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autologous bone marrow mononuclear
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  自体骨髓
    AIM: To protect the ischemic myocardium to be infarct, we study the effects of intracoronary autologous bone marrow mononuclear cells and mesenchymal stem cells on the cardiac function and the changes of myocardium nuclear factor (NF)-кB and myocardium apoptosis of acute myocardial infarction.
    目的:为保护濒死心肌提供机会窗口,对比观察经冠脉移植自体骨髓单个核细胞或间充质干细胞后,实验性急性心肌梗死动物心功能变化及心肌组织核转录因子кB、心肌细胞凋亡情况。
短句来源
    The Efficacy and safety of autologous bone marrow mononuclear cells transplantation by intracoronary infusion in patients with acute myocardial infarction
    自体骨髓单个核细胞移植治疗急性心肌梗死的疗效与安全性随机对照研究
短句来源
    Long term follow-up on emergent intracoronary autologous bone marrow mononuclear cell transplantation for acute inferior-wall myocardial infarction
    急诊经冠脉自体骨髓单个核细胞移植治疗急性下壁心肌梗死长期随访观察
短句来源
    Intracoronary autologous bone marrow mononuclear cells and mesenchymal stem cells for improving the cardiac function of acute myocadial infarction models
    经冠状动脉移植自体骨髓单个核细胞和间充质干细胞对急性心肌梗死模型心功能的改善
短句来源
    The efficacy of autologous bone marrow mononuclear cells transplantation by intracoronary infusion in patients with acute or old myocardial infarction
    自体骨髓单个核细胞移植治疗急性心肌梗死与陈旧性心肌梗死的疗效对比研究
短句来源
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  “autologous bone marrow mononuclear”译为未确定词的双语例句
    The patients were divided into trial group[PCI+normal saline(NS)] and control group[PCI+autologous bone marrow mononuclear cells(BM-MNCs)] randomly.
    随机分为对照组[PCI+生理盐水(NS)]与试验组[PCI+自体骨髓单核细胞(BM-MNCs)]。
短句来源
    ①Twenty-four swines was anaesthetized by intramuscularly injection 200 mg Ketamine, then 20 mL marrow was extracted from right thighbone. According Fercoll method autologous bone marrow mononuclear cells were gotten and mixed with colloid gold solution, cultured for 12-16 hours.
    ①24只猪均以盐酸氯胺酮200mg臀部肌肉注射麻醉后,分别于各自右侧股骨抽取骨髓20mL,采用Fercoll法分离获得骨髓单个核细胞,加入胶体金溶液,培养12~16h待用。
短句来源
    CONCLUSION: Intracoronary transplant autologous bone marrow mononuclear cells and mesenchymal stem cells can improve cardiac function in acute myocardial infarction swine, which is associated with decreasing of expression of NF-кB and myocardial apoptosis.
    结论:经冠脉移植骨髓单个核细胞和间充质干细胞均可改善实验性急性心肌梗死动物的心功能,与梗死边缘区核转录因子кB表达降低及心肌细胞凋亡减少有关。
短句来源
    Comparison study of intracoronary autologous bone marrow mononuclear cells and mesenchymal stem cells used in treatment of acute myocardial infarction
    经冠脉移植骨髓单个核细胞和间充质干细胞治疗急性心肌梗死的对比实验研究
短句来源
    Objective To study the effects and mechanism of intracoronary autologous bone marrow mononuclear cells(BM-MNC) and mesenchymal stem cells(MSC) on the cardiac function of acute myocardial infarction(AMI).
    目的对比研究经冠脉骨髓单个核细胞(BM-MNC)和间充质干细胞(MSC)移植对实验性急性心肌梗死(AMI)心功能的影响及其机制。
短句来源
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  autologous bone marrow mononuclear
Autologous bone marrow mononuclear cells were transplanted by intracoronary infusion to patients with myocardial infarction after recovery of coronary perfusion.
      
Recently, the effectiveness and safety of therapeutic angiogenesis by transplantation of autologous bone marrow mononuclear cells (BM-MNCs) to ischemic limbs have been reported.
      
Dual-head coincidence gamma camera FDG-PET before and after autologous bone marrow mononuclear cell implantation in ischaemic st
      


ObjectiveTo investigate the survival and differentiation of autologous bone-marrow mononuclear cell (ABM-MNCs) after transplanted to infarcted area and border area, and the effect of ABM-MNC on the cardiac function.Methods40 male big-ear Japanese rabbits were divided randomly into the transplanted group and control group with 20 animals in each group. Acute myocardial infarction model was made by ligating left anterior descending artery. 7 days later, Brdu labeled ABM-MNCs were injected...

