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individualized treatment regimen
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  个体化治疗方案
     Objective To explore the clinical and biological features,prognostic factors and individualized treatment regimen of acute myelogenous leukemia patients over 70 years old.
     目的探讨70岁以上老年急性髓性白血病临床及生物学特征、影响预后的因素及个体化治疗方案
短句来源
  “individualized treatment regimen”译为未确定词的双语例句
     Clinical Efficacy and Safety of Adapalene0.1%Gel with Individualized Treatment Regimen for Acne Vulgaris
     阿达帕林凝胶个体化治疗寻常痤疮的临床研究
短句来源
     Objective: To explore the prognostic factors of patients with nasopharyngeal carcinoma (NPC) after treatment and to establish a predictive model of prognostic index (PI) for physicians to give individualized treatment regimen.
     目的:探讨鼻咽癌患者预后的影响因素,建立预后预测模型,为临床治疗提供参考。
短句来源
     Objective:To explore the rule and clinically influential factors of distant metastasis after treatment in patients with nasopharyngeal carcinoma (NPC), and to establish a predictive model of distant metastasis for physicians to formulate individualized treatment regimen.
     目的:探讨鼻咽癌患者治疗后发生远处转移的特点和临床影响因素,建立远处转移预测模型,为临床提供参考。
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  相似匹配句对
     Individualized Treatment of Osteoporosis
     骨质疏松多层次个体化治疗
短句来源
     Individualized treatment in cancer
     癌症的个体化治疗
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     L. P. treatment.
     L. P.
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     ON the Treatment of leukorrhea
     妇女带下症论治
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     Music Aesthetics and Regimen
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Objective: To explore the prognostic factors of patients with nasopharyngeal carcinoma (NPC) after treatment and to establish a predictive model of prognostic index (PI) for physicians to give individualized treatment regimen. Methods: From December 1996 to December 1997, 406 patients with nasopharyngeal carcinoma who were treated in our department were analyzed retrospectively. Prognostic factors were analyzed and PI equation was built using Cox regression model. The prognostic index (PI) of patients...

Objective: To explore the prognostic factors of patients with nasopharyngeal carcinoma (NPC) after treatment and to establish a predictive model of prognostic index (PI) for physicians to give individualized treatment regimen. Methods: From December 1996 to December 1997, 406 patients with nasopharyngeal carcinoma who were treated in our department were analyzed retrospectively. Prognostic factors were analyzed and PI equation was built using Cox regression model. The prognostic index (PI) of patients was calculated on basis of the multivariate analysis. According to PI values, patients were classified into 4 different risk groups. The survival curves of each group were obtained. Results: Single factors analysis showed that age, T stage, N stage, M stage, clinical stage, invasion of skull base, cervical lymph nodes metastasis and radiotherapy doses were prognostic factors; Multivariate analysis revealed that N stage, M stage, clinical stage and having chemotherapy or not were independent factors for overall survival. Conclusions: The N stage, M stage, clinical stages as well as performance of chemotherapy or not are the important prognostic factors of NPC. PI value will be very useful in predicting patients' prognosis and may provide the valuable information for physicians to give stratified or individualized treatment regimen.

目的:探讨鼻咽癌患者预后的影响因素,建立预后预测模型,为临床治疗提供参考。方法:对1996年12月至1997年12月接受治疗的鼻咽癌初治患者406例的分期、颈淋巴结转移情况等进行分析。应用COX回归模型分析预后影响因素,建立预后指数(prognosticindex,PI)方程,并根据PI值将全部患者分为不同的危险组,计算各组的生存曲线。结果:单因素分析显示年龄,T、N、M分期和临床分期,颅底骨质破坏,颈淋巴结转移情况,放射剂量等因素影响预后(P<0.05)。多因素分析显示N、M分期、临床分期和化疗与否是影响预后的主要因素。结论:PI值能较好的反映预后,为临床进行分层个体化治疗和预后预测提供参考。

Objective To investigate the clinical features, treatment modalities and the prognosis of nasal type NK/T cell lymphoma. Methods The data of 39 such patients treated from June 2000 to December 2003 were retrospectively reviewed. Twenty three patients were treated by combined chemoradiotherapy, basing on anthracycline-containing CHOP or similar regimens (median 5 cycles). Eleven patients by chemotherapy alone, 2 by radiotherapy alone and 2 aged patients by palliative chemotherapy or radiotherapy....

Objective To investigate the clinical features, treatment modalities and the prognosis of nasal type NK/T cell lymphoma. Methods The data of 39 such patients treated from June 2000 to December 2003 were retrospectively reviewed. Twenty three patients were treated by combined chemoradiotherapy, basing on anthracycline-containing CHOP or similar regimens (median 5 cycles). Eleven patients by chemotherapy alone, 2 by radiotherapy alone and 2 aged patients by palliative chemotherapy or radiotherapy. Radiotherapy was given by high energy photon ray combined with electron beam with a median curative dose of 56Gy in conventional fractionation. Bivariate correlations and univariate prognostic factors were analyzed. Results Median follow-up time for the 21 patients who were still alive was 22.5 months. The overall remission rate (RR) after initial treatment was 66.7% (21 CR, 3 PR). Chemotherapy alone got a CR rate of only 37.5%. The overall local control rate was 59.4%. Local relapse rate after curative radiotherapy was 25.0%. Radiotherapy was positively correlated with local control (P=0.000) and time to disease progression (TTP, P=0.002). Skin and intestine were among the extranodal relapse sites. Fifteen patients had highly aggressive tumors with a median survival time of only 5 months. Univariate analysis showed that significant favorable survival prognostic factors were: radiotherapy (P= 0.001); lower risk International Prognostic Index (IPI, P=0.001); complete remission after primary treatment (P=0.000); pre-diagnostic history >2 months (P=0.024); and free of skin involvement (P=0.034). Conclusion Most of nasal type NK/T cell lymphoma are in early stage when diagnosed. Radiotherapy remains to be the mainstay of treatment. Combined chemoradiotherapy needs further improvement for the progressive disease type. Some patients may have highly aggressive tumors with poor prognosis. Optimal prognostic factors and individualized treatment regimens need to be investigated.

