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   p 53 genes 在 内分泌腺及全身性疾病 分类中 的翻译结果: 查询用时:1.835秒
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  “p 53 genes”译为未确定词的双语例句
    Mutations and Polymorphisms of the P Gene Associated With Oculocutaneous Albinism TypeⅡ
    眼皮肤白化病Ⅱ型相关的P基因突变与DNA多态性
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    Objective To study the microsatellitepolymorphism of tumor necrosis factor P gene(TNFc)In Grav es' Disease, to analyse the association between TNFc polymor phism and the susceptibility in Graves' Disease, and to further explore the mechanism in Graves' Disease.
    目的 研究Graves病患者TNF(tumornecrosis factor)β基因的微卫星多态性(TNFc),分析TNFc与Graves病发病的关联,进一步探讨Graves病的发病机制。
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    Results Compared with health controls, the frequency of X and P gene in female patients with RA were significantly increased (P<0.05).
    结果女性RA患者的ER基因X、P基因频率均明显高于健康对照组,ER基因的XX和PP基因亚型的阳性率分别高于正常对照组(P<0.05)。
短句来源
    It is caused by mutations in the P gene,which is located on chromosome 15q11.1-q12 and divided into 24 exons and 23 introns.
    P基因为其致病基因,定位于15q11.1-q12,由24个外显子和23个内含子构成。
短句来源
    P gene codes for 838-amino-acid integral membrane protein with 12 putative transmembrane domains,but the exact function is not clear yet.
    P基因编码838个氨基酸残基构成的110 KDa跨膜蛋白,该蛋白含12个跨膜区,其确切功能尚未完全清楚。
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  p genes
The objective was to relate the response of the HSP70 and P53 genes to the cessation and the recovery of cardiac muscle cell functions when submitted to ischemia-reperfusion.
      
Comparative study of the expression Rb and p53 genes in human colorectal cancers, color carcinoma cell lines and synchronized hu
      
Comparative study of the expression of Rb and p53 genes in human colorectal cancers, colon carcinoma cell lines and synchronized
      
Concurrent abnormal expression of ERBB-2, EGFR, and p53 genes and clinical disease progression of breast carcinoma
      
These p53 genes were individually mutated at amino acid residues 143, 175, 248 and 273.
      
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AIM: To investigate the effect of parathyroid hormone (PTH) on gene transcription of transforming growth factor-β1 (TGF-β1) in rat osteoblast(ROB). METHODS: The ROB were cultured with 3 kinds of treatment: (1) control (Ctr), the cells were cultured without PTH at either the first 6 h and subsequent 42 h in an 48-hour cycle; (2) intermittent exposure to FTH(Itm), the cells were cultured with PTH at the first 6 h, but without PTH at subsequent 42 h; (3)continuou3 exposure to PTH(Ctu), the cells were cultured...

AIM: To investigate the effect of parathyroid hormone (PTH) on gene transcription of transforming growth factor-β1 (TGF-β1) in rat osteoblast(ROB). METHODS: The ROB were cultured with 3 kinds of treatment: (1) control (Ctr), the cells were cultured without PTH at either the first 6 h and subsequent 42 h in an 48-hour cycle; (2) intermittent exposure to FTH(Itm), the cells were cultured with PTH at the first 6 h, but without PTH at subsequent 42 h; (3)continuou3 exposure to PTH(Ctu), the cells were cultured with PTH at either the first 6 h and subsequent 42 h. Cellular TGF-β, mRNA contents at the 3rd cycle were determined by reverse transcrip-tase-polymerase chain reaction(RT-PCR) . RESULTS: The flunctuations of TGF-β1 mRNA contents in various groups at the 3rd cycle were as follows: at 6 h, the TGF-β1 mRNA content of Itm was the highest, while those of Ctr and Ctu were similar; at 24 h, that of Itm was the highest and that of Ctu the lowest; at 48h, those of Itm and Ctr were similar, while that of Ctu were the lowest CONCLUSION: Both the intermittent and continuous exposure to PTH can markedly affect TGF-β1 gene transcription, the enhanced TGF-P| gene transcription might be one of the mechanisms for PTH to promote bone formation.

