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transdermal fentanyl
相关语句
  透皮芬太尼
    A clinical study on the transdermal fentanyl used for postoperative pain relief
    透皮芬太尼贴剂用于术后镇痛的临床研究
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  “transdermal fentanyl”译为未确定词的双语例句
    Methods: 10mg morphine and 25μg/h (or 50μg/h) fentanyl were immediately used in 34 patients who had underwent interventional embolization therapy, then the abirritation and side effect of transdermal fentanyl were obseved.
    方法介入治疗栓塞术病人34例,于术后即刻给予吗啡10mg肌注及使用TDF,剂型25μg/h和50μg/h二种,术后观察镇痛效果及相关的副作用。
短句来源
    Transdermal fentanyl for the relief of pain after upper abdominal surgery
    多瑞吉用于术后镇痛的临床研究
短句来源
    Clinical observation of abirritation and side-effect of transdermal fentanyl (TDF) in interventional embolization therapy
    芬太尼缓释透皮贴剂治疗介入栓塞术后疼痛的疗效观察
短句来源
    Object To research the feasibility, efficacy and method of transdermal fentanyl(TDF) in the treatment of postoperative pain.
    目的:探讨芬太尼缓释透皮贴剂(TDF)用于术后镇痛的可行性、优越性及具体实施方案。
短句来源
    The direct conversion ratio from oral morphine to transdermal fentanyl system (TFS) was 100:1 daily.
    40例晚期癌痛患者作为研究对象 ,试验前口服吗啡的患者按 10 0 :1的比例转换为芬太尼贴剂 ;
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  transdermal fentanyl
Pain Recurrence on the Third Day after Application of a Transdermal Fentanyl Patch
      
Neurophysiologic disorders developed in three patients after discontinuation of transdermal fentanyl (TDF) at a daily dose of 0.6?mg (2.5?mg per a patch), although direct removal of a 2.5?mg patch is permitted by the manufacturer as the
      
Withdrawal symptom after discontinuation of transdermal fentanyl at a daily dose of 0.6 mg
      
Transdermal fentanyl treatment in opioid-na?ve cancer patients
      
Transdermal fentanyl seems to be a good palliative measure to treat CNH in patients who have advanced neoplasms.
      
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Objective To evaluate the pain control, general condition and well-being of the patients with advanced cancer treated with transdermal fentanyl as well as the effects of transdermal fentanyl on heart rate variability (HRV) and endocrine function. Methods This open prospective study included 40 patients with advanced cancer. The direct conversion ratio from oral morphine to transdermal fentanyl system (TFS) was 100:1 daily. In patients who had never received any opioid before the initial...

Objective To evaluate the pain control, general condition and well-being of the patients with advanced cancer treated with transdermal fentanyl as well as the effects of transdermal fentanyl on heart rate variability (HRV) and endocrine function. Methods This open prospective study included 40 patients with advanced cancer. The direct conversion ratio from oral morphine to transdermal fentanyl system (TFS) was 100:1 daily. In patients who had never received any opioid before the initial dose of TFS was 25μg/h. The transdermal system was changed every 72h and the dosage was adjusted to the need of the patients according to the VAS scores and the requirement of morphine. 8 hospitalized patients were monitored by 24h Holter for changes in HRV. Blood samples were taken before transdermal fentanyl patch when pain was severe and 24h after TFS for determination of ACTH,β-endorphin, growth hormone(GH) and insulin levels.Results Pain relief during treatment with transdermal fentanyl was significant accoring to VAS scores. Well-being scores showed that patients' quality of life including appetite, sleep, mental state and daily activities was significantly improved after two weeks treatment. The ratio of LF vs HF, which is one of HRV frequency indices, was obviously reduced at 24h after transdermal fentanyl patch as compared with that before TFS (P<0.05). TFS significantly reduced plasma ACTH, β-endorphin and insulin levels, but the change in GH was not significant. No respiratory depression was observed. The incidences of constipation, nausea and vomiting and skin pruritus did not markedly changed following long-term TFS.Conclusions Transdermal fentanyl provides an effective , safe treatment modality in patients with cancer pain with low side effects.

目的 评价芬太尼贴剂的镇痛效果 ,和对心率变异性 (HRV)及机体应激状态的影响。方法 本研究为前瞻、开放试验。 40例晚期癌痛患者作为研究对象 ,试验前口服吗啡的患者按 10 0 :1的比例转换为芬太尼贴剂 ;未用过阿片类药物者 ,初始芬太尼剂量为 2 5 μg/h贴剂。透皮系统每 72h更换一次 ,剂量根据患者疼痛自我评分 (VAS)和对注射吗啡的需要量调整。结果 芬太尼贴剂治疗期间患者疼痛明显缓解 ,VAS评分与治疗前相比明显降低 (P <0 0 1)。治疗 2周时 ,问卷调查显示患者的睡眠、精神状态以及日常生活较治疗前明显改善。贴剂治疗 2 4h后HRV的低频功率 (LF)与高频功率 (HF)之比明显低于治疗前 ,而应激激素促肾上腺皮质激素 (ACTH)、β 内啡肽和胰岛素也明显降低 (P <0 0 1) ,但生长激素波动不明显。无一例发生呼吸抑制 ,便秘、恶心呕吐及皮肤瘙痒发生率 ,用药前后均无显著性变化。结论 芬太尼贴剂用于治疗晚期癌痛有效、安全、副作用小 ,其良好的镇痛效果对机体的应激反应和植物神经功能平衡均产生有益影响

Objective To evaluate the safety and efficacy of transdermal fentanyl for postoperative pain management.Methods 27 patients undergoing elective upper abdominal surgery were randomly entered into two groups,durogesic group (group D,13 cases)and placebo group (group C,14 cases).45min before the operation two patchs of durogesic each rated to deliver fentanly at 25μg/h were applied to the subclavian skin and worn for 24 hours in group D,and...

