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fentanyl plasma
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  芬太尼
     Fentanyl 3 ng/kg bolus injection produced a fentanyl plasma concentration of (0.64±0.13) μg/L at skin incision and resulted in a MAC for sevoflurane of (1.03±0.07)%.
     而单次静脉给芬太尼3ng/kg,20分钟后芬太尼血浆质量浓度为(064±013)μg/L,此时七氟醚的MAC体积分数为(103±007)%,比Ⅰ组减少了6213%;
短句来源
     Fentanyl 6 ng/kg bolus injection produced a fentanyl plasma concentration of (1.51±0.18) μg/L at skin incision and resulted in a MAC for sevoflurane of (0.64±0.01)%. By the stimulation of skin incision, the Hr, MAP of group Ⅰ increased 39%, 29%, compared with group Ⅱ 14%, 15%, group Ⅲ 20%, 14%, respectively.
     给芬太尼6ng/kg20分钟后,芬太尼血浆质量浓度为(151±018)μg/L,七氟醚的MAC体积分数为(064±001)%,比Ⅰ组减少了76%。
短句来源
  “fentanyl plasma”译为未确定词的双语例句
     Ionpair RPHPLC method for determination of fentanyl plasma concentration
     反相离子对色谱法测定人血浆中芬太尼浓度
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  fentanyl plasma
Maternal blood samples were collected at various times after injection (1-840?min), and the fentanyl plasma concentrations were determined by gas chromatography-mass spectrometry.
      
Fentanyl plasma concentration remained essentially unchanged during hypothermia (6.45 ng/ml 5 min into hypothermia and 5.26 ng/ml 100-140 min later; p>amp;gt;0.1).
      
Fentanyl plasma protein binding capacity decreases with increasing ionization of the drug.
      


Objective To determine the interaction between fentanyl and sevoflurane following a bolus injection of fentanyl after induction iwth sevoflurane inhalation only.Methods Sixty children aged 5~10 years who were diagnosed as having VSD or ASD were randomly allocated into three groups. The first group received sevoflurane in oxygen without any other drugs. The second group received sevoflurane in oxygen with fentanyl 3 ng/kg, and the third group received sevoflurane in oxygen with fentanyl 6 ng/kg. MAC determination,...

Objective To determine the interaction between fentanyl and sevoflurane following a bolus injection of fentanyl after induction iwth sevoflurane inhalation only.Methods Sixty children aged 5~10 years who were diagnosed as having VSD or ASD were randomly allocated into three groups. The first group received sevoflurane in oxygen without any other drugs. The second group received sevoflurane in oxygen with fentanyl 3 ng/kg, and the third group received sevoflurane in oxygen with fentanyl 6 ng/kg. MAC determination, in response to the stimulus of skin incision, was made using the "up down" method.Results The MAC of sevoflurane in oxygen was (2.72±0.08)%. Fentanyl 3 ng/kg bolus injection produced a fentanyl plasma concentration of (0.64±0.13) μg/L at skin incision and resulted in a MAC for sevoflurane of (1.03±0.07)%. Fentanyl 6 ng/kg bolus injection produced a fentanyl plasma concentration of (1.51±0.18) μg/L at skin incision and resulted in a MAC for sevoflurane of (0.64±0.01)%. By the stimulation of skin incision, the Hr, MAP of group Ⅰ increased 39%, 29%, compared with group Ⅱ 14%, 15%, group Ⅲ 20%, 14%, respectively. These results were significantly different ( P <0.01).Conclusion The MAC of sevoflurane is significantly reduced 20 minutes after a single dose of 3 ng/kg of fentanyl and that increasing the fentanyl dose to 6 ng/kg produces a little further decrease in MAC of sevoflurane.

目的观察芬太尼不同血药浓度对七氟醚最小肺泡气浓度(MAC)的影响。方法选择60例5~10岁先天性心脏病室间隔缺损(VSD)、房间隔缺损(ASD)患儿,按美国麻醉医师协会(ASA)分级,60例患儿均为Ⅱ级。将其分为3组:Ⅰ组:单用七氟醚;Ⅱ组:七氟醚+芬太尼(后者剂量为3ng/kg);Ⅲ组:七氟醚+芬太尼(后者剂量为6ng/kg)。用体动反应交叉点的方法测定七氟醚最小肺泡气浓度,用反相离子对高效液相色谱法测定芬太尼血浆浓度。结果Ⅰ组七氟醚的MAC体积分数为(272±008)%;而单次静脉给芬太尼3ng/kg,20分钟后芬太尼血浆质量浓度为(064±013)μg/L,此时七氟醚的MAC体积分数为(103±007)%,比Ⅰ组减少了6213%;给芬太尼6ng/kg20分钟后,芬太尼血浆质量浓度为(151±018)μg/L,七氟醚的MAC体积分数为(064±001)%,比Ⅰ组减少了76%。各组间的MAC比差异有显著意义,P<001。结论芬太尼能明显降低七氟醚的MAC;增大芬太尼用量,七氟醚MAC降低幅度明显减缓。

Objective To determine the dose-effect curve of fentanyl with respect to the suppression of somatic or hemodynamic responses to skin incision when plasma propofol concentration was maintained at 3 μg·ml-1 by target-controlled infusion (TCI) .Methods Twenty-four ASA Ⅰ-Ⅱ patients aged 31-65 yrs undergoing elective surgery under general anesthesia were enrolled in this study. Anesthesia was induced with TCIs of fentanyl and propofol. The patients were randomized to receive fentanyl by TCI at a target plasma concentration...

