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   9-cis retinoic acid 在 肿瘤学 分类中 的翻译结果: 查询用时:0.111秒
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-cis
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retinoic    
acid    
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  “9-cis retinoic acid”译为未确定词的双语例句
    Objective: To investigate the anti-tumor effects of 9-cis retinoic acid (9-cisRA) against gastric cancer and the corresponding mechanism.
    目的探讨9-顺式维甲酸(9-cisRA)抑制胃癌细胞生长及其机制。
短句来源
    Conclusion The expression of PPARγ and RXRα in MGC803,SMMC7721 and LOVO cell lines predicts them response to pioglizatone and 9-cis-retinoic acid treatment,the inhibitory effect is different in these three kinds of cell lines,it may be related to ligands-mediated signal pathway.
    结论在MGC803、LOVO和SMMC7721肿瘤细胞中,MGC803细胞PPARγ和RXRα表达最强,这对配体发挥作用可能是必需的,配体发挥的抑制细胞生长的效应可能与其介导的信号途径有关。
短句来源
    Objective To investigate the synergistic effects of 9-cis-retinoic acid(9-cis-RA) and 8-cl-cAMP on growth inhibition and apoptosis induction in H460 and H292 cell lines of non-small-cell lung cancer(NSCLC).
    目的探讨9-顺式-维甲酸(9-cis-RA)联合8-cl-cAMP对人非小细胞肺癌(NSCLC)细胞株(H460和H292)的生长抑制和诱导凋亡的协同作用。 方法实验分为9-cis-RA 1、5、10、20μmol/L组;
短句来源
    Biological Effect of 9-cis-retinoic Acid on Cell Cycle and Differentiation in Human Lung Squamous Carcinoma Cells
    9-顺维甲酸对肺鳞癌细胞周期及细胞分化的生物学作用
短句来源
    Effects of 9-cis retinoic acid on biological characteristics in lung squam ous cancer cells
    9-顺维甲酸对肺鳞癌细胞生物学特性的影响
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  -cis retinoic acid
In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.
      
A retinoid X receptor (RXR)-specific analogue of 9-cis retinoic acid had similar effects on gene expression to 9-cis retinoic acid alone.
      
RAR-β, a gene which may mediate retinoic acid responsiveness and be of prognostic significance, is also more-effectively induced by 9-cis retinoic acid.
      
In vivo, 13-cis will isomerise to both all-trans and 9-cis retinoic acid, believed to be the main biologically-active isomers.
      
9-cis retinoic acid - a better retinoid for the modulation of differentiation, proliferation and gene expression in human neurob
      
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All trans retinoic acid(ATRA), 13-cis retinoic acid (CRA) and vitamin A (Vit A)were investigated in the plasma, leukocytes and erythrocytes from leukemia patients and healthy individuals by reverse phase high pressure liquid chromatography(HPLC). The following results were obtained. The ATRA, CRA and Vit A levels of plasma and erythrocytes from leukemia patients were within the range of control value, while ATRA(0.075±0.045 ng/106 cells) and CRA (0.13 ± 0.096 ng/106 cells) contents in leukemic cells were...

All trans retinoic acid(ATRA), 13-cis retinoic acid (CRA) and vitamin A (Vit A)were investigated in the plasma, leukocytes and erythrocytes from leukemia patients and healthy individuals by reverse phase high pressure liquid chromatography(HPLC). The following results were obtained. The ATRA, CRA and Vit A levels of plasma and erythrocytes from leukemia patients were within the range of control value, while ATRA(0.075±0.045 ng/106 cells) and CRA (0.13 ± 0.096 ng/106 cells) contents in leukemic cells were reduced when compared to control (ATRA 0.16 ± 0.06 ng/106 cells)(P < 0.05). These data suggested that there is probably abnormal retinoic acid metabolism in leukocytes from leukemic patients, and this abnormality may be responsible for the leukemogenesis.

