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   cute hepatitis 在 感染性疾病及传染病 分类中 的翻译结果: 查询用时:0.497秒
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Cytomegalovirus(CMV) DNA in serum samples of 159 patients with hepatitis B was detected by polymerase chain reaction(PCR).Simultaneously,CMVIgM was also determined by enzyme linked immunosorbent assay(ELISA)Positive CMVDNA and(or) CMVIgM were used as diagnostic criteria for active CMV infectionResults:the positive rates of CMVDNA and CMVIgM were 3019% and 1447% respectivelyThe rate of active infection for these patients was 3370%,which was significantly higher than that(543%) of the healthy controlsAmong...

Cytomegalovirus(CMV) DNA in serum samples of 159 patients with hepatitis B was detected by polymerase chain reaction(PCR).Simultaneously,CMVIgM was also determined by enzyme linked immunosorbent assay(ELISA)Positive CMVDNA and(or) CMVIgM were used as diagnostic criteria for active CMV infectionResults:the positive rates of CMVDNA and CMVIgM were 3019% and 1447% respectivelyThe rate of active infection for these patients was 3370%,which was significantly higher than that(543%) of the healthy controlsAmong these 159 patients,the active infection rates of cute hepatitis,mild chronic hepatitis,moderate chronic hepatitis,severe chronic hepatitis and liver cirrhosis were 1786%,1667%,4286%,5000% and 3478% respectivelyIn the peripheral blood of patients with active infection,the percentage of CD4 was significantly lower,and the persentage of CD8 higher than those of the controlsHence,the ratio of CD4/CD8 was significantly lowered in active CMV infectionOur results suggest that the sensitivity of PCR is higher than ELISAAnd early,prompt and correct diagnosis of active CMV infection of patients with hepatitis B can be achieved by the combined use of these two assaysThe superinfection of CMV and HBV may futher aggravate the impairment of the cellular immune function,worsen the disease and prolong its course

应用聚合酶链反应(PCR)技术检测159例乙型肝炎患者血清中巨细胞病毒脱氧核糖核酸(CMV-DNA),结合酶联免疫吸附法(ELISA)检测血清中CMV-IgM,以CMV-DNA和(或)CMV-IgM阳性为活动性CMV感染诊断标志。结果显示:CMV-DNA和CMV-IgM阳性率分别为30.19%、14.47%。乙肝患者活动性CMV感染率为33.70%,明显高于健康对照5.43%。其中急性肝炎、慢性轻度肝炎、慢性中度肝炎、慢性重度肝炎及肝硬化感染率分别为17.86%、16.67%、42.86%、50.00%、34.78%。与对照组相比,合并活动性CMV感染的乙肝患者外周血CD4百分率降低而CD8百分率升高,导致CD4/CD8比值明显下降。提示:PCR技术敏感性明显高于ELISA法,两法联合使用可早期、快速、准确诊断乙肝患者活动性CMV感染。CMV与HBV重合感染可进一步抑制乙肝患者机体细胞免疫功能,使患者病情加重或迁延不愈。

Aim:This study was aimed at investigating the epidemiologic and clinical characteristics. Methods:28 cases wsa hospitalized in our hospital of the 28 patients 16 were male and 12 female, aged 23--69 years. Of them, 8 were acute hepatitis, 4 were mild (CH), 4 moderate (CH), 3 chronic severe hepatitis, 9 active hepatocirrhosis. HGV RNA was detected by RT-PCR. Result; 15 patients had received blood or plasma transfusion (53. 6%), 1 was an intravenous drug abuser (3. 6% ). The other 12 had no direct...

Aim:This study was aimed at investigating the epidemiologic and clinical characteristics. Methods:28 cases wsa hospitalized in our hospital of the 28 patients 16 were male and 12 female, aged 23--69 years. Of them, 8 were acute hepatitis, 4 were mild (CH), 4 moderate (CH), 3 chronic severe hepatitis, 9 active hepatocirrhosis. HGV RNA was detected by RT-PCR. Result; 15 patients had received blood or plasma transfusion (53. 6%), 1 was an intravenous drug abuser (3. 6% ). The other 12 had no direct cause (42. 6% ). The main clinical manifestation was loss of appetite (100%), fatigue (92. 9%), greenish -brown colour urine (75% ) , nausea (53. 6%). Virus marks tests showed 4patients were infected HGV only. 13 HBV coinfection HGV, 6 HCV coinfection HGV, 3 HCV, HBV, HGV coinfection. Sera tests of hepato-function showed: TBil 45. 08±22.48μmol/L, ALT 318. 64±359. 95U/L Sera tests of fibrosis marks showed: HA 515. 39±800. 79μg/L,LN 323±578. 13μg/L,PCⅡ151. 71±47. 34μ/L,CLIV 67. 35±15. 27ng/L. Conclusion: ①HGV infections is a parenteral transmission route of viruses (blood transfusion) . ② HGV infection can cause a-cute hepatitis and develop a chronic course. ③ HGV infection occurs frequently in coinfection with HBV or/and HCV. ④ Hepatitis G seems to have a mild course as ALT values are concerned.

