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two-drugs
相关语句
  二联疗法
     Compared with the two - drugs group, mortality rate of the three - drug group decreased by half.
     三联疗法组比二联疗法组死亡几乎减少一半.
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  “two-drugs”译为未确定词的双语例句
     As for active treatment single drug consisted of 49%,two-drugs 27%,three-drugs 7%,and four-drugs 1%,local use accounted for 16%.
     治疗用药中单一用药占49%、二联用药占27%、三联7%、四联1%、局部占16%;
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  相似匹配句对
     Two.
     二.
短句来源
     Two.
     二、末日意识
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     Two results on g-functions
     关于g-函数的两个结果
短句来源
     4)drugs;
     ④药物因素;
短句来源
     NewAntiepileptic Drugs
     现代新抗癫痫药
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Experiments on the metabolism of nucleic acids have shown that N- formyl-sarcolysin(N-F)may reduce the content of DNA both in normal animal tissues and in transplantable tumors.In view of these findings,the effect of N-F upon p~(32) incorporation into nucleic acids was investigated,and this was compared with the effect of sarcolysin. Mice and rats were used in the experiments.Fifteen μc of P~(32) in the form of Na_2HP~(32)O_4 solution were injected intraperitoneally into the animals 24 hours after the last dose...

Experiments on the metabolism of nucleic acids have shown that N- formyl-sarcolysin(N-F)may reduce the content of DNA both in normal animal tissues and in transplantable tumors.In view of these findings,the effect of N-F upon p~(32) incorporation into nucleic acids was investigated,and this was compared with the effect of sarcolysin. Mice and rats were used in the experiments.Fifteen μc of P~(32) in the form of Na_2HP~(32)O_4 solution were injected intraperitoneally into the animals 24 hours after the last dose of N-F.The animals were sacrificed 5—6 hours after the isotope injection, RNA and DNA were isolated by the procedure described in our previous paper.Sam- ples were plated and their radioactivities were counted,and the results obtained were expressed according to the method of Davidson and Freeman. The results indicate that N-F(80mg/kg)and sarcolysin(10mg/kg)administered once daily for 4 consecutive days inhibited markedly the incorporation of P~(32) into RNA and DNA of the spleens in normal rats and in mice bearing Ehrlich ascites car- cinoma.A marked depression of P~(32) incorporation into DNA of Yoshida ascites sar- coma was also noted when N-F was administered orally at 50 or 160 mg/kg,and sarco- lysin at 5 or 20mg/kg respectively for 2 consecutive days.However,these two drugs failed to produce any significant depression of P~(32) incorporation into RNA.It is very interesting that N-F produced marked depression of P~(32) incorporation into both RNA and DNA of Yoshida solid tumors with three doses of 160 mg/kg,while with a single dose of 160 mg/kg only depression of incorporation into DNA was observed.N-F had no effect upon P~(32) incorporation into the RNA and DNA in mice bearing Ehrlich solid tumors at daily doses of 50 or 100 mg/kg for 7—9 days,as well as in mice bearing reticulo-sarcoma L_2 at daily doses of 50 or 80 mg/kg.However,under the same con- ditions N-F and sarcolysin inhibited markedly the incorporation of P~(32) into DNA of the Ehrlich ascites cells.It thus appears that N-F and sarcolysin exert a similar pattern of influence upon nucleic acid metabolism.

本文报告 N-甲对 P~(32)参入正常及肿瘤组织(或细胞)中核酸的影响。N-甲在治疗剂量下对 P~(32)参入大鼠吉田肉瘤(腹水及实体型)及小鼠艾氏癌腹水型的肿瘤细胞(或组织)核酸有明显抑制作用,且以对参入 DNA 的影响最强。N-甲对 P~(32)参入小鼠艾氏癌实体型肿瘤组织核酸无影响;在小剂量下对 P~(32)参入小鼠网织细胞肉瘤组织核酸亦无明显影响。N-甲对 P~(32)参入正常及肿瘤动物脾脏核酸有明显抑制作用。N-甲与溶肉瘤素对 P~(32)参入正常及肿瘤组织核酸的影响类似,但在等毒性剂量下其作用较溶肉瘤素稍弱。

Reserpine antagonism to morphine analgesia could be clearly demonstrated in mice with methods of applying to the tail nociceptive stimuli, either mechanical, thermal or electrical. The analgesic ED_50 increased 2—7 times. No antagonism, however, was found in the hot-plate method or in experiments with electrical stimulation on the tail if vocalizations, instead of motor responses, were regarded as nociceptive reaction. Pretreatment with a single large dose(2. 5mg/kg) of reserpine could not prevent tolerance...

