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water maze     
相关语句
  水迷宫
     The Study of Memory and Learning of Aged and Young Rats in Morris Water Maze
     青、老年大鼠在Morris水迷宫中的学习记忆行为
短句来源
     Methods At different timepoints after microwave exposure of 65mW/cm~2 for 20min,learning and memory ability was evaluated with shuttle box test and Morris' water maze test,long-term potentiation(LTP) was detected in hippocampal slices in rats.
     方法采用功率密度为65mW/cm2的微波全身一次辐照大鼠20 min,在辐照后不同时相点观察大鼠学习记忆行为的改变(穿梭箱试验和Morris水迷宫试验)和海马离体脑片LTP的诱导变化。
短句来源
     The expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus was investigated by immunohistochemistry staining and image analysis. Results: ①Morris water maze test learning scores(place navigation): After 5 days training,the escape latency in CIH rats was significantly longer than that in UC rats(P<0.05);
     结果:①Morris水迷宫学习成绩(定位航行实验):第5天训练结束时,CIH组大鼠逃避潜伏期明显长于UC组,两组之间差异有统计学意义(P<0.05);
短句来源
     ②Morris water maze test memory scores: The number of times of crossing the platform in CIH group(1.38±0.92) was significantly reduced than that in UC group [(3.75±1.04),P<0.01];
     ②Morris水迷宫记忆成绩:CIH组的穿越平台次数(1.38±0.92)次较UC组显著减少[(3.75±1.04),P<0.01];
短句来源
     Methods: An experiment was designed to investigate the effects of chronic low level lead exposure(0.05% of lead acetate to pollute their drinking water for 28 days) on the spatial learning and memory of rats by Morris water maze.
     方法:0.05%水平醋酸铅污染大鼠饮用水28天,用Morris水迷宫试验测定大鼠的学习记忆功能。
短句来源
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  水迷宫实验
     METHODS Memory impairments induced in rats by scopolamine (1 mg·kg -1 ) were assessed in the Morris water maze test. After rats were injected intraperitoneally with scopolamine for 6 days, the mRNA expression level of five voltage dependent potassium channels, Kv1 4, Kv1 5, Kv2 1, Kv4 2 and Kv4 3 were detected in the rat cortex and hippocampus by RT PCR.
     方法 Morris水迷宫实验检验大鼠空间学习记忆能力 ,用RT PCR方法检测大脑皮层和海马中 5种电压依赖性钾通道Kv1 4 ,Kv1 5 ,Kv2 1,Kv4 2及Kv4 3mRNA的表达。
短句来源
     ResultsAS compared with the control group, the time of average escape potential was prolonged(24.34±2.1)s,the mistakes were increased to enter the blind terminal of water maze(7.12±1.24), the apoptotic cells and the expression of bax were remarkably increased(24.75(±2.66)), bcl-2 protein expression were decreased(17.07±3.47) in model group.
     结果与正常组比较,模型组在水迷宫实验中平均逃避潜伏期延长(24. 34±2. 1),进入盲端错误次数增多(7. 12±1. 24),bcl 2表达减少(17. 07±3. 47),bax表达明显增多(24. 75 ±2. 66);
短句来源
     Results ①In the result of Morris water maze, there was significantly more prolonged in latency to platform in group ethanol (E) than that in group normal saline (NS), group anisodamine (ANI)+NS and group ANI+E (P<0.05).
     结果①在Morris水迷宫实验中,酒精(E)组寻找平台的潜伏期时间显著高于生理盐水(NS)组、山莨菪碱+生理盐水(ANI+NS)组、山莨菪碱+酒精(ANI+E)组(P<0.05)。
短句来源
     ResultsTo blank grouprthe times and percentage of correct searching of rats in water maze were 64 and 88.9%,the average latent period in after experiment[ (12.30 ± 2.95 ) s] had less time than before [ (18.05 ± 3.92 ) s] (p < 0.01 );
     1 空白对照组:大鼠在水迷宫实验中正确搜寻次数和百分比分别为64次和88.9%,实验后平均潜伏期[(12.30±2.95)s]和实验前[(18.05±3.92)s]相比显著缩短(p<0.01);
短句来源
     ①At 30 days post-operative, the time of swimming the whole course in water maze was obviously longer in model group than in sham-operated group (P < 0.05), and identical as that of dementia recovery preparation group (P > 0.05).
     ①造模后30d,模型组大鼠水迷宫实验游完全程时间明显长于假手术组(P<0.05),与痴呆康复冲剂组相近(P>0.05)。
短句来源
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  水迷路
     injection, Gal. (0.3mg/kg and 1.0mg/kg) had no effects on Morris water maze task and step-through test.
     腹腔注射加兰他敏0.3mg/kg,1.0mg/kg对1小时后进行的学习记忆试验(水迷路、明暗箱和Y迷路)均没有影响。
短句来源
     In water maze test, the average right reactionnumber arriving terrace within 10 seconds of NGF-Tf group wassignificantly more raised than that of model group(p<0.05).
     水迷路试验中,NGF-Tf组在10秒内抵达平台的正确反应平均数有明显提高,与模型组比较P<0.05。
短句来源
     Results In water maze test, the average right reaction number arriving terrace of NGF-Tf group within 10 seconds was higher than that of model group (p<0.05).
     结果 水迷路试验中 ,NGF -Tf组在 10s内抵达平台的正确反应平均数提高 (p <0 .0 5 ) .
短句来源
     Step through test and water maze test were employed to investigate ability of learning and memory in AD model rats,immumohistochemical method and image pattern analysis quantitative method were used to detect the deposition number and cross area of Aβin cerebral cortex and hippocampus CA1 in experimental AD model rats.
     应用避暗法和水迷路法测定AD模型大鼠学习记忆功能,免疫组化及图像分析定量法检测模型大鼠大脑皮质和海马结构CA1区Aβ沉积斑数目及截面积。
短句来源
     In water maze test, the average right reaction rate of arriving at terrace of NGF Tf group within 10 seconds was higher than that of the model group(P<0 05).
     水迷路试验中 ,NGF- Tf组在 1 0 s内抵达平台的正确反应平均数提高 ,与模型组比较 ,差异有统计学意义 (P <0 .0 5 )。
短句来源
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  水迷宫的
     ①The learning and memory results in Morris water maze test:The escape latency,swimming distance and memory ability were significantly lower in the model group than in the saline group(P< 0.01),but higher in the aricept group and Jinsiwei group than in the model group(P< 0.05), and there was no difference between the aricept group and Jinsiwei group (P >0.05).
     ①Morris水迷宫的学习、记忆测试结果:模型组大鼠逃避潜伏期、游泳距离及记忆能力显著低于生理盐水组(P<0.01),盐酸多奈哌齐组、金思维组大鼠逃避潜伏期、游泳距离及记忆能力较模型组高(P<0.05),盐酸多奈哌齐组和金思维组无差异(P>0.05)。
短句来源
     Results Among scopolamine,400 ml/L alcohol and D-galactose induced mouse dysmnesia models,the comparison between polysaccharide group and model groups showed that the differences were statistically significant in the correct times of water maze (P<0.05).
     结果 在东莨菪碱、40 0ml/L乙醇和D -半乳糖复制记忆障碍小鼠模型中 ,龙眼参多糖组与模型组比较 ,水迷宫的正确次数差异均有显著性 (P <0 .0 5 )。
短句来源
     NGF IMPROVED THE BEHAVIORS OF LEARNING AND MEMORY OF AGED RATS IN THE MORRIS WATER MAZE TASK
     NGF改善老年大鼠Morris水迷宫的学习记忆行为
短句来源
     Results: When exposed to 65G/50Hz magnetic field, the locomotor activity increased and spatial discrimination memory impaired in Y-maze, however, showing no effect on performance in Morris water maze.
     结果表明:65高斯/50Hz磁场显著增高小鼠的活动性,并损伤小鼠Y-迷宫的空间辨别能力,但对Morris水迷宫的空间、非空间学习记忆无明显影响。
短句来源
     RESULTS: Mice in camphor group and perfume group have longer latency and more error times in water maze test compared with control and apple group (P<0.05).
     结果:樟脑组和香水组水迷宫的潜伏期较对照组延长,错误次数增多(P<0.05)。
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      water maze
    The bulbectomized mice displayed sharp impairment in spatial memory when tested in the Morris water maze.
          