目的:探讨甲状旁腺激素(PTH)对大鼠成骨细胞(ROB)的转化生长因子-β1-(TGF-β1)基因转录的影响。方法:ROB被分成3组培养:(1)对照组,在每个培养周期(48h)的前6h和后42h的培养液中均不加PTH;(2)PTH间歇刺激组(间刺组),仅在前6h的培养液中加PTH;(3)PTH持续刺激组(持刺组),前6h和后42h的培养液中均加PTH。第3周期细胞内mRNA含量用RT-PCR测定。结果:第3周期细胞内mRNA含量变化情况为:第6小时以间刺组最高,其余二组相似;第24小时依次是间刺组>对照组>持刺组;第48小时间刺组与对照组相似,持刺组最低。结论:PTH间歇与持续刺激对TGF-β1基因转录均有明显影响,该基因转录增强可能是PTH间歇刺激促成骨机制之一。

Objective To investigate the estrogen receptor (ER) gene polymorphisms in female patients with rheumatoid arthritis (RA). To study the relationship between the ER gene subtypes and HLA-DRβ1*04 genotype, rheumatoid factor, clinical features of rheumatoid arthritis. Methods XbaⅠ and PvuⅡrestriction fragment length polymorphisms of ER gene were analysed in 81 female patients with RA and 146 female controls. ER gene typing was preformed using PCR-RELP techniques. The clinical features,...

Objective To investigate the estrogen receptor (ER) gene polymorphisms in female patients with rheumatoid arthritis (RA). To study the relationship between the ER gene subtypes and HLA-DRβ1*04 genotype, rheumatoid factor, clinical features of rheumatoid arthritis. Methods XbaⅠ and PvuⅡrestriction fragment length polymorphisms of ER gene were analysed in 81 female patients with RA and 146 female controls. ER gene typing was preformed using PCR-RELP techniques. The clinical features, RF and HLA-DRβ1*04 genotyp between different motif of ER gene were analyzed. Results Compared with health controls, the frequency of X and P gene in female patients with RA were significantly increased (P<0.05). The frequency of XX and PP genotype of ER gene were higher in RA female patients than those in normal controls, while the frequency of xx genotype were lower than those in normal controls (P<0.05). The frequency of XXPP genotype of ER gene polymorphisms were significantly increased, while the frequency of xxpp genotype were significantly decreased (P<0.05). The positive rate of HLA-DRβ1*04 genotype in the patients with PP genotype was higher than pp genotype and Pp genotype (P<0.05). The number of joint involved increased in the patients with pp genotype? XXpp and xxPP genotype (P<0.05). Conclusion The results suggest that X and P genotype are significantly increased in female patients with RA in China. The XX, PP and XXPP genotype of ER gene may be associated with RA in the female patients. The ER-PP genotype may have closely relationship with HLA-DRβ1*04 genotype. The arthropathy severity of RA is related to the ER-pp, XXpp and xxPP genotype.

目的分析雌激素受体(ER)基因XbaⅠ和PvuⅡ酶切多态性在女性类风湿关节炎(RA)中的分布,探讨其与人类白细胞抗原(HLA)-DRβ1*04基因亚型、类风湿因子(RF)以及RA患者临床表现的关系。方法采用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)技术,对81例女性RA患者和146名女性正常对照者的ER基因(XbaⅠ、PvuⅡ位点)进行分型,并计算基因分布频率。分析患者的HLA-DRβ1*04基因亚型、RF以及临床表现与ER基因多态性之间的关系。结果女性RA患者的ER基因X、P基因频率均明显高于健康对照组,ER基因的XX和PP基因亚型的阳性率分别高于正常对照组(P<0.05)。而RA患者的xx基因亚型的阳性率明显低于健康对照组(P<0.05)。RA患者XXPP基因型的阳性率明显高于健康对照组,而xxpp基因型的阳性率明显低于健康对照组(P<0.05)。携带PP基因型的RA患者HLA-DRβ1*04基因亚型的阳性率明显升高(P<0.05)。ER基因中pp基因型、XXpp和xxPP基因型的患者关节受累数明显增高(P<0.05)。结论女性RA患者ER基因的X和P的基因频率表达明显增高。ER基因酶切多态性...

