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osteocalcin oc
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     ⑦ assay of osteocalcin.
     ⑦骨钙素的测定结果。
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     Osteocalcin and children's growth and development
     骨钙素与儿童生长发育
短句来源
     The serum was isolated to measure serum osteocalcin (BGP).
     分离血清 ,测定血清骨钙素 (BGP)水平。
短句来源
     Characteristics of Osteocalcin after Spinal Cord Injury (review)
     骨钙素与脊髓损伤
短句来源
     Objective:To study the serum levels of osteocalcin(BGP)in different ages.
     目的:探讨不同年龄段血清骨钙素水平的变化。
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  osteocalcin oc
The level of Osteoprotegerin (OPG), Osteocalcin (OC) and alkaline phosphatase activity (ALP) were evaluated.
      
When rabbit marrow stromal cells were cocultured with the composite, the alkaline phosphatase (ALP) and osteocalcin (OC) showed a dose response to the rhBMP-2 released from the composite, indicating that the activity of rhBMP-2 was retained.
      
The expression of selected markers typical of differentiated osteoblasts, such as alkaline phosphatase activity (ALP), type I collagen (CICP) and osteocalcin (OC) production, were also monitored in MG63 cells cultured on the tested materials.
      
The present study was designed to investigate relationships between urinary free pyridinolines (F-Pyr), serum osteocalcin (OC) and appendicular bone mineral density (BMD).
      
To investigate the role of osteocalcin (OC) in bones, bone parameters in warfarin (WF)-treated rats after ovariectomy (OVX) were compared with those in intact rats.
      
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Objective To study the bone metabolism of psoriasis vulgaris patients. Method The serum level of osteocalcin(Oc), parathyroid hormone(PTH) and calcium ion (Ca 2+ ) were determined by radioimmunoassay and EDTA trace in 46 psoriasis vulgaris patients and 36 control subjects. Result In psoriasis patients, the serum Oc level was significantly higher than in the control group( t=3.024,P <0 01), while the serum PTH and Ca 2+ values were much lower group(PTH: t=2.431,P <0 05;Ca...

Objective To study the bone metabolism of psoriasis vulgaris patients. Method The serum level of osteocalcin(Oc), parathyroid hormone(PTH) and calcium ion (Ca 2+ ) were determined by radioimmunoassay and EDTA trace in 46 psoriasis vulgaris patients and 36 control subjects. Result In psoriasis patients, the serum Oc level was significantly higher than in the control group( t=3.024,P <0 01), while the serum PTH and Ca 2+ values were much lower group(PTH: t=2.431,P <0 05;Ca 2+ : t=2.135,P <0 05). Conclusion There was abnormal bone metabolism in patients with psoriasis vulgaris.

①目的探讨银屑病病人骨组织代谢的变化。②方法应用放免分析法及EDTA滴定法测定46例寻常型银屑病及36例其他轻症皮肤病病人的血清骨钙素(Oc)、甲状旁腺素(PTH)和钙离子(Ca2+)的含量。③结果银屑病组血清Oc水平明显高于对照组(t=3.024,P<0.01),血清PTH及Ca2+水平低于对照组(PTH:t=2.431,P<0.05;Ca2+:t=2.153,P<0.05)。④结论银屑病病人的骨组织代谢存在异常。

Serum osteocalcin (OC), phosphorus (P), creatinine (Cr), urine pyridinol (PYD)and bone mineral density were measured in 38 cases. These patients include 10 cases of chronic renal failure, 18 cases surviving within two years following renal transplantation ,and 10 cases surviving over two years after transplantation. Marked elevation of serum osteocalcin (189. 7 ±45. 6), urine PYD( 68. 8 ±15 ) and bone mineral density of lumber spine were noted preoperatively. Serum osteocalcin levels...

