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cyclic nucleotide phosphodiesterase
相关语句
  环核苷酸磷酸二酯酶
     Effect of GM_1 on Cyclic Nucleotide Phosphodiesterase
     GM_1激活环核苷酸磷酸二酯酶的作用
短句来源
     Benzylisoquinoline compounds antagonize calmodulin (CaM) and inhibit the activity of cyclic nucleotide phosphodiesterase which is CaM-dependent (CaM-PDE) .
     苄基异喹啉类化合物拮抗钙调素(CaM)并抑制依赖CaM的环核苷酸磷酸二酯酶(CaM-PDE)的活力;
短句来源
     Using the reactive system of calmodulin-independent cyclic nucleotide phosphodiesterase (PDE-Ⅱ), The effects of API0134 on the activity and kinetic parameters of PDE-Ⅱ were observed.
     采用钙调素非依赖型环核苷酸磷酸二酯酶(PDE-Ⅱ)测定方法,观察API0134对PDE-Ⅱ的作用。
短句来源
     Effects of nitidine (Nit ), berberine (Ber ), sinomenine (Sin ), ephedrine (Eph ), houttuynin (Hou ), quercetin (Que ) and trifluoprazine (TFP ) on calmodulin-dependent cYclic nucleotide phosphodiesterase (CaM-PDE ) were investigatcd by orthogonal design. Our observation came out that Nit, Que and TFP significantly inhibited the CaM-activated PDE activity (P<0.01 ) in ,the order of Que>TFP>Nit.
     用正交设计观察了6种中草药有效成分和三氟啦嗪(TFP)对钙调素依赖环核苷酸磷酸二酯酶(CaM-PDE)激活活性的影响,结果表明:a)两面针碱(Nit)、槲皮素(Que)和TFP对CaM-PDE激活活性具有明显抑制作用(P<0.01),其抑制强度:Qne>TFP>Nit;
短句来源
     Benzylisoquinoline compounds antagonized calmodulin ( CaM ) to inhibit the activity of CaM-dependent cyclic nucleotide phosphodiesterase ( CaM-PDE ) .
     苄基异喹啉类化合物拮抗钙调素(CaM),对环核苷酸磷酸二酯酶(CaM-PDE)产生抑制作用。
短句来源
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  钙调素依赖性环核苷酸磷酸二酯酶
     The Mechanism of Inhibiton of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase by Dihydropyridine Calcium Antagonists
     二氢吡啶类钙拮抗剂对钙调素依赖性环核苷酸磷酸二酯酶的抑制机理
短句来源
  “cyclic nucleotide phosphodiesterase”译为未确定词的双语例句
     Identification and Characterization of PDE5 cGMP-specific Cyclic Nucleotide Phosphodiesterase
     磷酸二酯酶同工酶PDE5的纯化及性质研究
短句来源
     A Research of the Inhibitory Eifeet of Fiavoaoids oa Cyclic Nucleotide Phosphodiesterase
     某些中药的黄酮类化合物对磷酸二酯酶抑制作用的研究
短句来源
     A Method of Plasma Calmodulin Microassay——By Radioenzymatic Assay Using CaM-dependent Cyclic Nucleotide Phosphodiesterase Activation
     血浆钙调素微量测定方法
短句来源
     Progress in selective inhibitors of cyclic nucleotide phosphodiesterase
     选择性磷酸二酯酶抑制剂研究进展
短句来源
     The other two may be PDE2 and PDE3. Conclusion: The cGMP-specific cyclic nucleotide phosphodiesterase 5(PDE5) was mainly found in corpus cavernosum tissue of mammalia,especially rich in corpus cavernosum arteries.
     结论 :哺乳类海绵体组织有cGMP特异性PDE5存在 ,在海绵体血管尤为丰富。
短句来源
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  cyclic nucleotide phosphodiesterase
PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes.
      
Adenyl cyclase (AC) and cyclic nucleotide phosphodiesterase (PDE) have been studied in muscle from patients affected with muscular and neuromuscular diseases as well as in muscle of rats after experimental denervation.
      
Cyclic nucleotide-mediated regulation of vascular smooth muscle cell cyclic nucleotide phosphodiesterase activity
      
cDNAs encoding two PDE-3 or cyclic GMP-inhibited (cGI) cyclic nucleotide phosphodiesterase (PDE) isoforms, RPDE-3B (RcGIP1) and HPDE-3A (HcGIP2), were cloned from rat (R) adipose tissue and human (H) heart cDNA libraries.
      
Thermostable extracellular cyclic nucleotide phosphodiesterase of the Physarum polycephalum plasmodium
      
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Benzylisoquinoline compounds antagonized calmodulin ( CaM ) to inhibit the activity of CaM-dependent cyclic nucleotide phosphodiesterase ( CaM-PDE ) . The anti-CaM ability was relevant to the hydrophobicity of non-polar terminus in the antagonist molecule. The antagonistic potency increased with the increase of hydrophobicity while the anti-CaM ability did not change whether the polar terminus is tertiary amine or quaternary amine. As far as our knowledge goes, compound D3, with IC54 value 2.8 μmol/L,...

