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retinoic acid receptors     
相关语句
  维甲酸受体
     OBJECTIVE:Study the effect of diet Retinoic Acid on retinoic acid receptors(RARs) α,β,γof rat liver.
     目的:研究口服维甲酸(retinoic acid,RA)对鼠肝中维甲酸受体(RAR)α、β、γ水平的影响。
短句来源
     In order to better understand the mechanisms that underlie the antiproliferative effects of retinoids and RA induced differentiation/apoptosis, we have examined the response of human carcinoma cell lines to all-trans retinoic acid (ATRA) and N-(4-hydroxyphenyl) retinamide (4HPR) in terms of cell growth, apoptosis and regulation of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) mRNA.
     为更好地理解维甲类物质抑制细胞增殖诱导分化的分子机制,我们根据细胞生长、凋亡和维甲酸受体RARs (retinoic acid receptors)、RXRs(retinoid X receptors)mRNA表达的调节检测了人类恶性肿瘤细胞系对全反式维甲酸(all trans retinoic acid,ATRA)和N-(4-羟苯)-维甲酰胺[N-(4-hydroxyphenyl)retinamide,4HPR]的反应性。
短句来源
     Clinical study on expression of retinoic acid receptors in breast cancer tissues
     乳腺癌维甲酸受体表达的临床研究
短句来源
     The effect of inhalation 13-cis-retinoic acid on retinoic acid receptors of rat lung
     吸入13顺式维甲酸对鼠肺部维甲酸受体的影响
短句来源
     Effects of 9-cis-retinoic acid on transcription of retinoic acid receptors in lung adenocarcinoma cell
     9-顺维甲酸对人肺腺癌细胞维甲酸受体转录的影响
短句来源
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  视黄酸受体
     Effects of Vitamin A Deficiency on the Expression of Retinoic Acid Receptors and Hoxa1, Hoxb1 in Rats Embryonic Brain
     维生素A缺乏对大鼠胚胎脑视黄酸受体及Hoxa1、Hoxb1表达的影响
短句来源
     Distinct Ways of Retinoic Acid Receptors on Inhibition of AP-1 Activity in Gastric Cancer Cells
     胃癌细胞中视黄酸受体抑制AP-1活性的不同方式
短句来源
     EXPRESSION AND REGULATION OF RETINOIC ACID RECEPTORS IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES
     人外周血淋巴细胞视黄酸受体基因的表达与调控
短句来源
     The expression of retinoic acid receptors in mRNA level was quantitatively analyzed by reversed transcription and fluorescent quantitative PCR.
     采用RT-荧光定量PCR对6种视黄酸受体基因在不同年龄儿童淋巴结的表达水平进行定量分析,分析其与淋巴结B细胞个体发育的关系。
短句来源
     Method:The expression of the human retinoic acid receptors (hRARs)genes and its regulation by mitogens and RA were determined by RT PCR (Reverse transcription polymerase chain reaction)in human cord blood lymphocytes (CBL) and adult peripheral blood lymphocytes (PBL).
     方法:采用RT-PCR技术,检测分析人视黄酸受体(hRARs)基因在脐血和成人外周血淋巴细胞(PBL)的表达,及丝裂原和视黄酸(RA)对其的调节。
短句来源
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  视黄酸核受体
     Effects and mechanism of retinoic acid receptors on brain development
     视黄酸核受体在脑发育中的作用及机制
短句来源
  “retinoic acid receptors”译为未确定词的双语例句
     Effects of 9-cis-retinoic Acid on Transcripton of Retinoic Acid Receptors RXR in Lung Cancer Cells
     9-顺维甲酸诱导的肺癌细胞RXR_S受体转录水平的变化
短句来源
     Effects of 9-cis-retinoic Acid on Transcripton of Retinoic Acid Receptors RARγ in Lung Cancer Cells
     不同肺癌细胞RARγ受体转录水平对9-顺维甲酸诱导的反应
短句来源
     Retinoids have been shown to be highly effective in the treatment of psoriasis and mediate their biologic effects through binding to nuclear receptors known as retinoic acid receptors (RARs) or retinoid X receptors (RXRs).
     虽然核受体超家族成员的配体及其衍生物是目前临床治疗银屑病的一线药物,但是核受体超家族的具体功能和在银屑病发病机制中的具体角色仍不清楚。 这不利于银屑病发病机制的进一步阐明,也严重阻碍了相关药物的开发和利用。
短句来源
     The actions of retinoids are mediated through binding and activation of the retinoic acid receptors (RARs) or retinoid X receptors (RXRs), which function as ligand-dependent transcription factors.
     类维A酸受体(RAR)和类维A酸X受体(RXR)是配体依赖的转录因子,研究表明类维生素A是通过与之结合并激活受体而表现活性并发挥作用的。
短句来源
     The actions of retinoids are mediated through binding and activation of the retinoic acid receptors or retinoic acid X receptors, which function as ligand-dependent transcription factors.
     研究表明类维生素A是通过与其受体和X受体结合并激活受体而表现活性并发挥作用的。
短句来源
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  retinoic acid receptors
55 kDa nuclear retinoic acid receptors, a number of structurally similar 15-20 kDa proteins are involved in the transport, and possibly metabolism, of these compounds.
      