    In this study we evaluated the effect of quercetin on D-galactose-induced aged mice using the Morris water maze (MWM) test.
          
    The effects ofbis(7)-tacrine, a novel acetylcholinesterase inhibitor, on cognitive impairment and neuronal degeneration induced by permanent ligation of bilateral common carotid arteries (2VO) were investigated using the Morris water maze in rats.
          
    In the present study, we investigated the effects of non-specific HCN1 blocker CsCl on spatial learning and memory by using Morris water maze andin situ hybridization in mice.
          
    Significantly suppressed Morris water maze performance was found in 23-wk SHR in comparison with age-matched SD rats.
          
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    Effects of inhibition of catecholamines biosynthesis on learning insocially isolated rats were investigated. Both gregarious rats and isolatedrats were divided into α-MT,DDC and control groups, It was foundthat more training was required in the learning of positional watermaze for isolated rats after α-MT injection (250mg/kg, ip), but not sofor gregarious rats. No significant effects of DDC (500mg/kg, ip) on thelearning of positional water maze were observed both in isolated andgregarious rats. A decrease...

    Effects of inhibition of catecholamines biosynthesis on learning insocially isolated rats were investigated. Both gregarious rats and isolatedrats were divided into α-MT,DDC and control groups, It was foundthat more training was required in the learning of positional watermaze for isolated rats after α-MT injection (250mg/kg, ip), but not sofor gregarious rats. No significant effects of DDC (500mg/kg, ip) on thelearning of positional water maze were observed both in isolated andgregarious rats. A decrease of 38% in cerebral cortex (including hippocampus) con-tents of noradrenaline was observed in isolated rats after α-MT injection,and only a decrease of 20% in gregarious rats. These results suggestthat the decrease of learning ability. in isolated rats is related to thedecrease of brain contents of catecholamines, particularly the contentsof noradrenaline in the cerebral cortex.

