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secretory pathway     
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  分泌途径
     The probable general secretory pathway transmembrane protein (GSP) gene cluster is the center of the type II secretory system.
     Ⅱ型分泌系统主要以分泌途径转膜蛋白(GSP)基因簇为中心。
短句来源
     Non-classical Secretory Pathway
     非经典的蛋白质分泌途径
短句来源
     Advance in Secretory Pathway of Yeast
     酵母蛋白分泌途径的研究进展
短句来源
     C-terminal transmembrane-like domain of hZP3, although removed as the proteins proceed through the secretory pathway and not present in the mature proteins, possibly has the effects on the protein expression due to its hydrophobic group.
     天然hZP3的C端跨膜区在分泌途径中已经被切除,并没有出现在成熟肽中,但是由于这段序列的疏水性,可能会对重组蛋白的表达过程产生影响。
短句来源
     It recognizes specific amino acid sequence and after two self-cleavages in endoplasmic reticulum and Golgi's body,it cleaves many crucial precursors of peptides and proteins in the secretory pathway,helping the precursors gain their bioactivity.
     Furin能识别特定的氨基酸序列,在内质网-高尔基体中经两次自剪切活化后,对分泌途径中许多重要的多肽和蛋白的前体进行剪切加工,使之具有生物活性。
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  蛋白质分泌途径
     Non-classical Secretory Pathway
     非经典的蛋白质分泌途径
短句来源
  蛋白分泌途径
     Advance in Secretory Pathway of Yeast
     酵母蛋白分泌途径的研究进展
短句来源
  “secretory pathway”译为未确定词的双语例句
     Yip1p and Yif1p are essential for transport from ER to Golgi stack during the early secretory pathway in budding yeast.
     这里我们报道和鉴定人源的Yif1基因(HsYif1)。
短句来源
     The TBEV M and E proteins are translocated to the endoplasmic reticulum and acquire their mature conformations in the secretory pathway, where prM is cleaved into its mature form, M. These proteins have also been expressed in recombinant expression systems in mammalian cells, where they have been shown to form secreted virus-like particles.
     M和E蛋白是森林脑炎病毒的结构蛋白,E蛋白能诱导保护性抗体,具有与受体结合、细胞膜融合的功能和血凝活性。
短句来源
     Linkage analysis mapped the gene responsible for HHD to chromosome 3q21-q24. Recent studies have revealed that HHD is caused by mutations in the ATP2C1 gene encoding the human secretory pathway calcium ATPase1(hSPCA1).
     基因型与表型的关联研究并没有发现基因突变位点与HHD的疾病表型之间存在相关性。 在此研究中,我们收集了两个中国汉族人HHD家系,并通过直接测序的方法对这两个家系成员进行了ATP2C1基因的突变检测。
短句来源
     Cpn60 content decreased,which was accompanied by an increase of lipase or chymotrypsinogen content in the pancreatic secretory pathway.
     内质网、高尔基体、酶原颗粒等细胞器中Cpn6 0明显减少 ,然而胰脂肪酶含量升高 ,糜蛋白酶原保持在高浓度水平。
短句来源
     Conclusion:These findings demonstrate that intracellular antibody technology represents a novel and efficient way to selectively abrogate the activity of gelatinase in the protein trafficking and secretory pathway and effectively inhibits tumor cell invasion and proliferation in vitro. Anti-gelatinase intrabody may be further used in cancer gene therapy.
     结论 :内质网滞留型胞内抗体技术可以在蛋白加工、分泌这一关键通路中抑制肿瘤细胞明胶酶的活性 ,进而抑制与明胶酶直接相关的侵袭和增殖 ,在肿瘤基因治疗中具有应用前景
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  secretory pathway
lipolytica secretory pathway and directed the secretion of active EGI into the culture medium.
      
TACE's zymogen inhibition is mediated by its Pro domain, a 197-amino acid region that serves this function as well as aiding in the secretion of this enzyme through the secretory pathway.
      
The only role for this motif seems to be in decreasing TACE's susceptibility to proteolytic degradation during its biogenesis and maturation within the secretory pathway.
      
