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protein
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  蛋白
    THE RELATIVE STUDY OF HEAT SHOCK PROTEIN 70 AND GASTROINESTINAL TUMOR
    热休克蛋白70与胃肠肿瘤相关性的研究
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    Antitumor Effects of the Fusion Protein Transmembrane Superantigen SEA
    跨膜型超抗原SEA融合蛋白的抗肿瘤作用研究
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    To Fish the Human UROC-28 Binding Protein by the Yeast Two Hybrid System
    酵母双杂交技术钓取人UROC28结合蛋白
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    Expression of Some Multidrug Resistant Gene and Protein in Breast Cancer Cases
    部分耐药基因和蛋白在乳腺癌病例中的表达
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    The Constructions of Heat-Shock Protein 70 and MAGE-1 Fusion DNA Vaccine and Protein Vaccine and Their Antitumor Effects in Vivo
    热休克蛋白70与MAGE-1融合基因疫苗和蛋白疫苗的构建及体内抑瘤效应的研究
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  基因蛋白
    Studying DNA Repair Capacity and Checkpoint Gene Protein (ATM Protein) of Lung Cancer Patients and Breast Cancer Patients
    肺癌和乳腺癌病人DNA修复能力及关卡基因蛋白(ATM蛋白)的研究
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    Quantitative study of P53 gene protein expression in the benign disease and cancer of breast
    P53基因蛋白在乳腺良性病变和癌细胞表达的定量研究
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    Loss of Rb gene protein expression and P_(53) gene mutation in human testicular seminoma
    人类睾丸精原细胞瘤组织中P_(53)基因突变和Rb基因蛋白产物表达的缺失
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    P53 GENE PROTEIN EXPRESSION OF BREAST CANCER CORRELATED WITH CLINICAL PROGNOSIS
    乳腺癌P53基因蛋白的表达与临床预后的关系
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    Selection of antibodies and problems in studies on P53 protein accumulation
    P53基因蛋白表达研究中的抗体选择与存在问题
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    Cloning, Identification and Functional Analysis of the Gene Encoding a Gastric Cancer Multidrug Resistance Associated Protein MGr1-Ag
    胃癌耐药相关分子Mgr1-Ag编码基因的克隆、鉴定与功能分析
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    Experimental Study on SH2 Domain Containing Protein Tyrosine Phosphatase SHP-1 and SHP-2 in γ-ray Irradiation Induced Tumor
    SHP-1和SHP-2在γ射线诱发的恶性肿瘤中作用的实验研究
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    Functional Study of Novel Human Centrosomal Protein Oncogene-cepo
    中心体定位的具有原癌基因属性的人源新基因cepo的功能研究
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    Study on the Biological Characteristics and Metastasis-Related Function of SNC19 Protein
    新型丝氨酸蛋白酶SNC19生物学特性及肿瘤转移功能的研究
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    The Study on the Function of Colorectal Tumor Related ST13 Gene and Protein
    大肠癌相关基因ST13功能研究
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  protein
Polyamines May Modulate Both G Protein-Coupled Receptors and G Proteins
      
Heterodimerization of G-Protein-Coupled Receptors Reveals an Unexpected Level of Pharmacological Diversity
      
The Activation Mechanism of Class-III G-Protein Coupled Receptors
      
Hepatic glutathione, lipid peroxides, glutathione peroxidase, alcohol dehydrogenase, aldehyde dehydrogenase, glycogen and total protein in liver were also significantly altered.
      
3D QSAR STUDIES OF INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN (CETP) BY CoMFA, CoMSIA AND GFA METHODOLOGIES
      
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(1) A comparative study has been made on the induction of tryptophan pyrrolase by substrate and corticoids in liver tumor and the precancerous liver induced by 3'-MeDAB.(2) The liver tumor, contrary to normal liver, was inactive in response to both tryptophan and hydrocortisone for the induction of tryptophan pyrrolase, while the tissue adjacent to the tumor was active with respect to both substrate and hormonal induction.(3) A decrease in both substrate and hormonal induction was observed in the precancerous...

