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diclofenac acid
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  双氯芬酸
     Methods: The chondrocyte and synoviocyte monolayer were stimulated and cotreatment with IL 1β, TGF β 1, TNF α, diclofenac acid, dexamethasone and doxycycline, for 72 h.
     方法 :以白介素 1β(IL- 1β)、转化生长因子 β1 (TGF- β1 )、肿瘤坏死因子 α(TNF- α)、双氯芬酸钠、多西环素和地塞米松分别处理骨关节炎患者的单层软骨细胞和滑膜细胞 72 h。
短句来源
     Methods The chondrocyte and synoviocyte monolayer was stimulated with IL 1β,TGF β 1,TNF α,diclofenac acid,dexamethasone and doxycycline individually for 72 hours.
     方法 骨关节炎患者的单层软骨细胞和滑膜细胞均以白细胞介素 1β、转化生长因子 β1、肿瘤坏死因子 α、双氯芬酸钠、多西环素和地塞米松分别处理 72h。
短句来源
     Conclusion: Diclofenac acid choline eye drops can inhibit synthexsis and release of prostaglandin in eyes.
     结论 :双氯芬酸胆碱滴眼液可抑制眼局部前列腺素的合成与释放 ,从而发挥抗炎作用 ,发展前景较好。
短句来源
     Methods:The effects of diclofenac acid choline eye drops (1.0 g/L) were observed by using the eye inflammatiory model owing to stabbing the rabbits eyes loculus and AA irritating.
     方法 :采用兔眼前房穿刺和花生四烯酸 (简称AA)刺激眼前部炎症模型 ,对 1 0g/L双氯芬酸胆碱滴眼液局部抗炎作用进行了研究。
短句来源
     The experiments showed that the stimulation of diclofenac acid lysine to rabbit's eyes was lower than that of diclofenac sodium(P<0.01).
     刺激性实验结果表明:本品对免眼结膜的刺激性明显低于双氯芬酸钠(P<0.01)。
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  “diclofenac acid”译为未确定词的双语例句
     Diclofenac arginine salt was prepared by reacting diclofenac acid with arginine and its absorbance was determined by ultraviolet spectrophotometer at λ_(max)~(MeOH) 282nm. The calculated content of diclofenac arginine salt was 94.87%.
     用精氨酸制成双氯灭痛精氨酸盐,然后用紫外分光光度计在λ_(max)~(MeOH)282nm处测定吸收度,计算含量结果为94.87%。
短句来源
     Synthesis of diclofenac acid lysine
     双氯芬酸赖氨酸盐的研制
短句来源
     The Preparation of Diclofenac Acid Lysinel Slow Release Tablets
     双氯芬酸赖氨酸盐缓释片制备工艺的研究
短句来源
  相似匹配句对
     Synthesis of diclofenac acid-choline
     双氯芬酸胆碱的研制
短句来源
     Synthesis of diclofenac acid lysine
     双氯芬酸赖氨酸盐的研制
短句来源
     Acid Deposition
     酸性降水
短句来源
     The Super Acid
     超强酸
短句来源
     SYNTHESIS OF DICLOFENAC SODIUM
     二氯芬酸钠的合成
短句来源
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  diclofenac acid
A chemical reaction forming diclofenac acid might occur on the surface of the sodium diclofenac compact during exposure to the acidic medium, which was confirmed by diffuse-reflectance spectroscopy.
      
Our patient suffered excruciating pain despite receiving diclofenac acid, naprosyn, and codeine phosphate for weeks.
      


Diclofenac arginine salt was prepared by reacting diclofenac acid with arginine and its absorbance was determined by ultraviolet spectrophotometer at λ_(max)~(MeOH) 282nm. The calculated content of diclofenac arginine salt was 94.87%.

用精氨酸制成双氯灭痛精氨酸盐,然后用紫外分光光度计在λ_(max)~(MeOH)282nm处测定吸收度,计算含量结果为94.87%。

OBJECTIVE:To study diclofenac acid lysine for a new diclofenac acid salt with less stimulation than diclofenac sodium salt.METHODS:Uniform design was used to get the best synthetic conditions,and spectral and elementary analyses to identify the product.The rabbit's eyes were used in stimulative experiments.RESULTS:The best synthetic line was obtained through uniform design researches,with a yield up to 77.6%(purity above 98%).The product,with a molecular formula of C 20 H 25 O 4N...

