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mice transplanted tumors
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  移植性肿瘤
     Method The pharmacodynamics of oral doseforms of benzaldehyde derivant, including thesynthetic preparation from chemical cyclodextrinbenzaldehyde (β-CDBA1) and semisyntheticcyclodextrin benzaldehyde from naturalReceptaculum Fici Caricae (β-CDBA2), werestudied in mice transplanted tumors with cervicalcarcinoma V14, ascites S18o and EAS.
     方法采用小鼠移植性肿瘤模型,就制备的半合成品和全合成品β-环糊精苯甲醛(β-CyclodextrinBenzaldehyde简称β-CDBA2和β-CDBA1)。 口制剂抗癌药效学进行探讨。
短句来源
  小鼠移植性肿瘤
     Method The pharmacodynamics of oral doseforms of benzaldehyde derivant, including thesynthetic preparation from chemical cyclodextrinbenzaldehyde (β-CDBA1) and semisyntheticcyclodextrin benzaldehyde from naturalReceptaculum Fici Caricae (β-CDBA2), werestudied in mice transplanted tumors with cervicalcarcinoma V14, ascites S18o and EAS.
     方法采用小鼠移植性肿瘤模型,就制备的半合成品和全合成品β-环糊精苯甲醛(β-CyclodextrinBenzaldehyde简称β-CDBA2和β-CDBA1)。 口制剂抗癌药效学进行探讨。
短句来源
  小鼠种植瘤的
     The Therapeutic Effect of Chemotherapy Combined with Recombinant Endostatin on Mice Transplanted Tumors
     化疗联合重组Endostatin对小鼠种植瘤的治疗作用
短句来源
     Objective: To investigate the therapeutic effect of chemotherapy combined with recombinant endostatin on mice transplanted tumors.
     目的 :了解化疗联合重组Endostatin对小鼠种植瘤的治疗作用 ,为肿瘤的免疫治疗提供条件。
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  “mice transplanted tumors”译为未确定词的双语例句
     Methods Cell culture and nude mice experiment in vivo were used, F 1, S 1 and nude mice transplanted tumors were analyzed for DNA ploidy and cell cycle distribution by feulgen staining and image analysis.
     方法 采用细胞培养及裸鼠体内实验,用Feulgen染色法和图像分析方法观察F1、S1细胞及其裸鼠移植瘤的DNA倍体及细胞周期的分布情况。
短句来源
     And mice of 5 groups were injected with esophageal carcinoma EC9706 cells transfected with 20 μmol/L ASODNs for 72 h (ASODN-1,ASODN-2,ASODN-3,ASODN-4, and ASODN-3 ) and N-ODN as experimental groups, with liposomes without ASODN as control group, and PBS as negative control group, respectively. The growth of nude mice transplanted tumors were observed for five weeks.
     将20μmol/L不同基因位点的hTRASODN(ASODN1、ASODN2、ASODN3、ASODN4及ASODN5)和无关序列寡核苷酸(N ODN)分别转染食管癌EC9706细胞,72h后采用裸鼠背部皮下注射的方法进行裸鼠体内成瘤实验,连续5周观察裸鼠体内食管癌移植瘤的生长情况。
短句来源
     Studies on Antitumor Effect of Matrine Liposome on Mice Transplanted Tumors
     苦参碱脂质体增强抗肿瘤效应的动物实验研究
短句来源
     Method:By extracting,separating and purifying polyprenols over 75% from Ginkgo biloba L.,with various doses of polyprenols,the pharmacologic experiments on mice transplanted tumors of Heps? S 180 and EC were done,in contrast to 5 Fu.
     方法 :通过提取、分离、精制 75 %以上银杏叶聚戊烯醇 ,以氟脲嘧啶 (5 Fu)为对照 ,选择肝癌 (Heps)实体型、肉瘤 (S180 )、艾氏癌 (EC)实体型等瘤谱 ,用不同剂量的聚戊烯醇进行小鼠移植性抗肿瘤药效实验。
短句来源
     Conclusion: ASODN against the hTR function region could effectively inhibit proliferation and producing of malignant phenotype in nude mice transplanted tumors.
     结论:封闭hTR功能区的反义寡核苷酸可有效抑制裸鼠食管癌移植瘤的增殖及恶性表型的产生。
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    Successful heterotransplantation of human mucinous adenocareinoma of the colon to nude mice (BALB/Nu/Nu/JCLB) is reported. These experiments were made on 8—17 week-old nude mice of both sexes. The tumors were passaged up to 18 generations in 40 recipients. During these passages, all the tumors retained the histological, histochemical and ultrastructural appearance of the inoculated human material. Chromosome analysis of the tumor cells revealed human karyotype. There were two metastasized...

    Successful heterotransplantation of human mucinous adenocareinoma of the colon to nude mice (BALB/Nu/Nu/JCLB) is reported. These experiments were made on 8—17 week-old nude mice of both sexes. The tumors were passaged up to 18 generations in 40 recipients. During these passages, all the tumors retained the histological, histochemical and ultrastructural appearance of the inoculated human material. Chromosome analysis of the tumor cells revealed human karyotype. There were two metastasized to the lungs and one to lymph node. The nude mouse transplanted tumors can be used as a model for the study of tumor biology of human colon carcinoma as well as for the evaluation of therapeutic agents.