ObjectiveTo investigate the survival and differentiation of autologous bone-marrow mononuclear cell (ABM-MNCs) after transplanted to infarcted area and border area, and the effect of ABM-MNC on the cardiac function.Methods40 male big-ear Japanese rabbits were divided randomly into the transplanted group and control group with 20 animals in each group. Acute myocardial infarction model was made by ligating left anterior descending artery. 7 days later, Brdu labeled ABM-MNCs were injected into myocardium in the transplanted group, while the control rabbits were injected with saline. Six weeks later, tests of histology and immunohistochemistry were performed.ResultsViable cells labeled with Brdu can be identified in the infarcted area, and myocytes and endothelial cells labeled with Brdu can also be found in the border area, these cells demonstrated myogenic differentiation with the expression of α-actin by immunostaining. While, no cells labeled with Brdu were found in the control group. Moreover, the vessel density of the transplanted group in the borders of the infarction was higher than the control group ( P<0.05), but there was no difference in infarcted area between two groups ( P>0.05). At the 6 weeks after experiment, the cardiac function was improved in both groups, but there was a significant difference between two groups ( P<0.05).ConclusionABM-MNCs injected into the infarcted myocardium can survive in both the infarcted and border areas, and differentiate into endothelial cells and other cells which are able to obtain the characters of myocytes, and increase the vessel density in border area, improve the cardiac function.

目的探讨自体骨髓单核细胞(ABM-MNCs)移植至心肌梗死区及周边区后的存活、分化状况,以及对心功能的影响。方法将40只日本大耳雄兔随机分为细胞移植组和对照组各20只。采用结扎左冠状动脉前降支的方法建立急性心肌梗死(AMI)模型。细胞移植组于梗死后第6天于自体髂骨处抽取骨髓,分离得到单核细胞后,以Brdu标记,经心外膜注射到梗死区及周边区。对照组仅注射等量的生理盐水。移植6周后,进行组织学及免疫组织化学检查。结果移植后6周,两组动物的心功能均有改善,但两组间有显著性差异。Brdu标记示移植组梗死区内存在阳性染色的移植细胞,而周边区可见Brdu染色阳性的心肌细胞及血管内皮细胞。免疫荧光染色示梗死区内Brdu染色阳性的移植细胞抗心肌特异性肌动蛋白抗体阴性,而周边区内Brdu染色阳性的移植细胞抗心肌特异性肌动蛋白抗体阳性。对照组未发现Brdu染色阳性的细胞。移植组梗死周边区及远离梗死区的毛血管密度均高于对照组(P<0.05),但梗死区内的毛细血管密度两组间无显著性差异(P>0.05)。结论ABM-MNCs移植至急性梗死心肌后,可在梗死区内及周边区存活,并可在周边区分化为具有心肌功能的细胞及血管内皮细胞,增加梗死周边...

目的探讨自体骨髓单核细胞(ABM-MNCs)移植至心肌梗死区及周边区后的存活、分化状况,以及对心功能的影响。方法将40只日本大耳雄兔随机分为细胞移植组和对照组各20只。采用结扎左冠状动脉前降支的方法建立急性心肌梗死(AMI)模型。细胞移植组于梗死后第6天于自体髂骨处抽取骨髓,分离得到单核细胞后,以Brdu标记,经心外膜注射到梗死区及周边区。对照组仅注射等量的生理盐水。移植6周后,进行组织学及免疫组织化学检查。结果移植后6周,两组动物的心功能均有改善,但两组间有显著性差异。Brdu标记示移植组梗死区内存在阳性染色的移植细胞,而周边区可见Brdu染色阳性的心肌细胞及血管内皮细胞。免疫荧光染色示梗死区内Brdu染色阳性的移植细胞抗心肌特异性肌动蛋白抗体阴性,而周边区内Brdu染色阳性的移植细胞抗心肌特异性肌动蛋白抗体阳性。对照组未发现Brdu染色阳性的细胞。移植组梗死周边区及远离梗死区的毛血管密度均高于对照组(P<0.05),但梗死区内的毛细血管密度两组间无显著性差异(P>0.05)。结论ABM-MNCs移植至急性梗死心肌后,可在梗死区内及周边区存活,并可在周边区分化为具有心肌功能的细胞及血管内皮细胞,增加梗死周边区的血管密度,改善心功能。

Objective To assess the efficacy and safety of autologous bone marrow mononuclear cells transplantation by intracoronary infusion in patients with AMI. Methods We studied 32 patients who underwent percutaneous coronary intervention (PCI) after AMI with NYHAⅡ- Ⅲ class. Thirty- two patients (21males and 11females) , who had AMI within previous four weeks, were divided into trial group and control group randomly. Normal saline or autologous bone marrow mononuclear cells (BM- MNCs) was infused into the...

