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antitumor     
相关语句
  抗肿瘤
     STUDY ON SYNTHESIS AND ANTITUMOR ACTIVITIES OF DERIVATIVES OF PODOPHYLLOTOXIN
     鬼臼毒素衍生物的合成及其抗肿瘤活性的研究
短句来源
     Antitumor effect of combined immunotherapy based on FIt3 Ligand expression and CTLA-4 blockade
     基于FIt3L基因和Anti-CTLA4抗体的抗肿瘤免疫联合治疗的实验研究
短句来源
     Recombinant Expression of Interleukin-18 and Its Antitumor Effects
     IL-18的重组、表达及其抗肿瘤作用的研究
短句来源
     Screening of marine actinomycetes with antitumor activity and isolation and identification of the cytotoxic compounds produced by strain N350
     海洋放线菌抗肿瘤活性菌株的筛选及菌株N350抗肿瘤活性物质的研究
短句来源
     Antitumor Effects of the Fusion Protein Transmembrane Superantigen SEA
     跨膜型超抗原SEA融合蛋白的抗肿瘤作用研究
短句来源
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  抗肿瘤
     STUDY ON SYNTHESIS AND ANTITUMOR ACTIVITIES OF DERIVATIVES OF PODOPHYLLOTOXIN
     鬼臼毒素衍生物的合成及其抗肿瘤活性的研究
短句来源
     Antitumor effect of combined immunotherapy based on FIt3 Ligand expression and CTLA-4 blockade
     基于FIt3L基因和Anti-CTLA4抗体的抗肿瘤免疫联合治疗的实验研究
短句来源
     Recombinant Expression of Interleukin-18 and Its Antitumor Effects
     IL-18的重组、表达及其抗肿瘤作用的研究
短句来源
     Screening of marine actinomycetes with antitumor activity and isolation and identification of the cytotoxic compounds produced by strain N350
     海洋放线菌抗肿瘤活性菌株的筛选及菌株N350抗肿瘤活性物质的研究
短句来源
     Antitumor Effects of the Fusion Protein Transmembrane Superantigen SEA
     跨膜型超抗原SEA融合蛋白的抗肿瘤作用研究
短句来源
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  抗癌
     Antitumor Effects of A_(10), 5Fu, GM-CSF and IL-2
     抗瘤酮A_(10)、5Fu、GM-CSF和IL-2的抗癌效果
短句来源
     Studies on the synthesis of tetrazines and their antitumor activities (I) The N,N′ diphenyl 3,6 dimethyl 1,4 dihydro 1,2,4,5 tetrazine 1,4 dicaboamide
     四嗪衍生物的合成及其抗癌性能研究(Ⅰ)──N,N'-二苯基-3,6-二甲基-1,4-二氢-1,2,4,5-四嗪-1,4-二甲酰胺
短句来源
     ONYX-015 and H101 are E1B 55-kDa protein-deficient replicating C group adenoviruses that are currently in clinical trials as antitumor agents.
     ONYX-015和H101为可复制E1B55-kDa蛋白缺陷的C族腺病毒,它们正作为抗癌药物进行临床研究.
短句来源
     Synthesis, Structure and Antitumor Activity of 2-Alkylthio-5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazole Compounds
     2-取代硫醚-5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑类化合物的合成、结构与体外抗癌活性
短句来源
     Synthesis and Antitumor Activity of Lanthanum(Ⅲ) Complexes to N-Alkyl-1,10-phenanthroline-2-methanamine
     N-烷基-1,10-菲咯啉2-甲胺La(Ⅲ)配合物的合成及抗癌活性
短句来源
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  抗瘤
     Antitumor Effects of A_(10), 5Fu, GM-CSF and IL-2
     抗瘤酮A_(10)、5Fu、GM-CSF和IL-2的抗癌效果
短句来源
     Purpose: The aim was to study the immunologic activity and antitumor effects of Ser125 interleukin- 2 (Ser125 IL-2).
     研究 Ser125白介素-2(Ser125IL-2)的免疫活性及抗瘤作用。
短句来源
     Experimental Research on Antitumor Effect of J558 Tumor Cell Vaccine Transfected by mIL-12 Gene
     mIL-12基因转染J558肿瘤细胞疫苗的抗瘤实验研究
短句来源
     Study on 515 Anti Tumor Recipe in Inducing Leukemic HL-60 Cells Apoptosis
     515抗瘤方剂诱导白血病HL60细胞凋亡的研究
短句来源
     The antitumor activity of the three pig pineal body extracts, Songlesu A, B and C were tested in mice Sarcoma 180 (S180), Sarcoma 37 (S37) and Melonoma (Me).
     作者应用猪松果体提取物,松乐素A、B、C三种制剂在小鼠肉瘤180(S_(180)),肉瘤37(S_(37))和B_(16)黑色素瘤研究了其抗瘤活性。
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  antitumor
Antitumor and Anti-Pneumocystis Carinii Activities of Novel Bisbenzamidines
      
