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rb proteins
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  rb蛋白
     Influence of HPV16/18 infection on expressions of p16~(Ink4a) and Rb proteins in adenocarcinoma of cervix
     子宫颈腺癌中HPV16/18感染对p16~(Ink4a)、Rb蛋白表达的影响
短句来源
     Aberrant expression of p53、BRCA1、BRCA2、PTEN、Rb proteins in breast cancer development
     乳腺癌发生过程中p53、BRCA1、BRCA2、PTEN、Rb蛋白异常表达
短句来源
     Study on the Roles of HSP70, Rb Proteins and HPV16E7 Proteins in the Pathogenesis of Human Laryngeal Carcinoma
     HSP70、Rb蛋白、HPV16E7蛋白在人喉癌发生中作用的研究
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     The Expression of c-Myc, CyclinE and CyclinD_1, Rb Proteins in Breast Carcinoma
     乳腺癌中c-Myc、cyclinE及cyclinD1、Rb蛋白的表达及其意义
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     Expression of P16 and Rb Proteins in Gastric Carcinoma
     胃癌中P16、Rb蛋白表达分析
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  rb基因蛋白
     Expression of cyclinD 1 and Rb proteins in breast carcinoma
     cyclinD_1、Rb基因蛋白在乳腺癌中的表达
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     Methods Paraffin-embedded blocks containing four lesions of breast invasive carcinoma,carcinoma in situ,atypical ductal hyperplasia and simple hyperplasia were employed for immunohistochemical S-P stain with antibodies against BRCA1,BRCA2,PTEN,Rb proteins and mutant p53 protein.
     方法选取同时存在浸润癌、导管内癌、不典型增生和单纯性增生的乳腺癌档案蜡块,应用免疫组化SP法检测p53、BRCA1、BRCA2、PTEN、Rb基因蛋白在各例的异常表达。
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     Methods:Flow cytometry and Immunofluorescence technique were used to perform the quantitative detection for the expression of p27,CyclinD1,CDK4 and Rb proteins in 40 cases with papillary carcinoma of the thyroid(PTC),16 with thyroid adenoma(TA),21 with nodular goiter(NG)and 10 with normal thyroid(NT).
     方法:应用流式细胞术和免疫荧光技术对甲状腺乳头状癌(40例)、甲状腺腺瘤(16例)、结节性甲状腺肿(21例)、正常甲状腺组织(10例)的CyclinD1、CDK4、p27、Rb基因蛋白的表达进行定量检测。
短句来源
     Methods The immunohistochemical mehod(SP)was used to study the expression of p16and Rb proteins in 58 cases of gastric cardea carcinoma.
     方法用SP免疫级化法对58例贲门癌进行p16和Rb基因蛋白的检测。
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  “rb proteins”译为未确定词的双语例句
     Expression of p21~(WAF1/CIP1)and Rb Proteins in Hepatocelluar Carcinoma by Tissue Chip
     利用组织芯片研究p21~(WAF1/CIP1)和Rb基因在肝细胞肝癌中的表达
短句来源
     Expression of p16 and Rb Proteins with High Arsenic Coal Intoxication
     P16和视网膜母细胞瘤蛋白在高砷煤引起的砷中毒患者皮损中的表达
短句来源
     The expression of P16 and Rb proteins in 106 cases of lung cancer
     P16蛋白和视网膜母细胞瘤蛋白在106例患者肺癌组织中的表达
短句来源
     Four out of the 10 (40%) HCC tissues expressing p16 protein and Rb protein simultaneously turned up NF-κB with transcription activity, while 18 out of the 20 (90%) HCC tissues not expressing both p16 and Rb proteins turned up NF-κB with transcription activity (P<0.05).
     p16蛋白和pRb均表达的HCC中NF κB有转录活性者占 4 0 % (4/ 10 ) ,两者均无表达的HCC中NF κB有转录活性者占 90 % (18/ 2 0 ) ,两组间差异有显著性 (P <0 0 1) ;
短句来源
     Objective To study the expression of p16 and Rb proteins in lesion s of patients with high arsenic coal poisoning.
     目的研究P16和视网膜母细胞瘤蛋白(Rb)在高砷煤引起的砷中毒患者皮损中的表达。
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  rb proteins
Similar to other types of cancer, essential pathways regulating apoptosis are also disrupted in malignant gliomas, notably the cell cycle control mechanisms regulated by the p53 and retinoblastoma (RB) proteins and their homologs.
      
Similar to other types of cancer, essential pathways regulating apoptosis are also disrupted in malignant gliomas, notably the cell cycle control mechanisms regulated by the p53 and retinoblastoma (RB) proteins and their homologs.
      
This review assesses the potential roles of Rb proteins in plant cell cycle control and development.
      
In cl-2 cells in semisolid culture, DEX suppressed the expression of P27Kip1, whereas it stimulated the expression of cyclin A and hyperphosphorylated retinoblastoma (Rb) proteins.
      
