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susceptible rates
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  敏感率
    Results 29 strains were all multidrug resistant. The susceptible rates to piperacillin/tazobactam and amikacin were 69.7% and 60.6% respectively.
    结果29株细菌均为多重耐药株,11种常用抗菌药物中,仅对哌拉西林/三唑巴坦和阿米卡星敏感率较高,分别为69.7%和60.6%。
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  susceptible rates
The non-susceptible rates for chloramphenicol, and co-trimoxazole were similar for the two groups.
      


Objective To investigate the resistance and homology of imipenem-resistant Pseudomonas aeruginosa and its metallo-β-lactamases type.Methods Agar dilution method was used to determine the minimal inhibitory concentrations(MIC) of 29 strains of imipenem-resistant Pseudomonas aeruginosa collected from Tongji Hospital from January to September,2004.The metallo-β-lactamases produced by these strains were typed by the modified Hodge test,double-disk synergy test,polymerase chain reaction and sequence analysis methods.The...

Objective To investigate the resistance and homology of imipenem-resistant Pseudomonas aeruginosa and its metallo-β-lactamases type.Methods Agar dilution method was used to determine the minimal inhibitory concentrations(MIC) of 29 strains of imipenem-resistant Pseudomonas aeruginosa collected from Tongji Hospital from January to September,2004.The metallo-β-lactamases produced by these strains were typed by the modified Hodge test,double-disk synergy test,polymerase chain reaction and sequence analysis methods.The metallo-β-lactamase activity was determined spectrophotometrically.Results 29 strains were all multidrug resistant.The susceptible rates to piperacillin/tazobactam and amikacin were 69.7% and 60.6% respectively.Two strains produced VIM-2 metallo-β-lactamases.Conclusion The prevalence of imipenem-resistant Pseudomonas aeruginosa was due to nosocomial infection.The prevalent strains were multi-drug resistant.

目的了解耐亚胺培南铜绿假单胞菌对其它抗菌药物的耐药性及其产金属β-内酰胺酶的类型。方法收集同济医院2004年1月~9月耐亚胺培南铜绿假单胞菌29株,琼脂稀释法测定最低抑菌浓度(MIC);通过改良Hodge试验、双纸片协同试验(DDST)、聚合酶链反应(PCR)、序列分析等方法分析金属β-内酰胺酶类型,紫外分光光度法测定金属β-内酰胺酶的活性。结果29株细菌均为多重耐药株,11种常用抗菌药物中,仅对哌拉西林/三唑巴坦和阿米卡星敏感率较高,分别为69.7%和60.6%。29株菌中有2株产VIM-2金属β内酰胺酶(6.9%)。结论本院耐亚胺培南铜绿假单胞菌流行主要为医院感染所致,且呈多重耐药,有2株发现产VIM-2型金属β-内酰胺酶。

 
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