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autologous bone marrow mononuclear
相关语句
  自体骨髓
    Autologous bone marrow mononuclear cells implantation and ischemia myocardial neovascularization
    自体骨髓单个核细胞移植与缺血心肌血管再生
短句来源
    A CLINICAL STUDY ON IMPLANTATION OF AUTOLOGOUS BONE MARROW MONONUCLEAR CELLS AFTER BONE MARROW STIMULATION FOR TREATMENT OF LOWER LIMB ISCHEMIA
    骨髓动员刺激后自体骨髓源单个核细胞移植治疗下肢缺血的初步临床研究
短句来源
    Effect of cardiac transplantation of autologous bone marrow mononuclear cells on cardiac function of swine with chronic ischemic myocardium
    自体骨髓单个核细胞心肌移植对猪慢性缺血心肌心功能的影响
短句来源
    Therapeutical effect of autologous bone marrow mononuclear cell injection along the meridians according to syndrome differentiation on ischemia in artery of lower extremity
    辨证循经注射自体骨髓单个核细胞联合中药治疗下肢动脉缺血性疾病的临床研究
短句来源
    Transplantation of autologous bone marrow mononuclear cells through intervention approaches for treating the necrosis of femoral head:A follow-up of 12 months in 54 cases
    自体骨髓单个核细胞经介入途径移植治疗股骨头坏死54例:12个月疗效随访
短句来源
  “autologous bone marrow mononuclear”译为未确定词的双语例句
    Augmentation of Revascularization by Implantation of Autologous Bone Marrow Mononuclear Cells in a Rat Ischemic Hindlimb Model
    骨髓单个核细胞局部移植促进大鼠缺血后肢血管再生实验研究
短句来源
    Donor and recipient inbred isogenic adult (8-10 weeks old) Lewis rats were used as models to mimic intracoronary transplantation of autologous bone marrow mononuclear cells in clinical setting.
    骨髓单个细胞(Bone Marrow Mononuclear Cells,BMMNCs)中含有大量多能干细胞,国外学者发现经体外诱导后骨髓干细胞可分化为肌源性细胞(myogenic cells)或心肌细胞。
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  autologous bone marrow mononuclear
Autologous bone marrow mononuclear cells were transplanted by intracoronary infusion to patients with myocardial infarction after recovery of coronary perfusion.
      
Recently, the effectiveness and safety of therapeutic angiogenesis by transplantation of autologous bone marrow mononuclear cells (BM-MNCs) to ischemic limbs have been reported.
      
Dual-head coincidence gamma camera FDG-PET before and after autologous bone marrow mononuclear cell implantation in ischaemic st
      


Objective To investigate the efficacy of the integrated therapy of autologous bone marrow mononuclear cell transplantation and TCM drugs in the treatment of lower limb ischemia. Method 6 Cases of lower limb ischemia were involved in the clinical study. Before the operation, granulocyte colony stimulating factor (G-CSF) was used in the patients for making their bone marrow be in an active proliferation state. And then, the bone marrow fluid was aspirated for the separation of mononuclear...

Objective To investigate the efficacy of the integrated therapy of autologous bone marrow mononuclear cell transplantation and TCM drugs in the treatment of lower limb ischemia. Method 6 Cases of lower limb ischemia were involved in the clinical study. Before the operation, granulocyte colony stimulating factor (G-CSF) was used in the patients for making their bone marrow be in an active proliferation state. And then, the bone marrow fluid was aspirated for the separation of mononuclear Cells. The amount of the mononuclear cells in the separated fluid was over 1×10 9. The transplantation of the mononuclear cells was performed by the method of multipoint injection in the ischemic lower limb, and the TCM drugs were given to the patients from the first day after the operation. The efficacy of the integrated therapy was assessed by scoring lower limb pain intensity, poikilothermia, ankle-brachial index (ABI), and the area of the ulcerative surface in the patients before and after the operation. Results The scores of the lower limb pain intensity and poikilothermia markedly decreased in the patients one week after the treatment, then rebounded to some degree two weeks after the treatment, and went down again one month after the treatment. ABI increased gradually after the treatment, and the average value of the increased ABI was 0.23 one month after the treatment. After the treatment, the ulcerative area markedly shrank in the 3 cases with ulcerative surface; and toe amputation was performed in the 2 cases with severe putrescence one month after the treatment, and the incision got healed by first intention. Conclusion The integrated therapy of autologous bone marrow mononuclear cell transplantation and TCM drugs can relieve the clinical symptoms and signs in the patients of lower limb ischemia.