Some new benzenesulfonamides, disubstituted sulfonylureas, and sulfonylthioureas substituted basically with 3-(2-thienyl or 3-pyridyl)-indeno[1,2-c]pyrazol(in)e counterpart were synthesized to be evaluated for their in vitro antitumor activity.
      
According to the protocol of the National Cancer Institute (NCI) in vitro disease-oriented human cells screening panel assay, 13 compounds showed promising broad spectrum antitumor activity.
      
In general, compounds containing the thienyl moiety displayed better antitumor spectra than those containing the pyridyl moiety.
      
Podophyllotoxin and related analogs present numerous challenges associated with optimal antitumor activity and severe unpredictable toxicity.
      
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Four 5-(p-substituted-phenylazo)-uracils (Ⅴ:Ⅴa,Ⅴb,Ⅴc and Ⅴd)and six 5-(p- substituted-phenylazo)-6-methyluracils (Ⅵ:Ⅵa,Ⅵb,Ⅵc,Ⅵd,Ⅵe and Ⅵf)were pre- pared as antitumor agents,However,none of them showed any significant activity against Ehrlich ascites tumour in mice. (Ⅴa)R=C1 mp.280°dec.(Ⅵa)R=G1 mp.235°dec. (Ⅴb)R=Br mp.270°dec.(Ⅵb)R=Br mp.227°dec. (Ⅴc)R=CH_3 mp.264°dec.(Ⅵc)R=CH_3 mp.223°dec. (Ⅴd)R=SCN mp.171°dec.(Ⅵd)R=OCH_3 mp.235°dec. (Ⅵe)R=SCN mp.147°dec. (Ⅵf)R=SCH_3 mp.222°dec. A of 5-substituted uracils...

Four 5-(p-substituted-phenylazo)-uracils (Ⅴ:Ⅴa,Ⅴb,Ⅴc and Ⅴd)and six 5-(p- substituted-phenylazo)-6-methyluracils (Ⅵ:Ⅵa,Ⅵb,Ⅵc,Ⅵd,Ⅵe and Ⅵf)were pre- pared as antitumor agents,However,none of them showed any significant activity against Ehrlich ascites tumour in mice. (Ⅴa)R=C1 mp.280°dec.(Ⅵa)R=G1 mp.235°dec. (Ⅴb)R=Br mp.270°dec.(Ⅵb)R=Br mp.227°dec. (Ⅴc)R=CH_3 mp.264°dec.(Ⅵc)R=CH_3 mp.223°dec. (Ⅴd)R=SCN mp.171°dec.(Ⅵd)R=OCH_3 mp.235°dec. (Ⅵe)R=SCN mp.147°dec. (Ⅵf)R=SCH_3 mp.222°dec. A of 5-substituted uracils and methyluracils (Ⅶ:Ⅶa,Ⅶb,Ⅶc,Ⅶd and Ⅷ: Ⅷa,Ⅷb,Ⅷc,Ⅷd,Ⅷe,Ⅷf,Ⅷg,Ⅷh)were also prepared.These uracils did not show any significant inhibiting action against Sarcoma 180 in mice.The phar- macological actions of the above compounds will be reported eleswhere. ~*(Ⅶa)R=NO_2 ~*(Ⅷa)R=NO_2 ~*(Ⅶb)R=NHCHO mp.312°dec.(Ⅷb)R=NHCHO mp.290°dec. ~*(Ⅶc)R=NHCOCH_2Cl mp.274°dec.(Ⅷc)R=NHCOCH_2Cl mp.252°dec. (Ⅶd)R=NHCSNH_2 mp.>320°(Ⅷd)R=NHCOCHCl_2 mp.280°dec. (Ⅷe)R=NHCOCH_2I mp.236°dec. (Ⅷf)R=NHCOCF_3 mp.282°dec. (Ⅷg)R=NHCOOC_2H_5 mp.265°dec. (Ⅷh)R=NHCSNH_2 mp.268°dec. *These compounds are known in literatures.