Thus, retinoic acid likely plays important roles in T cell development in thymus and perhaps by affecting the relative expression of retinoic acid receptors.
      
The Expression of Retinoic Acid Receptors in Thymus of Young Children and the Effect of All-Transretinoic Acid on the Developmen
      
The Expression of Retinoic Acid Receptors in Lymph Nodes of Young Children and the Effect of All-trans-Retinoic Acid on the B Ce
      
Expression and Regulation of Nuclear Retinoic Acid Receptors in Human Lymphoid Cells
      
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Molecular studies of chromosomal translocation (15; 17) in acute promyelo-cytic leukemia (APL) have shown that retinoic acid receptor A (RARA) gene on chromosome 17 is juxtaposed to the PML gene on chromosome 15. This results in a PML-RARA chimeric gene. Our work has demonstrated that the PML breakpoints in APL patients are clustered in two limited regions, PML-bcrl and PML-bcr2, separated from each other by about 10 kb. DNA sequence of PML-bcrl and primary structure of the junctional region of reciprocal...

Molecular studies of chromosomal translocation (15; 17) in acute promyelo-cytic leukemia (APL) have shown that retinoic acid receptor A (RARA) gene on chromosome 17 is juxtaposed to the PML gene on chromosome 15. This results in a PML-RARA chimeric gene. Our work has demonstrated that the PML breakpoints in APL patients are clustered in two limited regions, PML-bcrl and PML-bcr2, separated from each other by about 10 kb. DNA sequence of PML-bcrl and primary structure of the junctional region of reciprocal chromosomal translocation in a patient have been determined in this paper. Compared to those of two previously reported cases abroad, we found that the breakpoint may be situated in the topoi-somerase Ⅱ cleavage site. A working model has been proposed for the mechanism of DNA illegitimate recombination in t (15; 17).

对急性早幼粒细胞白血病(APL)中t(15;17)染色体易位的分子生物学研究显示,17号染色体上的维甲酸受体α(RARA)基因与15号染色体上的PML基因并置,并产生PML-RARA融合基因。我们以前的工作证明APL患者中PML基因断裂点集中于2个有限区域,即PMLbcr 1和PML-bcr 2,二者相距约10kb。本文确定了PML-bcr 1的DNA顺序,并确定了一例APL患者染色体相互易位接合部的基本结构。与以前国外所报道的二例病例进行了比较,发现断裂点可能处于拓扑异构酶Ⅱ裂解位点,由此,我们对t(15;17)中DNA异常重组的机制提出了一个工作模型。

Is the phenotype of malignant cells reversible? For a long time, scientists have been working on a new approach of cancer treatment,the differentiation therapy, by triggering malignant cells' maturation and programmed cell death. Acute promyelocytic leukemia (APL) has been the first example of human cancer which can be effectively treated with a differentiation inducer-all-trans retinoic acid (ATRA). APL is also characterized by the specific chromosomal translocation t (15; 17 ). In studying the...

Is the phenotype of malignant cells reversible? For a long time, scientists have been working on a new approach of cancer treatment,the differentiation therapy, by triggering malignant cells' maturation and programmed cell death. Acute promyelocytic leukemia (APL) has been the first example of human cancer which can be effectively treated with a differentiation inducer-all-trans retinoic acid (ATRA). APL is also characterized by the specific chromosomal translocation t (15; 17 ). In studying the mechanisms responsible for the response of APL cells to ATRA, we and others have been able to characterize the molecular biology of t (15; 17 ) which fuses the retinoic acid receptor aaaaaaaaaaaaaaa(RARA) gene with a chromosome 15q locus, PML. Functional studies demonstrate that PML- RARA behaves differently from the wild-type RARA. A direct clinical application of this leukemia marker has been the development of the retrotranscriptase/PCR analysis of PML-RARA fusion transcripts which allows the rapid diagnosis of APL. Recently, we have identified a new, variant translocation t (11; 17) and showed that RARA is fused with a new gene on chromosome 11q23. This gene named PLZF for promyelocytic leukemia zinc finger encodes a protein containing 9 zinc-finger motifs and is probably a transcription factor. The fact that RARA is the common target in both t (15; 17 ) and t ( 11; 17) suggests its crucial role in the pathogenesis of APL. Using transient transfection systems in COS cells as well as in human myeloid cell lines, we show that the PLZF-RARA, like PML-RARA, has a "dominant negative" effect on the wild-type RARA. Recently, similar cases have also been found in Caucasian APL. It has been shown that although APL patients with t(15;17) have good response to ATRA, those cases bearing t (11; 17 ) respond poorly and could represent a special clinical syndrome within APL. A comparative study on PML-RARA and PLZF- RARA will certainly give new insight for understanding the mechanism underlying the ATRA-induced cell differentiation.