目的 研究自体骨髓单个核细胞移植与中药合用对下肢缺血的治疗作用。方法 治疗对象为 6例严重下肢缺血患者。术前用集落细胞刺激因子使患者骨髓处于增生活跃状态 ,抽取骨髓液后在血管外科专属干细胞工作室分离单个核细胞 ,细胞总量达到 1× 10 9L-1以上。移植采用缺血肢体多点注射。移植后 1d起服中药。观察患者手术前后肢体疼痛、冷感评分、踝肱指数 (ABI)以及溃疡创面情况 ,评价治疗效果。结果 治疗后 1周患者肢体疼痛评分及冷感评分明显下降 ,2周时又有回升 ,术后 1月再下降。ABI在术后逐渐升高 ,术后 1月平均升高 0 2 3。 3例有溃疡的患者创面明显缩小 ,2例有严重坏死者术后 1月行截趾 ,创面 1期愈合。结论 自体骨髓单个核细胞移植合用中药可以改善下肢缺血患者的临床症状及体征。

Objective To observe the possibility and the clinical result of autologous intracoronary transplantation of bone marrow mononuclear cells (BMCs) in treating dilated cardiorayopathy. Methods A female patient with 45 year old was diagnosed with idiopathic dilated cardiomyopathy and in cardiac function NYHA VI. BMCs were isolated by Ficoll density gradient centrifugation from the marrow blood obtained from patient herself. After intracoronary transplantated with bone marrow mononuclear cells, the patient had been...

Objective To observe the possibility and the clinical result of autologous intracoronary transplantation of bone marrow mononuclear cells (BMCs) in treating dilated cardiorayopathy. Methods A female patient with 45 year old was diagnosed with idiopathic dilated cardiomyopathy and in cardiac function NYHA VI. BMCs were isolated by Ficoll density gradient centrifugation from the marrow blood obtained from patient herself. After intracoronary transplantated with bone marrow mononuclear cells, the patient had been followed up to observe the symptoms, heart function, cardiovascular events. Result During or after BMCs transplantation, there was no any complications and negative effects with patient, no newly and seriously arrhythmia had been found, patient's heart function was stable. But in third day after transplantation, patient had a six hours fever followed a sore-throat and cough. In fifth day, patient had been discharged from hospital and with the capability of exercise increased. Conclusion The technique and performance of intracoronary transplantation of autologous bone marrow mononuclear cells in treating idiopathic dilated cardiomyopathy are simple, safe and feasible with capability of exercise increased, without significantly complications and severe cardiovascular events during a short period observation, however a long term follow-up should be performed.

目的观察自体骨髓单个核细胞经冠状动脉移植治疗扩张型心肌病的可行性及临床效果。方法原发性扩张型心肌病1例,心功能NYHA Ⅳ级。抽取患者骨髓,用密度梯度法分离骨髓单个核细胞,经左、右冠状动脉分别直接注入经分离自体骨髓单个核细胞,术后观察及随访患者症状,心功能,心血管事件。结果术中和术后未见不良影响,无新发严重心律失常,心功能稳定。术后第三天患者因咽痛干咳伴发热6 小时,第五天出院,运动能力增加。结论自体骨髓单个核细胞经冠状动脉移植治疗扩张型心肌病技术简单, 安全,对患者创伤小,短期观察对患者未见不良影响,而运动能力增加,长期效果有待随访观察。

AIM: To observe the therapeutic effects of autologous bone marrow mononuclear cells implantation on chronic lower limb ischemia at the stages of intermintternt claudication, rest pain, ulcer and gangrene. METHODS: From March 2003 to February 2005, 102 diseased limbs were selected from 94 patients with lower extremity ischemia (59 males and 35 females) with an average age of 69.5 years, who were treated in the Xuanwu Hospital, Capital University of Medical Sciences. Of the diseased limbs, 90 were caused...

