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-cis
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retinoic
acid    
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  “9-cis retinoic acid”译为未确定词的双语例句
    Effect of 9-cis-retinoic acid on the functional expression of MS gene in cultured human breast cancer cells
    维甲酸对人乳腺癌细胞NIS基因表达和摄碘功能的影响
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    Objective To investigate the effect of 9-cis-retinoic acid (9-cis-RA) on the functional expression of sodium/iodide symporter (NIS) in cultured human breast cancer cells.
    目的探讨9-顺-维甲酸(9-cis—RA)对人乳腺癌细胞钠/碘同向转运体(NIS)基因功能表达的影响。
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  -cis retinoic acid
In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.
      
A retinoid X receptor (RXR)-specific analogue of 9-cis retinoic acid had similar effects on gene expression to 9-cis retinoic acid alone.
      
RAR-β, a gene which may mediate retinoic acid responsiveness and be of prognostic significance, is also more-effectively induced by 9-cis retinoic acid.
      
In vivo, 13-cis will isomerise to both all-trans and 9-cis retinoic acid, believed to be the main biologically-active isomers.
      
9-cis retinoic acid - a better retinoid for the modulation of differentiation, proliferation and gene expression in human neurob
      
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Objective To investigate the effect of 9-cis-retinoic acid (9-cis-RA) on the functional expression of sodium/iodide symporter (NIS) in cultured human breast cancer cells. Methods Two breast cancer cell lines including estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 were incubated with different doses ( 10-8, 10-7 or 10-6 mol/L) of either 9-cis-RA or all-trans-retinoic acid (ATRA) for various durations (0-44 h). Total RNA was isolated, and then reverse...

Objective To investigate the effect of 9-cis-retinoic acid (9-cis-RA) on the functional expression of sodium/iodide symporter (NIS) in cultured human breast cancer cells. Methods Two breast cancer cell lines including estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 were incubated with different doses ( 10-8, 10-7 or 10-6 mol/L) of either 9-cis-RA or all-trans-retinoic acid (ATRA) for various durations (0-44 h). Total RNA was isolated, and then reverse transcription-polymerase chain reaction (RT-PCR) was performed to measure the expression levels of NIS mRNA. 131I uptake was determined in breast cancer cells after treated with RA under the same culture condition for expression of NIS transport. Results RT-PCR analysis revealed a dose-dependent induction effect on the expression of NIS mRNA in MCF-7 cells exposed to 9-cis-RA (F = 114. 17, P < 0. 001). The maximal up-regulation of NIS mRNA expression appeared at 16 h after treated with 9-cis-RA ( 10 -6 mol/L) , which was 8. 2 times higher than that of control (q = 8. 32, P <0. 01) . Moreover, 9-cis-RA (10 -6 mol/L, 24 h) enhanced NIS mRNA expression more effectively than ATRA (t =6. 572, P <0. 01). No expression of NIS mRNA was detected in untreated MDA-MB-231 cells; however, unregulated NIS mRNA expression was induced after incubation with 9-cis-RA (10 -6 mol/L) but the expression was far lowered than MCF-7 (t = 20. 195, P < 0.001). As to the 131I uptakes it increased in MCF-7 cells at 12 h and reached to the maximum at 24 h (3. 2-fold over that of baseline) after treated with 10-6 mol/L 9-cis-RA. Also, 131I uptake could be blocked by 3 × 10-5 mol/L KCIO4 , a specific inhibitor of NIS. Conclusion 9-cis-RA can significantly enhance the functional expression of NIS and increase the uptake of 131I in ER-positive MCF-7 human breast cancer cells.

目的探讨9-顺-维甲酸(9-cis—RA)对人乳腺癌细胞钠/碘同向转运体(NIS)基因功能表达的影响。方法应用9-cis—RA和全反式维甲酸(ATRA)分别在不同浓度下对雌激素受体(ER) 阳性的乳腺癌细胞(MCF-7)和ER阴性的乳腺癌细胞(MDA-MB-231)进行干预,于不同时间点提取细胞总RNA,通过半定量逆转录-聚合酶链反应(RT—PCR)检测乳腺癌细胞NIS mRNA表达水平的变化;在体外培养条件下研究RA刺激后乳腺癌细胞对放射性碘的摄取情况。结果9-cis-RA处理后, MCF-7细胞NIS mRNA表达增强,呈浓度依赖性(F=114.17,P<0.001),在10-6mol/L浓度下NIS mRNA的表达随时间上调,16 h时达到最高,是对照组(0 h)的8.2倍(q=8.32,P<0.01),此后随时间逐渐下调;且9-cis-RA(10-6mol/L,24 h)的作用强于ATRA(t=6.572,P<0.01)。MDA-MB-231 基础状态下几乎无NIS表达,9-cis-RA刺激后可上调其表达(t=20.195,P<0.001),但表达量(NIS/ β-actin)远低于MCF-7(t=1...

目的探讨9-顺-维甲酸(9-cis—RA)对人乳腺癌细胞钠/碘同向转运体(NIS)基因功能表达的影响。方法应用9-cis—RA和全反式维甲酸(ATRA)分别在不同浓度下对雌激素受体(ER) 阳性的乳腺癌细胞(MCF-7)和ER阴性的乳腺癌细胞(MDA-MB-231)进行干预,于不同时间点提取细胞总RNA,通过半定量逆转录-聚合酶链反应(RT—PCR)检测乳腺癌细胞NIS mRNA表达水平的变化;在体外培养条件下研究RA刺激后乳腺癌细胞对放射性碘的摄取情况。结果9-cis-RA处理后, MCF-7细胞NIS mRNA表达增强,呈浓度依赖性(F=114.17,P<0.001),在10-6mol/L浓度下NIS mRNA的表达随时间上调,16 h时达到最高,是对照组(0 h)的8.2倍(q=8.32,P<0.01),此后随时间逐渐下调;且9-cis-RA(10-6mol/L,24 h)的作用强于ATRA(t=6.572,P<0.01)。MDA-MB-231 基础状态下几乎无NIS表达,9-cis-RA刺激后可上调其表达(t=20.195,P<0.001),但表达量(NIS/ β-actin)远低于MCF-7(t=10.395,P<0.001)。碘摄取实验表明,10-6mol/L 9-cis-RA干预12 h后。MCF-17细胞摄碘开始增加,干预24 h时碘摄取达最大,是基础状态下的3.2倍.其摄碘能力可被KClO4抑制。结论9-cis—RA能明显增强ER阳性的MCF-7细胞NIS基因的表达及摄碘功能。

 
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