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osteocalcin bgp
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     ⑦ assay of osteocalcin.
     ⑦骨钙素的测定结果。
短句来源
     Osteocalcin and children's growth and development
     骨钙素与儿童生长发育
短句来源
     The serum was isolated to measure serum osteocalcin (BGP).
     分离血清 ,测定血清骨钙素 (BGP)水平。
短句来源
     Characteristics of Osteocalcin after Spinal Cord Injury (review)
     骨钙素与脊髓损伤
短句来源
     Objective:To study the serum levels of osteocalcin(BGP)in different ages.
     目的:探讨不同年龄段血清骨钙素水平的变化。
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  osteocalcin bgp
Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and po
      
Characterization of Osteocalcin (BGP) and Matrix Gla Protein (MGP) Fish Specific Antibodies: Validation for Immunodetection Stud
      
Serum T4 and osteocalcin (BGP), urinary pyridinolines (Pyr), and creatinine (creat) were determined.
      
In all patients we measured serum levels of total alkaline phosphatase (ALP), type I procollagen carboxy-terminal propeptide (PICP), osteocalcin (BGP), urinary excretion of hydroxyproline (HOP/Cr), and pyridinoline crosslinks (Pyr/Cr).
      
These findings suggest that β2-microglobulin behaves similarly to osteocalcin (BGP) in Paget's bone disease and that its concentration remains within normal levels perhaps because of the rate of reuptake of β2-microglobulin in bone neoformation.
      
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Osteocalcin(BGP)is a Vitamin K-dependent protein that is synthesized by os-teoblasts and present in circulation.We measured serum BGP concentration inCushing's disease before and after treatment.Before treatment,serum BGP levelswere decreased in 12 patients(mean±SE=2.5±0.5ng/ml)and were significantly lowerthan those observed in normals(4.8±1.3 ng/ml,P<0.01).Serum AKP levels werein the normal range.After surgical treatment,in the 8 cured patients,BGP levelswere significantly higher...

Osteocalcin(BGP)is a Vitamin K-dependent protein that is synthesized by os-teoblasts and present in circulation.We measured serum BGP concentration inCushing's disease before and after treatment.Before treatment,serum BGP levelswere decreased in 12 patients(mean±SE=2.5±0.5ng/ml)and were significantly lowerthan those observed in normals(4.8±1.3 ng/ml,P<0.01).Serum AKP levels werein the normal range.After surgical treatment,in the 8 cured patients,BGP levelswere significantly higher than before treatment and reached the normal range(5.1±1.8ng/ml).The data suggested BGP as a sensitive marker of corticosteroid induceddepression of osteoblast activity.

本文用自己建立的放射免疫分析方法测定了12例肾上腺皮质机能亢进患者的血清骨钙素(BGP)含量。治疗前,肾上腺皮质机能亢进患者平均血清 BGP(?)±2SE 为2.5±0.5ng/ml,显著低于正常值(4.8±1.3ng/ml,P<0.01)。8例患者于手术治疗后2周复查,血清 BGP 恢复至正常水平(5.1±1.8ng/ml),本文结果提示,骨钙素测定是皮质类固醇抑制成骨细胞活性的一个敏感指标。

bjectives To evaluate the efficacy of luteinizing hormone releasing hormone agonist(LHRH-A)in the treatment of endometriosis Em),uterine leiomyoma and adenomyosis,and its impact on bone metabolism. Methods Twenty patients .Em 13(stage II4,III7,IV2),leiomyoma 4 and adenomyosis 3,were selected to receove LHRH-A 200μintramuscular daily for 3 months。Clinical and ultrasound features,serum follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_2),osteocalcin(BGP)concentrations were compared...

