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induced rat
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  诱导型
     Objective To approach mainly the actions of nitric oxide(NO)and inducible nitric oxide synthase (iNOS) on endotoxin (lipopolysaccharidePaO 2<6 7kPa,LPS)induced rat acute lung injury (ALI) and the affeciton of rhubarb on them.
     目的 主要探讨一氧化氮(NO) 和诱导型一氧化氮合酶(iNOS)在内毒素(LPS) 诱导的大鼠急性肺损伤(ALI)的作用机制及大黄对其影响。
短句来源
     Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack.
     结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长; 而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。
短句来源
     Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.
     结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察; 免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。
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  “induced rat”译为未确定词的双语例句
     Expression of P21~(ras) and P21~(WAF1) protein in AFB_1 induced rat hepatic putative preneoplastic lesions alleviated by Li_2CO_3 and it's significance
     P21~(ras)、P21~(WAF1)在Li_2CO_3对抗AFB_1诱导大鼠肝癌过程中的表达及意义
短句来源
     Effect of HSPB1 on the loss of mitochondrial membrane potential in H_2O_2 induced rat cardiomyocytes oxidative injury
     HSPB1对H_2O_2诱导大鼠心肌细胞损伤中线粒体膜电位的影响
短句来源
     Feasibility of ~1H-MRS in the DEN induced rat hepatocellular carcinoma by a new 1.5T MR scanner
     新型1.5T MR对大鼠诱发肝癌进行~1H-MRS扫描可行性的初步分析
短句来源
     Objective To investigate the relationship between p16 INK4a and p19 ARF gene deletions and induced rat lung squamous cell carcinogenesis.
     目的 :研究p16 INK4a和p19ARF基因的缺失与大鼠肺鳞癌发生发展的关系。
短句来源
     The Effect of 16, 16-dimethyl Prostaglandin E2 on Bleomycin Induced Rat Pulmonary Fibrosis and Its Mechanism
     16,16-二甲基前列腺素E2对博莱霉素诱导大鼠肺纤维化的影响及机制
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  相似匹配句对
     Induced into E.
     将表达载体转化E.
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     Rat
     鼠(美国电影故事)
短句来源
     The rat model was induced by alloxan.
     动物模型用四氧嘧啶塑造。
短句来源
     SHEAR INDUCED NEUROPEPTlDE Y IN RAT PLATELETS
     等剪切场中剪切诱导血小板释放神经肽Y
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  induced rat
PAF and 1-alkenyl-PAF induced rat paw edema in the range of doses 0.1-10 and 10-100 μg per paw, respectively.
      
The latter also exhibited significant antiinflammatory effect by inhibiting PAF- or car-rageenan-induced rat paw edema, and this effect exceeded that of dexamethasone.
      
Isoproterenol induced rat endomyocardial damage in relationship to local capillary geometry
      
The major, extensively studied, experimentally-induced rat and mouse models of arthritis with features resembling rheumatoid arthritis are reviewed here.
      
Because zinc is essential for growth and cancer is characterized by uncontrolled growth, this zinc accumulation suggests an involvement of zinc in N-methyl-N-nitrosourea-induced rat mammary tumorigenesis.
      
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In a previous paper we have shown that the high molecular weight RNAs isolated from the substrate and the hormonal induced rat livers were capable of inducing tryptophan pyrrolase (TP). In the present investigation, it was found that during the substrate and the hormanal induction of TP, ~(32)P pulse-labeled RNAs formed. The pattern of changes in the radio-specific activity of the pulse-labelling (Na_2H~(32)PO_4 injected 20 min. before sacrifice of the animals) in RNAs isolated from the rat...

In a previous paper we have shown that the high molecular weight RNAs isolated from the substrate and the hormonal induced rat livers were capable of inducing tryptophan pyrrolase (TP). In the present investigation, it was found that during the substrate and the hormanal induction of TP, ~(32)P pulse-labeled RNAs formed. The pattern of changes in the radio-specific activity of the pulse-labelling (Na_2H~(32)PO_4 injected 20 min. before sacrifice of the animals) in RNAs isolated from the rat livers in each case was parallel to that in the inductive activities for TP by these RNAs. The formation of the pulse-labeled RNAs was inhibited by actinomycin K_2. However, changes in the radio-specific activity of the ~(32)P long term-labeled RNAs (Na_2H~(32)PO_4 injected 2 hours before sacrifice of the animals) were quite different from those observed for the pulse-labeled RNAs. Furthermore, the RNAs isolated from both the substrate and the hormonal induced animals at the time corresponding to the high radio-specific activity of the long term-labeled RNAs showed no significant difference in stimulating TP activity from that of the normal RNA.

