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mannan-binding lectin
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  甘露聚糖结合凝集素
     Construction of CGT52TGT and GGA57GAA mutants of mannan-binding lectin gene
     CGT52TGT和GGA57GAA甘露聚糖结合凝集素突变体的构建
短句来源
     Objective To investigate the effects of mannan-binding lectin (MBL) on TNF-α and IL-12 production induced by lipopolysaccharide (LPS) in differentiated and activated THP1/CD14 cells.
     目的探讨甘露聚糖结合凝集素(MBL)对脂多糖(LPS)刺激的不同分化和活化状态THP1/CD14细胞产生TNF-α和IL-12的影响。
短句来源
     Objective To investigate the frequencies of three point mutations,CGT52TGT,GGC54GAC and GGA57GAA,in exon 1 of mannan-binding lectin(MBL)structural gene in Chinese Uyghur population.
     目的了解我国维吾尔族人群甘露聚糖结合凝集素(MBL)结构基因外显子1第52、54和57位密码点突变(CGT52TGT、GGC54GAC和GGA57GAA)的情况。
短句来源
     Objective To construct two mutants of human mannan-binding lectin (MBL) gene, CGT52TGT and GGA57GAA.
     目的 构建CCT52TGT和GGA57GAA 2种甘露聚糖结合凝集素(MBL)基因突变体。
短句来源
     Objective To obtain full-length cDNA encoding mouse mannan-binding lectin C(MBL-C) polypeptide.
     目的获得小鼠甘露聚糖结合凝集素-C(MBL-C)基因的全长编码区cDNA。
短句来源
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  甘露糖结合凝集素
     Mannan-Binding Lectin and Infectious Diseases
     甘露糖结合凝集素与感染性疾病
短句来源
     Background and Objective: Mannan-binding lectin (syn: mannose-binding lectin, MBL) is a Ca2+-dependent (C-type) serum lectin. It has an important role in the innate immune system against pathogenic microorganisms, especially for children of 6 months to 2 years old. MBL is an oligomer comprised of several identical subunits.
     研究背景与目的:甘露聚糖结合凝集素(mannan-binding lectin,MBL),又称甘露糖结合凝集素(mannose-binding lectin,MBL),是一种钙离子依赖的(C型)血清凝集素,在防御抵抗多种病原微生物的天然免疫中起着重要的作用,对6个月到2岁的婴幼儿尤其重要。
短句来源
     The collectins, including mannan-binding lectin (MBL), surfactant protein A and D (SP-A and SP-D), CL-L1, CL-46 and conglutinin, are oligomeric proteins composed of agglutinin-like domains (CRDs) and collagenous regions. The collectins play an important role in the innate immunity of the vertebrates.
     胶凝素是一组具有以胶原蛋白和凝集素区结构为特征的蛋白,包括甘露糖结合凝集素、肺表面活性物质脱辅基蛋白A和D、CL-L1、CL-46、胶固素等,是脊椎动物天然免疫中的重要因子。
短句来源
  “mannan-binding lectin”译为未确定词的双语例句
     Effects of mannan-binding lectin on TNF-α and IL-12 production induced by lipopolysaccharide in differentiated and activated THP1/CD14 cells
     MBL对LPS刺激的不同分化和活化状态THP1/CD14细胞产生TNF-α和IL-12的影响
短句来源
     Construction of GGC54GAC mutant of mannan-binding lectin
     GGC54GAC MBL突变体的构建
短句来源
     AIM: To explore preliminarily the mechanisms of immunodeficiency resulted from the CGT52TGT point mutation of mannan-binding lectin(MBL) gene.
     目的: 初步探索MBL基因CGT52TGT点突变引起调理吞噬缺损的机制。
短句来源
     Frequency of GGC54GAC point mutation of mannan-binding lectin gene in a Han population from Guangdong
     广东地区汉族人MBL基因GGC54GAC点突变的初步筛查
短句来源
     Study on the point mutation in the codon 54 mutant allele in mannan-binding lectin gene in populations of Hans and Uigurs in China
     中国汉族、维吾尔族人群甘露聚糖结合凝素基因多态性的检测
短句来源
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  mannan-binding lectin
Possible disease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and ad
      
Mannan-binding lectin (MBL), a human plasma protein, plays an important role in the innate immune defence.
      
Phase I Safety, Tolerability, and Pharmacokinetic Study of Recombinant Human Mannan-Binding Lectin
      
Mannan-binding lectin (MBL) is an activator of the complement system, and Apolipoprotein A-1 (Apo A-1) is pivotal in the cholesterol homeostasis and has anti-inflammatory properties.
      
Mannan-binding lectin (MBL) is the central protein in the activation of complement through the lectin pathway.
      
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The intact cDNA encoding the mannan binding lectin polypeptide including the signal sequence was isolated by using RT PCR method with total RNA extracted from fresh liver tissue of a Han nationality foetus, linked into pGEM T vector and transformed into E.coli TG1. The result of sequencing indicated that the sequence of our cDNA is different greatly from that of the reported human MBL cDNA but identical with that of the mRNA for...

