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   9-cis retinoic acid 在 药学 分类中 的翻译结果: 查询用时:1.302秒
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-cis
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retinoic
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  “9-cis retinoic acid”译为未确定词的双语例句
    Simultaneous Determination of All- trans-and 13- cis -Retinoic Acid in Human Serum by HPLC
    高效液相色谱法同时检测人血清中全反式及13-顺式维甲酸浓度
短句来源
    The effect of inhalation 13-cis-retinoic acid on retinoic acid receptors of rat lung
    吸入13顺式维甲酸对鼠肺部维甲酸受体的影响
短句来源
    Objective: To investigate the effect of alltrans retinoic acid (ATRA) and 9cis retinoic acid (9cis RA) on the expression of Fas and the sensitivity to antiFas induced apotosis in HL-60 cells.
    目的:探讨全反式维甲酸(ATRA)和9顺式维甲酸(9cisRA)对HL60细胞Fas表达水平及维甲酸对抗Fas抗体诱导的细胞凋亡敏感性的影响。
短句来源
    Objective:To develop an isocratic HPLC for the simultaneous determination of all- trans -and 13- cis -retinoic acid(ATRA,13-cRA)in human serum.
    目的 :建立高效液相色谱方法同时检测人血清中全反式及 13 -顺式维甲酸浓度。
短句来源
    Objective Study the effect of inhalation 13-cis-retinoic acid(13-cis-RA)on retin- oic acid receptors of rat lung.
    目的研究吸入13顺式维甲酸(13-cis-RA)对鼠肺部维甲酸受体(RAR)的影响。
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  -cis retinoic acid
In view of these results, 9-cis retinoic acid or stable analogues of this retinoid may have potential for the treatment of neuroblastoma.
      
A retinoid X receptor (RXR)-specific analogue of 9-cis retinoic acid had similar effects on gene expression to 9-cis retinoic acid alone.
      
RAR-β, a gene which may mediate retinoic acid responsiveness and be of prognostic significance, is also more-effectively induced by 9-cis retinoic acid.
      
In vivo, 13-cis will isomerise to both all-trans and 9-cis retinoic acid, believed to be the main biologically-active isomers.
      
9-cis retinoic acid - a better retinoid for the modulation of differentiation, proliferation and gene expression in human neurob
      
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Objective: To investigate the effect of alltrans retinoic acid (ATRA) and 9cis retinoic acid (9cis RA) on the expression of Fas and the sensitivity to antiFas induced apotosis in HL-60 cells. Methods: Fas expression was detected by flow cytometry. Anti-Fas induced apoptosis (AFIA) was determined by morphological features, DNA fragment electrophoresis, and flow cytometric cell cycle analysis. Results: Fas antigen was weakly expressed on HL-60 cells. After incubation of HL-60 cells with 10~-6mol/L...

Objective: To investigate the effect of alltrans retinoic acid (ATRA) and 9cis retinoic acid (9cis RA) on the expression of Fas and the sensitivity to antiFas induced apotosis in HL-60 cells. Methods: Fas expression was detected by flow cytometry. Anti-Fas induced apoptosis (AFIA) was determined by morphological features, DNA fragment electrophoresis, and flow cytometric cell cycle analysis. Results: Fas antigen was weakly expressed on HL-60 cells. After incubation of HL-60 cells with 10~-6mol/L ATRA or 9cis RA for 4 days, both the Fas expression and AFIA were significantly enhanced. 9cis RA was more potent than ATRA in increasing the sensitivity to AFIA. Conclusion: RA might upregulate Fas expression. Further elucidation of its molecular mechanisms might provide a rationale for new therapeutic strategies of malignant diseases.

目的:探讨全反式维甲酸(ATRA)和9顺式维甲酸(9cisRA)对HL60细胞Fas表达水平及维甲酸对抗Fas抗体诱导的细胞凋亡敏感性的影响。方法:用流式细胞仪检测HL60细胞膜Fas蛋白表达水平;分别采用形态学观察、DNA电泳和流式细胞仪检测抗Fas抗体诱导的细胞凋亡。结果:HL60细胞Fas弱表达。经10-6mol/LATRA或9cisRA分别预处理4天后,HL60细胞Fas表达水平及对抗Fas抗体诱导凋亡的敏感性均显著提高。9cisRA提高HL60细胞对抗Fas抗体诱导凋亡的敏感性的能力强于ATRA。结论:维甲酸可上调HL60细胞表达Fas,这可能与维甲酸诱导HL60细胞分化相关。进一步深入探讨其分子机制,将为肿瘤治疗,特别是自体骨髓移植中骨髓净化提供新方法

Objective:To develop an isocratic HPLC for the simultaneous determination of all- trans -and 13- cis -retinoic acid(ATRA,13-cRA)in human serum.Methods:The serum sample(1 mL)was extracted with 5 mL of ether for twice.The extract was analyzed on an μBondapak C 18 (3 9 mm×300 mm)column with a mobile phase consisting of 85 Vols of methanol and 15 Vols of NH 4Ac buffer(pH 6 0)at 22 ℃.The flow rate was 0 8 mL·min -1 .The retinoids were detected at 340 nm and quantitated by internal...

