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   fulminant hepatitis b 的翻译结果: 查询用时:0.209秒
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fulminant hepatitis b
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  重症乙型肝炎
     A Preliminary Study on Gene Mutation of HBV DNA in Patients with Fulminant Hepatitis B and HBV Genotyping in Henan
     重症乙型肝炎HBV DNA CP 区及前S区基因变异与河南地区HBV DNA 基因型的研究
短句来源
     (2) The most common viral genotype was B in the patients of henna with fulminant hepatitis B;
     (2)河南地区重症乙型肝炎患者HBV DNA以B基因型为主,而慢性乙型肝炎患者以B、C混合型为主,HBV DNAB基因型和重症乙型肝炎关系密切。
短句来源
     METHOD: (1)HBV DNA extracted from fulminant hepatitis B patients weresubjected to polymerase chain reaction and then polyacrylamide gel electrophoresis.
     (1)自16例重症乙型肝炎患者的血清提取HBV DNA,聚合酶链反应(PCR)扩增,PCR产物聚丙烯酰胺凝胶电泳。
短句来源
     The main indications for liver transplantation were HCC (26 cases), liver cirrhosis (21), fulminant hepatitis B (12), sclerosing cholangitis (4) and other terminal liver diseases (7).
     肝移植的主要指征是原发性肝癌(2 6例 )、肝硬化 (2 1例 )、重症乙型肝炎 (12例 )、硬化性胆管炎 (4例 )以及其它终末期肝病 (7例 )。
短句来源
     CONCLUSION: (1) The gene variation was randomly occurred in Pre-S gene of HBV DNA getted from patients with fulminant hepatitis B , especially in the right end Pre-S i ^ Pre-S2;
     (l)基因变异在重症乙型肝炎患者的HBV DNA的前S区随机出现,主要集中在前S;
短句来源
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  重型肝炎
     There was no significant difference in the serum levels of HBV DNA between the group of chronic fulminant hepatitis B(107.3731±1.4381copies/ml) and the non-fulminant group(106.6516±1.8046copies/ml).
     慢性重型肝炎组HBV DNA含量(107.3731±1.4381copies/ml)与非慢性重型肝炎组HBV DNA含量(106.6516±1.8046copies/ml)比较差异无统计学意义(P>0.05);
短句来源
     Results:The content ration of serum IL-18 in patients with different types of viral hepatitis was significantly higher than that in normal controls(P<0.01) . Serum IL-18 level was significantly different among patients with mild, media ,severe chronic hepatitis and fulminant hepatitis B (F=19.49,P<0.001).
     结果:病毒性肝炎患者血清IL-18水平均高于正常对照组(P<0.01),在轻、中、重度慢性乙型肝炎及重型肝炎各组间血清IL-18水平存在显著性差异,(F=19.49,P<0.001);
短句来源
     Then,the fragment was sequenced. ResultsOut of 30 patients with fulminant hepatitis B,the positive number of cases and the mean content of HBV DNA with BCP mutation were 18 and 2.71×10~7copies/ml,while the number of cases and the mean content of HBV DNA without BCP mutation were 12 and 5.35×10~6 copies/ml.
     结果30例乙型重型肝炎患者中BCP变异有18例,HB-VDNA平均水平为2.71×107copies/mL,未发生BCP变异者有12例,HBVDNA平均水平为5.35×106copies/mL,两者间有显著差异。
短句来源
     The percentage of hepatitis B virus precore A83 mutant and its dynamic change in fulminant hepatitis B
     重型肝炎血清HBV前C区A83变异株比率的动态观察
短句来源
     The positive rates of HDV markers were significantly higher in fulminant hepatitis B than those in acute hepatitis B (27.8% vs 5.3% P<0.05).
     结果发现重型肝炎组HOV-M检出率明显高于急性乙肝组(27.8%比5.3%.P<0.05)。
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  “fulminant hepatitis b”译为未确定词的双语例句
     Results 61cases (76.5%) developed bacterial infection in total of 68 cases with chronic fulminant hepatitis B and 33 cases developed bacterial infection in more than 2 sites.
     结果68例病人中发生继发感染者61例(76.5%),其中33例出现2个以上部位感染。
短句来源
     Among 143 samples tested, positive rate were found to be 62.1%, 63.6%, 66.0%, 100.0%, 22.2% and 0.0%, respectively in 58 cases of acute hepatitis B, 32 cases of chronic active hepatitis B, 9 cases of cirrhosis hepatitis B,8 cases of fulminant hepatitis B, fulminant subacute hepatitis B, liver cancer, 9 cases of chronic persistant hepatitis and 32 cases of assymptomatic carriers.
     在检测抗HBcIgA的148份临床血清标本中,58份急性乙肝、32份慢性活肝、9份肝硬化和8份重肝、亚重肝及肝癌的抗HBcIgA阳性率分别为62.1%、63.6%、66.0%和100.0%; 9例慢迁肝和32例无症状携带者的阳性率分别为22.2%和0.0%;
短句来源
     [Objective] To study the relationship between the expression of NKG2D gene in immunocytes and the severity of patients with chronic hepatitis B.[Methods] Blood samples were obtained from 20 patients with chronic fulminant hepatitis B,10 with asymtomatic surface antigen carriers and 10 healthy people(control group). NK cells were sorted and expression of NKG2D gene were quantitatively determined by Flow cytometry and immunofluorescent techniques.
     目的分析乙型肝炎免疫细胞NKG2D表达与肝病重型化的关系。 方法应用免疫荧光技术和流式细胞术(FCM)分选20例慢性重型乙肝(FHB)、10例无症状表面抗原携带者(ASC)、10例健康对照的外周血NK细胞,并定量分析NKG2D表达。
短句来源
     The Study on Quasispecies and Mutation of HBV Precore in Liver Tissue and Serum with Fulminant Hepatitis B Patients
     重型乙型肝炎患者肝组织和血清中HBV前C基因准种及变异特点研究
短句来源
     Study of Genes Expressed Differentially in Immunocyte of Patients with Fulminant Hepatitis B
     重型乙型肝炎免疫细胞差异表达基因研究
短句来源
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  fulminant hepatitis b
The association of HBV precore mutants and HBV core gene variations with fulminant hepatitis B and not acute hepatitis B suggested that these variations may be important in modulating the clinical course of HBV infection.
      