    本文报导了在裸鼠(BALB/cANu/NuJCLB)身上建立的人肠粘液腺癌移植瘤。所用实验动物鼠令为8~17周,兼用雌雄性,相继传代十八代。40只裸鼠全部出现了移植瘤。组织学、组织化学和超微结构检查,证明移植瘤保存了原人体肿瘤的结构与功能。染色体分析显示了人染色体的特征。在40只裸鼠移植瘤中,还出现了转移现象,二例至肺,一例至淋巴结。这项研究工作为进一步研究人类肠癌的生物学特性和开展实验治疗提供了模型。

    Results of a preliminary experimental studyon aluminum sulphonated phthalocyanine(AISPc)in diagno-sis and treatment for mouse transplanted tumors are reported.It was demonstrated by fluorescence mea-surement that AISPc is more rapidly released from the body than HpD,the toxicity of ALSPc is very low,the statistically greatest significant difference(P<0.05)of AlSPc concentration in tumors,skin and stomach oc-cured at 24-48 hours after injection of the photosensitizer.Evident necrosis and growth inhibition...

    Results of a preliminary experimental studyon aluminum sulphonated phthalocyanine(AISPc)in diagno-sis and treatment for mouse transplanted tumors are reported.It was demonstrated by fluorescence mea-surement that AISPc is more rapidly released from the body than HpD,the toxicity of ALSPc is very low,the statistically greatest significant difference(P<0.05)of AlSPc concentration in tumors,skin and stomach oc-cured at 24-48 hours after injection of the photosensitizer.Evident necrosis and growth inhibition of subcuta-neously transplanted hepatic and mammary tumors in mice,which received AISPc in a dose of 20 or 40mg/kg I.V.24hrs before argon dye laser irradiation. Our findings indicate that AISPc is a promising new photosensi-tizer,which might be used in both diagnosis and photodynamic therapy of tumors in future.

    本文总结了激光与三磺酸铝酞菁(AISPc)诊断治疗移植瘤的系列研究,实验共分三部分:实验一以小鼠移植瘤──乳腺癌为实验模型、处死后荧光光谱分析的诊断研究;实验二小鼠移植瘤──肝癌为实验模型的活体荧光检测的诊断研究;实验三小鼠移植瘤──肝癌为实验模型的光敏治疗研究。结果证明AISPc在体内清除速度快,光毒反应低,特征荧光峰的相对荧光强度在AISPc注入机体后24~48小时时肿瘤与正常组织的反差最大。分别与胃内、皮肤内荧光强度比较,经t检验P<0.05,差异有显著性。注射AISPc的小鼠移植瘤经激光照射后24小时照光部位结痂变黑,肿瘤生长速度明显受抑,较对照组照光前、后5天肿瘤面积差值经秩和检验多组比较得P<0.05,差异显著,证明AISPc既可用于恶性肿瘤的诊断,又可用于治疗,是一种很有发展前途的新光敏剂。

    Objective The aim of this paper was to studythe antineoplastic effects of benzaldehyde derivative.Method The pharmacodynamics of oral doseforms of benzaldehyde derivant, including thesynthetic preparation from chemical cyclodextrinbenzaldehyde (β-CDBA1) and semisyntheticcyclodextrin benzaldehyde from naturalReceptaculum Fici Caricae (β-CDBA2), werestudied in mice transplanted tumors with cervicalcarcinoma V14, ascites S18o and EAS. Data ofgroups were treated statistically with analysis ofvariance, t and...

    Objective The aim of this paper was to studythe antineoplastic effects of benzaldehyde derivative.Method The pharmacodynamics of oral doseforms of benzaldehyde derivant, including thesynthetic preparation from chemical cyclodextrinbenzaldehyde (β-CDBA1) and semisyntheticcyclodextrin benzaldehyde from naturalReceptaculum Fici Caricae (β-CDBA2), werestudied in mice transplanted tumors with cervicalcarcinoma V14, ascites S18o and EAS. Data ofgroups were treated statistically with analysis ofvariance, t and x2 test.Results It was shown that semisyntheticβ-CDBA2possessed obviously antitumoral effectsand its inhibitory rate for cervical carcinomaV14was 37% under 21.9mg. kg-1 perig (compared with control group, P<0. 001). Therewere little antineoplastic effects of β-CDBA2onascites S180 and EAC were obseaved. But, notantitumor activities was obseaved in β-CDBA1.Conclusion The semisynthetic β-CDBA2 hasobviously antineoplastic activity. This effect maybe relation to chemical composition containedmicromolecule aromatic compound from naturalReceptaculum Fici Caricae that possessingantitumer actiVity. It is possible thatβ-CDBA2from natural benzaldehyde derivant is abetter assistant drug for antineoplastic treatment.

    目的研究苯甲醛类衍生物的抗癌作用。方法采用小鼠移植性肿瘤模型,就制备的半合成品和全合成品β-环糊精苯甲醛(β-CyclodextrinBenzaldehyde简称β-CDBA2和β-CDBA1)。口制剂抗癌药效学进行探讨。组间比较用方差分析、t检验及X2检验统计学处理。结果半合成品,即以植物无花果提取物为原料制备的β-CDBA2有明显抗癌活性。对小鼠宫颈癌(U14)抑瘤率为37%。最适剂量为每次21.9mg·kg-1(灌胃);对(S-180)肉瘤腹水型和(EAC)艾氏腹水癌表现有较小抑瘤作用。而全合成品即以化学试剂苯甲醛为原料合成的β-CDBA1无抗癌活性。结论半合成品无毒性,且有抗癌活性,该抗癌作用可能与半合成品的天然无花果植物原料中含有苯甲醛类小分子芳香化合物等抗癌活性物质有关。天然苯甲醛类衍生物是较好的抗癌辅助药。)

     
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