应用反相高压液相色谱(HPLC)技术,检测了正常人和白血病病人血浆、白细胞及红细胞内生理性全反式维甲酸(ATRA)、13-顺式维甲酸(13-cis-RA,CRA)和维生素A(VitA)的含量。结果表明,急性早幼粒白血病患者及其它白血病患者血浆及红细胞中内源性ATRA、CRA和VitA均在正常范围内。白血病患者白细胞内ATRA(0.08±0.05ng/106细胞,单位下同)、CRA(0.13±0.10)水平均低于正常人(ATRA0.16±0.06,CRA0.33±0.16)(P<0.05)。提示白血病患者的白细胞内维甲酸代谢可能存在异常,并可能与白血病的发病有关。

Objective: In a human leukemic megakaryocytic cell line HIMeg, differentially expressed genes regulated by induced differentiation will be cloned, and from which the key genes in the process of induced differentiation will be identified. Methods: The human megakaryocytic leukemia cell line HIMeg was treated with 13 cis retinoic acid for 4 d, then total cellular RNA was extracted and reverse transcribed to first strand cDNA. The first strand cDNA was subjected to PCR based mRNA differential...

Objective: In a human leukemic megakaryocytic cell line HIMeg, differentially expressed genes regulated by induced differentiation will be cloned, and from which the key genes in the process of induced differentiation will be identified. Methods: The human megakaryocytic leukemia cell line HIMeg was treated with 13 cis retinoic acid for 4 d, then total cellular RNA was extracted and reverse transcribed to first strand cDNA. The first strand cDNA was subjected to PCR based mRNA differential display, cloning and sequence analysis. Results: From 5 cDNA fragment candidates obtained, RNA dot blot analysis demonstrated non regulation in 3 fragments, undetectable signals in one fragment, and altered gene expression in one cDNA fragment which was designated MDI 1 (mRNA downregulated after induced differentiation).The nucleotide sequence data reported here will appear in the GenBank under the accession number AF026526. Conclusion: A cDNA fragment encoded by a unknown gene was cloned. Further studies are required to determine its full length sequence, gene structure and biological function(s).

目的:克隆巨核白血病细胞诱导分化后表达变化的mRNA,从中寻找对诱导分化起关键作用的基因,最终揭示巨核白血病细胞诱导分化的分子机制。方法:人巨核白血病细胞HIMeg经13-顺式维甲酸处理4d后,收集细胞总RNA,进行mRNA差别显示、cDNA片段克隆和序列分析。结果:获得5个差示cDNA片段,经RNA点杂交分析后发现其中3个为假阳性,1个因没有杂交信号而无法确定,只有1个cDNA片段得到证实,其对应的mRNA在诱导分化后表达下降。该cDNA片段的核苷酸序列已在GenBank中登录,登录号为AF026526。结论:克隆到一个未知基因的cDNA片段,其全长cDNA序列、基因结构及生物功能有待进一步研究

In this paper,the effects of all-trans retinoic and 9-cis retinoic acid on the proliferation and apoptosis of HL-60 cell line were investigated.The expressions of Homeobox gene HOX A1 in human myeloid leukemia cell line HL-60 were determined by using semi-quantitative reverse transcription (RT-PCR) method.The results indicated that both all-trans retinoic acid and 9-cis retinoic acid showed an ability to suppress the proliferation of the HL-60 cells,and could promote apoptosis of the...

In this paper,the effects of all-trans retinoic and 9-cis retinoic acid on the proliferation and apoptosis of HL-60 cell line were investigated.The expressions of Homeobox gene HOX A1 in human myeloid leukemia cell line HL-60 were determined by using semi-quantitative reverse transcription (RT-PCR) method.The results indicated that both all-trans retinoic acid and 9-cis retinoic acid showed an ability to suppress the proliferation of the HL-60 cells,and could promote apoptosis of the cell line specifically,when combinative treatment of the two drugs were used,their efficacy was more obviously than used alone. On the basis of the data,we consider that one of mechanisms for the anti-cancer synergism of the two compounds might be influence on the network regulation system of HOXA1 gene expression,and the extent of the influence has some difference in different leukemias.Therefore,the anticancer regular pattern of the two drugs should further be explored,in order to make a more effective combinative chemotherapy scheme.

本文研究了全反式维甲酸和 9-顺维甲酸对HL - 6 0细胞增殖及凋亡的影响 ,并用半定量RT -PCR技术检测了人髓系白血病细胞株HL - 6 0细胞中同源盒HOXA1基因的表达。结果表明 ,全反式维甲酸及 9-顺维甲酸均能抑制HL - 6 0细胞增殖并能促进其凋亡 ,这种效应在两药联用时更为明显 ,根据上述结果 ,我们认为两药联用的抗癌机制之一可能是通过影响HOXA1基因表达的网络调节系统来实现的 ,但在不同的白血病中 ,其影响程度可能有所差异。因此 ,有必要更进一步探讨两种药物的抗癌调节模式 ,以便制定一个更有效的联合化疗方案

 
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