(1) A comparative study has been made on the induction of tryptophan pyrrolase by substrate and corticoids in liver tumor and the precancerous liver induced by 3'-MeDAB.(2) The liver tumor, contrary to normal liver, was inactive in response to both tryptophan and hydrocortisone for the induction of tryptophan pyrrolase, while the tissue adjacent to the tumor was active with respect to both substrate and hormonal induction.(3) A decrease in both substrate and hormonal induction was observed in the precancerous liver developed by feeding 3'-MeDAB for different time intervals. In experiments by injecting intraperitoneally the carcinogen into animals,for 25 hours, similar results were obtained as in the feeding experiments.(4) 2-MeDAB, a non-carcinogenic substance, caused the same effect on the induction of tryptophan pyrrolase in every case as did 3'-MeDAB. It thus appears that the effect of 3'-MeDAB on the enzyme induction may not be specific.(5) No inhibitors of tryptophan pyrrolase or activators of kynureninase were found in the cell sap of liver tumor and the liver of rats fed 3'-MeDAB or 2-MeDAB in the course of induction.(6) The cell sap from liver tumor (non-induced) contained only a small amount of enzyme protein, as shown by the fact that the enzyme activity being only slightly increased by the addition of either normal microsome or hematin, of which the level has not elevated by the administration of tryptophan or hydrocortisone.(7) Similar experiments have shown that the cell sap from the substrate and hormonal induced liver in the precancerous stage contained a decreased amount of enzyme protein as compared to that of the control. The same was true of the rats fed 2-MeDAB.(8) Microsomes from liver tumor have lost almost completely the ability of activating tryptophan pyrrolase in the cell sap. The ability of activation due to microsomes from the precancerous liver was remarkably reduced, though not yet completely lost, while the microsomes from the liver of rats fed 2-MeDAB were normal. It was in this respect that the effect of non-carcinogen (2-MeDAB) was found to be different from that of the carcinogen (3'-MeDAB).(9) From the results presented, it was concluded that the default of tryptophan pyrrolase induction observed in the liver tumor and the precancerous liver was mainly due to an inadequate amount of apoenzyme, rather than a deficiency of co-factor (hematin) or an increment of protein other than the enzyme. The possible cause of these effects was briefly discussed.

本文对大鼠肝癌及癌前期肝内TP的底物诱导和激素诱导作了比较研究。在3′-MeDAB诱发的肝癌中,TP活性很低,且不因注射色氨酸或氢可地松而升高,而癌周组织则仍保留对底物和激素诱导的能力。喂3′-MeDAB 13天、28天、90天大鼠肝内TP的底物诱导效应都较对照组为低。急性注射3′-MeDAB25小时,以100毫克/100克体重的L-色氨酸进行诱导,TP的诱导效应亦较对照组为低。氢可地松诱导的结果与底物诱导的相似,无论在喂或急性注射3′-MeDAB的情况下,TP的诱导效应都受到抑制。但在相同条件下,非致癌物,2-MeDAB,对TP的底物诱导和激素诱导(慢性的或急性的实验)也有相似的作用。诱导后肝癌组织或喂偶氮染料的肝组织中都未发现有TP的抑制物或狗尿酸酶的激活物。微粒体及正铁血红素与上清液的加合实验表明:(1)肝癌微粒体几乎完全不具有激活TP的活力;癌前期(3′-MeDAB组)肝微粒体已部分失去此种生化功能,但2-MeDAB组微粒体则否。3′-MeDAB对肝微粒体中辅助因子(正铁血红素)的结构并无破坏,而可能使辅助因子的含量减少。(2)微粒体对激活上清液TP的效果较自由的正铁血红素差,即使加入过量微粒体亦不能...