Reserpine antagonism to morphine analgesia could be clearly demonstrated in mice with methods of applying to the tail nociceptive stimuli, either mechanical, thermal or electrical. The analgesic ED_50 increased 2—7 times. No antagonism, however, was found in the hot-plate method or in experiments with electrical stimulation on the tail if vocalizations, instead of motor responses, were regarded as nociceptive reaction. Pretreatment with a single large dose(2. 5mg/kg) of reserpine could not prevent tolerance formation by short-term repeated morphine administration. α-methyl-DOPA 200 or 400mg/kg injected intraperitoneally did not exert antagonism to morphine administered 2, 6, 12, or 24 hours after. Interactions of reserpine and α-methyl-DOPA on morphine analgesia were also studied. α-methyl-DOPA, given simultaneously with or prior to reserpine, could eliminate the antagonistic action of reserpine to morphine, but failed to do so if given 2 or 4 horus after reserpine. The dependence of the α-methyl-DOPA antagonism to reserpine on the sequence of administering these two drugs may have some bearing on the nature of binding and release of catecholamines, and further studies are thus indicated.

(一) 利血平对抗吗啡鎮痛并不是普遍的现象。在烫尾法、夹尾法及以挣扎为指标时的电刺激尾法实驗中,存在明显的对抗,ED_(50)提高2—7倍。但在热板法及以嘶叫为指标时的电刺激尾法实驗中,没有对抗现象出现。一次大剂量利血平化后,也不能阻止吗啡耐葯性的形成。 (二) α-甲基-DOPA200或400毫克/公斤,注射后2、6、12和24小时再注射吗啡,吗啡的鎮痛作用并不受影响。先注射α-甲基-DOPA,然后注射利血平,或者二药同时注射,則利血平的对抗吗啡鎮痛和排便作用都消失。但先注射利血平,然后给α-甲基-DOPA,則利血平的这些效应仍保存。

(1) The analgesic potency of acepromazine in a dose of 0.5 mg/kg was somewhat inferior to that of morphine (2mg/kg). By combining these two drugs, the analgesic effect was summated and the duration of action was prolonged. (2) After intracerebral injection, acepromazine produced more prominent tranquilizing and hypothermic effects than those elicited by hypodermic administration. It could also potentiate the hypothermic action of chloral hydrate and antipyrin. (3) Acepromazine, applied locally or injected...

(1) The analgesic potency of acepromazine in a dose of 0.5 mg/kg was somewhat inferior to that of morphine (2mg/kg). By combining these two drugs, the analgesic effect was summated and the duration of action was prolonged. (2) After intracerebral injection, acepromazine produced more prominent tranquilizing and hypothermic effects than those elicited by hypodermic administration. It could also potentiate the hypothermic action of chloral hydrate and antipyrin. (3) Acepromazine, applied locally or injected subcutaneously, produced definite surface anaesthesia in rabbit's cornea and potentiated the anaesthetic action of procaine. (4) The vasopressor response to 5 γ/kg of adrenaline in the anaesthetized cats was reduced by 2.5 γ/kg of acepromazine and reversed by 5 γ/kg of the antagonist. The contraction of the nictitating membrane due to preganglionic sympathetic stimulation and injection of adrenaline was reduced by the larger dose. (5) When the periarterial nerves of Finkleman's preparation were stimulated, the motor activity of the isolated rabbit's ileum was decreased and the tone was reduced. This inhibitory response to the nerve stimulation was potentiated by acepromazine and chlorpromazine in the concentrations of 1:1,000,000-4:1,000,000. It is concluded that acepromazine and chlorpromazine do not interfere, with the release of noradrenaline from the post-ganglionic sympathetic nerve endings.

(1)采用热水刺激小白鼠尾巴法試驗鎮痛作用,乙酰普馬嗪0.5毫克/公斤可使“疼痛”反应出現时間延迟,較盐酸嗎啡(2毫克/公斤)为弱;二者均以半量合并应用,鎮痛作用强度虽未見加强,但鎮痛时間則延长。(2)脑室內注射乙酰普馬嗪,可立即引起小白鼠安靜,并使其体溫明显下降;皮下注射同剂量时,安靜及降溫作用均不显著,但可明显加强安替比林及水合氯醛的降溫作用。(3)乙酰普馬嗪局部滴药及皮下注射均可产生角膜麻醉,并可加强普魯卡因的表面麻醉作用,尤以皮下注射法为强。(4)乙酰普馬嗪2.5微克/公斤即可減弱腎上腺素的升压作用;5微克/公斤时,使后者作用翻轉,并使电刺激交感神經节前纤維及注射腎上腺素所引起的瞬膜收縮反应減弱。(5)在离体兔神經——迴腸标本,电刺激交感神經节后纤維引起腸张力下降,运动減弱,乙酰普馬嗪及氯丙嗪均可加强此交感反应。

 
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