目的分析雌激素受体(ER)基因XbaⅠ和PvuⅡ酶切多态性在女性类风湿关节炎(RA)中的分布,探讨其与人类白细胞抗原(HLA)-DRβ1*04基因亚型、类风湿因子(RF)以及RA患者临床表现的关系。方法采用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)技术,对81例女性RA患者和146名女性正常对照者的ER基因(XbaⅠ、PvuⅡ位点)进行分型,并计算基因分布频率。分析患者的HLA-DRβ1*04基因亚型、RF以及临床表现与ER基因多态性之间的关系。结果女性RA患者的ER基因X、P基因频率均明显高于健康对照组,ER基因的XX和PP基因亚型的阳性率分别高于正常对照组(P<0.05)。而RA患者的xx基因亚型的阳性率明显低于健康对照组(P<0.05)。RA患者XXPP基因型的阳性率明显高于健康对照组,而xxpp基因型的阳性率明显低于健康对照组(P<0.05)。携带PP基因型的RA患者HLA-DRβ1*04基因亚型的阳性率明显升高(P<0.05)。ER基因中pp基因型、XXpp和xxPP基因型的患者关节受累数明显增高(P<0.05)。结论女性RA患者ER基因的X和P的基因频率表达明显增高。ER基因酶切多态性分析中,XX、PP及XXPP基因型可能与女性RA的易感性相关。PP基因型可能与HLA-DRβ1*04基因有一定的相关性,pp基因型、XXpp和xxPP基因型可能与RA关节病变的程度相关。

Oculocutaneous albinism typeⅡ(OCA2),the most common type of albinism,is an autosomal recessive disorder.It is caused by mutations in the P gene,which is located on chromosome 15q11.1-q12 and divided into 24 exons and 23 introns.P gene codes for 838-amino-acid integral membrane protein with 12 putative transmembrane domains,but the exact function is not clear yet.There are at least 60 pathologic mutations and 43 non-pathologic polymorphisms have been found.The pathologic mutations include missense...

Oculocutaneous albinism typeⅡ(OCA2),the most common type of albinism,is an autosomal recessive disorder.It is caused by mutations in the P gene,which is located on chromosome 15q11.1-q12 and divided into 24 exons and 23 introns.P gene codes for 838-amino-acid integral membrane protein with 12 putative transmembrane domains,but the exact function is not clear yet.There are at least 60 pathologic mutations and 43 non-pathologic polymorphisms have been found.The pathologic mutations include missense mutations,nonsense mutations,frameshift mutations and splice-sit mutations.But unlike TYR gene,most of P gene mutations are located on the C-terminal and don′t cluster in defined regions.It is difficult to define the pathologic mutations since many non-pathologic polymorphisms also lie in exons.Some non-pathologic missense mutations may be associated with phenotypic variation in normally pigmented individuals and need to further study.

眼皮肤白化病Ⅱ型(OCA2)是白化病中最常见的类型,呈常染色体隐性遗传。P基因为其致病基因,定位于15q11.1-q12,由24个外显子和23个内含子构成。P基因编码838个氨基酸残基构成的110 KDa跨膜蛋白,该蛋白含12个跨膜区,其确切功能尚未完全清楚。迄今至少已报道P基因内60种导致OCA2的病理性突变和43种多态性变异。病理突变主要为错义突变、无义突变、移码突变和剪切位点突变,多数位于肽链的C末端,但并不象OCA1的TYR基因突变那样多成簇出现。P基因多态性变异中的大部分位于外显子,这增加了对致病性突变定义的难度,其中一些导致氨基酸替换的多态性变异可能与正常人色素沉着的表型变异有关,值得进一步研究。

 
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