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   autologous bone marrow mononuclear 在 心血管系统疾病 分类中 的翻译结果: 查询用时:0.063秒
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autologous bone marrow mononuclear
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  自体骨髓
    Clinical Study on Intracoronary Autologous Bone Marrow Mononuclear Cells Transplantation on the Cardiac Function in Patients with Anterior-wall Myocardial Infarction
    经冠状动脉自体骨髓单个核细胞移植治疗前壁心肌梗死后心功能不全的临床研究
短句来源
    ③changes of cardiac functional parameter and motor ability at different times after autologous bone marrow mononuclear cell transplantation: As compared with that before operation, NYHA cardiac functional grading, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDD) and six-minute walking distance were improved obviously (t =3.034-5.064,P < 0.05).
    ③自体骨髓单个核细胞移植后不同时间心功能指标与运动能力的变化:与术前比较,自体骨髓单个核细胞移植术后1,3个月NYHA心功能分级、左心室射血分数、左心室舒张末期直径、6min行走距离均得到明显改善(t=3.034~5.064,P<0.05)。
短句来源
    AIM: To protect the ischemic myocardium to be infarct, we study the effects of intracoronary autologous bone marrow mononuclear cells and mesenchymal stem cells on the cardiac function and the changes of myocardium nuclear factor (NF)-кB and myocardium apoptosis of acute myocardial infarction.
    目的:为保护濒死心肌提供机会窗口,对比观察经冠脉移植自体骨髓单个核细胞或间充质干细胞后,实验性急性心肌梗死动物心功能变化及心肌组织核转录因子кB、心肌细胞凋亡情况。
短句来源
    Transcoronary transplantation of autologous bone marrow mononuclear cells in the treatment of heart failure after myocardial infarctiona
    经冠状动脉移植自体骨髓单个核细胞用于治疗心肌梗死后的心力衰竭
短句来源
    Treatment of lower limb ischemia with combination of traditional Chinese medicine and transplantation of autologous bone marrow mononuclear cells: A report of 23 cases
    自体骨髓单个核细胞移植联合益气活血中药治疗下肢动脉缺血性疾病23例
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  “autologous bone marrow mononuclear”译为未确定词的双语例句
    The patients were divided into trial group[PCI+normal saline(NS)] and control group[PCI+autologous bone marrow mononuclear cells(BM-MNCs)] randomly.
    随机分为对照组[PCI+生理盐水(NS)]与试验组[PCI+自体骨髓单核细胞(BM-MNCs)]。
短句来源
    ①Twenty-four swines was anaesthetized by intramuscularly injection 200 mg Ketamine, then 20 mL marrow was extracted from right thighbone. According Fercoll method autologous bone marrow mononuclear cells were gotten and mixed with colloid gold solution, cultured for 12-16 hours.
    ①24只猪均以盐酸氯胺酮200mg臀部肌肉注射麻醉后,分别于各自右侧股骨抽取骨髓20mL,采用Fercoll法分离获得骨髓单个核细胞,加入胶体金溶液,培养12~16h待用。
短句来源
    CONCLUSION: Intracoronary transplant autologous bone marrow mononuclear cells and mesenchymal stem cells can improve cardiac function in acute myocardial infarction swine, which is associated with decreasing of expression of NF-кB and myocardial apoptosis.
    结论:经冠脉移植骨髓单个核细胞和间充质干细胞均可改善实验性急性心肌梗死动物的心功能,与梗死边缘区核转录因子кB表达降低及心肌细胞凋亡减少有关。
短句来源
    Comparison study of intracoronary autologous bone marrow mononuclear cells and mesenchymal stem cells used in treatment of acute myocardial infarction
    经冠脉移植骨髓单个核细胞和间充质干细胞治疗急性心肌梗死的对比实验研究
短句来源
    Intracoronary administration of autologous bone marrow mononuclear cells after induction of short ischemia is safe and may improve hibernation and ischemia in patients with ischemic cardiomyopathy
    缺血性心肌病患者在诱导短暂缺血后冠状动脉内注射自体骨髓单核细胞是安全的,可能改善心肌冬眠和缺血
短句来源
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  autologous bone marrow mononuclear
Autologous bone marrow mononuclear cells were transplanted by intracoronary infusion to patients with myocardial infarction after recovery of coronary perfusion.
      
