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   invasive fungal infection 在 呼吸系统疾病 分类中 的翻译结果: 查询用时:0.202秒
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invasive fungal infection
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  侵袭性真菌感染
    Methods Fourteen patients with invasive fungal infection in ICU, received 1~2 weeks of intravenous itraconazole (200 mg twice daily for 2 days, then 200 mg once daily for 3~14 days) followed by 2 weeks of oral itraconazole capsules 200 mg twice daily.
    方法回顾分析重症监护病房(ICU)中,老年MODS患者侵袭性真菌感染14例,最初应用伊曲康唑注射液7~14d,第1~2d,200mg,1次/12h,第3~14d,200mg,1次/d;
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  invasive fungal infection
The Microascus genus rarely causes invasive fungal infection in humans and can be very difficult to treat because of the resistance to available antifungal agents.
      
Voriconazole was administered for suspected or proven invasive fungal infection (IFI) (57%), as empirical treatment in patients with fever of unknown origin (21%) and secondary (19%) as well as primary (3%) prophylaxis of IFI.
      
Invasive fungal infection is one of the major causes of death in neutropenic patients undergoing allogeneic stem cell transplantation (SCT).
      
Definitive diagnoses of invasive fungal infection are too scarce at the national level.
      
The incidence of invasive fungal infection in these patients has increased dramatically in recent years.
      
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ObjectivesTo survey the risk factors and clinical significance of low respiratory tract fungal colonization (LRTFC) in ventilator associated pneumonia (VAP).MethodsThe epidemiological data of LRTFC were collected from fifty three VAP patients who were admitted and treated in our ICU during Jan.1999~Dec.2000. They were divided into fungal colonization group and non fungal colonization group according to results of fungi culture. Risk factors and their effects on the outcome of VAP patients were compared...

ObjectivesTo survey the risk factors and clinical significance of low respiratory tract fungal colonization (LRTFC) in ventilator associated pneumonia (VAP).MethodsThe epidemiological data of LRTFC were collected from fifty three VAP patients who were admitted and treated in our ICU during Jan.1999~Dec.2000. They were divided into fungal colonization group and non fungal colonization group according to results of fungi culture. Risk factors and their effects on the outcome of VAP patients were compared and analyzed between both groups.ResultsForty nine strains of fungi were isolated from the LRT in 30 out of 53 patients, accounting for 56.6% (30/53) of VAP patients ; 98% of the isolates were Candida species, in which 51% belonged to Candida albicans. There was statistically significant difference in whether potent antibiotics with broad spectrum had been used at prior stage between fungal colonization group and non fungal colonization group (P=0.006), while no statistically significant differences were found in age, sex, APACHE Ⅱ scores, SAPS Ⅱ scores and whether glucocorticosteroid and antiacid were administered previously. No significant difference also existed in hospital mortality and number of days required for respirator application between both groups.ConclusionLRTFC is quite prevalent in VAP patients. Prior administration of potent antibiotics with broad spectrum is one of main risk factors. LRTFC exerts no distinct effect on essential outcomes of the patients. As for VAP patients without immunodeficiency, it is unnecessary to initiate antifungal therapy based on the results of LRTFC. Judgment made from other risk factors of invasive fungal infection and clinical manifestation should be emphasized.

目的调查分析呼吸机相关肺炎 (VAP)下呼吸道真菌定植的危险因素及临床意义。方法调查1999年 1月至 2 0 0 0年 12月本科收治的 5 3例VAP患者下呼吸道真菌定植的流行病学情况 ,根据真菌培养结果 ,将患者分为真菌定植组与非真菌定植组 ,对比分析其危险因素和对VAP患者结局的影响。结果5 3例患者中 ,共 30例患者在下呼吸道培养分离出 4 9株真菌 ,占VAP患者的 5 6 .6 % (30 / 5 3) ,其中念珠菌属占 98.0 % ,白色念珠菌占 5 1%。真菌定植组与非真菌定植组在前期是否使用强力广谱抗生素上有非常显著差异(P =0 .0 0 6 ) ,而在年龄、性别、APACHEⅡ评分、SAPSⅡ评分、前期是否使用激素和抑酸剂方面未发现有统计学显著差异。两组在死亡率和呼吸机使用天数上没有显著差异。结论在VAP患者中下呼吸道真菌定植很普遍 ,前期使用强力广谱抗生素是主要的危险因素之一。下呼吸道真菌定植对VAP患者的主要结局没有显著影响。对于没有免疫缺陷的VAP患者 ,没有必要根据下呼吸道真菌定植的结果来启动抗真菌治疗 ,而应强调结合其他深部真菌感染危险因素和临床表现进行衡量

Objective To evaluate the clinical efficacy and safety of intravenous itraconazole(Sporanox) in treatment of invasive fungal infected patients with multiple organ dysfunction syndrome(MODS).Methods Fourteen patients with invasive fungal infection in ICU, received 1~2 weeks of intravenous itraconazole (200 mg twice daily for 2 days, then 200 mg once daily for 3~14 days) followed by 2 weeks of oral itraconazole capsules 200 mg twice daily. The patients with ARF(acute renal failure ) received CRRT(continuous...

Objective To evaluate the clinical efficacy and safety of intravenous itraconazole(Sporanox) in treatment of invasive fungal infected patients with multiple organ dysfunction syndrome(MODS).Methods Fourteen patients with invasive fungal infection in ICU, received 1~2 weeks of intravenous itraconazole (200 mg twice daily for 2 days, then 200 mg once daily for 3~14 days) followed by 2 weeks of oral itraconazole capsules 200 mg twice daily. The patients with ARF(acute renal failure ) received CRRT(continuous renal replace therapy) treatment.Results Itraconazole was effective in treatment of invasive fungal infection in ICU.The eradication rate of fungi was 92.9,effective rate 85.7,and incidence of adverse reaction 42.9.Conclusion Intravenous itraconazole followed by oral itraconazole is an effective choice for the treatment of invasive fungal infections.

目的观察伊曲康唑序贯疗法治疗老年多脏器功能障碍综合征(MODS)患者侵袭性肺部真菌感染的疗效。方法回顾分析重症监护病房(ICU)中,老年MODS患者侵袭性真菌感染14例,最初应用伊曲康唑注射液7~14d,第1~2d,200mg,1次/12h,第3~14d,200mg,1次/d;然后,采用伊曲康唑胶囊或口服液序贯治疗,400mg/d剂量水平,疗程2~4周。结果临床有效率85.7%,真菌清除率为92.9%,真菌清除平均天数为6.1d;患者28d生存率85.7%,不良反应发生率为42.9%。结论对老年MODS合并侵袭性真菌感染患者在综合治疗的基础上,应用广谱抗真菌药物———伊曲康唑序贯疗法,是巩固疗效,防止复发值得推广的给药方式。临床应用伊曲康唑时,应注意适应证、药物不良反应及药物的相互作用。

Invasive pulmonary aspergillosis is a disease of invasive fungal infections which is characterized with diagnostic difficulties and extreme mortality.The incidence of invasive pulmonary aspergillosis has increased dramatically during the last two decades.On the same time,the antifungal drugs and treatment have also markedly developed.Here is a brief review on the the advances of diagnosis and treatment for invasive pulmonary aspergillosis.

侵袭性肺曲霉菌病是深部真菌感染性疾病,近年来发病率大大增加,死亡率极高,传统的诊断方法非常困难,治疗效果不佳。近年来,该病在诊断治疗上有很大的进展,本文就此进行综述。

 
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