1.合成了四个5-对-取代基苯偶氮尿嘧啶(Ⅴ)和六个5-对-取代基苯偶氮-6-甲基尿嘧啶.上述十个化合物口服对小白鼠艾氏腹水瘤无显著抑制作用.2.又合成了四个5-取代基尿嘧啶(Ⅶ)和八个5-取代基-6-甲基尿嘧啶(Ⅷ),此十二个化合物口服或腹腔注射对肉瘤180无明显抑制作用.

The antitumor activity of Sb-derivatives of complexones has not yet been reported in the literature.In this work we found that Sb-26 (Sb Na ethylenediamine tetraacetate 15—20 mg/kg), Sb-57(Sb Na propylenediamine tetraacetate 30—50 mg/kg),Sb-66(Sb β-hydroxyethyl imino- diacetic acid 25—30 mg/kg)and Sb-71(Sb ammonia triacetic acid 20—40 mg/kg)could significantly inhibit the growth of Ehrlich ascites carcinoma of mice and prolonged the survival time for 4—22 days(36—147%,P<0.05)in comparison with the control...

The antitumor activity of Sb-derivatives of complexones has not yet been reported in the literature.In this work we found that Sb-26 (Sb Na ethylenediamine tetraacetate 15—20 mg/kg), Sb-57(Sb Na propylenediamine tetraacetate 30—50 mg/kg),Sb-66(Sb β-hydroxyethyl imino- diacetic acid 25—30 mg/kg)and Sb-71(Sb ammonia triacetic acid 20—40 mg/kg)could significantly inhibit the growth of Ehrlich ascites carcinoma of mice and prolonged the survival time for 4—22 days(36—147%,P<0.05)in comparison with the control group.These com- pounds at the above mentioned dosages inhibited also the growth of Guerin’s carcinoma.The degree of inhibition was about 58—70%(P<0.05).The survival time of mice bearing spindle cell sarcoma(in ascitic form)was also prolonged for 5—16 days(50—160%,P<0.05)by treatment with the latter three drugs,among which Sb-71 was most active. Experiments were carried out on mice bearing sarcoma 180 or sarcoma AK treated with Sb-26,Sb-57,Sb-71 or Sb-66 and on mice bearing Ehrlich carcinoma or lymphatic leucemia (solid form)treated with the former three drugs.It was found that only Sb-71 possessed certain inhibitory action on sarcoma 180. In the present study,Sb-8,Sb-11,Sb-42,Sb-15,Sb-64 and Sb-85 were all lacking in inhibitory effect on Ehrlich ascites carcinoma of mice. In mice,the acute LD_(50)levels after intraperitoneal injections of Sb-57 and Sb-71 were found to be 131 and 62 mg/kg respectively;the subacute LD_(50)(10 injections)were equal to 75 and 58 mg/kg respectively.