Objective To determine the dose-effect curve of fentanyl with respect to the suppression of somatic or hemodynamic responses to skin incision when plasma propofol concentration was maintained at 3 μg·ml-1 by target-controlled infusion (TCI) .Methods Twenty-four ASA Ⅰ-Ⅱ patients aged 31-65 yrs undergoing elective surgery under general anesthesia were enrolled in this study. Anesthesia was induced with TCIs of fentanyl and propofol. The patients were randomized to receive fentanyl by TCI at a target plasma concentration of 1.0, 1.5, 2.25 or3.38 ng·ml-1 . The target plasma propofol concentration was set at 3 μg·ml-1 in all patients. The patients were intubated when the patients failed to respond to verbal command and eyelash reflex was lost. Tracheal intubation was facilitated with succinylcholine 1 mg·kg-1. MAP, HR, ECG and SpO2 were monitored before and during anesthesia. The duration between the start of TCIs and skin incision was longer than 30 min for fentanyl and 15 min for propofol to ensure that the effect-site drug concentrations reached the steady-state. The changes in BP and HR and body / limb movement and other signs of inadequate depth of anesthesia like lacrimation, flushing and sweating during and immediately after skin incision were recorded. The fentanyl plasma concentrations (predicted target concentration) at which 50% of the patients did not respond to skin incision (Cp50) were calculated. Results The Cp50 of fentanyl based on somatic response was 1.84 ng·ml-1 . Its 95% confidince interval ranged from 1.46 ng·ml-1 to 2.33 ng·ml-1 . The Cp50 of fentanyl based on hemodynamic response was 2.67 ng·ml-1 with a 95% confidence interval from 1.96 ng·ml-1 to3.62 ng·ml-1. Conclusion When anesthesia is induced with TCIs of propofol and fentanyl, if target plasma propofol is set at 3 μg·ml-1 , target fentanyl plasma concentration should be set at least at 5.12 ng·ml-1 to ensure adequate depth of anesthesia for skin incision.

目的 研究以血浆靶浓度(Ct)3μg/ml靶控输注(TCI)异丙酚时,50%和95%病人对切皮刺激无体动或心血管反应的芬太尼设定血浆靶浓度(Cp50和Cp95)及其量效关系。方法 24例择期行全身麻醉手术的病人,ASAⅠ-Ⅱ级,年龄31-65岁,按芬太尼血浆靶浓度随机分为四组,每组6例。麻醉诱导时通过TCI系统使所有病人异丙酚血浆靶浓度达到和维持3μg/ml,使各组芬太尼的血浆靶浓度分别达到1.00、1.50、2.25、3.38 ng/ml。观察和记录手术切皮刺激引起的体动反应和心血管反应。分别计算抑制切皮时体动反应和心血管反应的Cp50、Cp95,并建立对切皮刺激反应的芬太尼量-效关系曲线。结果 切皮时体动无反应率随设定的芬太尼靶浓度(当异丙酚Ct=3μg/ml)增加而逐渐增高,病人对切皮刺激无体动反应的Cp50为1.84 ng/ml,其95%可信区间为1.46-2.33 ng/ml,相应的Cp95为5.12 ng/ml,靶浓度对数剂量(X)与体动无反应率的概率单位(Y)间的回归方程为:Y=2.45X+4.35。同样,病人心血管无反应率随设定的芬太尼靶浓度增加而逐渐增高,Cp50为2.67 ng/ml,其9...

目的 研究以血浆靶浓度(Ct)3μg/ml靶控输注(TCI)异丙酚时,50%和95%病人对切皮刺激无体动或心血管反应的芬太尼设定血浆靶浓度(Cp50和Cp95)及其量效关系。方法 24例择期行全身麻醉手术的病人,ASAⅠ-Ⅱ级,年龄31-65岁,按芬太尼血浆靶浓度随机分为四组,每组6例。麻醉诱导时通过TCI系统使所有病人异丙酚血浆靶浓度达到和维持3μg/ml,使各组芬太尼的血浆靶浓度分别达到1.00、1.50、2.25、3.38 ng/ml。观察和记录手术切皮刺激引起的体动反应和心血管反应。分别计算抑制切皮时体动反应和心血管反应的Cp50、Cp95,并建立对切皮刺激反应的芬太尼量-效关系曲线。结果 切皮时体动无反应率随设定的芬太尼靶浓度(当异丙酚Ct=3μg/ml)增加而逐渐增高,病人对切皮刺激无体动反应的Cp50为1.84 ng/ml,其95%可信区间为1.46-2.33 ng/ml,相应的Cp95为5.12 ng/ml,靶浓度对数剂量(X)与体动无反应率的概率单位(Y)间的回归方程为:Y=2.45X+4.35。同样,病人心血管无反应率随设定的芬太尼靶浓度增加而逐渐增高,Cp50为2.67 ng/ml,其95%可信区间为(1.96-3.62)ng/ml,相应的Cp95为15.85 ng/ml,靶浓度对数剂量(X)与心血管无反应率的概率单位(Y)间的回归方程为:Y=2.13X+4.09。结论 靶控输注异丙酚(Ct=3μg/ml)复合芬太尼麻醉,设定芬太?

 
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