恶性细胞的表型是否可能逆转?长期以来,科学家们一直在研究一种肿瘤治疗的新途径,即通过启动恶性细胞的成熟和程序化死亡达到分化治疗。急性早幼粒细胞白血病(APL)是应用分化诱导剂——全反式维甲酸(ATRA)治疗成功的第一个人类肿瘤。该病的另一特点是有特异染色体易位t(15;17)。在研究APL细胞对ATRA的应答机理中,我们和其他作者阐明了t(15;17)的分子生物学,发现它使维甲酸受体α基因(RARA)与15号染色体上的一个位点PML发生融合。功能研究显示PML-RARA的行为不同于野生型RARA。这一白血病标志的直接临床应用是发展了一种针对PML-RARA融合转录本的逆转录酶/PCR分析。最近,我们又发现了一种新的变异型易位t(11;17),该易位使RARA与11q23上一个被称之为早幼粒白血病锌指蛋白(PLZF)的基因发生融合。PLZF编码一个含有9个锌指的蛋白,可能是一个转录因子。在t(15;17)和t(11;17)两种易位中,RARA是共同靶子的事实提示RARA在APL发病原理中起着重要作用,应用转染试验,我们显示PLZF-RARA和PML-RARA一样,对野生型RARA具有“显性负”作用。近来在白种人...

恶性细胞的表型是否可能逆转?长期以来,科学家们一直在研究一种肿瘤治疗的新途径,即通过启动恶性细胞的成熟和程序化死亡达到分化治疗。急性早幼粒细胞白血病(APL)是应用分化诱导剂——全反式维甲酸(ATRA)治疗成功的第一个人类肿瘤。该病的另一特点是有特异染色体易位t(15;17)。在研究APL细胞对ATRA的应答机理中,我们和其他作者阐明了t(15;17)的分子生物学,发现它使维甲酸受体α基因(RARA)与15号染色体上的一个位点PML发生融合。功能研究显示PML-RARA的行为不同于野生型RARA。这一白血病标志的直接临床应用是发展了一种针对PML-RARA融合转录本的逆转录酶/PCR分析。最近,我们又发现了一种新的变异型易位t(11;17),该易位使RARA与11q23上一个被称之为早幼粒白血病锌指蛋白(PLZF)的基因发生融合。PLZF编码一个含有9个锌指的蛋白,可能是一个转录因子。在t(15;17)和t(11;17)两种易位中,RARA是共同靶子的事实提示RARA在APL发病原理中起着重要作用,应用转染试验,我们显示PLZF-RARA和PML-RARA一样,对野生型RARA具有“显性负”作用。近来在白种人APL中发现了具有t(11;17)的病例。虽然伴t(15;17)的APL患者对ATRA均有良好疗效,伴t(11;17)的患者则反应不佳,提示可能是APL中的一种新的临床综合征。对PML-RARA和PLZF-RA

Retinoids mediate their actions via RARs(retinoic acid receptors)and RXRs(retinoid X receptors).Each classes of these nuclear retinoid receptor is further subdiviede into three species namelyα,βand γ.Recent studies demonstrate that ER-positive HBC cell lines are sensitive and ER-negative cell lines are resistant to growth inhibitory effects of retinoic acid(RA). In this study we look at the expresion of RARs and RXRs in 6 HBC cell lines, we found only RARαmRNA level was strong correlated...

Retinoids mediate their actions via RARs(retinoic acid receptors)and RXRs(retinoid X receptors).Each classes of these nuclear retinoid receptor is further subdiviede into three species namelyα,βand γ.Recent studies demonstrate that ER-positive HBC cell lines are sensitive and ER-negative cell lines are resistant to growth inhibitory effects of retinoic acid(RA). In this study we look at the expresion of RARs and RXRs in 6 HBC cell lines, we found only RARαmRNA level was strong correlated with ER-status. To further inestigate the major role of RARαin retinoidmediated inhibition of growth, we transfected RARαcDNA in two RA-resistant ER-negative HBC cell lines.Analyses of different clonal populations of RARα transfectants from each cell line revealed growth inhibition by retinoids. Our results demonstrates that RARα Plays a major role in mediating retinoids inhibition of growth in HBC cells and adequate levels are required for such actions.

RETINOICACIDNUCLEARRECEPTORα(RARα),AMAJORROLEINMEDIATINGRETINOIDSINHIBITIONOF GROWTHINHUMANBREASTCARCINOMACELLSShaoZhimin邵志敏;...

 
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