Objective To evaluate the safety and efficacy of transdermal fentanyl for postoperative pain management.Methods 27 patients undergoing elective upper abdominal surgery were randomly entered into two groups,durogesic group (group D,13 cases)and placebo group (group C,14 cases).45min before the operation two patchs of durogesic each rated to deliver fentanly at 25μg/h were applied to the subclavian skin and worn for 24 hours in group D,and two patches without drugs were used in group C.All patients experienced general anesthesia with propofol,fentanyl,isoflurane,and vecuronium.As soon as the operations ended,all patients were transferred to the PACU.After extubation,the patient controlled analgesia pumps were used if patients complained of pain.All patients were monitored ECG,RR,SpO 2,NBP for 44h and the administered dosage of morphine and VAS were recorded every 4h.Results (1)The group D demanded significantly less morphine than the group C after 8h;(2)The VAS of group D was significantly lower than that of group C during the whole monitoring period;(3)The evidence of respiratory depression was not found in any patients;(4)There was no difference between two groups in the incidence of adverse effects such as nause,vomiting,urinary retention,pruritus.Conclusions Transdermal fentanyl may be useful in the treatment of pain after surgery if proper dosage and proper method were selected.

目的 探讨多瑞吉用于术后镇痛的效能和安全性。方法 择期上腹部手术病人 2 7例 ,随机分为两组 ,多瑞吉组 (D组 ) 13例 ,对照组 (C组 ) 14例。术前 45分钟 ,D组两侧锁骨下各贴 1片 2 5 μg/h的贴膜 ,C组予不含药物的贴片。贴膜应用 2 4小时后 ,两组病人均去除贴膜。术中两组均采用气管插管静吸复合麻醉 ,手术结束病人立即送PACU ,拔管、病人清醒诉痛后 ,应用吗啡PCA泵 ,所有病人持续监测SpO2 、RR、ECG、NBP 44小时 ,每隔 4小时记录一次吗啡用量、VAS评分 ,并观察有无恶心、呕吐、瘙痒、尿潴留等副反应。结果  (1)镇痛效果 :术后各时段D组VAS评分均明显优于C组 ;(2 )吗啡用量 :术后 4小时、8小时D组吗啡用量与C组无统计学差异 ,8小时后D组吗啡用量明显少于C组 ;(3)呼吸影响 :两组病例均未出现SpO2 低于 90 % ,D组呼吸频率术后与术前无明显差异 ;(4)副反应 :恶心、呕吐、瘙痒、尿潴留发生率两组相似。结论  5 0 μg/h多瑞吉用于成人 1小时左右上腹部手术是安全有效的 ,并且不明显增加副反应发生

Objective To observe the effect of transdermal fentanyl and intravenous morphine on postoperative pain relieve and stress. Methods Thirty patients undergoing upper abdominal surgery were divided into three groups: group A (transdermal fentanyl) , group B (intravenous morphy) , group C (placebo). The VAS was assessed at 4, 8, 12, 24h postoperatively and adverse effects such as nause and vomiting were also recorded. The plasma cortisol was examined on the afternoon of the surgical day and the day before...

Objective To observe the effect of transdermal fentanyl and intravenous morphine on postoperative pain relieve and stress. Methods Thirty patients undergoing upper abdominal surgery were divided into three groups: group A (transdermal fentanyl) , group B (intravenous morphy) , group C (placebo). The VAS was assessed at 4, 8, 12, 24h postoperatively and adverse effects such as nause and vomiting were also recorded. The plasma cortisol was examined on the afternoon of the surgical day and the day before surgery. Results The VAS in group A and B were significently lower than group C at 8, 12h (P < 0. 05). There were no siginificent differences on VAS between group A and B. All patients plasma cortisol were significently increased postoperatively. Although the mean values of group A B were lower than group C, the plasma cortisol was not significently different among three groups. Conclusion The transdermal fentanyl can effectively relieve the postoperative pain with similar analgesic effect and occurrence of adverse events in comparison with morphine.

目的 探讨芬太尼透皮贴剂与吗啡静注用于术后镇痛效果的比较及其对机体应激状态的影响。方法30例上腹部手术的病人随机分为A、B、C三组,分别予以芬太尼透皮贴剂、吗啡及安慰剂,术后4、8、12、24、48h行VAS评分,记录恶心呕吐等副反应的发生情况,并在术前日及术当日测血浆皮质醇浓度。结果VAS评分,A、B组8、12h明显低于C组(P<0.05),A、B两组无显著性差异;三组病人的术后血浆皮质醇浓度明显高于术前(P<0.05),而术后A、B、C三组之间,虽A、B组明显低于C组,但无显著性差异。结论 芬太尼透皮贴剂能有效地缓解术后疼痛,其镇痛效果等同于吗啡,同时不增加副作用的发生率。

 
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