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   9-cis retinoic acid 在 心血管系统疾病 分类中 的翻译结果: 查询用时:0.098秒
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-cis
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retinoic
acid    
相关语句
  “9-cis retinoic acid”译为未确定词的双语例句
    Oral 9-cis retinoic acid (Alitretinoin) in the treatment of myelodysplastlc syndromes: results from a pilot study
    口服9-顺式视黄酸(Alitretinoin)治疗骨髓增生异常综合征:实验性研究结果
短句来源
    The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated.
    本文报道了两种生理性诱导剂——活性维生素D_3[1,25(OH)_2D_3,简称D_3]和维甲酸(RA)对原始巨核白血病细胞的增殖抑制作用。
短句来源
    The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.
    本文报道了13-顺式维甲酸(RA)和[1,25-二羟维生素 D_3 1,25(OH)_2D_3]合用对两种白血病细胞系的体外实验结果。
短句来源
    Methods: The human megakaryocytic leukemia cell line HIMeg was treated with 13 cis retinoic acid for 4 d, then total cellular RNA was extracted and reverse transcribed to first strand cDNA. The first strand cDNA was subjected to PCR based mRNA differential display, cloning and sequence analysis.
    方法:人巨核白血病细胞HIMeg经13-顺式维甲酸处理4d后,收集细胞总RNA,进行mRNA差别显示、cDNA片段克隆和序列分析。
短句来源
    In this paper,the effects of all-trans retinoic and 9-cis retinoic acid on the proliferation and apoptosis of HL-60 cell line were investigated. The expressions of Homeobox gene HOX A1 in human myeloid leukemia cell line HL-60 were determined by using semi-quantitative reverse transcription (RT-PCR) method.
    本文研究了全反式维甲酸和 9-顺维甲酸对HL - 6 0细胞增殖及凋亡的影响 ,并用半定量RT -PCR技术检测了人髓系白血病细胞株HL - 6 0细胞中同源盒HOXA1基因的表达。
短句来源
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  -cis retinoic acid
In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.
      
A retinoid X receptor (RXR)-specific analogue of 9-cis retinoic acid had similar effects on gene expression to 9-cis retinoic acid alone.
      
RAR-β, a gene which may mediate retinoic acid responsiveness and be of prognostic significance, is also more-effectively induced by 9-cis retinoic acid.
      
In vivo, 13-cis will isomerise to both all-trans and 9-cis retinoic acid, believed to be the main biologically-active isomers.
      
9-cis retinoic acid - a better retinoid for the modulation of differentiation, proliferation and gene expression in human neurob
      
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The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can...

The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 [1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of [3H]-TdR and [3H]-UR, and cloning efficiency. From above, it can further explain the m.echanism of differentiation-inducers and the effect of 1,25(OH)2D3 on myelofibrosis. It is possible for 1,25(OH)2D3 and RA to be used for a new -treatment.

本文报道了两种生理性诱导剂——活性维生素D_3[1,25(OH)_2D_3,简称D_3]和维甲酸(RA)对原始巨核白血病细胞的增殖抑制作用。采用活细胞计数、[~3H]-TdR和[~3H]-UR参入以及克隆形成率测定3项指标,对一株新建的人原始巨核白血病细胞系(HIMeg)进行实验,结果表明:10~(-9)~10~(-6)mol/LD_3和RA对巨核白血病细胞的生长抑制作用呈明显量效与时效关系,10~(-7) mol/L D_3可使其克隆形成率减少90%以上。从而进一步说明了诱导分化剂对白血病及D_3对骨髓纤维化的治疗机制,提示D_3和RA可能有新的治疗用途。

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe...

The action of 13-cis-retinoic acid(RA)in combination with 1,25-dihydroxyvitaminD_3(D_3)on two kinds of leukemia cell lines in vitro is reported.At the concentrationof 10~(-7) mol/L,RA and D_3 could inhibit the cell proliferation and they have additiveeffect on the human promyelocytic leukemia cell line(HL-60),and also have synergiceffect on the human megakaryoblastic leukemia cell line(HIMeg)in inducing celldifferentiation.The results suggest that RA in combination with D_3 may be used forthe treatment of acute megakaryoblastic leukemia and acute promyelocytic leukemia.It ispresumed that they had additive or synergic action in the differentiation of hemopoieticcells in vivo.

本文报道了13-顺式维甲酸(RA)和[1,25-二羟维生素 D_3 1,25(OH)_2D_3]合用对两种白血病细胞系的体外实验结果。在10~(-7)mol/L 浓度下,应用 ~3H-TdR 掺入、NBT 还原试验、流式细胞分析等技术,测得:RA 和1,25(OH)_2D_3合用后可进一步抑制细胞的增殖;在诱导分化作用方面,二者对人原始巨核白血病细胞株(HIMeg)有相加作用,而对人早幼粒细胞白血病细胞系(HL-60)则有一定协同作用。上述结果提示可将 RA 联合1,25(OH)_2D_3试用于治疗白血病;推测二者在体内巨核系和粒单系造血细胞分化中发挥着相加或协同的促进效应。

Objective: In a human leukemic megakaryocytic cell line HIMeg, differentially expressed genes regulated by induced differentiation will be cloned, and from which the key genes in the process of induced differentiation will be identified. Methods: The human megakaryocytic leukemia cell line HIMeg was treated with 13 cis retinoic acid for 4 d, then total cellular RNA was extracted and reverse transcribed to first strand cDNA. The first strand cDNA was subjected to PCR based mRNA differential...

Objective: In a human leukemic megakaryocytic cell line HIMeg, differentially expressed genes regulated by induced differentiation will be cloned, and from which the key genes in the process of induced differentiation will be identified. Methods: The human megakaryocytic leukemia cell line HIMeg was treated with 13 cis retinoic acid for 4 d, then total cellular RNA was extracted and reverse transcribed to first strand cDNA. The first strand cDNA was subjected to PCR based mRNA differential display, cloning and sequence analysis. Results: From 5 cDNA fragment candidates obtained, RNA dot blot analysis demonstrated non regulation in 3 fragments, undetectable signals in one fragment, and altered gene expression in one cDNA fragment which was designated MDI 1 (mRNA downregulated after induced differentiation).The nucleotide sequence data reported here will appear in the GenBank under the accession number AF026526. Conclusion: A cDNA fragment encoded by a unknown gene was cloned. Further studies are required to determine its full length sequence, gene structure and biological function(s).

目的:克隆巨核白血病细胞诱导分化后表达变化的mRNA,从中寻找对诱导分化起关键作用的基因,最终揭示巨核白血病细胞诱导分化的分子机制。方法:人巨核白血病细胞HIMeg经13-顺式维甲酸处理4d后,收集细胞总RNA,进行mRNA差别显示、cDNA片段克隆和序列分析。结果:获得5个差示cDNA片段,经RNA点杂交分析后发现其中3个为假阳性,1个因没有杂交信号而无法确定,只有1个cDNA片段得到证实,其对应的mRNA在诱导分化后表达下降。该cDNA片段的核苷酸序列已在GenBank中登录,登录号为AF026526。结论:克隆到一个未知基因的cDNA片段,其全长cDNA序列、基因结构及生物功能有待进一步研究

 
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