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acute ischemic stroke ais
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     There are controversies in the anticoagulation therapy of acute ischemic stroke (AIS).
     急性缺血性卒中的抗凝治疗存在着很大的争议。
短句来源
     Thrombolytic therapy for acute ischemic stroke
     急性缺血性卒中溶栓治疗
短句来源
     The intraarterial thrombolysis in acute ischemic stroke
     急性缺血性脑梗死的动脉溶栓治疗
短句来源
     Ischemic Penumbra and Acute Ischemic Stroke
     缺血性半暗带与急性缺血性中风
短句来源
     Thrombolytic Therapy for Acute Ischemic Stroke
     急性缺血性卒中的溶栓治疗
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  acute ischemic stroke ais
Heparin is a classic anticoagulant that is commonly used in the treatment of acute ischemic stroke (AIS).
      
Acute ischemic stroke (AIS) is a significant cause of death and disability in the United States.
      
In the USA, recombinant tissue plasminogen activator (rt-PA) has been approved for therapy of acute ischemic stroke (AIS) within a 3 hour time window based on the results of the NINDS [1] trial.
      


Objective To investigate the gene frequencies of 5 major human platelets alloantigens (HPA 1 5) in Chinese population and to assess if polymorphism of HPA is associated with acute myocardial infarction (AMI) and acute ischemic stroke (AIS) in the Chinese. Methods HPA 1 5 genotyping was performed with PCR using allele specific primers and restriction enzyme digestion based on PCR products in 95 AMI patients, 188 AIS patients and 270 normal controls. Gene frequency distribution...

Objective To investigate the gene frequencies of 5 major human platelets alloantigens (HPA 1 5) in Chinese population and to assess if polymorphism of HPA is associated with acute myocardial infarction (AMI) and acute ischemic stroke (AIS) in the Chinese. Methods HPA 1 5 genotyping was performed with PCR using allele specific primers and restriction enzyme digestion based on PCR products in 95 AMI patients, 188 AIS patients and 270 normal controls. Gene frequency distribution was tested by Hardy Weinberg equilibrium. Comparisons of HPA gene frequencies between the patient and control groups were made by χ 2 test. Results The gene frequencies of HPA 1 5 were listed as follows: HPA1a, 91%; HPA 1b, 9%; HPA 2a, 94%; HPA 2b, 6%; HPA 3a, 83%; HPA 3b, 17%; HPA 4a, 98%; HPA 4b, 2%; HPA 5a, 97%; HPA 5b, 3%. No significant differences were found in HPA 1 5 gene frequencies between AMI patients and normal controls. In AIS patient group, HPA 2a allele frequency was significantly higher than that in controls, but this allele gene frequency in the two groups was very close (0.99 and 0.94, respectively) and too many subjects in the two groups were overlapped. No differences were found in the other 4 HPA systems between patients and controls. Conclusion Polymorphism of HPA is not an inherited risk factor and is not associated with Chinese arterial thrombotic diseases, such as AMI and AIS.

目的 探讨湖南地区中国人群 5种血小板同种抗原 (HPA1 5 )基因频率以及人类血小板同种抗原 (HPA)多态性与中国人急性心肌梗死和缺血性脑卒中的关系。方法 采用等位基因特异引物PCR结合PCR产物限制性酶切技术 ,检测 95例急性心肌梗死患者 ,188例缺血性脑卒中患者和 2 70例正常对照HPA1~ 5基因频率。HPA基因频率群体分布采用H W平衡检验 ,患者组和对照组HPA频率差异比较采用 χ2 检验。结果 湖南地区人群HPA基因频率分别为HPA1a,91% ;HPA1b ,9% ;HPA2a ,94% ;HPA2b ,6 % ;HPA3a ,83 % ;HPA3b ,17% ;HPA4a,98% ;HPA4b ,2 % ;HPA5a,97% ;HPA5b ,3 %。急性心肌梗死组HPA1 5基因频率和正常对照比较差异无显著意义。在缺血性脑卒中组虽然HPA 2a高于对照组 (P <0 .0 5 ) ,但二组该基因频率非常接近 (94% ,99% ) ,患者数和正常人重叠部分比例大 ,其他 4个HPA系统 2组无差异。结论 中国人群HPA多态性不是动脉血栓的危险因素 ,与急性心肌梗死和缺血性脑卒中等无...