1.锑胺羧螯合物是一种新型的抗肿瘤药物,应用 Sb-26(EDTA-SbNa)、Sb-57(PDTA-SbNa)、Sb-66(HEDT-Sb)和 Sb-71(ATA-Sb)分别为15—20、30—50、25—30和20—40毫克/公斤剂量时,均能显著地抑制小白鼠 Ehrlich 腹水瘤的生长,平均延长生存时间4—22天,延长率36—147%.上述剂量对大白鼠 Guerin 氏癌也有抑制作用,抑制率为58—70%.后3个药物,还能使小白鼠梭形细胞肉瘤腹水型的生存时间延长5—16天,延长率50—160%,其中以 Sb-71的疗效最著.Sb-26、Sb-57、Sb-71、Sb-66对肉瘤180和 AK 肉瘤及前3者对 Ehrlich 固体瘤和淋巴白血病固体型的实验结果,除 Sb-71对肉瘤180有抑制作用外,其他均无疗效.2.4 类锑化合物:3个(月弟)酸化合物(Sb-8,Sb-11和 Sb-42)及1个酒石酸锑(Sb-15),与螯合的间苯二酚锑(Sb-64)和8羟基喹啉锑(Sb-85)各1个,对 Ehrlich 腹水瘤的实验结果,均无明显疗效.3.小白鼠的急性半数致死量,Sb-57和 Sb-71分别为131和62...

1.锑胺羧螯合物是一种新型的抗肿瘤药物,应用 Sb-26(EDTA-SbNa)、Sb-57(PDTA-SbNa)、Sb-66(HEDT-Sb)和 Sb-71(ATA-Sb)分别为15—20、30—50、25—30和20—40毫克/公斤剂量时,均能显著地抑制小白鼠 Ehrlich 腹水瘤的生长,平均延长生存时间4—22天,延长率36—147%.上述剂量对大白鼠 Guerin 氏癌也有抑制作用,抑制率为58—70%.后3个药物,还能使小白鼠梭形细胞肉瘤腹水型的生存时间延长5—16天,延长率50—160%,其中以 Sb-71的疗效最著.Sb-26、Sb-57、Sb-71、Sb-66对肉瘤180和 AK 肉瘤及前3者对 Ehrlich 固体瘤和淋巴白血病固体型的实验结果,除 Sb-71对肉瘤180有抑制作用外,其他均无疗效.2.4 类锑化合物:3个(月弟)酸化合物(Sb-8,Sb-11和 Sb-42)及1个酒石酸锑(Sb-15),与螯合的间苯二酚锑(Sb-64)和8羟基喹啉锑(Sb-85)各1个,对 Ehrlich 腹水瘤的实验结果,均无明显疗效.3.小白鼠的急性半数致死量,Sb-57和 Sb-71分别为131和62毫克/公斤,亚急性半数致死量分别为75和58毫克/公斤.

AT-290, p-bis (2-chloroethyl) aminomethyl phenylalanine, synthesized at our Institutc, is a new derivative of nitrogen mustard. Animal experiments showed that AT-290 had a significant antitumor activity. The results on toxicity and antitumor activity were as follows: 1. The acute and subacute intraperitoneal LD_(50) for mice were 4 and 1.6 mg/kg/day respectively. The subacute oral LD_(50) in mice was 11 mg/kg/day and the subacute intraperitoneal LD_(50) in rats was 1 mg/kg/day. 2. In 3 dogs, intravenous...