Objective To assess the efficacy and safety of autologous bone marrow mononuclear cells transplantation by intracoronary infusion in patients with AMI. Methods We studied 32 patients who underwent percutaneous coronary intervention (PCI) after AMI with NYHAⅡ- Ⅲ class. Thirty- two patients (21males and 11females) , who had AMI within previous four weeks, were divided into trial group and control group randomly. Normal saline or autologous bone marrow mononuclear cells (BM- MNCs) was infused into the infarct related artery (IRA) through the guiding catheter after PCI in control group and trial group respectively. ECG, Holter, SPECT were assessed before PCI , 45d, 90d after that. Results (1) BM- MNCs was cultured and harvested by the method of Ficoll. 1.6×108- 5.8×108 (3.5±1.8×108) BM- MNCs were obtained and more than 92% cells were alive.(2)SPECT scan.Results showed that perfusion defect decreased 34.32% and 23.05% than base- line at 45d in trial and control group respectively (P<0.05).The perfusion defect decreased 14.77% and 3.82% at 90d than 45d in trial and control group respectively (P <0.05). (3)24 h electrocardiographic monitoring demonstrated that there was no difference in the occurrence of ventriarrhythmia or bradycardia before PCI, 45 and 90 d after that (P>0.05).Conclusions BM- MNCs transplantation by intracoronary infusion have some efficacy in patients with AMI and malignant arrhythmias is not increased.

目的研究自体骨髓单个核细胞梗死相关冠脉内移植治疗急性心肌梗死的临床疗效与安全性。方法入选32例NYHA心功能分级Ⅱ~Ⅲ级行择期PCI术的AMI患者,年龄32~77(48.8±15.2)岁,心肌梗死病史时间小于4周,女性11例,男性21例。随机分为对照组(PCI+NS)与试验组(PCI+BM-MNCs)。对照组与试验组在PCI术结束后分别通过大腔导管于梗塞相关血管注入NS与BM-MNCs。对所有患者于PCI术前,术后45d、90d行ECG、24h动态心电图、静息Te99mSPECT检查。结果①试验组用Ficoll密度梯度离心法获得单个核细胞1.6×108~5.8×108[(3.5±1.8)×108]个,细胞活性均大于92%。②试验组与对照组术后45d静息Te99mSPECT灌注缺损区面积较术前分别缩小34.32%和23.05%(P<0.05),且两组组内比较差异有统计学意义(P<0.05);试验组与对照组术后90d静息Te99mSPECT灌注缺损区面积较术后45d分别缩小14.77%和3.82%(P<0.05),但两组组内比较仅试验组差异有统计学意义(P<0.05)。③24hHolter监测,室性心律失常及心动...

目的研究自体骨髓单个核细胞梗死相关冠脉内移植治疗急性心肌梗死的临床疗效与安全性。方法入选32例NYHA心功能分级Ⅱ~Ⅲ级行择期PCI术的AMI患者,年龄32~77(48.8±15.2)岁,心肌梗死病史时间小于4周,女性11例,男性21例。随机分为对照组(PCI+NS)与试验组(PCI+BM-MNCs)。对照组与试验组在PCI术结束后分别通过大腔导管于梗塞相关血管注入NS与BM-MNCs。对所有患者于PCI术前,术后45d、90d行ECG、24h动态心电图、静息Te99mSPECT检查。结果①试验组用Ficoll密度梯度离心法获得单个核细胞1.6×108~5.8×108[(3.5±1.8)×108]个,细胞活性均大于92%。②试验组与对照组术后45d静息Te99mSPECT灌注缺损区面积较术前分别缩小34.32%和23.05%(P<0.05),且两组组内比较差异有统计学意义(P<0.05);试验组与对照组术后90d静息Te99mSPECT灌注缺损区面积较术后45d分别缩小14.77%和3.82%(P<0.05),但两组组内比较仅试验组差异有统计学意义(P<0.05)。③24hHolter监测,室性心律失常及心动过缓在术前,术后45d、90d同期两组间比较差异无统计学意义(P>0.05)。结论自体骨髓单个核细胞梗死相关冠脉内移植治疗急性心肌梗死有一定的疗效,并且不增加心律失常的发生率。

Objective To investigate the effects of emergent intracoronary autologous bone marrow mononuclear cell (BM-MNC) transplantation on left ventricular function and myocardium lesion area in patients with first acute inferior-wall myocardial infarction. Methods Forty patients with first onset of acute inferior-wall myocardial infarction, 28 males and 12 females, aged ≤75, treated with emergent percutaneous coronary intervention (PCI) were randomly divided into 2 equal groups: group undergoing intracoronary...

