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   9-cis retinoic acid 的翻译结果: 查询用时:0.168秒
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-cis retinoic acid
相关语句
  9-顺式维甲酸
     Inducement Effect of 9-Cis Retinoic Acid on Cell Cycle Arrest and Apoptosis of Gastric Carcinoma Cell Line MGC803 and Its Mechanism
     9-顺式维甲酸诱导胃癌MGC803细胞周期阻滞和凋亡的作用机制
短句来源
     The Study of Differentiation in Human Neuroblastoma Cells with 9-cis Retinoic Acid in Vitro
     9-顺式维甲酸体外诱导神经母细胞瘤细胞分化的研究
短句来源
     Objective: To study the effect of 9-cis retinoic acid(9-cisRA) on proliferation, cell cycle and apoptosis in thecultured human gastric cancer cell line MGC80-3. To measurethe mRNA level of RXRa, CyclinDl and CDK4 to furtherinvestigate its mechanism of 9-cisRA induced apoptosis.
     目的:本研究采用人胃低分化黏液腺癌细胞(MGC80-3)为靶细胞,观察9-顺式维甲酸(9-cisRA)对肿瘤细胞生长抑制、细胞周期影响和凋亡诱导作用,以及9-cisRA对RXRα核受体表达及细胞周期蛋白CyclinD1和细胞周期蛋白依赖性激酶CDK4表达的影响,探讨9-cisRA抑制肿瘤的作用机制。
短句来源
     Objective: To investigate the anti-tumor effects of 9-cis retinoic acid (9-cisRA) against gastric cancer and the corresponding mechanism.
     目的探讨9-顺式维甲酸(9-cisRA)抑制胃癌细胞生长及其机制。
短句来源
     Combined effects of 9-cis retinoic acid and chemotherapeutic agents on human cholangiocarcinoma cell line QBC939
     联合应用9-顺式维甲酸和化疗药物对人胆管癌细胞系QBC_(939)的作用
短句来源
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  9-顺维甲酸
     Effects of 9-cis retinoic acid on biological characteristics in lung squam ous cancer cells
     9-顺维甲酸对肺鳞癌细胞生物学特性的影响
短句来源
     Effects of 9-cis retinoic acid on RAR_α、RAR_ and RXR_α transcription in human lung tumor tissue
     9-顺维甲酸对人肺癌组织RAR_α、RAR_β及RXR_α转录的影响
短句来源
     In this paper,the effects of all-trans retinoic and 9-cis retinoic acid on the proliferation and apoptosis of HL-60 cell line were investigated. The expressions of Homeobox gene HOX A1 in human myeloid leukemia cell line HL-60 were determined by using semi-quantitative reverse transcription (RT-PCR) method.
     本文研究了全反式维甲酸和 9-顺维甲酸对HL - 6 0细胞增殖及凋亡的影响 ,并用半定量RT -PCR技术检测了人髓系白血病细胞株HL - 6 0细胞中同源盒HOXA1基因的表达。
短句来源
  9-顺式视黄酸
     Oral 9-cis retinoic acid (Alitretinoin) in the treatment of myelodysplastlc syndromes: results from a pilot study
     口服9-顺式视黄酸(Alitretinoin)治疗骨髓增生异常综合征:实验性研究结果
短句来源
  “9-cis retinoic acid”译为未确定词的双语例句
     Objective To investigate the combined effects of 9-cis retinoic acid (RA) and che-motherapeutic teae agents and provide experimental basis for inducing differentiation of cholangiocarci-noma.
     目的 观察联合应用分化诱导剂9-cis RA和化疗药物对人胆管癌细胞QBC939细胞的作用,为临床诱导分化治疗胆管癌提供实验基础。
短句来源
     Methods Four bladder cancer cell lines and two retinoids,all-trans-retinoic acid (ATRA),9-cis retinoic acid (9cRA),combined with interferon α-2a(IFN),were used in the study. The abilities of these agents to inhibit growth,induce apoptosis were compared and the expression of nuclear retinoid receptors,Stat1 protein were measured by means of TUNEL,FCM,RT-PCR and Western blot.
     方法 应用全反式维甲酸 (ATRA)、9 顺式维甲酸 (9cRA)、联合干扰素α 2a(IFNα 2a)作用于 4组膀胱癌细胞 ,应用TUNEL、FCM、RT PCR及Western等技术观察维甲酸、干扰素单独或联合应用时对不同膀胱癌细胞株的生长抑制、诱导凋亡作用以及核维甲酸类受体、Stat1蛋白等方面的改变。
短句来源
     PXR is activated by a large number of endogenous and exogenous chemicals including steroids,antibiotics,antimycotics,bile acids,and the herbal antidepressant St. John′s wort. PXR binds as a heterodimer with the 9-cis retinoic acid receptor(NR2B) to DNA response elements in the regulatory regions of CYP3A genes.
     PXR与另一重要核受体RXR结合形成二聚体结合于CYP3A基因顺式反应元件,参与对CYP3A基因表达的调控作用。
短句来源
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  -cis retinoic acid
In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.
      
