HL-60 cell resisted to ATRA responsed well to the apoptosis and differentiation induction of As2O3. Our results suggest that: As2O3 mainly induce HL-60 cells to apoptosis,low concentration of As2O3 can also induce HL-60 cells to differentiation,and has no cross resistance with ATRA.
11.43 and it also showed cross-resistance to Mitomycin C (MMC), 5-fluorouracil(5-Fu) and Adriamycin(ADM),the resistance index was 4.81,4.94 and 10.45,respectively.
Results LS174T/5-Fu cell line was developed after 6 months with stable resistance to 5-Fu and a resistance index of 40.24.The cells exhibited cross-resistance to cisplatin,etoposide,doxifluridine and hydeoxycamptothecin.
Danofloxacin is a kind of fluoroquinolones exclusive used in veterinary medicine, and it has better water-solubility and can be administered by many pathway, it has wide antibacterial spectrum, and its antimicrobial activity is powerful, it also has good pharmacokinetics character Meanwhile its adverse effect is less, its cross tolerance with other antibacterials is less. Danofloxacin has been used in veterinary surgeon to treat bacterial infection of some animals.
A novel VCR resistant cell line was developed by gradually increasing dose and shortly acting with VCR and its tolerance,cross tolerance, VCR content of cell and the multidrug resistance gene (MDR 1) of cell and glutathion transferase π(GST π) was measured. A2780/VCR cell was 61000 fold to VCR and released characterization of multidrug resistance.
The cross-drug-resistance of three kinds of different source and characteristic strains in Eimeria tenella were tested by means of Diclazuril solution and Toltrazuril solution respectively.
More than 70% of strains resistant to ampicillin, sulfamethoxazole or trimethoprim were sensitive to fosfomycin indicating that cross resistance is not presently a problem.
Fosfomycin trometamol proved to be effective with the advantage of no risk of cross resistance, practical pharmaceutical formulation with good patient compliance, good safety profile with few side effects and a satisfactory cost/benefit ratio.
The only antimicrobial to which all of the ciprofloxacin-multi-resistant isolates were resistant, was ampicillin, indicating an absence of cross resistance.
The number of strains exhibiting cross resistance with structurally unrelated antibiotics was 11 after pefloxacin treatment, eight after exposure to ciprofloxacin, six after ceftazidime, and one after imipenem or cefpirome.
It is shown that cross-resistance to stressors and cell-to-cell communication, mediated by chemical metabolites, affect bacterial survival in food products.
The cells of the both derived sublines demonstrate cross-resistance to these xenobiotics, while the subline resistant to 2-(4"-dimethylaminostyryl)quinoline 1-oxide is also resistant to ethidium bromide and colchicine.
Even though there can be cross-resistance between tylosin and erythromycin, the increasing use of tylosin in animal feeds has not caused an increase of resistance to erythromycin in human isolates of Staphylococcus aureus.
No cross tolerance between hydralazine and ethanol was found.5.Tolerance did not develop to the blood pressure lowering effect of hydralazine.6.Hydralazine similarly induced hypothermia when administered i.p.
In these animals cross tolerance to morphine's effect on DA metabolism was present in s.nigra but not in the other two areas, indicating that s.nigra is particularly sensitive to opiate-induced tolerance on DA metabolism.
交叉耐药性
cross resistance
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