bjectives To evaluate the efficacy of luteinizing hormone releasing hormone agonist(LHRH-A)in the treatment of endometriosis Em),uterine leiomyoma and adenomyosis,and its impact on bone metabolism. Methods Twenty patients .Em 13(stage II4,III7,IV2),leiomyoma 4 and adenomyosis 3,were selected to receove LHRH-A 200μintramuscular daily for 3 months。Clinical and ultrasound features,serum follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_2),osteocalcin(BGP)concentrations were compared before and at the end of treatment.Furthermore,24-hour urinary calcium(Ca),phosphate (P)excretions and bone mineral density(BMD)of radius and lumbar spine measured by single photon absorptiometry (SPA)and dual energy X-ray absorptiometry(DEXA)were also analysed before and at the end of treatment.Patients were followed-up 3~19 months after discon-tinuation of the drug. Results At the end of treatment dysmenorrhea disappeared in all 15 cases。Pelvic tenderness and in- duration irnproved in 18,endometrioma shrinked in 13 cases。Mean uterine volume of 7 patients with leiomyoma or adenomyosis was reduced by 35% from the basal volume。Serum LH,E_2 levels were sup- pressed significantly(P<0.05),mean E_2 concentration declined from 459.5±292.0 to 160.3±110.7 pmol /L(P<0.001).No significant change was found in serum BGP,urinary Ca,P,and BMD of radius and lumbar spine at the end of therapy.The only side effect was mild not flushes and sweating during treatment.After stopping the drug,17 patients resumed menses within 2 months。Dysmenor- rhea and pelvic mass recurred in 6 months with less severity,One became pregnant in 3 months。Conclusions LHRH-A administration is effective in the treatment of Em,leiomyoma and adeno-myosis。No signmcant adverse effect was shown on bone metabolism at the end of 3-month therapy.

应用促黄体激素释放激素激动剂(LHRH-A)200μg,每日肌内注射,连续3个月为1疗程,治疗轻、中型子宫内膜异位症、子宫肌瘤、子宫腺肌症共20例。结果:用药结束时,促卵泡成熟激素(FSH)、黄体生成素(LH)、雌二醇(E_2)均受抑制,分别为4.8±2.9IU/L(P>0.05)、4.0±3.5IU/(P<0.05)、160.3±110.7pmol/L(P<0.001)。临床上体征改善,痛经消失,副反应轻,易为病人接受。20例用药前后骨钙素(osteocalcin)与尿钙、磷测定比较,差异均无显著性(P>0.05)。双能X线吸收法(DEXA)测量腰椎2~4骨密度,用药3个月下降2%,停药3个月下降1%,尚属正常范围(P>0.05);单光子吸收法(SPA)测量桡、尺骨骨密度也未见影响(P>0.05)。

Fasting urine and blood samples were collected from 1928 healthy subjects aged 0~87 years and 5345 patients in Beijing and the biochemical markers were measured. The results indicated that serum 25 hydroxy vitamin D(25OHD), alkaline phosphatase(ALP), osteocalcin(BGP), parathyroid hormone(PTH) urine type I collegen crosslinked N-telopeptides creatinine ratio(NTX/Cr) and hydroxyproline creatinine ratio (HOP/Cr) were significant correlates with age. Serum 25OHD, BGP,urine NTX/Cr and HOP/Cr could...

Fasting urine and blood samples were collected from 1928 healthy subjects aged 0~87 years and 5345 patients in Beijing and the biochemical markers were measured. The results indicated that serum 25 hydroxy vitamin D(25OHD), alkaline phosphatase(ALP), osteocalcin(BGP), parathyroid hormone(PTH) urine type I collegen crosslinked N-telopeptides creatinine ratio(NTX/Cr) and hydroxyproline creatinine ratio (HOP/Cr) were significant correlates with age. Serum 25OHD, BGP,urine NTX/Cr and HOP/Cr could be used to predict bone mass. 1, 25 ((OH)2D3, 25OHD,NTX/Cr, HOP/Cr are able to discriminate between premenopansal and late osteoprotic patients. Agerelated bone loss may be due to a fall in 1,25(OH)2D3 and a rise in PTH and renal dysfunction. Postmenopausal bone loss could be due to estrogen deficiency.

本文收集了北京地区1928名不同年龄(0~87岁)健康人及5345例20余种疾病患者空腹尿及血,并对其骨代谢生化指标进行测定。结果表明:血清25羟基维生素D(25OHD),碱性磷酸酶(ALP),骨钙素(BGP),甲状旁腺激素(PTH),尿Ⅰ型胶原交联N末端肽与肌酐比值(NTX/Cr)及羟脯氨酸与肌酐比值(HOP/Cr)与年龄显著相关。血清25OHD,BGP,尿NTX/Cr及HOP/Cr可用于预测骨量。1,25(ON)2D3,25OHD,NTX/Cr和NOP/Cr可用于区分绝经前与绝经后骨质疏松妇女。与年龄有关的骨丢失可能与1,25(OH)2D3的降低、PTH的升高及肾功能减退有关;绝经后骨丢失与雌激素缺乏有关。

 
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