Objective\ To observe the expression patterns of matrix metalloproteinase_3 and its inhibitor, tissue inhibitor metalloproteinases (TIMP)_1, in remodeling phase of mandibular distraction osteogenesis.
Objective: To study the enhancement effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on mandibular distraction osteogenesis in rabbits.
目的:研究重组人骨形成蛋白2(recombinant human bone morphogenetic protein2,rhBMP2)对兔下颌牵张成骨的作用。
Conclusion Thesuitable rates of mandibular distraction osteogenesis should be limited between 0.5mm/d and 1.5mm/d.
结论下颌骨牵引成骨术的速度宜控制在0.5-1.5mm/d 范围内;
Objective To examine the expression of activin A (ACT A) and transforming growth factor|β1 (TGF|β 1)during mandibular lengthening and elucidate the difference between the role of ACT A and TGF|β 1 during mandibular distraction osteogenesis.
Methods: An animal model of bilateral mandibular distraction osteogenesis in rabbits was established. RhBMP-2 adhering to absorbable collagen sponge (ACS) was implanted to the right side of the mandible, while the left side was implanted with ACS as control.
Results:The regenerated bone resulted from mandibular distraction at rates of 0.5mm/d and 1mm/d showed eariler bone formation and better mineralization than those distracted at a rate of 2mm/d.
Continuous mandibular distraction osteogenesis using superelastic shape memory alloy (SMA)
Mandibular distraction osteogenesis is a clinical procedure used for modifying the mandibular geometry when problems of dental overcrowding and arch shrinkage occur.
The Influence of Expansion Rates on Mandibular Distraction Osteogenesis: A Computational Analysis
The Effect of Pulsed Ultrasound on Mandibular Distraction
The aim of this study was to test the null hypothesis that there is no correlation between new bone formation during mandibular distraction osteogenesis and NOS expression in the trigeminal ganglion of rats.
Objective To establish the animal models of mandibular distraction osteogenesis in rabbits and study its osteogenetic mechanism.Methods The right mandibles just anterior to the first molars of 12 rabbits were performed osteotomies, and the mandibles were positioned with distractors. The left mandibles were control group without operation. After 1 week, the distractors were streched 0.9 mm every day for 10 days progressively. One day, 2,4,8 weeks after distraction, the mandibles were studied with...
Objective To establish the animal models of mandibular distraction osteogenesis in rabbits and study its osteogenetic mechanism.Methods The right mandibles just anterior to the first molars of 12 rabbits were performed osteotomies, and the mandibles were positioned with distractors. The left mandibles were control group without operation. After 1 week, the distractors were streched 0.9 mm every day for 10 days progressively. One day, 2,4,8 weeks after distraction, the mandibles were studied with gross measurement, X ray, and histological examination.Results The right mandible were lengthened 8.3 mm on average without bone nonunion and deformity healing.It was observed that the gaps between the distracted bone edges were first occupied by fibrous tissue. Two weeks after distraction. it was found that the gaps were bridged by callus in X ray, the new bone and the normal bone could not be differentiated clearly after 8 weeks. In histological sections, there were collagen bundles in early distraction, then those collagen bundles were calcificated and become trabeculaes. No Cartilage was found during distraction.Conclusion It suggests that the rabbit mandible can be lengenthed by distraction osteogenesis, and the new bone is formed by intramembranous ossification.
目的 建立兔下颌骨牵拉成骨动物模型,研究了解颅面部牵拉骨生成的规律。方法 将12 只新西兰大白兔右侧下颌骨第一磨牙前完全截骨后用牵拉器固定,左侧不做手术为对照侧。1周后以每天一次0.9 m m 的速度逐步牵拉,连续10 天。牵拉完成后1 天,2、4 和8 周每组处死3只兔,取下完整下颌骨进行大体测量,X线摄片,新骨组织学观察。结果 12只兔右侧下颌骨平均延长8.3 m m ,与对照侧比较有显著性差异(P< 0.01),无骨不连及畸形愈合。X线摄片发现,延长完成后2周牵拉间隙已被骨痂桥接,8 周时,X线片上很难分辨新骨和正常骨。组织学观察牵拉早期即有胶原束形成,随后钙化成骨,未发现软骨中介体。结论 运用牵拉成骨技术可成功地延长兔下颌骨,无骨不连和畸形愈合等并发症,新骨以膜内成骨方式生成
Objective To review the early results of lengthening of the mandible by distraction osteogenesis for the correction of micrognathia deformity and treatment of the obstructive sleep apnea syndrome (OSAS) simultaneously. Methods 5 cases with micrognathia deformity associated with OSAS resulted from unilateral/bilateral temporomandibular joint ankylosis had undergone mandibular distraction osteogenesis. In all of the patients intraoral device was employed. Cephalometric radiographs and polysomnograms were...
Objective To review the early results of lengthening of the mandible by distraction osteogenesis for the correction of micrognathia deformity and treatment of the obstructive sleep apnea syndrome (OSAS) simultaneously. Methods 5 cases with micrognathia deformity associated with OSAS resulted from unilateral/bilateral temporomandibular joint ankylosis had undergone mandibular distraction osteogenesis. In all of the patients intraoral device was employed. Cephalometric radiographs and polysomnograms were obtained preoperatively and postoperatively. Results The average distraction distance was 15.28 mm (range 8.5 mm to 24.4 mm). The micrognathia deformity was corrected effectively, at the mean time the incapacious pharyngeal airway was ameliorated. The patients' Apnea Index (AI)had been decreasing, SaO 2 during sleep had got to rise. Conclusions Compared with the traditional surgery for the micrognathia associated with OSAS, the technique of mandibular distraction osteogenesis has the advantages of avoiding bone grafting and donor side morbidity, expanding the surrounding soft tissue concurrently, reducing the extent of operation and stability of the treatment effects.
Objective To study the application of intraoral distraction osteogenesis in correction of various dentofacial deformities Methods From 1997, 12 cases with various dentofacial deformities were corrected by using 6 kind of intraoral distractor 3 cases of them were the patients with cleft palate who have severe secondary maxillary hypoplasia 4 cases with hemifacial microsomia, 2 cases with micrognathia and 3 cases with partial mandibular defect The maxillae were elongated from 10 mm to 15 mm, the mandibles...
Objective To study the application of intraoral distraction osteogenesis in correction of various dentofacial deformities Methods From 1997, 12 cases with various dentofacial deformities were corrected by using 6 kind of intraoral distractor 3 cases of them were the patients with cleft palate who have severe secondary maxillary hypoplasia 4 cases with hemifacial microsomia, 2 cases with micrognathia and 3 cases with partial mandibular defect The maxillae were elongated from 10 mm to 15 mm, the mandibles were elongated from 15 mm to 25 mm, the vertical mandibular distraction was from 10 15 mm Results All cases were corrected satisfactorily and have no any complications In 1 case the distracor did not work during distraction and was replaced Another case the mandibular margin fractured after distraction, the rigid fixation was performed for it Conclusions The intraoral distraction osteogenesis provides a new method with many advantages for those dentofacial deformities that are difficult correct by using ordinary orthognathic surgery
mandibular distraction
下颌骨牵张
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