Objective To investigate the effects of emergent intracoronary autologous bone marrow mononuclear cell (BM-MNC) transplantation on left ventricular function and myocardium lesion area in patients with first acute inferior-wall myocardial infarction. Methods Forty patients with first onset of acute inferior-wall myocardial infarction, 28 males and 12 females, aged ≤75, treated with emergent percutaneous coronary intervention (PCI) were randomly divided into 2 equal groups: group undergoing intracoronary transplantation of autologous BM-MNC via a micro-catheter right after PCI (BM-MNC group), and control group receiving normal saline and heparin. Blood routine examination, myocardium zymogram, and serum high sensitive C reactive protein (hsCRP) were detected, and 24-hour dynamic electrocardiography, delayed-enhancement myocardial magnetic resonance imaging (CMR), and angiography of the coronary artery and left ventricle were conducted before the transplantation and immediately, 1 week, and 6 months after transplantation. Results CMR showed that 6 months later the left ventricular ejection fraction (LVEF) of the control group was 47.9%±6.7%, significantly higher than that 1 week later (43.4%±6.7%,P=0.001), and the LVEF of the BM-MNC group 6 months later was 51.5%±5.2%, significantly higher than that 1 week later (44.5%±7.1%,P=0.001;however, the absolute change of LVEF (△LVEF) of the BM-MNC group was 6.95% ±3.33%, significantly higher than that of the control group (4.05% ±1.68%,P=0.047). Six months later the myocardial lesion area of the BM-MNC group decreased more significantly in comparison with the control group. Nevertheless, there was no difference in change of left ventricular end diastolic volume (LVEDV) between these two groups. The serum hsCRP 48 h after transplantation of the BM-MNC group was 2.8 g/L±0.8 g/L, significantly lower than that before transplantation (13.4 g/L±3.6 g/L, P<0.001). ±No severe clinical events, such death, recurrent cardiac infarction, malignant arrhythmia, occur in these 2 groups. Conclusion Emergent intracoronary transplantation of autologous BM-MNC in patients with acute inferior-wall myocardial infarction improves the left ventricular function and myocardial infusion, minimizes the myocardial lesion area significantly.

目的采用前瞻性随机对照研究方法,评价经冠状动脉自体骨髓单个核细胞(BM-MNC)移植治疗急性下壁心肌梗死后6个月时患者心功能以及心肌缺血面积的变化。方法40例首次ST段抬高急性下壁心肌梗死患者,成功完成PCI术后,随机分为细胞移植组(n=20)和对照组(n=20),在急诊冠状动脉造影术同时,经微导管于梗死相关动脉内支架远端注入自体BM-MNC悬液或等量的肝素生理盐水。研究终点为术后6月时延迟增强核磁共振心肌灌注扫描(CMR)测定左室功能和心肌缺血面积。结果CMR记录左室射血分数(LVEF)、左室舒张末期容积(LVEDV)及心肌缺血面积的变化,结果显示与术前相比,两组患者LVEF均有显著提高(对照组47·9%±6·7%vs43·4%±6·7%,P=0·001;细胞移植组51·5%±5·2%vs44·5%±7·1%,P=0·001)。但细胞移植组患者LVEF升高程度(△LVEF)增加明显高于对照组LVEF改善程度(6·95%±3·33%vs4·05%±1·68%,P=0·047),且细胞移植组患者心肌缺血面积减少程度优于对照组,两组间左室舒张末容积变化未见明显差别。结论急性下壁心肌梗死患者经冠状动脉内自体骨髓单个...

目的采用前瞻性随机对照研究方法,评价经冠状动脉自体骨髓单个核细胞(BM-MNC)移植治疗急性下壁心肌梗死后6个月时患者心功能以及心肌缺血面积的变化。方法40例首次ST段抬高急性下壁心肌梗死患者,成功完成PCI术后,随机分为细胞移植组(n=20)和对照组(n=20),在急诊冠状动脉造影术同时,经微导管于梗死相关动脉内支架远端注入自体BM-MNC悬液或等量的肝素生理盐水。研究终点为术后6月时延迟增强核磁共振心肌灌注扫描(CMR)测定左室功能和心肌缺血面积。结果CMR记录左室射血分数(LVEF)、左室舒张末期容积(LVEDV)及心肌缺血面积的变化,结果显示与术前相比,两组患者LVEF均有显著提高(对照组47·9%±6·7%vs43·4%±6·7%,P=0·001;细胞移植组51·5%±5·2%vs44·5%±7·1%,P=0·001)。但细胞移植组患者LVEF升高程度(△LVEF)增加明显高于对照组LVEF改善程度(6·95%±3·33%vs4·05%±1·68%,P=0·047),且细胞移植组患者心肌缺血面积减少程度优于对照组,两组间左室舒张末容积变化未见明显差别。结论急性下壁心肌梗死患者经冠状动脉内自体骨髓单个核细胞移植,可显著长期改善患者左室收缩功能和心肌灌注,减少心肌缺血面积。

 
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