Recently, the effectiveness and safety of therapeutic angiogenesis by transplantation of autologous bone marrow mononuclear cells (BM-MNCs) to ischemic limbs have been reported.
      
Dual-head coincidence gamma camera FDG-PET before and after autologous bone marrow mononuclear cell implantation in ischaemic st
      


Objective: To evaluate the feasibility and efficacy of via coronary transplantation of bone marrow mononuclear cells in treating ischemic heart failure. Methods: 27 adults suffered from ischemic heart failure were enrolled in this study. Bone marrow mononuclear cells were isolated by Ficoll density gradient centrifugation from the marrow blood obtained from the patients. Results: These cells were injected into coronary artery through a peripheral artery puncture. A 3-month follow-up was performed to evaluate...

Objective: To evaluate the feasibility and efficacy of via coronary transplantation of bone marrow mononuclear cells in treating ischemic heart failure. Methods: 27 adults suffered from ischemic heart failure were enrolled in this study. Bone marrow mononuclear cells were isolated by Ficoll density gradient centrifugation from the marrow blood obtained from the patients. Results: These cells were injected into coronary artery through a peripheral artery puncture. A 3-month follow-up was performed to evaluate the clinical symptom, NYHA classification, and re-hospitalization because of cardiovascular events after the treatment. Conclusion:Cellular cardiomyoplasty through autologous bone marrow mononuclear cell transplantation is safe and feasible. The results show that the treatment improved the clinical status of the patients and ischemic stress of the local cardiomyocyte.

目的 :为研究自体骨髓单个核细胞经冠脉内移植治疗缺血性心力衰竭的可行性和疗效。方法 :成人缺血性心力衰竭病人 2 7例 ,抽取骨髓后密度梯度离心法分离出骨髓单个核细胞 ,经外周动脉穿刺插管 ,直接将自体骨髓单个核细胞注入冠脉。结果 :术后随访显示病人的活动能力明显改善 ,NYHA提高 >2级 12例 ,>1级 4例 ,EF明显提高 (36 .4± 12 .5 % ,vs 4 6 .3±10 .6 % ,P <0 .0 0 1) ,99Tc心脏ECT检查心肌缺血区可见岛状放射性同位素充盈 ,提示有部分新生心肌存在。因心肌再梗死住院 1例 ,其他 15例均无明显症状并院外存活。结论 :自体骨髓细胞移植心肌细胞成形术 ,对缺血心肌的恢复和改善病人临床心功能有肯定疗效 ,该方法在临床上安全、简单、可行 ,对病人没有明显的负影响。

Objective To examine whether the in vivo implantation of autologous bone-marrow mononuclear cells (BM-MNCs) can augment postnatal neovascularization in rat model of hind limb ischemia.Methods Rat BM-MNCs were isolated by centrifugation through a Ficoll-paque density gradient. The rat ischemic hind limb model was made by ligation of the right femoral artery and its branches of imbred Wistar rats. BM-MNCs (MNC group) or phosphate saline buffer (PBS group) were injected into 7 points...

Objective To examine whether the in vivo implantation of autologous bone-marrow mononuclear cells (BM-MNCs) can augment postnatal neovascularization in rat model of hind limb ischemia.Methods Rat BM-MNCs were isolated by centrifugation through a Ficoll-paque density gradient. The rat ischemic hind limb model was made by ligation of the right femoral artery and its branches of imbred Wistar rats. BM-MNCs (MNC group) or phosphate saline buffer (PBS group) were injected into 7 points of the ischemic muscles (20 μl/point). To assess angiogenesis, histologic evaluation was performed on tissue slices from adductor muscles with immunohistochemical staining at the 2nd and 4th weeks after the ligation. Severity of ischemic insult was evaluated by the femoral arteriovenous oxgen difference (AVDO 2) at the 2nd and 4th weeks after the ligation.Results The MNC groups had a higher capillary density and higher capillary/muscle fiber ratios than that of the sham and PBS groups(P<0.01)at the 2nd and 4th weeks after the ligation. AVDO 2 of the MNC group significantly decreased compared with that of the PBS groups(P<0.05).Conclusion The implantation of autologous BM-MNCs induced neovascularization in a rat ischemic hind limb model. The implantation of autologous BM-MNCs augmented the collateral perfusion of ischemic hind limb.