In addition, nine of the 10 fulminant hepatitis B patients had frequent nucleotide substitutions with corresponding changes in the predicted amino acid sequences in the mid-core and the 5' terminus region of the core gene.
      
For the 11 patients with fulminant hepatitis B, the precore/core regions were successfully amplified in 10 patients.
      
To determine the precore/core gene sequence in patients with acute and fulminant hepatitis B, 11 patients with fulminant hepatitis B and seven patients with acute hepatitis B were studied.
      
Whether this is also an important viral factor in the pathogenesis of acute and fulminant hepatitis B is unknown.
      
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A methoa of ACST-ELISA for the aetection ot anti-HBc IgA class in serum and its clinical significance was introduced. Among 143 samples tested, positive rate were found to be 62.1%, 63.6%, 66.0%, 100.0%, 22.2% and 0.0%, respectively in 58 cases of acute hepatitis B, 32 cases of chronic active hepatitis B, 9 cases of cirrhosis hepatitis B,8 cases of fulminant hepatitis B, fulminant subacute hepatitis B, liver cancer, 9 cases of chronic persistant hepatitis...

A methoa of ACST-ELISA for the aetection ot anti-HBc IgA class in serum and its clinical significance was introduced. Among 143 samples tested, positive rate were found to be 62.1%, 63.6%, 66.0%, 100.0%, 22.2% and 0.0%, respectively in 58 cases of acute hepatitis B, 32 cases of chronic active hepatitis B, 9 cases of cirrhosis hepatitis B,8 cases of fulminant hepatitis B, fulminant subacute hepatitis B, liver cancer, 9 cases of chronic persistant hepatitis and 32 cases of assymptomatic carriers. None was found to be positive in 98 cases without hepatitis. From this result it is seemed that Anti-HBc IgA in serum might be as if suggested of hepatic cellular damage in hepatitis B. Its detection might be helpful in the diagnosis of the disease and it prognosis as well. We recommended that the method of ACST-ELISA was good for use.

本文报道了用抗体捕获ELISA检测抗HBcIgA临床应用的初步结果。在检测抗HBcIgA的148份临床血清标本中,58份急性乙肝、32份慢性活肝、9份肝硬化和8份重肝、亚重肝及肝癌的抗HBcIgA阳性率分别为62.1%、63.6%、66.0%和100.0%;9例慢迁肝和32例无症状携带者的阳性率分别为22.2%和0.0%;正常对照组(98例健康献血员)无一例阳性。结果提示:抗HBcIgA与肝细胞损伤程度相关,是临床诊疗和预后判断的有价值的指标。表明本试剂盒具有良好的适用性和可用性。

In order to explore the role of HDV infection in fulminant hepatitis B, 54 patients with fulminant hepatitis B and 38 patients with acute hepatitis B were stuided for prevalence of anti-HD, anti-HD IgM and HDAg in serum with ELISA,and HDV RNA by dot- blot hybridization.The positive rates of HDV markers were significantly higher in fulminant hepatitis B than those in acute hepatitis B (27.8% vs 5.3% P<0.05).The positive rate of HDV RNA was 20.4%(11/54).The mortalities...