A retinoid X receptor (RXR)-specific analogue of 9-cis retinoic acid had similar effects on gene expression to 9-cis retinoic acid alone.
      
RAR-β, a gene which may mediate retinoic acid responsiveness and be of prognostic significance, is also more-effectively induced by 9-cis retinoic acid.
      
In vivo, 13-cis will isomerise to both all-trans and 9-cis retinoic acid, believed to be the main biologically-active isomers.
      
9-cis retinoic acid - a better retinoid for the modulation of differentiation, proliferation and gene expression in human neurob
      
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The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can...

The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can further explain the m.echanism of differentiation-inducers and the effect of 1,25(OH)2D3 on myelofibrosis. It is possible for 1,25(OH)2D3 and RA to be used for a new -treatment.

本文报道了两种生理性诱导剂——活性维生素D_3[1,25(OH)_2D_3,简称D_3]和维甲酸(RA)对原始巨核白血病细胞的增殖抑制作用。采用活细胞计数、[~3H]-TdR和[~3H]-UR参入以及克隆形成率测定3项指标,对一株新建的人原始巨核白血病细胞系(HIMeg)进行实验,结果表明:10~(-9)~10~(-6)mol/LD_3和RA对巨核白血病细胞的生长抑制作用呈明显量效与时效关系,10~(-7) mol/L D_3可使其克隆形成率减少90%以上。从而进一步说明了诱导分化剂对白血病及D_3对骨髓纤维化的治疗机制,提示D_3和RA可能有新的治疗用途。

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe...

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe treatment of acute megakaryoblastic leukemia and acute promyelocytic leukemia.It ispresumed that they had additive or synergic action in the differentiation of hemopoieticcells in vivo.

本文报道了13-顺式维甲酸(RA)和[1,25-二羟维生素 D_3 1,25(OH)_2D_3]合用对两种白血病细胞系的体外实验结果。在10~(-7)mol/L 浓度下,应用 ~3H-TdR 掺入、NBT 还原试验、流式细胞分析等技术,测得:RA 和1,25(OH)_2D_3合用后可进一步抑制细胞的增殖;在诱导分化作用方面,二者对人原始巨核白血病细胞株(HIMeg)有相加作用,而对人早幼粒细胞白血病细胞系(HL-60)则有一定协同作用。上述结果提示可将 RA 联合1,25(OH)_2D_3试用于治疗白血病;推测二者在体内巨核系和粒单系造血细胞分化中发挥着相加或协同的促进效应。

Changes of cell cycle kinetics of HL-60 cell line after ALL-trans retinoic acid(ATRA)and 9-cis retinoic acid(9-cis RA)induction were studied with BrdU/DNA bivariated flow cytometry. HL-60 cells were exposed to ATRA or 9-cis RA for 96 h. During the exposure, the RA-treated cells were obtained at 24,48,72 and 96 h and then the cell cycle kinetics was meas ured with BrdU/DNA bivariated flow cytometry.Data from 4 parameters of cell cycle showed that treatment with ATRA or 9-cis RA for 96...

Changes of cell cycle kinetics of HL-60 cell line after ALL-trans retinoic acid(ATRA)and 9-cis retinoic acid(9-cis RA)induction were studied with BrdU/DNA bivariated flow cytometry. HL-60 cells were exposed to ATRA or 9-cis RA for 96 h. During the exposure, the RA-treated cells were obtained at 24,48,72 and 96 h and then the cell cycle kinetics was meas ured with BrdU/DNA bivariated flow cytometry.Data from 4 parameters of cell cycle showed that treatment with ATRA or 9-cis RA for 96 h resulted in a decrease in the cell BrdU LI,production rate and an increase in Ts and Tpot. Mean while the ability of the cell to reduce NBT was enhanced by RA induction, and the percentage of matured cells was increased by cell morphology assessment.These results suggested that both ATRA and 9-cis-RA may induce HL-60 cell differentiation.

用Brdu/DNA双参数流式细胞仪技术研究了HL-60细胞经全反式维甲酸(ATRA)和9-顺式维甲酸(9-cisRA)诱导24,48和96h后,细胞周期动力学各参数,BrdULI,Ts,Tpot和PR的变化,同时测定细胞NBT还原试验和细胞形态学的变化,发现随着维甲酸诱导时间的延长,BrdULI逐渐降低,PR亦是逐渐减少,而Ts和Tpot则逐渐延长。NBT还原试验结果表明NBT阳性细胞百分比呈现上升趋势:细胞形态学观察显示稍成熟阶段细胞百分比上升,早幼粒阶段细胞所占百分比下降。本文观察了ATRA和9-cisRA在诱导HL-60细胞过程中以上各参数的变化,结果提示两类维甲酸对HL-60细胞均有诱导分化功能。

 
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