目的 :研究骨髓单个核细胞局部移植对缺血组织血运重建的影响。方法 :从大鼠胫骨及股骨采集骨髓细胞 ,密度梯度离心法分离出骨髓单个核细胞。分离、切断近交系Wistar大鼠右侧股动脉及其分支 ,建立单侧后肢缺血模型。分 7点在缺血后肢局部注射单个核细胞悬液 (MNC组 )或磷酸盐缓冲液 (PBS组 )。术后第 2 ,4周测定各组后肢动静脉氧差 (AVDO2 )并取内收肌制作组织切片 ,免疫组织化学法分析血管新生。结果 :术后第 2 ,4周MNC组内收肌毛细血管密度、毛细血管与肌纤维比值高于PBS组 (P <0 .0 1) ,AVDO2 低于同期PBS组 (P <0 .0 5 )。结论 :在大鼠缺血后肢局部直接植入骨髓单个核细胞可诱导新生血管形成 ,改善缺血组织的血流灌注

AIM: To investigate the effect of autologous bone marrow mononuclear cells (BM-MNCs) local transplantation (BM-LT) on a rabbit model of hindlimb ischemia. METHODS: After unilateral femoral artery and its branches were surgically ligated and excised in rabbits (n=14) 1 hour or so, autologous BM-MNCs were injected into the ischemic skeletal muscles in 7 rabbits, and phosphate buffered saline for another 7 ones as control. Hemodynamics parameters were measured at day 0, day 7 and day 28, respectively....

AIM: To investigate the effect of autologous bone marrow mononuclear cells (BM-MNCs) local transplantation (BM-LT) on a rabbit model of hindlimb ischemia. METHODS: After unilateral femoral artery and its branches were surgically ligated and excised in rabbits (n=14) 1 hour or so, autologous BM-MNCs were injected into the ischemic skeletal muscles in 7 rabbits, and phosphate buffered saline for another 7 ones as control. Hemodynamics parameters were measured at day 0, day 7 and day 28, respectively. On day 28, the animals were sacrificed in groups for pathological analysis. RESULTS: Compared with control group, color Doppler flow image in BM-LT group was recovered significantly, and its' systolic peak velocity and end-diastolic velocity were also improved (P<0.05). Resistance index and flow volume were significantly improved on day 28 (P<0.05). A higher capillary density was detected in BM-LT group than that in control group (P<0.01). Ratio of the number of capillary and the number of myocyte fiber were significant difference (P<0.05). CONCLUSION: BM-LT improves peripheral neovascularization. It might provide a new therapeutic method for ischemic peripheral vascular disease. [

目的探讨自体骨髓细胞局部移植对肢体缺血的治疗作用。方法14只雄性新西兰兔结扎并离断单侧股动脉及其分支动脉1h后,骨髓细胞局部移植组(n=7)于缺血局部肌肉注射新鲜分离的自体骨髓单个核细胞悬液,对照组(n=7)局部肌肉注射磷酸盐缓冲液,分别于实验前(0d)、7d和28d进行股部血流动力学检测,于28d时处死动物做组织病理学分析。结果7d和28d时,彩色多谱勒血流显像示骨髓细胞局部移植组血流信号较对照组丰富,且收缩期峰值血流速度与舒张期流速较快(P<005),28d时血管阻力指数、血流量两组间有显著差异(P<005);病理学分析骨髓细胞局部移植组单位面积毛细血管密度显著高于对照组(P<001),毛细血管数目与肌纤维数目的比值两组间显著差异(P<005)。结论自体骨髓细胞局部移植促进外周血管新生,可能成为缺血性外周血管疾病一种新的治疗方法。

 
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