Two compounds FW635I1 and FW635I2 with immunosuppressive activities were extracted by organic solvents from the culture broth and purified by silica gel column chromatography and high speed counter current chromatography. The structures of the two compounds were determined by physico-chemical properties and spectral analyses,the biological activities were assayed in vitro.
The results of preliminary pharmacological test showed that the activities of three compounds(I_1,I_8 and I_ 10)were stronger than aminoguanidine,especially for compound I_1.
RESULT:Ten compounds were isolated and identified as nigaichigoside F1(1),nigaichigoside F2(2),Chebuloside Ⅱ(3),7α-hydroxy-sitosterol(4),7β-hydroxysitosterol(5),pagoside(6),procumboside(7),β-sitosterol(8),trans-cinnamic acid(9)and fructose(10).
STUDIES ON VITAMIN D Ⅱ.THE SYNTHESIS OF COMPOUNDS OF 2-SUBSTITUTED CIS-CYCLOHEXYLIDENE ACETIC ACID TYPE (I)2, 2-DIHYDROXY-CYCLOHEXYLIDENE ACETIC ACID LACTONE AND ITS ISOMERS
STUDIES ON VITAMIN D Ⅳ. THE SYNTHESIS OF COMPOUNDS OF 2-SUBSTITUTED CISCYCLOHEXYLIDENE ACETIC ACID TYPE (3) 2-HYDROXYMETHYL-CIS-CYCLOHEXYLIDENE ACETIC ACID AND MANNICH-BRAUN COMPOUND
Isolation of the natural products from the stems of Jatropha maheshwarii yielded 5 compounds such as Friedelin (0.16%), epi-friedelinol (0.12%), n-octacosanol (0.11%), β-sitosterol (0.2%), and β-sitosterol-3-β-D-glucopyranoside (0.24%).
Guanidine-like compounds have been investigated since the first observations of their therapeutic potential some 30 years ago in fields of cancer and virology.
Guanidine-type compounds that reached clinical status include amongst others the potassium channel opener, pinacidil and the histamine H2-receptor antagonists (e.g.
A new method for the biological assay of vegetable purgatives based on the numbers of wet faeces excreted by groups of mice after dosing is described. The relation of the number of wet faeces per group of mice to the logarithm of the dose was found to be linear. A cage has been specially designed for this assay and it has been found advantageous to incorporate a definite proportion of water in the diet during test. 40 mice divided equally into 4 groups were used in each assay. 2 groups received the standa...
In view of the necessity of a rapid and accurate process for the deter-mination of fluorine applicable in the analysis of sodium fluoride and otherfluorine compounds,the author has established a new volumetric processconsisting in the titration in aqueous-alcoholic medium with ferric nitrate asstandard solution and sodium salicylate as indicator.All of the methods,published by Guyot,Greeff,Fairchild andVisintin proposed for the determination of fluorine using ferric solutionas standard,are based on th...
Six new compounds, namely, diacetone glucose monopalmitate, diacetone glucose monostearate, D-glucose monopalmitate, D-glucose monostearate, D-glucose tetraacetate monopalmitate,and D-glucose tetraacetate monostearate, have been synthesized and some of their properties have been described. Monoesters of glucose and higher fatty acids have been shown to be surface-active and possess good emulsifying property. Both D-glucose monopalmitate and monostearate exhibit polymorphism and each compotmd exists in...