Our knowledge of prohormone and proneuropeptide processing and its relationship to the secretory pathway has advanced significantly in the last five years.
      
Within the secretory pathway, chromogranins are involved in granulogenesis, and in sorting and processing of secretory proteincargo prior to, secretion.
      
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The distribution of vasopressin-containing neurons in the hypothalamus and their projections to the posterior pituitary were studied using the HRP and immunocytochem-istry double-labeling method in the rat. The possible secretory pathways of vasopressin were discussed. The results were as follows: the vasopressin-containing neurons were found in the supraopitic nucleus (SON), the retrochiasmatic SON, the paraventricular nucleus, the suprachiasmatic nucleus, the anterior commissural nucleus, the bed nucleus...

The distribution of vasopressin-containing neurons in the hypothalamus and their projections to the posterior pituitary were studied using the HRP and immunocytochem-istry double-labeling method in the rat. The possible secretory pathways of vasopressin were discussed. The results were as follows: the vasopressin-containing neurons were found in the supraopitic nucleus (SON), the retrochiasmatic SON, the paraventricular nucleus, the suprachiasmatic nucleus, the anterior commissural nucleus, the bed nucleus of the stria terminalis, the nucleus circularis, the fornical nucleus, the preoptic areas, the anterior hypothalamic area, the medial .and lateral areas of ; hypothalamus, and the periventricular nucleus. Some were found between the ependymal cells of the third ventricle and around the venous cavity. Several dense dendritic plexuses were found very close to the CSF in the SON, the retrochiasmatic SON, the ependymal layer and subependymal layer of the third ventricle, and around the venous cavity of the hypothalamus. All of nuclei metioned above, except the suprachiasmatic nucleus, were found projecting fibers to the posterior pituitary. The results indicate that vasopressin may be secreted to: (i) the posteiror pituitary, (2) the CSF, (3) the venous cavity of the hypothalamus. Words; Vasopressin-containing Neuron. HRP Immunocytochemistry

本文应用HRP与免疫组化结合的方法研究加压素神经元在下丘脑的分布及其与垂体后叶的关系,结果表明:下丘脑视上核、室旁核、视上核后部、视交叉上核、前连合核、终纹床核、环形核、穹窿核、视前区、下丘脑内、外侧区、室周灰质、室管膜层及下丘脑一些血管周围均有加压素神经元分布。室管膜层、视上核的软膜面及一些大血管周围有丰富的神经元突起,有些甚至接触到脑脊液或游离到血管腔中。除视交叉上核外,上述其余核区均有发纤维投射到垂体后叶。本文结果提示:加压素可能通过三种途经释放:①释放到垂体后叶;②直接释放到脑脊液;③直接释放到下丘脑的血管腔内。

We have cloned a new member of the granin family, termed human secretogranin III (SgIII), that encodes 468 amino acid residues. The human SgIII protein possesses an N terminal signal peptide, seven dibasic sites, and the repeated DSTK sequences. These structure characteristics are similar to other members of secretogranin family. The human SgIII has homologous proteins in mouse, rat , and Xenopus laevis . Genomic organization shows the gene includes 12 coding exons spanning 39 kb of genomic DNA on the...

We have cloned a new member of the granin family, termed human secretogranin III (SgIII), that encodes 468 amino acid residues. The human SgIII protein possesses an N terminal signal peptide, seven dibasic sites, and the repeated DSTK sequences. These structure characteristics are similar to other members of secretogranin family. The human SgIII has homologous proteins in mouse, rat , and Xenopus laevis . Genomic organization shows the gene includes 12 coding exons spanning 39 kb of genomic DNA on the human chromosome 15. Human SgIII is expressed widely as showed in Northern blot and its cDNA hybridizes to 2.2 kb and 1.9 kb bands in many tissues, with two additional 4.5 kb and 3.3 kb bands in brain. Subcelluar localization and immunoblotting indicated SgIII was secreted out of cell through trans Golgi network (TGN). SgIII may take effect in the biogenesis of secretory granules as a helper protein and be involved in the production or release of peptide hormones in the regulated secretory pathway.