AIM: To observe the therapeutic effects of autologous bone marrow mononuclear cells implantation on chronic lower limb ischemia at the stages of intermintternt claudication, rest pain, ulcer and gangrene. METHODS: From March 2003 to February 2005, 102 diseased limbs were selected from 94 patients with lower extremity ischemia (59 males and 35 females) with an average age of 69.5 years, who were treated in the Xuanwu Hospital, Capital University of Medical Sciences. Of the diseased limbs, 90 were caused by diabetic lower limb ischemia (n=84), 7 by atherosclerotic occlusion (n=6), and 5 by thromboangiitis obliterans (n=4); 13 were at the stage of intermintternt claudication (n=12) and 41 at rest pain (n=38), the stage of tissue damage included ulcer (26 diseased limbs, n=24) and gangrene (22 diseased limbs, n=20). ① All the received autologous bone marrow mononuclear cells implantation, the methods of lower limb local intramuscular injection, lower limb arterial intracavitary injection and the lower limb local intramuscular injection together with lower limb arterial intracavitary injection. Lower limb local intramuscular injection was to inject the isolated and purified autologous bone marrow mononuclear cells into the muscles at the ischemic sites of the diseased limbs by means of multiple points. Lower limb arterial intracavitary injection was to inject the bone marrow mononuclear cells into the arterial cavity of lower limbs, and the proximal blood flow at the occluded site of lower limb artery should be blocked with Foley's tube for 3-5 minutes. The method of lower limb local intramuscular injection together with lower limb arterial intracavitary injection was to implant by using the above two methods at the same time. ② Evaluation of the main clinical symptoms and subjective indexes of physical signs: According to the walking distance under normal velocity, the stage of intermintternt claudication was divided into 5 grades, which were grade 0: walking distance ≥ 500 m as painless; grade 1: walking distance of 400-499 m as painful; grade 2: walking distance of 300-399 m as painful; grade 3: walking distance of 100-299 m as painful; grade 4: could not walk or walking distance < 100 m as painful. According to painful or painless and severity of pain, the stage of rest pain was divided into 5 grades, which were grade 0: painless; grade 1: felt painful occasionally, could remember when being asked; grade 2: always felt painful but tolerable, common analgesic was not needed or needed occasionally; grade 3: common analgesic was always needed; grade 4: sleep was affected by the pain, and hard to be relieved by common analgesic. According to the existence of cold feeling or not and the severity of cold feeling, the cold feeling of the diseased limbs was divided into 5 grades, which were grade 0: no cold feeling; grade 1: the diseased limbs felt coldness and dreadful of cold weather occasionally; grade 2 the diseased limbs always felt cold and be dreadful of cold weather; grade 3: the diseased limbs felt coldness and dreadful of cold weather obviously, and could be relieved after measures of local warmth keeping; grade 4 the diseased limbs felt coldness and dreadful of cold weather obviously, and had no obvious amelioration after measures of local warmth keeping. ③ Evaluation of the main clinical symptoms and objective indexes of physical signs: The newly formed collateral vessels were classified as 4 grades according to their number, which were grade 0: no new collateral vessel; grade 1: a bit of new collateral vessels; grade 2: moderate amount of new collateral vessels; grade 3: plenty of new collateral vessels. The rate of limb-salvage took 2 months after implantation as the standard, and the rate of limb amputation and rate of limb-salvage at the stages were observed. ④ Evaluation of the therapeutic effects: No relief of pain, cold feeling and intermintternt claudication of diseased limb was taken as no change, grade 1 relief as improvement, grade 2 or 3 relief as obvious improvement, grade 0 as disappearance of symptoms; Healing of wounded surface and disappearance was taken as healing, decreased size of wounded surface as improvement, no change or amplification of wounded surface and pain as invalid. RESULTS: According to intention-to-treat analysis, all the 102 diseased limbs of the 94 patients were involved in the analysis of results. ① Comparison of the total effective rate of lower limb ischemia at different stages: The total effective rate was 100%, 92.7%, 83.3% and 59.1% at the stages of intermintternt claudication, rest pain, ulcer and gangrene respectively, it was close at the first 3 stages (χ2=1.01-2.23, P > 0.05), and there were no differences between the stages of rest pain and ucler (χ2 =1.11, P > 0.05), significantly higher at the first 3 stages than at the stage of gangrene (χ2=10.48, P < 0.01; χ2=5.18, P < 0.05; χ2=3.93, P < 0.05). ② Changes of ankle brachial index at different stages: The ankle brachial index increased by 46.2%, 31.7%, 34.6% and 27.3% at the stages of intermintternt claudication, rest pain, ulcer and gangrene respectively without t obvious differences.③ The rate of limb-salvage at different stages: The rate of limb-salvage was 100%, 97.6%, 88.5% and 59.1% at the stages of intermintternt claudication, rest pain, ulcer and gangrene respectively, it was close at the first 3 stages (χ2=0.32-0.41, P > 0.05), and there were no differences between the stages of rest pain and ucler (χ2=2.35, P > 0.05), significantly higher at the first 3 stages than at the stage of gangrene (χ2=15.87, P < 0.01; χ2=5.18, P < 0.05;χ2=5.48, P< 0.05). ④ The increase of transcutaneous oxygen pressure and angiogenesis at different stages: There was no obvious difference in the transcutaneous oxygen pressure among the stages. The arteriography of lower limb showed that the percentage of rich angiogenesis also had no obvious difference among the stages. CONCLUSION: Of the patients with lower limb ischemia treated with autologous bone marrow mononuclear cells implantation by means of local intramuscular injection of lower limb, the total effective rate and rate of limb-salvage had no obvious differences at the early, middle and ucler stages, which were all obviously higher than those at the late stage, it is fully indicated that autologous bone marrow mononuclear cells implantation is suitable especially for the patients with lower limb ischemia at the early and middle stages, and its therapeutic effect on late ischemia especially those with tissue gangrene of diseased limb still needs further improvement.