Objective:To develop an isocratic HPLC for the simultaneous determination of all- trans -and 13- cis -retinoic acid(ATRA,13-cRA)in human serum.Methods:The serum sample(1 mL)was extracted with 5 mL of ether for twice.The extract was analyzed on an μBondapak C 18 (3 9 mm×300 mm)column with a mobile phase consisting of 85 Vols of methanol and 15 Vols of NH 4Ac buffer(pH 6 0)at 22 ℃.The flow rate was 0 8 mL·min -1 .The retinoids were detected at 340 nm and quantitated by internal standard method,DMAB was used as an internal standard.Results:The linearity of method was in the range of 0 8 to 1 120 μg·L -1 for ATRA and 0 82 to 1 312 μg·L -1 for 13-cRA.The limit of determination was 0 6 μg·L -1 in serum for both ATRA and 13-cRA.Average recoveries were 98 86%~105 2% for ATRA ,101 6%~101 8% for 13-cRA.Within-day and between-day percision of determination were 0 84%~5 5% for ATRA and 1 4%~5 7% for 13-cRA.Conclusion:This method is sensitive,accurate and good enough to be utilized for the investigation of the clinical pharmacokinetics of ATRA.

目的 :建立高效液相色谱方法同时检测人血清中全反式及 13 -顺式维甲酸浓度。方法 :色谱柱 :μBondapakC18(3 9mm× 30 0mm) ,流动相 :甲醇 -醋酸铵缓冲液 (85∶15 ) ,流速 :0 8mL·min-1,紫外检测波长 :340nm ,柱温 :2 2℃ ,血清样品经乙醚 2次提取 ,按内标法定量 ,内标物选用对二甲氨基苯甲醛。结果 :全反式及 13-顺式维甲酸的线性范围分别在 0 8~ 112 0 μg·L-1和 0 82~ 1312 μg·L-1,最低检测浓度均为 0 6μg·L-1。全反式维甲酸测定的平均回收率为 98 86 %~ 10 5 2 % ,日内、日间精密度RSD为 0 84%~ 5 5 % ,13-顺式维甲酸测定的平均回收率为 10 1 6 %~ 10 1 8% ,日内、日间精密度RSD为 1 4%~ 5 7%。结论 :本方法灵敏、准确 ,样品处理简便易行 ,适用于全反式维甲酸的临床药动学研究

Cytochrome P4503As(CYP3As),the liver microsomal enzymes responsible for oxidative metabolism of numerous clinically used drugs,is known to be induced by a variety of compounds,including naturally occurring and synthetic glucocorticoids,pregnane compounds,and macrolide antibiotics.The pregnane X receptor(PXR;NR1I2) is an important component of the body′s adaptive defense against xenobiotics including drugs.PXR is activated by a large number of endogenous and exogenous chemicals including steroids,antibiotics,antimycotics,bile...

Cytochrome P4503As(CYP3As),the liver microsomal enzymes responsible for oxidative metabolism of numerous clinically used drugs,is known to be induced by a variety of compounds,including naturally occurring and synthetic glucocorticoids,pregnane compounds,and macrolide antibiotics.The pregnane X receptor(PXR;NR1I2) is an important component of the body′s adaptive defense against xenobiotics including drugs.PXR is activated by a large number of endogenous and exogenous chemicals including steroids,antibiotics,antimycotics,bile acids,and the herbal antidepressant St.John′s wort.PXR binds as a heterodimer with the 9-cis retinoic acid receptor(NR2B) to DNA response elements in the regulatory regions of CYP3A genes.Although PXR evolved to protect the body,its activation by a variety of prescription drugs represents the molecular basis for an important class of harmful drug interactions.

细胞色素P450 3A(cytochrom e P4503As,CYP3As)在药物代谢过程中起重要作用,外源性化学物对肝脏CYP3A基因表达有明显的诱导作用。孕烷X受体(pregnane X recep-tor,PXR)是新发现的孤儿核受体(系统名:NR1 I2)。PXR与另一重要核受体RXR结合形成二聚体结合于CYP3A基因顺式反应元件,参与对CYP3A基因表达的调控作用。大量临床处方药物通过激活PXR而诱导CYP3A基因表达,构成了临床药物间相互作用的分子基础。

 
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