研究了一个新的人分泌蛋白基因_分泌粒蛋白III(secretograninIII,SgIII)。SgIII蛋白序列共有 4 6 8个氨基酸残基 ,N端有一段疏水信号肽 ,序列中含有DSTK重复序列和 7对二元碱性氨基酸 (dibasicsites) ,这些结构特点同其他分泌粒蛋白家族成员相类似。人源SgIII蛋白在小鼠、大鼠和爪蟾中各有一个同源蛋白。基因组分析表明 ,SgIII基因位于人 15号染色体上 ,含有 12个外显子 ,分布在 39kb长的基因组DNA上。Western印迹和免疫细胞化学实验证实 ,SgIII蛋白同其他分泌粒蛋白家族成员一样 ,通过分泌途径被分泌到胞外。SgIII在多种组织中都有表达 ,Northern印迹显示SgIII的mRNA主要有 2 .2kb和 1.9kb两种形式 ,但在脑中还有 4 .5kb和 3.3kb大小的两种特异转录本。

AIM: To investigate the change of Cpn60 content,the alterations of pancreatic enzymes and lysosome,in order to better understand the mechanism of intrapancreatic enzyme activation in acute pancreatitis(AP). METHODS: The AP model was replicated by retrograde infusion of 4% sodium-deoxycholate in the choledocus of SD rats. The levels of amylase in plasma and TNF-α in pancreatic tissue were measured by biochemical technique at 5 h and 10 h after AP induction. The content of Cpn60 and pancreatic enzymes in different...

AIM: To investigate the change of Cpn60 content,the alterations of pancreatic enzymes and lysosome,in order to better understand the mechanism of intrapancreatic enzyme activation in acute pancreatitis(AP). METHODS: The AP model was replicated by retrograde infusion of 4% sodium-deoxycholate in the choledocus of SD rats. The levels of amylase in plasma and TNF-α in pancreatic tissue were measured by biochemical technique at 5 h and 10 h after AP induction. The content of Cpn60 and pancreatic enzymes in different compartments of the acinar cells were tested by quantitative protein A-gold immunocytochemistry technique. The change of lysosome in the acinar cells was observed under the electronic microscope. RESULTS: After AP was induced,the levels of amylase in the plasma and TNF-α in the pancreatic tissue increased significantly. Lysosomes with different forms were found inside the acinar cells,and some of them located in the Golgi apparatus. Cpn60 content decreased,which was accompanied by an increase of lipase or chymotrypsinogen content in the pancreatic secretory pathway. CONCLUSION: In the pancreatic acinar cells of AP rats,Cpn60 content decreased,suggesting an insufficient chaperone capacity,and combining with the change of lysosome both in its amount and location,which may take part in the intrapancreatic enzyme activation and the development of AP.

目的 :进一步探讨急性胰腺炎 (AP)时胰酶胞内激活的机制及蛋白伴侣因子 (Cpn6 0 )在其中的可能作用。方法 :用去氧胆酸钠逆行注入大鼠胰胆管复制AP模型 ,5h、10h分批采血、取胰腺 ,测血清及胰腺组织中淀粉酶活性及炎症介质TNF -α的含量 ;取 5h胰腺作光镜、电镜切片 ,检测胰腺组织和腺泡细胞各细胞器形态学的变化 ;用蛋白金标免疫细胞化学技术检测各细胞器中Cpn6 0及胰酶含量的变化。结果 :血清淀粉酶活性及胰腺组织匀浆TNF-α含量在 5h明显高于正常对照组 ,持续达 10h ;AP 5h的光镜病理检查见胰腺水肿、出血、坏死 ;电镜检查见腺泡内溶酶体增多 ,形态各异 ,散在于各处 ,甚至位于高尔基体中 ;内质网、高尔基体、酶原颗粒等细胞器中Cpn6 0明显减少 ,然而胰脂肪酶含量升高 ,糜蛋白酶原保持在高浓度水平。结论 :AP时腺泡细胞内溶酶体增多 ,分布异常 ,尤其胰脂肪酶以及蛋白酶含量增多 ,Cpn6 0含量减少 ,提示蛋白伴侣相对不足 ,这些异常变化可能引起胰酶在腺泡内的聚积和激活 ,从而参与AP的发生和发展。

 
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