目的:观察自体骨髓干细胞移植对慢性下肢缺血间歇性跛行期、静息痛期、溃疡期和坏疽期患者治疗效果的比较。方法:选取2003-03/2005-02首都医科大学宣武医院收治慢性下肢缺血患者94例(102条患肢),男59例,女35例,年龄平均69.5岁。病因:糖尿病性下肢缺血90条患肢(84例患者),单纯动脉硬化闭塞症7条患肢(6例患者),血栓闭塞性脉管炎5条下肢(4例患者)。间歇性跛行期13条患肢(12例患者);静息痛期41条患肢(38例患者);组织缺损期包括溃疡期和坏疽期,分别有26条患肢(24例患者)和22条患肢(20例患者)。①全部患者均行自体骨髓干细胞移植,采用下肢局部肌肉注射、下肢动脉腔内注射、下肢局部肌肉注射和动脉腔内注射同时进行3种方法。下肢局部肌肉注射是将经过分离、提纯的自体骨髓干细胞,采用多点方法注射在患肢缺血部位的肌肉内;下肢动脉腔内注射是将骨髓干细胞注射在下肢动脉腔内,注射时要用球囊导管阻断下肢动脉闭塞处的近端血流,时间3~5min;下肢局部肌肉注射并动脉腔内注射的方法是同时采用前2种方法进行移植。②主要临床症状与体征主观指标的评估:间歇性跛行期根据在正常速度下行走的距离分为5级(0级:行走≥5...