目的 探讨湖南地区中国人群 5种血小板同种抗原 (HPA1 5 )基因频率以及人类血小板同种抗原 (HPA)多态性与中国人急性心肌梗死和缺血性脑卒中的关系。方法 采用等位基因特异引物PCR结合PCR产物限制性酶切技术 ,检测 95例急性心肌梗死患者 ,188例缺血性脑卒中患者和 2 70例正常对照HPA1~ 5基因频率。HPA基因频率群体分布采用H W平衡检验 ,患者组和对照组HPA频率差异比较采用 χ2 检验。结果 湖南地区人群HPA基因频率分别为HPA1a,91% ;HPA1b ,9% ;HPA2a ,94% ;HPA2b ,6 % ;HPA3a ,83 % ;HPA3b ,17% ;HPA4a,98% ;HPA4b ,2 % ;HPA5a,97% ;HPA5b ,3 %。急性心肌梗死组HPA1 5基因频率和正常对照比较差异无显著意义。在缺血性脑卒中组虽然HPA 2a高于对照组 (P <0 .0 5 ) ,但二组该基因频率非常接近 (94% ,99% ) ,患者数和正常人重叠部分比例大 ,其他 4个HPA系统 2组无差异。结论 中国人群HPA多态性不是动脉血栓的危险因素 ,与急性心肌梗死和缺血性脑卒中等无明显关系

Objective: To evaluate the efficacy and safety of Fragmin in the treatment of acute ischemic stroke (AIS). Methods: 98 cases of AIS patients were studied by comparison randomly. There were 56 cases in Fragmin group, 42 cases in control group. The neurologic outcome of all these patients pre - and post - treatment was observed with CSS, and the occurrence of bleeding events and mortality. Results: The therapeutic effect of Fragmin group was superior to that of control group in all...

Objective: To evaluate the efficacy and safety of Fragmin in the treatment of acute ischemic stroke (AIS). Methods: 98 cases of AIS patients were studied by comparison randomly. There were 56 cases in Fragmin group, 42 cases in control group. The neurologic outcome of all these patients pre - and post - treatment was observed with CSS, and the occurrence of bleeding events and mortality. Results: The therapeutic effect of Fragmin group was superior to that of control group in all cases (P<0. 05). The data showed that the therapeutic effect in VBA system Fragmin group was better than in control group (P < 0. 025 ). Fragmin's use was not associated with the clinically relevant bleeding risks and mortality. Conclusions: Fragmin is effective and safe in the treatment of AIS of VBA system.

目的:探讨低分子肝素钠(法安明)在急性脑梗死(AIS)治疗中的有效性和安全性。方法:对入选的98例AIS病人随机对照研究,法安明组56例,对照组42例。根据CSS对两组AIS病人治疗前后的神经功能状况进行分析比较,同时对比观察两组病人出血性合并症及病死率发生情况。结果:法安明组总体疗效优于对照组( P< 0. 05)。在椎基底动脉( VBA)系统中法安明组优于对照组,疗效有显著差异( P< 0. 025)。在安全性方面,法安明与出血性合并症及病死率与对照组无显著差异。结论:法安明治疗VBA系统AIS安全、有效。

To observe the effect of Shennaokang capsule(SNKC)on nervous function,lipoprotein and apolipoprotein in patients with acute ischemic stroke(AIS). Methods:400 patients with AIS were randomly divided into SNK group (212 cases)and the control group(188 cases),who were given SNKC and Naoyiqin tablet respectively for 8 weeks. HDL,LDL,apoA,apoB and the nervous function deficit score were determined before and after treatment. Results:After treatment,the nervous function deficit score...

To observe the effect of Shennaokang capsule(SNKC)on nervous function,lipoprotein and apolipoprotein in patients with acute ischemic stroke(AIS). Methods:400 patients with AIS were randomly divided into SNK group (212 cases)and the control group(188 cases),who were given SNKC and Naoyiqin tablet respectively for 8 weeks. HDL,LDL,apoA,apoB and the nervous function deficit score were determined before and after treatment. Results:After treatment,the nervous function deficit score of the treatment group was higher than that of the control group(P

目的 观察神脑康胶囊对急性缺血性中风患者神经功能、脂蛋白、载脂蛋白的影响。方法 400例急性缺血性中风患者随机分为神脑康组 212例,口服神脑康胶囊;对照组 188例,口服脑益嗪片,疗程均 8周,疗程前后测定高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)以及载脂蛋白 apoA、 apoB,并对患者进行神经功能缺损评分。结果 神脑康组治疗后神经功能缺损评分与对照组比较显著升高(P<0.01),总有效率为 95.8%,显著高于对照组 85.1% ( =13.46, P<0.01); HDL、 apoA与对照组比较升高显著 (P<0.01), LDL、 apoB与对照组比较下降明显 (P<0.05)。结论神脑康胶囊治疗急性缺血性中风能明显改善神经功能缺损程度,并能使患者的脂代谢紊乱得到改善。

 
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