目的分析鼻型NK/T细胞淋巴瘤的临床特点、治疗方法和预后情况,并探讨其疗效的改进。方法39例患者多数做了化放综合治疗,化疗主要为含蒽环类的CHOP或类似方案,中位5个周期。放射治疗采用高能光子射线配合高能电子线,常规分割,中位根治剂量56Gy。对临床资料进行双变量相关分析和单因素生存分析。结果39例患者中,存活患者21例,其中位随访时间22.5个月。首程治疗后总缓解率66.7%(21例完全缓解,3例部分缓解),单纯化疗完全缓解率37.5%。全组肿瘤局部控制率59.5%,根治性放疗的局部失败率25.0%,放射治疗与局部控制(P=0.000)、疾病进展时间(TTP,P=0.002)呈正相关。治疗失败的结外部位还包括皮肤和肠道,15例患者病程急骤,中位生存5个月。生存分析显示,生存有利的预后因素包括放射治疗(P=0.001)、国际预后指数(IPI)低危(P=0.001)、首程治疗完全缓解(P=0.000)、病史>2个月(P=0.024)和无皮肤浸润(P=0.034)。结论此型淋巴瘤确诊时多为早期病变,放射治疗是重要的治疗手段。放化综合治疗对进展期患者的疗效尚待改进。部分患者病程急骤、预后不良,需要进一步的研究以确定...

目的分析鼻型NK/T细胞淋巴瘤的临床特点、治疗方法和预后情况,并探讨其疗效的改进。方法39例患者多数做了化放综合治疗,化疗主要为含蒽环类的CHOP或类似方案,中位5个周期。放射治疗采用高能光子射线配合高能电子线,常规分割,中位根治剂量56Gy。对临床资料进行双变量相关分析和单因素生存分析。结果39例患者中,存活患者21例,其中位随访时间22.5个月。首程治疗后总缓解率66.7%(21例完全缓解,3例部分缓解),单纯化疗完全缓解率37.5%。全组肿瘤局部控制率59.5%,根治性放疗的局部失败率25.0%,放射治疗与局部控制(P=0.000)、疾病进展时间(TTP,P=0.002)呈正相关。治疗失败的结外部位还包括皮肤和肠道,15例患者病程急骤,中位生存5个月。生存分析显示,生存有利的预后因素包括放射治疗(P=0.001)、国际预后指数(IPI)低危(P=0.001)、首程治疗完全缓解(P=0.000)、病史>2个月(P=0.024)和无皮肤浸润(P=0.034)。结论此型淋巴瘤确诊时多为早期病变,放射治疗是重要的治疗手段。放化综合治疗对进展期患者的疗效尚待改进。部分患者病程急骤、预后不良,需要进一步的研究以确定新的预后监测指标和个体化治疗方案。

Objective To explore the clinical and biological features,prognostic factors and individualized treatment regimen of acute myelogenous leukemia patients over 70 years old.Methods We retrospectively analyzed 58 acute myelogenous leukemia(AML) patients over 70 years old who were diagnosed from 1994 to 2005 in our hospital.Results There were 33 cases in group A,9 cases in group B and 8 cases in group C.The complete remission(CR) rate of group A had no remarkable difference with group B,39.4% and 22.2% respectively.The...

Objective To explore the clinical and biological features,prognostic factors and individualized treatment regimen of acute myelogenous leukemia patients over 70 years old.Methods We retrospectively analyzed 58 acute myelogenous leukemia(AML) patients over 70 years old who were diagnosed from 1994 to 2005 in our hospital.Results There were 33 cases in group A,9 cases in group B and 8 cases in group C.The complete remission(CR) rate of group A had no remarkable difference with group B,39.4% and 22.2% respectively.The mean survival time of group A was much longer than group B,167 and 68 days respectively.The mean survival time of group C was 176 days.There was no significant difference with that of group A.But the side effects of chemotherapy and the duration of hospitalization is observably reduced.The analysis of prognostic factors showed that PS,secondary AML,count of peripheral WBC>10×109/L,percentage of blasts in bone marrow,karyotype and immunological phenotype affected overall survival(OS) significantly.Conclusions AML in patients over 70 years present their own clinical or biological features.The therapy should be individualized and many factors affect its prognosis.

目的探讨70岁以上老年急性髓性白血病临床及生物学特征、影响预后的因素及个体化治疗方案。方法对我院1994~2005年收治58例老年AML患者(≥70岁)回顾性分析了其临床及生物学特征、影响预后的因素及治疗方案的比较。结果亚标准剂量组(A组)33例,减量组(B组)9例,支持治疗组(C组)8例。A组与B组缓解率差异无统计学意义(P>0.05),分别为39.4%,22.2%。生存期明显异常(P=0.01),分别为167天和68天。C组生存期176天,与亚标准化疗组差异无统计学意义(P>0.05),但化疗引起副反应明显减少,平均住院时间缩短(P<0.05)。预后因素分析表明:生存状态,继发性,PBWBC>10×109/L,骨髓原始细胞比率>50%,染色体核型,免疫表型是预后的显著影响因素。结论70岁以上AML患者有特殊的临床和生物学特征,治疗应个体化,其预后与多种因素有关。

 
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