目的:观察自体骨髓干细胞移植对慢性下肢缺血间歇性跛行期、静息痛期、溃疡期和坏疽期患者治疗效果的比较。方法:选取2003-03/2005-02首都医科大学宣武医院收治慢性下肢缺血患者94例(102条患肢),男59例,女35例,年龄平均69.5岁。病因:糖尿病性下肢缺血90条患肢(84例患者),单纯动脉硬化闭塞症7条患肢(6例患者),血栓闭塞性脉管炎5条下肢(4例患者)。间歇性跛行期13条患肢(12例患者);静息痛期41条患肢(38例患者);组织缺损期包括溃疡期和坏疽期,分别有26条患肢(24例患者)和22条患肢(20例患者)。①全部患者均行自体骨髓干细胞移植,采用下肢局部肌肉注射、下肢动脉腔内注射、下肢局部肌肉注射和动脉腔内注射同时进行3种方法。下肢局部肌肉注射是将经过分离、提纯的自体骨髓干细胞,采用多点方法注射在患肢缺血部位的肌肉内;下肢动脉腔内注射是将骨髓干细胞注射在下肢动脉腔内,注射时要用球囊导管阻断下肢动脉闭塞处的近端血流,时间3~5min;下肢局部肌肉注射并动脉腔内注射的方法是同时采用前2种方法进行移植。②主要临床症状与体征主观指标的评估:间歇性跛行期根据在正常速度下行走的距离分为5级(0级:行走≥500m,无疼痛;1级:行走400~499m,有疼痛;2级:行走300~399m,有疼痛;3级:行走100~299m,有疼痛;4级:静息痛,无法行走或行走<100m,有疼痛)。静息痛期根据疼痛与否及疼痛程度分为5级(0级:无疼痛;1级:偶有疼痛,被问及能回忆起;2级:疼痛经常出现但能耐受,不需或偶用一般止痛剂;3级:经常使用一般止痛剂;4级:因疼痛影响睡眠,一般止痛剂难以缓解)。患肢冷感根据患肢有无冷感及冷感的程度分为5级(0级:无冷感;1级:受累肢体偶有发凉、怕冷的感觉;2级:受累肢体经常有发凉、怕冷的感觉;3级:受累肢体明显有冷、凉的感觉,采用局部保温措施后症状能得到一定程度的缓解;4级:受累肢体明显有冷、凉的感觉,采用局部保温措施后症状仍无明显改善)。③主要临床症状与体征客观指标的评估:新生侧支血管评估根据其数量分为4级(0级:无新生侧支血管;1级:少许新生侧支血管;2级:中量新生侧支血管;3级:丰富新生侧支血管)。保肢率以术后2个月为基准,观查各期的截肢率和保肢率。④疗效评估:患肢疼痛、冷感和间歇性跛行未减轻为无变化,减轻1级为改善,减轻2或3级为明显改善,达到0级为症状消失;创面愈合并且疼痛消失为治愈,创面明显缩小为明显改善,创面缩小为改善,创面及疼痛无变化或扩大为无效。结果:按意向处理分析,纳入实验的94例患者102条患肢全部进入结果分析。①不同患病期的下肢缺血总有效率比较:间歇性跛行期100%,静息痛期92.7%,溃疡期83.3%,坏疽期59.1%。前3期比较基本相近(χ2=1.01~2.23,P>0.05);静息痛期与溃疡期比较仍无差异(χ2=1.11,P>0.05);前3期均显著高于坏疽期(χ2=10.48,P<0.01;χ2=5.18,P<0.05;χ2=3.93,P<0.05)。②不同患病期的踝肱指数变化:间歇性跛行期、静息痛期、溃疡期、坏疽期踝肱指数增加分别为46.2%,31.7%,34.6%和27.3%,无明显差异。③不同患病期保肢率:间歇性跛行期100%,静息痛期97.6%,溃疡期88.5%,坏疽期59.1%。前3期比较基本相近(χ2=0.32~0.41,P>0.05);静息痛期与溃疡期比较也基本相近(χ2=2.35,P>0.05);前3期均显著高于坏疽期(χ2=15.87,P<0.01;χ2=5.18,P<0.05;χ2=5.48,P<0.05)。④不同患病期经皮氧分压增加与血管生成情况:经皮氧分压测定各期之间无明显差异。下肢动脉造影显示,有丰富血管生成的百分比各期之间也没有明显差异。结论:自体骨髓干细胞下肢局部肌肉注射移植治疗下肢缺血患者,在病变的早、中阶段和单纯溃疡阶段,其有效率和保肢率均无明显差异,但以上3阶段的有效率和保肢率均明显高于晚期的有组织坏疽阶段,充分说明自体骨髓干细胞移植特别适合下肢缺血患者病变的早期与中期,对于缺血晚期特别是患肢存在组织坏疽者的治疗效果仍有待进一步提高。

 
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