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   (sds) 的翻译结果: 查询用时:0.306秒
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    The SDS-PAGE showed E.
    SDS-PAGE结果表明,出现了可溶性的表达产物。
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The subcutaneous administration of sodium dimercaptosuccinate (SDS) at a dose of 1500 mg/kg immediately after the intraperitoneal injection of trivalent antimonyl ammonium gluconate (AAG) increased the LD_(50) of the latter from 90—112 mg/kg to 1300—1460 mg/kg. The acute toxicity of the latter when injected intravenously in rabbits was also decreased when SDS was administered via the same route. Two hours after the intravenous injection of AAG (containing radioactive antimony) in rabbits, high radioactivity...

The subcutaneous administration of sodium dimercaptosuccinate (SDS) at a dose of 1500 mg/kg immediately after the intraperitoneal injection of trivalent antimonyl ammonium gluconate (AAG) increased the LD_(50) of the latter from 90—112 mg/kg to 1300—1460 mg/kg. The acute toxicity of the latter when injected intravenously in rabbits was also decreased when SDS was administered via the same route. Two hours after the intravenous injection of AAG (containing radioactive antimony) in rabbits, high radioactivity level was found in the liver. The levels in the spleen and the thyroid were very low. Intravenous administration of SDS immediately after the antimonyl decreased the radioactivity level in the liver. Fifteen minutes after the AAG injection, plasma radioactivity was 1.4—1.6 times the radioactivity in the blood cells. When SDS was also administered, the plasma level was 3.4—27.4 times as high as the level in the cells. Kidney was found to be the main route of excretion of antimony in rabbits. When SDS was used after AAG, about 96% of the administered dose of antimony was excreted in 72 hours, whereas only 36% was excreted in the same period if AAG was administered without SDS.

皮下注射二巯基丁二酸钠1500毫克/千克,司将小鼠一次腹腔注射锑铵的半数致死量从90—112毫克/千克提高至1300—1460毫克/千克。静脈注身锑~(124)铵予家兔後,如立刻经同一途径注射二巯基丁二酸钠,亦可降低锑铵的急性毒性。二巯基丁二酸钠的解毒机制为阻止血锑进入组织,减少锑在部分组织中的含量及增加锑自尿排泄的速度。锑主要自尿排出,用二巯基丁二酸钠後,72小时内锑由尿排出给药量的96%,而对照组动物在同时间内仅有36%由尿排出。

The present study is undertaken to compare the physico-chemical properties of foetal AFP and cancerous AFP of the liver purified by immunoadsorbent column with antibody specific to human AFP. For the AFP's from these two sources, it is found that the U. V. absorption maxima occured at 278 nm, their extinction coefficients, E_(1cm)~(1%), were 5.20±0.06 and their molecular weights, 71000. Two AFP fractions are observed in isoelectric focusing with pI's at 4.7 and 5.25±0.05. At 75.5℃ the kinetic constants of thermal...

The present study is undertaken to compare the physico-chemical properties of foetal AFP and cancerous AFP of the liver purified by immunoadsorbent column with antibody specific to human AFP. For the AFP's from these two sources, it is found that the U. V. absorption maxima occured at 278 nm, their extinction coefficients, E_(1cm)~(1%), were 5.20±0.06 and their molecular weights, 71000. Two AFP fractions are observed in isoelectric focusing with pI's at 4.7 and 5.25±0.05. At 75.5℃ the kinetic constants of thermal in activation for immunochemical activity are as follows: the rate constant of inactivation (k) 7.29×10~(-5) sec~(-1), the free energy of activation (E~+) 95.4 KCal·Mole~(-1), the enthalpy of activation (△H~+) 94.7 K Cal·Mole~(-1), and the entropy of activation (△S~≠) 193 Cal·Mole~(-1). Degree~(-1). From evidence furnished by SDS-polyacrylamide electrophoresis it appears most likely that both foetal AFP and cancerous AFP consist of single polypeptide chains. Their amino acid compositions are very much alike and their S-S bonds play a very important role in maintaining the immunochemical activity of AFP. Both GNBr-cleft AFP samples give 7 main peptide-fragments and corresponding peptides have closely similar molecular weights. From the above mentioned results it may be concluded that no differences in the nature of these two AFP's have been observed.

本文比较了胎儿AFP和肝癌AFP的物理化学性质,所测指标未发现本质差异。实验测得紫外吸收峰在278毫微米,消光系数E_(1厘米)~(1%)5.20±0.06。分子量71000左右。等电聚焦观察到AFP至少有两种形式,pI值分别为4.7和5.25±0.05。75.5℃热失活动力学参数:失活速度常数k7.29x10~(-5)秒~(-1),活化能E~≠95.4千卡/克分子,活化热焓ΔH~≠94.7千卡/克分子,活化自由能ΔF~≠27.2千卡/克分子,活化熵ΔS~≠193卡/度·克分子。分子量为71000的AFP分子可能由一条多肽链组成,二硫键对维持其免疫化学活性起重要作用,溴化氰裂解可得到分子量不等的七个多肽片段。

The chemical composition and the enzymatic activities of normal and silicotic alveolar macrophages were compared in order to investigate the changes occurring after the introduction of quartz into the lung. As shown from the SDS-PAGE results, the protein composition of the silicotic alveolar macrophages was different from the normal in three places. Two protein lines showed increased intensity and one protein line was absent from the gel of the silica containing cells.The lecithin and lysolecithin contents...

The chemical composition and the enzymatic activities of normal and silicotic alveolar macrophages were compared in order to investigate the changes occurring after the introduction of quartz into the lung. As shown from the SDS-PAGE results, the protein composition of the silicotic alveolar macrophages was different from the normal in three places. Two protein lines showed increased intensity and one protein line was absent from the gel of the silica containing cells.The lecithin and lysolecithin contents were both increased in the silicotic macrophages. The presence of an increased amount of lysolecithin may indicate that the cells were destroyed by the quartz.The acid phosphatase actvity and the oxygen consumption of the silica containing cells were both lower than normal cells.After treatment of the silicotic rats with PVNO, the composition and the enzymatic activities of the macrophages were all returned to the normal level. This shows that PVNO protects the alveolar macrophages from destruction by the quartz particles. Other drugs tested also showed some protective effect on the cells.

文中比较了正常大鼠与矽肺大鼠肺泡巨噬细胞中蛋白质与磷脂的组成,以及酸性磷酸酶活性与耗氧量的差别。根据SDS-PAG电泳的结果看到矽肺大鼠肺泡巨噬细胞的蛋白质区带比正常者多两条,但缺少了一条分子量较小的区带。矽肺大鼠肺泡巨噬细胞中含有大量卵磷脂,说明石英能引起肺表面活性物增多。同时,溶血卵磷脂也比正常者明显地增多,酸性磷酸酶活性与耗氧量均比正常者低,这些都说明石英改变了细胞的组成,破坏了细胞的功能。用克矽平(PVNO)治疗过的大鼠肺泡巨噬细胞的化学组成及酶活性都与正常者近似,证明此药能保护巨噬细胞防止被石英破坏。津_5、山梨醇铝等药物对细胞也表现有不同程度的保护作用。

 
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