Expression of p53 and RB Proteins in Squamous Cell Carcinoma of the Esophagus: Their Relationship With Clinicopathologic Charact
      
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Rb gene is a cancer suppressor gene. Its product, Rb protein has close relation with the regulation of cell transformation, cell cycle and transcription. A lot of carcinomas such as retionblastoma, brest cancer, small cell lung cancer, prostate cancer, bladder cancer, oesteosacoma, soft tissue sarcoma etc. are related to the deletion or inactivation of Rb gene. Stomach cancer is a very common carcinoma of the gastrointestinal system. Researchers have shown that the development of stomach cancer...

Rb gene is a cancer suppressor gene. Its product, Rb protein has close relation with the regulation of cell transformation, cell cycle and transcription. A lot of carcinomas such as retionblastoma, brest cancer, small cell lung cancer, prostate cancer, bladder cancer, oesteosacoma, soft tissue sarcoma etc. are related to the deletion or inactivation of Rb gene. Stomach cancer is a very common carcinoma of the gastrointestinal system. Researchers have shown that the development of stomach cancer is due to the activation of many oncogenes and the inactivation of antioncogenes. By Southern Blot hybridization, we have tested cancer tissues of nine stomach cancer patients and one cell line BGC-823 with Rb gene probe, finding that the Rb gene of all the tissues and the cell line are abnormal as compared with that of normal human blood tissues. Among the cancer tissues of the nine patients, five have partial deletion of Rb gene, three as well as the cell line have complete deletion of Rb gene. This indicates that the loss of Rb gene is the key link of cancer development. We believe that, with the more sensitive method of Polymerase Chain Reaction (PCR), we can test the fallen cells of stomach hoping that it would be helpful to the early diagnosis of stomach cancer. Meanwhile, this experiment provides target cells of gene therapy research of tumors.

Rb基因是一种抗癌基因,其产物Rb蛋白与细胞转化、细胞周期调节及转录调控有密切关系。许多肿瘤如视网膜母细胞瘤、乳腺癌、小细胞肺癌、前列腺癌、膀胱癌、骨肉瘤、软组织肉瘤等,都与Rb基因的失活或缺失有关。胃癌是消化道常见多发肿瘤,研究表明,其发生发展与多种癌基因的活化、抗癌基因的异常有关。我们用Southern印迹杂交法,以Rb基因为探针,检测了九例胃癌患者的癌组织和一个胃癌细胞株,发现它们与正常人血相比Rb基因全部呈现异常。其中5例发生Rb基因部分缺失,3例及人胃腺癌细胞株BGC-823全部缺失。这表明在胃癌发生过程中Rb基因的丢失是一个重要环节。我们相信用更灵敏的多聚酶链式反应(PCR)技术检测胃脱落细胞,对患癌危险性的早期预报会有很大帮助。同对,本实验也对肿瘤的基因治疗研究提供了靶细胞。

b cDNA 844bp fragment was inserted into the expression vector pBV221. The recombinant plasmid pRB844 highly expressed a 32kD protein in E.coli BL21. The percentage is 10%-15% of total bacterial protein. Primary purity of the expressed protein through ureapurification is 50%-60%,the puriry could reach more than 98% through further purification.Polyclonal rabbit serum against the Rb protein is also prepared.

Rb基因cDNA844bp片段,与高效原核表达载体pBV221重组,构建了重组表达质粒pRB844,在大肠杆菌中成功地表达了Rb基因的产物,其分子量约32kD,表达量约占菌体总蛋白的10%-15%,初步纯化其纯度可达50%-60%,进一步纯化其纯度可达98%以上。经家兔免疫后,获得了抗Rb基因产物的抗体,这为Rb基因的进一步深入研究提供了条件。

he RB gene is located at chromosome 13q14which spans more than 150kb, with one interalgap. and its product is a phosphoprotein ofabout 110kD which is constantly expressed innormal retina cells. The RB Protein canspecifically bind to SV40 large T. E1A and E7antigens. The deficiency of the RB gene is thecause of retinoblastoma. Besides, RB genemutations are detected in osteosarcomas.breast carcinomas, small-cell lung cancer( SCLC ) . soft - tissue sarcomas and hematopoie-tic proliferative...

he RB gene is located at chromosome 13q14which spans more than 150kb, with one interalgap. and its product is a phosphoprotein ofabout 110kD which is constantly expressed innormal retina cells. The RB Protein canspecifically bind to SV40 large T. E1A and E7antigens. The deficiency of the RB gene is thecause of retinoblastoma. Besides, RB genemutations are detected in osteosarcomas.breast carcinomas, small-cell lung cancer( SCLC ) . soft - tissue sarcomas and hematopoie-tic proliferative disorders. The tumorigenicitycan be partially or totally suppressed by intro-ducing the RB gene into the tumor cells.

RB基因位于13q14,全长150kb,编码一个由928个氨基酸组成的分子量为110000蛋白(pp110RB).它能特异性与SV40大T,E1A和E7结合.在视网膜细胞中,RB呈衡定组成性表达,其

 
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