Serum osteocalcin (OC), phosphorus (P), creatinine (Cr), urine pyridinol (PYD)and bone mineral density were measured in 38 cases. These patients include 10 cases of chronic renal failure, 18 cases surviving within two years following renal transplantation ,and 10 cases surviving over two years after transplantation. Marked elevation of serum osteocalcin (189. 7 ±45. 6), urine PYD( 68. 8 ±15 ) and bone mineral density of lumber spine were noted preoperatively. Serum osteocalcin levels decreased to near normal values within two years after transplantation, urine PYD maintain high levels,and bone density were still low. Serum osteocalcin,urine PYD and other markers basically decreased to normal levels over two years postoperatively,and the bone mineral densities were increased. The authors think that the serum osteocalcin ,urine PYD and bone mineral density can effectively monitor the variations of bone mineral metabolism in chronic renal failure and pre-or post-transplantation.

测定了38例病人的血清骨钙素(OC),肌酐(Cr),钙(Ca),磷(P)及尿吡啶酚(PYD),腰椎骨密度。其中肾移植前慢性肾衰病人10例,肾移植术后2年以内18例,术后超过2年的10例。本文认为慢性肾衰病人的骨代谢异常在肾移植术后不会迅速改善。血骨钙素,尿吡啶酚及骨密度可以有效的监测慢性肾病病人的骨代谢变化。

Ovariectomy has a proven pronounced effect on bone mass. Osteocalcin(OC) can be bound to hydroxyapatite. The aim of the study was to investigate the relationship between changes of three sorts of OC in serum and bone loss in rats ovariectomized for different periods. We measured serum total OC(OC(total)),OC with high affinity for hydroxyapatite (OC(bound)),OC with low affinity for hydroxyapatite (OC(free)), and bone mineral density in the third lumbar vertebra...

Ovariectomy has a proven pronounced effect on bone mass. Osteocalcin(OC) can be bound to hydroxyapatite. The aim of the study was to investigate the relationship between changes of three sorts of OC in serum and bone loss in rats ovariectomized for different periods. We measured serum total OC(OC(total)),OC with high affinity for hydroxyapatite (OC(bound)),OC with low affinity for hydroxyapatite (OC(free)), and bone mineral density in the third lumbar vertebra (L3). The results revealed that serum OC(total),OC(free) and OC(bound) significantly increased and bone mineral density in significantly decreased in rats ovariectomized for 15 days. Serum OC(total) had no change, but OC(free) significantly increased, OC(bound) and bone mineral density in L3 signlficantly decreased in rats ovariectomized for 30 days. Serum OC(total) and OC(free) significantly increased, serum OC(bround) had no change, and bone mineral density in L3 significantly reduced in rats ovariectomized for 60 days. The results suggest that the decrease in carboxylation effect on OC or uncoupling between increased secretion of OC by osteoblasts and carboxylation effect on OC in bones may be one of the important reasons for bone loss in ovariectomized rats. The possibility is put forward that serum OC(total) levels may be a marker of bone turnover, OC(bound) may be a marker of bone formation, and OC(free) may be a marker of bone loss.

本实验以卵巢切除(OVX)大鼠为动物模型,利用血骨钙素(Osteocalcin,OC)能够与羟磷灰石结合的特性,研究了OVX大鼠血清中总OC,与羟磷灰石具有高亲合力OC(结合型OC)和低亲合力OC(游离型OC)水平随时间变化的特点及与骨丢失的关系。实验结果显示,OVX15天大鼠血中总OC,结合型OC和游离型OC均显著增加,第3腰椎(L3)矿盐密度显著降低。OVX30天大鼠血清总OC水平无明显改变,但游离型OC水平显著增加,结合型OC水平显著降低,L3矿盐密度显著降低。OVX60天大鼠血清总OC和游离型OC显著增加,L3矿盐密度显著降低,但结合型OC无明显改变。实验结果提示,OVX大鼠骨盐丢失与骨内OC羧化作用降低或羧化作用与OC合成增加间脱偶联有关。血总OC可用于评价骨转换型的指标,血结合型OC可用于骨形成的指标,而游离型OC可用于判断骨丢失的指标。

 
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