In order to explore the role of HDV infection in fulminant hepatitis B, 54 patients with fulminant hepatitis B and 38 patients with acute hepatitis B were stuided for prevalence of anti-HD, anti-HD IgM and HDAg in serum with ELISA,and HDV RNA by dot- blot hybridization.The positive rates of HDV markers were significantly higher in fulminant hepatitis B than those in acute hepatitis B (27.8% vs 5.3% P<0.05).The positive rate of HDV RNA was 20.4%(11/54).The mortalities were both high in simple HBV group (51.3%)and HDV/HBV group 33.3%.The results showed that HB associated with HDV infection usually aggravated the liver lesion and more often promoted the development of liver failure.

为了探讨丁型肝炎病毒(HDV)感染在重型病毒性肝炎中的作用,对北京佑安医院1980年至1989年收治的54例急性和亚急性重型肝炎和38例急性乙肝患者血清,应用国产HDVELISA试剂测定抗-HD、抗-HDIgM和HDAg,应用斑点杂交技术测定HDVRNA。结果发现重型肝炎组HOV-M检出率明显高于急性乙肝组(27.8%比5.3%.P<0.05)。单独HBV感染和HDV/HBV混合感染的重型肝炎患者均有较高的病死率。提示HDV感染是重型肝炎中重要的病原学因素之一,HDV与HBV具有协同作用加重肝损害,导致肝衰竭。

Serum samples from 18 HBV-infected patients were collected and subjected to nested polymerase chain reaction for amplification of the precore/core gene. Thirteen samples (2 from fulminant hepatitis B patients, 3 from chronic hepatitis B patients and 8 from hepatocellular carcinoma patients) yielded PCR products for sequencing. Except in one sample from a HCC patient, which had a 324-nucleotide fragment deletion in the core region, all other 12 patients had point mutations (ranged from 7 to...

Serum samples from 18 HBV-infected patients were collected and subjected to nested polymerase chain reaction for amplification of the precore/core gene. Thirteen samples (2 from fulminant hepatitis B patients, 3 from chronic hepatitis B patients and 8 from hepatocellular carcinoma patients) yielded PCR products for sequencing. Except in one sample from a HCC patient, which had a 324-nucleotide fragment deletion in the core region, all other 12 patients had point mutations (ranged from 7 to 25 nucleotides) and amino acid substitutions (ranged from 2 to 12 amino acid changes) in this region. Amino acid changes widely dispersed in 37 amino acids, and were rarely seen from amino acid 139-183, indicating that this region is relatively conserved. Analysis of amino acid changes in regard to the reported functional regions of the core protein, not many changes were found in the functional regions. Higher frequency of amino acid changes were found in HBcAg B cell epitope and the HBeAg el epitope. From the present data, no significant association between core gene mutation and the severity of liver disease was observed, however, more cases should be studied to draw the conclusion. Amino acid changes in codons 19,63,93,97 were found in at least 3 separate samples, suggesting their possible significance. Site-directed mutagenesis in theses codons and expression of these mutated core proteins are necessary for revealing the antigenic and immunogenic significance of these variants.

对18份不同类型的乙型肝炎病毒(HBV)感染者血清及4份肝癌组织,用套式PCR扩增PreC/C基因,结果15份标本(2份重症乙肝,3份慢性乙肝,8份肝癌患者血清及2份肝癌组织)可供进行核苷酸序列分析。12份血清标本在C区均出现点突变(7-25个核苷酸)并导致氨基酸改变(2-12个氨基酸)。1份肝癌患者的血清及癌组织与另1份癌组织中获得的C基因克隆有213-324个核苷酸缺失。氨基酸的改变分布于37个氨基酸,但很少见于第139-183位氨基酸。根据已知C基因编码的功能区分析,以诱生HBcAg抗体的B细胞表位及HBe1的B细胞表位相对较多见。比较不同类型HBV感染者中HBVC基因变异率,未见明显差别,尚需对更多例数作研究。有4个氨基酸(第19,63,93,97位)改变在3份以上标本中重复出现。对这些密码子的核苷酸作定位点突变及抗原表达将进一步阐明其意义。

 
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