目的:调查庚型肝炎的流行病学及临床特点。方法:28例患者系我院住院病人,男16例,女12例,年龄23~69岁,其中急性肝炎8例,慢性肝炎轻度4例,慢性肝炎中度4例,慢性重型肝炎3例,活动性肝硬变9例;检测患者HGV-RNA采用RT-PCR法。结果:28例患者中有输血史者15例(53.6%),有静脉注射毒品史者1例(3.6%),不明原因者12例(42.6%);临床症状以纳差(100%),乏力(92.9%),尿色加深(75%)及恶心(53.6%)为主;病毒标志物检洲单纯庚型肝炎病毒感染4例(14.3%),乙、庚重叠感染13例(46.4%),丙、庚重叠感染6例(21.4%),乙、丙、庚重叠感染3例(10.7%);肝功能检测:TBil:45.08±22.48μmol/L,ALT 318.64±359.95U/L;纤维化指标:HA 515.39±800.79μg/L,LN 323±578.13μg/L,PCⅢ151.71±47.34μg/L,C Ⅳ 67.35±15.27ng//L。结论:①HGV主要经输血途径传播。同时存在其他肠道外途径传播如静脉注射毒品等。②HGV可引起急性、慢性、重型肝炎、肝硬变,易复发,易致慢性...

目的:调查庚型肝炎的流行病学及临床特点。方法:28例患者系我院住院病人,男16例,女12例,年龄23~69岁,其中急性肝炎8例,慢性肝炎轻度4例,慢性肝炎中度4例,慢性重型肝炎3例,活动性肝硬变9例;检测患者HGV-RNA采用RT-PCR法。结果:28例患者中有输血史者15例(53.6%),有静脉注射毒品史者1例(3.6%),不明原因者12例(42.6%);临床症状以纳差(100%),乏力(92.9%),尿色加深(75%)及恶心(53.6%)为主;病毒标志物检洲单纯庚型肝炎病毒感染4例(14.3%),乙、庚重叠感染13例(46.4%),丙、庚重叠感染6例(21.4%),乙、丙、庚重叠感染3例(10.7%);肝功能检测:TBil:45.08±22.48μmol/L,ALT 318.64±359.95U/L;纤维化指标:HA 515.39±800.79μg/L,LN 323±578.13μg/L,PCⅢ151.71±47.34μg/L,C Ⅳ 67.35±15.27ng//L。结论:①HGV主要经输血途径传播。同时存在其他肠道外途径传播如静脉注射毒品等。②HGV可引起急性、慢性、重型肝炎、肝硬变,易复发,易致慢性化。③HGV可与HGV和/或HCV同时或重叠感染。④HGV一般临床症状及肝功能损害较轻。

ter liver-targeted gene therapy. Methods Differences in immune response exhibited in 8 rhesus monkeys reeciving aden-ovirus (Ad) or lipofectamine-mediated gene transferred through varios routes were studied with HE staining and immunohisto-chemistry. Results The monkeys developed mild to acute hepatitis in 1 to 3 weeks after intravenous or intrabiliary injection of first-generation replication-defective adenovirus carrying Esh-erichia coli lacZ gene. The number of CD3+, CD4+ and CD8+ T cells was increased...

ter liver-targeted gene therapy. Methods Differences in immune response exhibited in 8 rhesus monkeys reeciving aden-ovirus (Ad) or lipofectamine-mediated gene transferred through varios routes were studied with HE staining and immunohisto-chemistry. Results The monkeys developed mild to acute hepatitis in 1 to 3 weeks after intravenous or intrabiliary injection of first-generation replication-defective adenovirus carrying Esh-erichia coli lacZ gene. The number of CD3+, CD4+ and CD8+ T cells was increased while there were no B cells in the liver with lesions. In addition, the expression of β2-MG and HLA-DR was enhanced on surface of hepatocytes. The development of a-cute hepatitis and the accompanying immune abnormalities were delayed in monkeys after immunosuppressive therapy. Conclusions Immune response to the hepatcoytes in liver-targeted gene therapy is restricted by MHC class I and mediated by T cells. Both adenoviral vector and foreign gene are related to the liver damage. Mild to moderate hepatic inflammation is reversible. Immunosuppression regimen can prolong transgene expression and delay the development of acute adenoviral hepatitis.

目的确定以肝脏为靶器官的基因治疗时急性肝炎的机制。方法用HE法和免疫组织化学法对8只恒河猴通过不同径路接受以腺病毒或Lipofectamine为载体的基因治疗时的免疫反应进行了研究。结果经静脉或胆管注入除去E_1,携带lacZ基因的腺病毒后1至3周发生了轻到中度急性肝炎。有病变的肝脏内 CD_3~+,CD_4~+和CD_8~+T细胞明显增多而B细胞缺如。肝细胞表面β_2-MG和HLA—DR也增多。免疫抑制治疗使急性肝炎和伴随的免疫反应延迟。结论腺病毒介导的基因治疗时肝脏的免疫反应是T细胞介导的,主要受Ⅰ型MHC限制。腺病毒载体和转基因均与肝损害有关。肝脏损害呈轻、中度,是可逆的。免疫抑制药物可延迟免疫性肝损害的发生并延长基因表达的时间。

 
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