AT-290, p-bis (2-chloroethyl) aminomethyl phenylalanine, synthesized at our Institutc, is a new derivative of nitrogen mustard. Animal experiments showed that AT-290 had a significant antitumor activity. The results on toxicity and antitumor activity were as follows: 1. The acute and subacute intraperitoneal LD_(50) for mice were 4 and 1.6 mg/kg/day respectively. The subacute oral LD_(50) in mice was 11 mg/kg/day and the subacute intraperitoneal LD_(50) in rats was 1 mg/kg/day. 2. In 3 dogs, intravenous injections of 75 γ/kg/day of AT-290 for 10 days produced no remarkable influence on the general behavior, erythrocyte, leukocyte and platelet counts, bleeding and coagulation time, urinalysis and EKG, but caused a significant lymphocytopenia in the peripheral blood. In another 6 dogs, AT-290 at the dosages of 150 and 300 γ/kg exhibited an inhibiting effect upon the bone marrow, as evidenced by a peripheral leukopenia and thrombopenia, delayed bleeding time, and hematopoitic depression in the bone marrow. The animals treated with 75 and 150 γ/kg gradually recovered after cessation of the drug, while those given 300 γ/kg died in 13—19 days. 3. AT-290 inhibited significantly the growth rate of Jensen sarcoma and fibrosarcoma M-57 in rats. Experiments on 3 ascites tumors of mice (Ehrlich ascites carcinoma, spindle cell sarcoma and mammary adenocarcinoma) showed that AT-290 significantly prolonged the survival time of the tumor-bearing mice.

本文介绍新的氮芥衍生物 AT-290 卽对-双(β-氯乙基)氨甲基苯丙氨酸二盐酸盐的毒性试验及实验治疗的结果。 1.本药在小鼠腹腔注射的急性LD_(50)为4毫克/公斤,亚急性口服和腹腔注射的LD_(50)分别为11及1.6毫克/公斤,大鼠腹腔注射的亚急性LD_(50)为1毫克/公斤。 2.狗毒性试验证明,AT-290 在75微克/公斤静脉注射每天1次连续10天,对狗的一般状态、体重、红、白血球数、血小板数、出血时间、凝血时间、尿及心电图检查均无明显影响;但却对淋巴细胞表现出明显抑制作用。150及300微克/公斤时,可抑制动物的骨髓机能,主要表现为白血球总数及血小板减少、出血时间延长、骨髓中幼稚细胞消失,对淋巴球的作用与75微克/公斤组同。这些情况在150微克/公斤组停药后一定时间自行恢复,而大剂量组(300微克/公斤)则动物死亡。 3.本药腹腔注射时对三种小白鼠腹水型肿瘤(Ehrlich腹水癌、梭形细胞肉瘤腹水型及腹水型乳腺癌)均有明显抑制作用,可延长动物的生存时间至2倍以上,对小白鼠实体型肿瘤(淋巴白血病L-2、Ehrlich癌、Crocker肉瘤及梭形细胞肉瘤) 均无明显抑制作用。对大白鼠Jensen肉...

本文介绍新的氮芥衍生物 AT-290 卽对-双(β-氯乙基)氨甲基苯丙氨酸二盐酸盐的毒性试验及实验治疗的结果。 1.本药在小鼠腹腔注射的急性LD_(50)为4毫克/公斤,亚急性口服和腹腔注射的LD_(50)分别为11及1.6毫克/公斤,大鼠腹腔注射的亚急性LD_(50)为1毫克/公斤。 2.狗毒性试验证明,AT-290 在75微克/公斤静脉注射每天1次连续10天,对狗的一般状态、体重、红、白血球数、血小板数、出血时间、凝血时间、尿及心电图检查均无明显影响;但却对淋巴细胞表现出明显抑制作用。150及300微克/公斤时,可抑制动物的骨髓机能,主要表现为白血球总数及血小板减少、出血时间延长、骨髓中幼稚细胞消失,对淋巴球的作用与75微克/公斤组同。这些情况在150微克/公斤组停药后一定时间自行恢复,而大剂量组(300微克/公斤)则动物死亡。 3.本药腹腔注射时对三种小白鼠腹水型肿瘤(Ehrlich腹水癌、梭形细胞肉瘤腹水型及腹水型乳腺癌)均有明显抑制作用,可延长动物的生存时间至2倍以上,对小白鼠实体型肿瘤(淋巴白血病L-2、Ehrlich癌、Crocker肉瘤及梭形细胞肉瘤) 均无明显抑制作用。对大白鼠Jensen肉瘤及纤维肉瘤M-57疗效则很显著。

 
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