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drug-hepatitis
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     Objective:To increase the understanding of drug hepatitis.
     目的 :提高对药物性肝炎的认识。
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     New Drug Hope for Hepatitis C Victims
     丙型肝炎新药有望
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     Drug-induced hepatitis during tiopronin treatment
     硫普罗宁片致药物性肝炎
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     Adefovir dipivoxil-A new drug for hepatitis B.
     抗乙型病毒性肝炎新药——阿德福韦酯
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     The Etiological Factors of Prevention and Cure of Drug-induced Hepatitis
     药物性肝炎的致病因素及防治
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On the basis of enzyme competitive inhibiton principle, we designed a simple, high precision method to estimate urine glucaric acid (UGA) with phenolphthalein giucuronic sodium as a substrate.The criteria of analytical performance were: within-run CV 3. 1%, day-to-day CV 4. 2%.average recovery 96. 5% and linear range 0~180 μmol/L. It's confidence limit of 95% was 1.8~31.3(16.6±7.38.x±s) ,19.6~553.3,4.2~56.8 μmol/g. Cr, in health group, drug hepatitis group (DHPD) and nondrug hepatitis group(NDHPD) respectivcly,...

On the basis of enzyme competitive inhibiton principle, we designed a simple, high precision method to estimate urine glucaric acid (UGA) with phenolphthalein giucuronic sodium as a substrate.The criteria of analytical performance were: within-run CV 3. 1%, day-to-day CV 4. 2%.average recovery 96. 5% and linear range 0~180 μmol/L. It's confidence limit of 95% was 1.8~31.3(16.6±7.38.x±s) ,19.6~553.3,4.2~56.8 μmol/g. Cr, in health group, drug hepatitis group (DHPD) and nondrug hepatitis group(NDHPD) respectivcly, t test showed: P<0. 001 in DHPD and NDHPD.We use 50 μmol/g. Cr as cut-off value, the positive rate of DHPD and NDHPD was 78. 9%(30/38), 9.2%(10/109) repectively, and the differential diagnosis efficiency was 87. 8%.It had been observed that some drugs could reduce the absorbance of blank. even lower than sample's. We confirmed cipfloxin and some chinese herbs, especially drugs mix-used in kidney transplant patients, may interfere with determination.

本文根据酶竞争抑制原理,应用自动生化分析仪测定尿液中葡萄糖二酸(UGA),提高了测定效率、精密度和准确性。本法天内CV为3.1%,回收率96.5%,线性范围0~180μmol/L。48例健康人UGA为1.8~31.3μmol/g.Cr,非药物性肝炎病人为4.2~56.8μmol/g.Cr、药物性肝炎病人为19.6~553μmol/g.Cr,以50μmol/g.Cr作为切割值,其鉴别诊断效率为87.8%。同时也观察到某些药物对测定有负干扰。

Hepatitis virus markers in all serum of 274 patients with acute hepatitis were detected by ELISA, polymerase chain reaction, dot hybridization. Results: HAV, HBV, HCV, HDV, HEV markers the positive rates were 51.82%, 25.91%, 8.39%, 0.36% and 20.07% respectively and the Co infected rate was 13.87%. Five types of hepatitis virus markers in 28 patients were negative. Eight of them had drug hepatitis and the others’ Virological were unknown. The highest infectious rates of HAV, HBV and HEV were for adolescents,...

Hepatitis virus markers in all serum of 274 patients with acute hepatitis were detected by ELISA, polymerase chain reaction, dot hybridization. Results: HAV, HBV, HCV, HDV, HEV markers the positive rates were 51.82%, 25.91%, 8.39%, 0.36% and 20.07% respectively and the Co infected rate was 13.87%. Five types of hepatitis virus markers in 28 patients were negative. Eight of them had drug hepatitis and the others’ Virological were unknown. The highest infectious rates of HAV, HBV and HEV were for adolescents, adults and elders respectively. Conclusion: There are sporadic acute infection of HAV, HBV, HCV, HDV, HEV, either single infection or Co infection. There may be a new type of viral hepatitis except the known five viral hepatitis and drug hepatitis.

为探讨成人散发急性病毒性肝炎的病原学构成,对近年住院的散发性急性肝炎274例,用ELISA、斑点杂交及PCR进行血清病原学分型并作初步统计分析。结果:甲、乙、丙、丁、戊型肝炎分别占51.82%,25.91%,8.39%,0.36%,20.07%,其中混合感染占13.89%。5型肝炎标志物均阴性,占10.20%,其中药物性肝炎,占2.90%。认为本地区甲、乙、丙、丁、戊5型肝炎均有散发,可单一感染,可混合感染,可能存在新型病毒性肝炎。此外,药物性肝炎应引起重视。

Dispersing blood stasis therapy coordinating with freeing gallbladder,regulating conception and thoroughfare vessels,cleansing fu organ and eliminating phlegm was applied to treat jaundice of hepatitis,hepatitis C,drug hepatitis and fatty liver in 4 cases.Results showed Dispersing blood stasis therapy had better clinical effects.

运用通瘀法为主 ,结合利胆、调理冲任、荡腑、涤痰等治疗肝炎黄疸、病毒性肝炎、药物性肝炎、脂肪肝等四则病例。提示通瘀法治疗肝病有较好疗效。

 
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