplanted into brains, and to get the genetically modified cells for autografting. Methods ADSCs were transfected by Ad5βgal adenovirus containing a report gene, LacZ gene, then they were transplanted into the adult brain of rats, or ADSCs labeled by Hoechst33258 were transplanted into the adult brain of rats to investigate the migration and distribution of...

Objective To investigate exogenous gene expressing ability of adipose tissue derived stromal cell (ADSCs) and cell distribution after they were transplanted into brains, and to get the genetically modified cells for autografting. Methods ADSCs were transfected by Ad5βgal adenovirus containing a report gene, LacZ gene, then they were transplanted into the adult brain of rats, or ADSCs labeled by Hoechst33258 were transplanted into the adult brain of rats to investigate the migration and distribution of cells. Results ADSCs showed a good expression of LacZ with X gal staining after transfecting and transplantation into adult brains, and they could incorporate into the host brain tissues and no disruption was observed. These cells showed good compatibility with the host brains. Conclusion The results indicate that ADSCs could incorporate into host brains and express exogenous gene steadily when they were transplanted into adult brain tissues, no overproliferation and gliosis were identified, and ADSCs may be used as a therapeutic gene delivery vehicle in treating CNS disorders in humans.

目的 观察大鼠脂肪组织源性基质细胞表达外源基因的能力和脑内移植后的分布 ,以获取基因治疗自体移植的载体细胞。方法 腺病毒载体 Ad5 βgal介导法将 L ac Z转入培养的大鼠脂肪组织源性基质细胞。Hoechst332 5 8标记细胞 ,立体定向移植到大鼠的纹状体 ,脑组织切片 ,在荧光显微镜下检查存活的细胞。结果 脂肪组织源性基质细胞能够在体内和体外稳定表达 L ac Z基因 ,细胞移植到脑内可以移行 ,移植细胞没有过渡增生和肿瘤形成 ,对宿主脑组织无破坏。结论 脂肪组织源性基质细胞可以稳定表达外源基因 ,与脑组织有很好的相容性 ,是中枢神经系统基因治疗的良好载体

 
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