本实验观察到在大鼠肝色氨酸吡咯酶的激素和底物诱导过程中都有~(32)P快速标记RNA的出现,它们在氢可地松诱导2小时和在色氨酸诱导3.5小时的比放射性较对照RNA者分别增加100%和60%左右。~(32)P长期标记高聚RNA的变化与快速标记RNA者显然不同,在激素诱导4~6小时和在底物诱导10小时的比放射性始有增高。激素和底物诱导后不同时间提取的~(32)P快速标记RNA的放射性动态变化与其相应RNA诱导TP活性的动态变化呈平行关系,而从~(32)P长期标记活性最高时提取的高聚RNA刺激TP的活力与正常鼠肝RNA刺激TP的活力无显著差别,激素和底物诱导过程中~(32)P快速标记RNA的生成为放线菌素K_2所抑制。去肾上腺大鼠底物诱导2小时和3.5小时也出现~(32)P快速标记RNA,其生成也为放线菌素K_2所抑制。自去肾上腺大鼠底物诱导3.5小时提取的RNA对TP的诱导活性高于相应的正常鼠肝RNA。以上结果说明,在TP的激素和底物诱导过程中所生成的具有体内诱导TP功能的高聚RNA,可能是一种“特异的mRNA”。

The effects of coke oven gas flyash extract, anthracene, pyrene, benz (a)anthracene, dibenz (a, b) anthracene on benzo(a)Pyrene (BaP) mutagenicity and metabolism were studied. The results indicated that the combined mutagenic activities of BaP and flyash extract or PAHs were antagonistic towards Salmonella typhimurium TA 100. The results of high-pressure liquid chromatography analysis indicated that the above mentioned PAHs had the function of inhibiting the formation of 7,8-diol-BaP and detoxifying metabolites...

The effects of coke oven gas flyash extract, anthracene, pyrene, benz (a)anthracene, dibenz (a, b) anthracene on benzo(a)Pyrene (BaP) mutagenicity and metabolism were studied. The results indicated that the combined mutagenic activities of BaP and flyash extract or PAHs were antagonistic towards Salmonella typhimurium TA 100. The results of high-pressure liquid chromatography analysis indicated that the above mentioned PAHs had the function of inhibiting the formation of 7,8-diol-BaP and detoxifying metabolites under the effect of 3-methylchol-anthrene induced rat liver microsomes. The inhibition was most likely due to the competition between BaP and PAH for the same eytoehrome P-450, which led to the inhibition of aryl hydrocarbon hydroxylase activity. Furthermore, the metabolites of PAHs also inhibited epoxide hydrase activity.

本文报告了焦炉尾气飘尘及几种多环芳烃(PAH)与苯并(a)芘(BaP)对鼠伤寒沙门氏菌/微粒体系统的联合致突变作用及其机理的研究。 沙门氏菌致突变试验的结果发现高剂量尾气飘尘提取物(相当于1.1m~3尾气飘尘)与BaP(40μM)联合时,致突变作用呈拮抗现象。用3-甲基胆蒽诱导大鼠肝微粒体BaP代谢产物为指标所进行的高压液相色谱分析表明,这四种PAH抑制了BaP近致癌物7,8-二氢二羟和灭活代谢产物的生成。四种PAH都抑制了芳烃羟化酶的活性,这最可能是由于不同的PAH在细胞色素P-450同一结合部位的竞争。而且,四种PAH经代谢后还抑制了环氧化物水化酶的活性。

In an attempt to perform experimental therapeutic trial of hepatcma comparison between 3'-Me-DAB induced and BERH-2 transplantable rat hepatoma models (including intraperito-neal, subcutaneous and intrahepatic transplantation) were carried out and transplantation of human hepatoma in nude mice^ were observed during the period from December 1979 to July 1981. Results indicated that (1) BERH-2 transplantable rat hepatoma models possessed advantages of relative short survival (16±4.7 days) stable biological characteristics,...

In an attempt to perform experimental therapeutic trial of hepatcma comparison between 3'-Me-DAB induced and BERH-2 transplantable rat hepatoma models (including intraperito-neal, subcutaneous and intrahepatic transplantation) were carried out and transplantation of human hepatoma in nude mice^ were observed during the period from December 1979 to July 1981. Results indicated that (1) BERH-2 transplantable rat hepatoma models possessed advantages of relative short survival (16±4.7 days) stable biological characteristics, etc. Hence, it is suitable for the study of different therapeutic trials. 3'-Me-DAB induced rat hepatoma model however, have long survival (153 ±19 days), its pathogenesis was mimicked to human hepa- toma, and might be employed as model for research on pathogenesis of human hepatoma. (2) Three ways of transplantation in BERH-2 model possessed their merit and demerit respectively, therefore, choice of used model in accordance with special requirement was important. (3) one surgical specimen of human hepatocellular carcinoma was successfully transplanted into nude mice with three passages. It was shown serologically and morphologically that transplanted hepatomas in nude mice were mimicked to the original human hepatoma.

AFP的发现导致肝癌诊断的重大进展,但治疗方法仍不多,因此,实验性治疗正日益受重视。本文报道1979年12月至1981年7月诱发性和移植性大鼠肝癌模型(包括腹腔、皮下.肝内三种途径)所进行的对比研究和对裸鼠人体肝癌移植所进行的初步观察。供开展实验性治疗者选用鼠肝癌模型的参考。其中有关甲胎蛋白方面的结果将另文报告。 1.BERH-2移植性大鼠肝癌模型有易于复制、生存期短等优点可用于多种实验性治疗。奶油黄诱发性大鼠肝癌模型较近似人肝癌,故可用于肝癌发病机理等研究。2。BERH-2腹腔、皮下、肝内三种移植途径各有优缺点,肝内移植尤适用于肿瘤的局部治疗,值得进一步研究。3.人肝癌标本移植于裸鼠成功并传代者,其形态学观察及血清学检测均与原来人肝癌极为近似。

 
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