OBJECTIVE:To study diclofenac acid lysine for a new diclofenac acid salt with less stimulation than diclofenac sodium salt.METHODS:Uniform design was used to get the best synthetic conditions,and spectral and elementary analyses to identify the product.The rabbit's eyes were used in stimulative experiments.RESULTS:The best synthetic line was obtained through uniform design researches,with a yield up to 77.6%(purity above 98%).The product,with a molecular formula of C 20 H 25 O 4N 3Cl 2,was identified on the basis of spectral data(UV,IR,MS, 1HNMR, 13 CNMR and DEPT).The experiments showed that the stimulation of diclofenac acid lysine to rabbit's eyes was lower than that of diclofenac sodium(P<0.01).CONCLUSION:The irritating of diclofenac acid lysine to rabbit's eyes is less than that of diclofenac sodium salt.Its synthetic line,easy and rapid,has high yield,and no industrial pollution.

目的为减轻双氯芬酸钠的刺激性,研制合成氯芬酸赖氨酸盐,以扩大其应用。方法采用均匀设计方法研究从优化双氯芬酸赖氨酸盐的合成条件;采用四大学谱和元素分析法鉴定其结构;采用兔眼结膜法进行刺激性实验。结果:均匀设计法预测出最佳合成条件,并依此对其优化验证,得率为77.6%(纯度98%以上);产品分子式为C20H25Q4N3Cl2,经UV,IR,MS,1HNMR,13CNMR,DEPT及元素分析确定无疑;刺激性实验结果表明:本品对免眼结膜的刺激性明显低于双氯芬酸钠(P<0.01)。结论:双氯芬酸赖氨酸盐的刺激性明显较双氯芬酸钠小,而且合成工艺简单、快速、得率高、无污染,适于推广使用和大批量生产

OBJECTIVE:To study the diffusive properties of diclofenac sodium in gel systems and the effect on diffusive rate of diclofenac sodium through the skin of mice.METHODS:Regression method was used to analyze cumulative amounts of diclofenac sodium penetrated from carbopol and calcium alginate gel in acidic and basic conditions.RESULTS:The diffusive rate of diclofenac sodium from the two kinds of hydrophilic polymer gel was higher than that of diclofenac acid.The penetrative rate of diclofenac acid was...

OBJECTIVE:To study the diffusive properties of diclofenac sodium in gel systems and the effect on diffusive rate of diclofenac sodium through the skin of mice.METHODS:Regression method was used to analyze cumulative amounts of diclofenac sodium penetrated from carbopol and calcium alginate gel in acidic and basic conditions.RESULTS:The diffusive rate of diclofenac sodium from the two kinds of hydrophilic polymer gel was higher than that of diclofenac acid.The penetrative rate of diclofenac acid was greater than that of diclofenac sodium in calcium alginate gel.The penetrative rate of diclofenac acid was smaller than that of diclofenac sodium in carbopol.The penetrative rate of diclofenac through the skin of mice was enhanced inconsiderably by azone in the vehicle.Especially for that of diclofenac sodium as ion pair form in carbopol gel,the enhancement ratio was only 1.17 .

目的:研究双氯芬酸钠在凝胶贮库中的扩散特征及其对双氯芬酸钠透皮扩散速率的影响。方法:以改良的 Franz 扩散池为实验装置,回归分析双氯芬酸钠在二种凝胶基质、共十二种条件下经微孔滤膜或透过离体小鼠皮的累积透过量。结果:在亲水的高分子凝胶基质中,离子形式的双氯芬酸钠扩散速率大于分子形成的扩散速率。经皮扩散时,分子形式的双氯芬酸钠在海藻酸凝胶中的扩散速率大于离子形式的扩散速率;在卡波普凝胶中结果则相反。双氯芬酸钠从含有月桂氮苷卓酮的凝胶中透皮扩散的速率比从相应没有月桂氮苷卓酮的凝胶中透皮扩散的速率有所增加,但增加的程度不明显。特别是当卡波凝胶中是离子形式的双氯芬酸钠时,其有无促透剂的24 h 累积透过量之比值只为1 .17 。

 
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