本文对大鼠肝癌及癌前期肝内TP的底物诱导和激素诱导作了比较研究。在3′-MeDAB诱发的肝癌中,TP活性很低,且不因注射色氨酸或氢可地松而升高,而癌周组织则仍保留对底物和激素诱导的能力。喂3′-MeDAB 13天、28天、90天大鼠肝内TP的底物诱导效应都较对照组为低。急性注射3′-MeDAB25小时,以100毫克/100克体重的L-色氨酸进行诱导,TP的诱导效应亦较对照组为低。氢可地松诱导的结果与底物诱导的相似,无论在喂或急性注射3′-MeDAB的情况下,TP的诱导效应都受到抑制。但在相同条件下,非致癌物,2-MeDAB,对TP的底物诱导和激素诱导(慢性的或急性的实验)也有相似的作用。诱导后肝癌组织或喂偶氮染料的肝组织中都未发现有TP的抑制物或狗尿酸酶的激活物。微粒体及正铁血红素与上清液的加合实验表明:(1)肝癌微粒体几乎完全不具有激活TP的活力;癌前期(3′-MeDAB组)肝微粒体已部分失去此种生化功能,但2-MeDAB组微粒体则否。3′-MeDAB对肝微粒体中辅助因子(正铁血红素)的结构并无破坏,而可能使辅助因子的含量减少。(2)微粒体对激活上清液TP的效果较自由的正铁血红素差,即使加入过量微粒体亦不能使TP活性增高到加入正铁血红素的水平;微粒体对3′-MeDAB组上清液的激活不如对2-MeDAB组及对照组上清液(底物或激素诱导)的激活显著,而正铁血红素对三组上清液都有显著激活。(3)肝癌细胞上清液只合有极少量的TP蛋白,且不因注射色氨酸或氢可地松而增加;癌前期肝细胞上清液的TP蛋白因底物或激素诱导而增加的量都较对照粗低。2-MeDAB组也有相似现象。以上结果表明,肝癌及癌前期肝内TP诱导的受损,主要是由于诱导后TP蛋白的缺少,而不是由于辅助因子(如正铁血红素)的不足,或非酶蛋白的增多。

Transfer factor (TP) is a dialysable (ultrafilterable) extract of sensitised leukocytes. It transfers cellular immunity from a skin test positive donor to a skin test negative recipient. Currently TF is recognized as one of the most potent immunological reagents. In this paper the detailed method for preparation of transfer factor from normal blood bank donors has been described and some physico-chemical and biological properties of the TF preparations have been examined. The production of TF is briefly as follows:...

Transfer factor (TP) is a dialysable (ultrafilterable) extract of sensitised leukocytes. It transfers cellular immunity from a skin test positive donor to a skin test negative recipient. Currently TF is recognized as one of the most potent immunological reagents. In this paper the detailed method for preparation of transfer factor from normal blood bank donors has been described and some physico-chemical and biological properties of the TF preparations have been examined. The production of TF is briefly as follows: After separation of the plasma (for plasma products), the buffy coats are harvested and pooled. The contaiminating red blood cells are disrupted by tris buffered or isotonic NH_4Cl solution. The pooled leukocytes having been washed iwice with cold normal saline are then alternately frozen and thawed ten times with dry ice in acetone and a 37℃ water bath. The cell lysate is placed in dialysis tubing and dialysed in the cold for 36~48 hours against running pyrogenfree deionized water. The dialysate is lyophilized. The yellowish white powder is saved and redissolved in the desired volume of pyrogen-free deionized water, and passed through a Seitz filter (EKS). 2ml of the sterile TF solution (equivalent to the dialysate of 4×10~8 leukocytes) are placed in each ampoule. The final product is stored at -20℃.The TF preparation is protein-free as determined by protein precipitating reagents. It contains ca. 148μg of peptides and 14μg of ribose per mg of dry powder. The ultraviolet absorption curve gives a peak at 250~251nm. Adenine, guanine and uracil are present in the paper chromatogram of the TF acid hydrolysate. Silica- gel thin layer chromatography reveals four spots stained with ninhydrin. Sephadex G-25 filtration gives reproducibly a characteristic elution pattern yielding 3 main peaks and several small peaks with many of the eluted peaks beyond the total volume of the column. The results of animal experiments show that the TF preparations are non-toxic, non-anaphylactic and non-antigenic.So far over 160 patients (variously afflicted with herpes zoster, chronic hepatitis B, systemic lupus erythematosus, primary carcinoma of the liver, carcinoma of the lung and leukemia) have been treated with the TF preparations. The results will be published elsewhere.