Benzylisoquinoline compounds antagonized calmodulin ( CaM ) to inhibit the activity of CaM-dependent cyclic nucleotide phosphodiesterase ( CaM-PDE ) . The anti-CaM ability was relevant to the hydrophobicity of non-polar terminus in the antagonist molecule. The antagonistic potency increased with the increase of hydrophobicity while the anti-CaM ability did not change whether the polar terminus is tertiary amine or quaternary amine. As far as our knowledge goes, compound D3, with IC54 value 2.8 μmol/L, was the most potent CaM antagonist among benzylisoquinoline compounds according to the PDE assay system.

苄基异喹啉类化合物拮抗钙调素(CaM),对环核苷酸磷酸二酯酶(CaM-PDE)产生抑制作用。它们的拮抗能力与分子中非极性端的疏水性相关,增强疏水性能增强拮抗性;极性端为叔胺或季铵离子时,抗CaM性基本不变;在受试的化合物中,D_3的抗CaM活性最强,IC_(50)值为2.8μmol/L。

Localization of 3', 5'-cyclic nucleotide phosphodiesterase activity in thyroid follicular cells and endothelium was examined by cytochemical methods for electron microscopy. In thyroid follicular cells reaction product deposition associated with 3', 5'-cyclic nucleotide phosphodiesterase activity was localized at the plasma membrane. In these cells, the enzyme activity appeared mostly localized on the apical and lateral plasma membrane, and also appeared on the outer surface of nuclear envelope,...

Localization of 3', 5'-cyclic nucleotide phosphodiesterase activity in thyroid follicular cells and endothelium was examined by cytochemical methods for electron microscopy. In thyroid follicular cells reaction product deposition associated with 3', 5'-cyclic nucleotide phosphodiesterase activity was localized at the plasma membrane. In these cells, the enzyme activity appeared mostly localized on the apical and lateral plasma membrane, and also appeared on the outer surface of nuclear envelope, endoplasmic reticulum and Golgi apparatus. However, when cAMP and snake venom were omitted simultaneously, no enzyme activity was observed. 3', 5'-cyclic nucleotide phosphodiesterase activity also appeared on the luminal surface of endothelium of small blood vessels.

本研究用酶电镜细胞化学法观察了大白鼠甲状腺细胞3′,5′-环核苷酸磷酸二酯酶活性的定位。结果证明,3′,5′-环核苷酸磷酸二酯酶的活性定位于甲状腺滤泡细胞的顶部细胞膜和微绒毛,在内质网则存在于膜的外表面,在甲状腺滤泡细胞核也位于核膜的外表面。在甲状腺滤泡上皮细胞之间的微血管内皮细胞膜上也观察到了大量3′,5′-环核苷酸磷酸二酯酶的阳性反应颗粒。

Calmodulin (CaM) was separated from Peking duck brain extract by Phenyl-Sepharose affinity ohromatography and further purified by Sephadex G-50. The purified CaM was shown to be homogeneous by SDS-PAGE and IEF with a molecular weight of 19,000, pI of 4.15, and an extinction coefficient ε2761m 1% of 1.83. The characteristic mobility change of CaM in the presence of Ca2+ was observed.The Ca2+-activition of bovine cyclic nucleotide phosphodiesterase could be enhanced by the addition of CaM. Among 146 amino...

Calmodulin (CaM) was separated from Peking duck brain extract by Phenyl-Sepharose affinity ohromatography and further purified by Sephadex G-50. The purified CaM was shown to be homogeneous by SDS-PAGE and IEF with a molecular weight of 19,000, pI of 4.15, and an extinction coefficient ε2761m 1% of 1.83. The characteristic mobility change of CaM in the presence of Ca2+ was observed.The Ca2+-activition of bovine cyclic nucleotide phosphodiesterase could be enhanced by the addition of CaM. Among 146 amino acid residues, there are 23 aspartic acid, 25 glutamic acid, and no cysteine and tryptophan, the phenylala-nine/tyrosine ratio is high (8:2). Its UV absorption peaks occur at about 252,259, 265, 268.5 and 276nm. The enhancement of fluorescence of CaM could be induced by Ca2+. Some of physical properties of porcine, bovine and duck CaM are compared.

钙调素(Calmodulin,简称CaM)是一种多生理功能的调节蛋白,在脑的功能活动中有重要作用。本文采用苯基琼脂糖(phenyl-Sepharose CL 4B)层析和葡聚糖凝胶(Sephadex G-50)过滤法,从北京鸭脑中分离纯化出CaM。纯化的CaM经SDS-聚丙烯酰胺凝胶电泳(SDS-PAGE)和等电聚焦(IEF)电泳鉴定均为一条区带。分子量为19kD,等电点(pI)为4.15,消光系数为1.83。 对纯化的鸭脑CaM的活性和性质进行了研究。它可明显地激活牛环核苷酸磷酸二酯酶活性,在有Ca~(2+)存在的条件下,SDS-PAGE中出现电泳迁移速度的改变,紫外吸收光谱具有已知CaM特有的吸收多峰形,并观察了Ca~(2+)对荧光发射光谱的影响。其氨基酸组成中,1/3是酸性氨基酸,苯丙氨酸和酪氨酸的比例为8:2。与猪CaM和牛CaM的物理化学性质作了比较。

 
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