The intact cDNA encoding the mannan binding lectin polypeptide including the signal sequence was isolated by using RT PCR method with total RNA extracted from fresh liver tissue of a Han nationality foetus, linked into pGEM T vector and transformed into E.coli TG1. The result of sequencing indicated that the sequence of our cDNA is different greatly from that of the reported human MBL cDNA but identical with that of the mRNA for human MBL in GenBank except two nuc leotides, and that its encoded product consists of a typical hydrophobic signal sequence of 20 amino acids and a mature MBL polypeptide of 228 amino acids.

从中国汉族人胎肝组织提取总RNA,以RT-PCR方法获取了编码含信号顺序的全长甘露聚糖结合凝集素(MBL)肽链的cDNA片段,将其与pGEM-T载体连接,转化大肠杆菌TG1,建立了MBL的cDNA克隆。序列分析表明:与文献报道的人MBLcDNA序列比较,差异颇大,但与GenBank中的人MBLmRNA比较,仅2个位置的核苷酸不同;其编码产物是20个残基的信号顺序和228个残基的成熟MBL多肽。

Objective To obtain the gene fragment encoding human mannan-binding lectin (MBL)-associated serine protease-2 (MASP-2). Methods The target cDNA fragment was amplified from the total RNA extracted from human fetal liver tissue by RT-nested PCR, cloned into pGEM-T vector and identified by restriction analysis and sequencing. Results The cDNA fragment encoding MASP-2 polypeptide with the signal sequence was isolated, linked with pGEM-T vector and transformed into E.coli TGI. The restriction maps of the selected...

Objective To obtain the gene fragment encoding human mannan-binding lectin (MBL)-associated serine protease-2 (MASP-2). Methods The target cDNA fragment was amplified from the total RNA extracted from human fetal liver tissue by RT-nested PCR, cloned into pGEM-T vector and identified by restriction analysis and sequencing. Results The cDNA fragment encoding MASP-2 polypeptide with the signal sequence was isolated, linked with pGEM-T vector and transformed into E.coli TGI. The restriction maps of the selected clones were consistent with those generated by computer analyses. The result of sequencing of one selected clone showed that its sequence was identical with that of reported human MASP-2 cDNA. Conclusion The human MASP-2 gene was successfully cloned, which prepares the ground for studying the molecular mechanisms by which MBL activates the complement lectin pathway and the mutations of MBL gene cause immunodeficiency.

目的 获得人甘露聚糖结合凝集素相关丝氨酸蛋白酶-2(MASP-2)编码区基因。方法采用 RT-巢式 PCR技术从 人胎肝组织总RNA扩增目的cDNA片段,克隆人pGEM-T载体,酶切图谱分析和测序鉴定。结果获得了编码合信号 顺序的MASP-2肽链全长cDNA,将其与pGEM-T载体连接,转化大肠杆菌TG1,建立了MASP-2的重组克隆。酶切图 谱与微机分析结果无异;序列分析表明,与报道的人 MASP-2cDNA序列一致。结论成功克隆了人 MASP-2基因,为深 入研究补体凝集素途径的激活机制和甘露聚糖结合凝集素基因突变引起免疫缺损的发病机制奠定了基础。

Objective To prepare monoclonal antibodies (mAbs) to mannan binding lectin (MBL) and develop a method for detection by using it Methods Mannan binding lectin in human serum was isolated by affinity chromatography and used as antigen to immunize Balb/c mice Three hybridome cell lines that could steadily secret antiMBL mAb were established The mAbs were used for ELISA Results The mAbs specifically recognized MBL molecule with Mr 31 000 and markedly inhibited the effect of anti complement...

Objective To prepare monoclonal antibodies (mAbs) to mannan binding lectin (MBL) and develop a method for detection by using it Methods Mannan binding lectin in human serum was isolated by affinity chromatography and used as antigen to immunize Balb/c mice Three hybridome cell lines that could steadily secret antiMBL mAb were established The mAbs were used for ELISA Results The mAbs specifically recognized MBL molecule with Mr 31 000 and markedly inhibited the effect of anti complement of MBL mannan complex The MBL levels (2 69±1 58 mg/L) in 186 sera from normal subjects were detected by ELISA Conclusion The monoclonal antibodies to mannan binding lectin were successfully prepared and used for ELISA

目的 制备抗人甘露聚糖结合凝集素单克隆抗体及建立应用方法。方法 用亲和层析法自人血清中提取甘露聚糖结合凝集素 (MBL) ,免疫Balb/c小鼠 ,通过细胞融合的方法 ,得到 3株稳定分泌抗人MBL单克隆抗体 (mAb)的杂交瘤细胞株。建立检测MBL的ELISA。结果 本组mAb识别相对分子质量 (Mr)为 310 0 0的MBL分子 ,与MBL作用后可明显抑制MBL 甘露聚糖复合物的抗补体效应。用ELISA检测 186例健康人血清中MBL水平为 2 6 9± 1 5 8mg/L。结论 成功地获得了抗MBL的mAb并用于建立ELISA。

 
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