转移因子是致敏白细胞中的可透析物质,能将一个有免疫能力的人的某些细胞免疫力转移给无免疫力的人。所以供给转移因子可能是一种有效的免疫治疗措施。本文详细介绍综合利用血源制备正常人转移因子的方法,并分析其某些理化性质和生物学性质。收集分离血浆后的白细胞层,用三羟甲基氨基甲烷缓冲的或等渗的氯化铵溶液破坏其中污染的红细胞,白细胞经生理盐水洗涤后进行10次冻融,白细胞匀浆对流动去离子水透析,透析液冷冻干燥、除菌分装。每安瓿2毫升转移因子注射液相当4×10~8个白细胞的透析物,保存于-20℃备用。本制剂蛋白质定性检查阴性;每毫克干粉约含多肽148微克、核糖14微克;在250~251毫微米有吸收高峰;转移因子酸水解液硷基纸层析有三种硷基;硅胶薄板层析呈四个茚三酮显色点;葡聚糖G-25凝胶过滤呈可重复的特征性洗脱图谱,具有3个主要峰及若干个小峰,主要洗脱部分在V_t之后。动物实验表明此制剂无毒性、无过敏性和抗原性。本制剂已用于临床治疗带状疱疹、系统性红斑狼疮、慢性乙型肝炎、原发性肝癌、肺癌及白血病等一百六十余例,结果将另文发表。

The chemical composition and the enzymatic activities of normal and silicotic alveolar macrophages were compared in order to investigate the changes occurring after the introduction of quartz into the lung. As shown from the SDS-PAGE results, the protein composition of the silicotic alveolar macrophages was different from the normal in three places. Two protein lines showed increased intensity and one protein line was absent from the gel of the silica containing cells.The lecithin and lysolecithin...

The chemical composition and the enzymatic activities of normal and silicotic alveolar macrophages were compared in order to investigate the changes occurring after the introduction of quartz into the lung. As shown from the SDS-PAGE results, the protein composition of the silicotic alveolar macrophages was different from the normal in three places. Two protein lines showed increased intensity and one protein line was absent from the gel of the silica containing cells.The lecithin and lysolecithin contents were both increased in the silicotic macrophages. The presence of an increased amount of lysolecithin may indicate that the cells were destroyed by the quartz.The acid phosphatase actvity and the oxygen consumption of the silica containing cells were both lower than normal cells.After treatment of the silicotic rats with PVNO, the composition and the enzymatic activities of the macrophages were all returned to the normal level. This shows that PVNO protects the alveolar macrophages from destruction by the quartz particles. Other drugs tested also showed some protective effect on the cells.

文中比较了正常大鼠与矽肺大鼠肺泡巨噬细胞中蛋白质与磷脂的组成,以及酸性磷酸酶活性与耗氧量的差别。根据SDS-PAG电泳的结果看到矽肺大鼠肺泡巨噬细胞的蛋白质区带比正常者多两条,但缺少了一条分子量较小的区带。矽肺大鼠肺泡巨噬细胞中含有大量卵磷脂,说明石英能引起肺表面活性物增多。同时,溶血卵磷脂也比正常者明显地增多,酸性磷酸酶活性与耗氧量均比正常者低,这些都说明石英改变了细胞的组成,破坏了细胞的功能。用克矽平(PVNO)治疗过的大鼠肺泡巨噬细胞的化学组成及酶活性都与正常者近似,证明此药能保护巨噬细胞防止被石英破坏。津_5、山梨醇铝等药物对细胞也表现有不同程度的保护作用。

 
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