    本文观察了儿茶酚胺的生物合成抑制剂——α-甲基酪氨酸(α-MT)和二乙基二硫氨基甲酸酯钠(DDC)——对群体隔离大白鼠学习和记忆的影响。结果发现α-MT(250mg/公斤体重)对群居动物学习方位水迷津无明显影响,但对隔离动物的学习有明显影响。α-MT对群居和隔离动物的记忆的影响不明显,DDC(500mg/公斤体重)对群居和隔离动物的学习和记忆均无明显影响。注射α-MT后隔离动物大脑皮质内去甲肾上腺素的含量降低了38.1%,而群居动物仅降低了20.1%。结果提示隔离动物对方位水迷津学习能力的降低可能与脑内去甲肾上腺素和多巴胺的含量下降尤其是与大脑皮质内去甲肾上腺素含量的下降有关。

    Nimodipine was shown to improve anisodine-induced impairments of active and passive avoidance responses, while nifedipine and vincamine increased passive avoidance response only in rats. The potency of nimodipine on amnesia was 100~200 and 1,000~2,000 times as large as nifedipine and vineamine respectively. Nimodipine was capable of antagonizing pentobarbital-induced impairment of learning in water maze and cycloheximide-elicited deficit of consolidation of memory in step down and step through tests in...

    Nimodipine was shown to improve anisodine-induced impairments of active and passive avoidance responses, while nifedipine and vincamine increased passive avoidance response only in rats. The potency of nimodipine on amnesia was 100~200 and 1,000~2,000 times as large as nifedipine and vineamine respectively. Nimodipine was capable of antagonizing pentobarbital-induced impairment of learning in water maze and cycloheximide-elicited deficit of consolidation of memory in step down and step through tests in mice. However, nifedipine and vincamine did not show significant effect on the parameters mentioned above. Effects of the three cerebral vasodilators on alcohol-induced deficit of retrieval of mice were also studied in step down test. Good result was obtained with vincamine, but not with nimodipine and nifedipine.

    采用多次性训练的主动和被动迴避反应和水迷宫法,观察了尼莫地平、硝苯吡啶和长春胺对樟柳碱和戊巴比妥钠引起的大鼠和小鼠记忆障碍的改善作用。三种药物皆有不同程度的改善作用,其中尼莫地平的作用强度比硝苯吡啶和长春胺各大200和2,000倍。尼莫地平还可拮抗环己酰亚胺引起的记忆巩固不良,而其它两种药物则无此作用。长春胺对40%乙醇引起的小鼠记忆再现缺失有明显改善作用,其它两药则否。

    Previous studies have demonstrated that methamidophos markedly inhibited ChE activity in rat brain. Developmental retardation in rats produced by in utero exposure to methamidophos was also reported. This study was designed to examine the effects of perinatal methamidophos exposure in mice at lower dose levels (1/6 LD50-1/60 LD50) on the development of behaviour and cerebral cortex in their off spring. Methamidophos 0,0.4, 2.2 and 4mg/ (kg·d) were given to adult Kunming female mice from the 16 th gestation day...

    Previous studies have demonstrated that methamidophos markedly inhibited ChE activity in rat brain. Developmental retardation in rats produced by in utero exposure to methamidophos was also reported. This study was designed to examine the effects of perinatal methamidophos exposure in mice at lower dose levels (1/6 LD50-1/60 LD50) on the development of behaviour and cerebral cortex in their off spring. Methamidophos 0,0.4, 2.2 and 4mg/ (kg·d) were given to adult Kunming female mice from the 16 th gestation day to the 21 th postnatal day (the weaning day of the offspring) with feeding needles. A positive control group exposed to an antithyroid drug, methimazole (100 mg/ (kg·d) at the same time. The offsprings were assessed on a series of tests referring to the Cincinnatipsychoteratogenicity screening test battery. Differences between methamidophos (2.2,4 mg/ kg) and normal control group were observed in gestation length, eye opening, surface righting, auditory startle, reflex suspension, swimming development, T-water maze and neuron density in cerebral cortex. Treatment with 0.4 mg/kg methamidophos significantly delayed auditory startle and swimming ability development, shortened the time of reflex suspension and lowered T-water maze learning abilities of the offspring. The results showed that methamidophos produced evidence of both physical and behavioral toxicity in developing mice at lower dose levels.

    实验选用多项行为检测指标及定量组织学方法,以对硫咪唑为阳性对照,研究了有机磷农药甲胺磷的小鼠行为致畸效应。结果表明小鼠围产期接触对硫咪唑和低剂量甲胺磷影响其仔代的躯体发育、反射发育及学习能力,并导致大脑皮质神经元密度增加。

     
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